田中 明人
| 化学系薬学分野 | 教授 |
Last Updated :2024/12/13
研究者情報
研究活動情報
論文
- Identification of HUHS190, a human naftopidil metabolite, as a novel anti-bladder cancer drug.
Tadashi Shimizu; Keiko Yamaguchi; Momoka Yamamoto; Rina Kurioka; Yukari Kino; Wataru Matsunaga; Syuhei Nakao; Hiroshi Fukuhara; Akito Tanaka; Akinobu Gotoh; Miyuki Mabuchi
Bioorganic & medicinal chemistry letters, 2020年01月 - Novel Metabolically Stable PCA-1/ALKBH3 Inhibitor Has Potent Antiproliferative Effects on DU145 Cells In Vivo.
Masahiro Ueda; Tadashi Shimizu; Miyuki Mabuchi; Kota Horiike; Kaori Kitae; Hiroaki Hase; Yuko Ueda; Kazutake Tsujikawa; Akito Tanaka
Anticancer research, 2018年01月 - Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor.
Syuhei Nakao; Miyuki Mabuchi; Shenglan Wang; Yoko Kogure; Tadashi Shimizu; Koichi Noguchi; Akito Tanaka; Yi Dai
Bioorganic & medicinal chemistry letters, 2017年07月 - Selective degradation of splicing factor CAPERα by anticancer sulfonamides.
Taisuke Uehara; Yukinori Minoshima; Koji Sagane; Naoko Hata Sugi; Kaoru Ogawa Mitsuhashi; Noboru Yamamoto; Hiroshi Kamiyama; Kentaro Takahashi; Yoshihiko Kotake; Mai Uesugi; Akira Yokoi; Atsushi Inoue; Taku Yoshida; Miyuki Mabuchi; Akito Tanaka; Takashi Owa
Nature chemical biology, 2017年06月 - Systematic Trial for Evaluating Docetaxel in a Human Prostate Cancer Cell DU145 Xenograft Model.
Miyuki Mabuchi; Masahiro Ueda; Yuri Yoshida; Kota Horiike; Kenta Yamaoka; Syuhei Nakao; Tadashi Shimizu; Yuko Ueda; Kazutake Tsujikawa; Akito Tanaka
Anticancer research, 2017年04月 - Combination of PKCε Activation and PTP1B Inhibition Effectively Suppresses Aβ-Induced GSK-3β Activation and Tau Phosphorylation.
Takeshi Kanno; Ayako Tsuchiya; Akito Tanaka; Tomoyuki Nishizaki
Molecular neurobiology, 2016年09月 - The phosphatidylethanolamine derivative diDCP-LA-PE mimics intracellular insulin signaling.
Tomoyuki Nishizaki; Akinobu Gotoh; Tadashi Shimizu; Akito Tanaka
Scientific reports, 2016年06月 - HUHS1015 Suppresses Colonic Cancer Growth by Inducing Necrosis and Apoptosis in Association with Mitochondrial Damage.
Yoshiko Kaku; Ayako Tsuchiya; Tadashi Shimizu; Akito Tanaka; Tomoyuki Nishizaki
Anticancer research, 2016年01月 - Phosphatidylinositol Derivatives Induce Gastric Cancer Cell Apoptosis by Accumulating AIF and AMID in the Nucleus.
Masato Ohyama; Ayako Tsuchiya; Yoshiko Kaku; Takeshi Kanno; Tadashi Shimizu; Akito Tanaka; Tomoyuki Nishizaki
Anticancer research, 2015年12月 - Identification and purification of target protein using affinity resin bearing a photo-labile linker.
Miyuki Mabuchi; Tadashi Shimizu; Masayuki Haramura; Akito Tanaka
Bioorganic & medicinal chemistry letters, 2015年08月 - Improvement of solid material for affinity resins by application of long PEG spacers to capture the whole target complex of FK506.
Miyuki Mabuchi; Tadashi Shimizu; Masahiro Ueda; Kuniko Mitamura; Shigeo Ikegawa; Akito Tanaka
Bioorganic & medicinal chemistry letters, 2015年07月 - Linoleic acid derivative DCP-LA ameliorates stress-induced depression-related behavior by promoting cell surface 5-HT1A receptor translocation, stimulating serotonin release, and inactivating GSK-3β.
Takeshi Kanno; Akito Tanaka; Tomoyuki Nishizaki
Molecular neurobiology, 2015年04月 - The newly synthesized anticancer drug HUHS1015 is useful for treatment of human gastric cancer.
Yoshiko Kaku; Ayako Tsuchiya; Takeshi Kanno; Shuhei Nakao; Tadashi Shimizu; Akito Tanaka; Tomoyuki Nishizaki
Cancer chemotherapy and pharmacology, 2015年03月 - Improving the bioavailability and anticancer effect of the PCA-1/ALKBH3 inhibitor HUHS015 using sodium salt.
Miyuki Mabuchi; Tadashi Shimizu; Masahiro Ueda; Yuka Sasakawa; Syuhei Nakao; Yuko Ueda; Akio Kawamura; Kazutake Tsujikawa; Akito Tanaka
In vivo (Athens, Greece), 2015年 - DCP-LA Activates Cytosolic PKCε by Interacting with the Phosphatidylserine Binding/Associating Sites Arg50 and Ile89 in the C2-Like Domain.
Takeshi Kanno; Ayako Tsuchiya; Tadashi Shimizu; Miyuki Mabuchi; Akito Tanaka; Tomoyuki Nishizaki
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2015年 - 1-[2-(2-Methoxyphenylamino)ethylamino]-3-(naphthalene-1- yloxy)propan-2-ol may be a promising anticancer drug.
Tomoyuki Nishizaki; Takeshi Kanno; Ayako Tsuchiya; Yoshiko Kaku; Tadashi Shimizu; Akito Tanaka
Molecules (Basel, Switzerland), 2014年12月 - Newly synthesized anticancer drug HUHS1015 is effective on malignant pleural mesothelioma.
Yoshiko Kaku; Hisao Nagaya; Ayako Tsuchiya; Takeshi Kanno; Akinobu Gotoh; Akito Tanaka; Tadashi Shimizu; Syuhei Nakao; Chiharu Tabata; Takashi Nakano; Tomoyuki Nishizaki
Cancer science, 2014年07月 - A novel PP2A enhancer induces caspase-independent apoptosis of MKN28 gastric cancer cells with high MEK activity.
Ayako Tsuchiya; Takeshi Kanno; Tadashi Shimizu; Syuhei Nakao; Akito Tanaka; Chiharu Tabata; Takashi Nakano; Tomoyuki Nishizaki
Cancer letters, 2014年05月 - Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs.
Syuhei Nakao; Miyuki Mabuchi; Tadashi Shimizu; Yoshihiro Itoh; Yuko Takeuchi; Masahiro Ueda; Hiroaki Mizuno; Naoko Shigi; Ikumi Ohshio; Kentaro Jinguji; Yuko Ueda; Masatatsu Yamamoto; Tatsuhiko Furukawa; Shunji Aoki; Kazutake Tsujikawa; Akito Tanaka
Bioorganic & medicinal chemistry letters, 2014年02月 - DCP-LA-phosphatidylinositol and its enantiomer exhibit different bioactivities.
Ayako Tsuchiya; Takeshi Kanno; Tadashi Shimizu; Syuhei Nakao; Akito Tanaka; Tomoyuki Nishizaki
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2014年 - The linoleic acid derivative DCP-LA increases membrane surface localization of the α7 ACh receptor in a protein 4.1N-dependent manner.
Takeshi Kanno; Ayako Tsuchiya; Akito Tanaka; Tomoyuki Nishizaki
The Biochemical journal, 2013年03月 - Regulation of GluA1 AMPA receptor through PKC phosphorylation induced by free fatty acid derivative HUHS2002.
Takaaki Nishimoto; Takeshi Kanno; Tadashi Shimizu; Akito Tanaka; Tomoyuki Nishizaki
Lipids, 2013年01月 - Effects of newly synthesized DCP-LA-phospholipids on protein kinase C and protein phosphatases.
Takeshi Kanno; Ayako Tsuchiya; Tadashi Shimizu; Syuhei Nakao; Akito Tanaka; Tomoyuki Nishizaki
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2013年 - 1-[2-(2-Methoxyphenylamino)ethylamino]-3-(naphthalene-1-yloxy)propan-2-ol as a potential anticancer drug.
Takeshi Kanno; Akito Tanaka; Tadashi Shimizu; Takashi Nakano; Tomoyuki Nishizaki
Pharmacology, 2013年 - Free fatty acid derivative HUHS2002 potentiates α7 ACh receptor responses through indirect activation of CaMKII.
Takeshi Kanno; Tadashi Shimizu; Akito Tanaka; Takaaki Nishimoto; Tomoyuki Nishizaki
Lipids, 2012年09月 - 8-[2-(2-Pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid and its diastereomers improve age-related cognitive deterioration.
Takeshi Kanno; Takahiro Yaguchi; Tadashi Shimizu; Akito Tanaka; Tomoyuki Nishizaki
Lipids, 2012年07月 - Indomethacin enhances learning and memory potential by interacting with CaMKII.
Takeshi Kanno; Takahiro Yaguchi; Tetsu Nagata; Tadashi Shimizu; Akito Tanaka; Tomoyuki Nishizaki
Journal of cellular physiology, 2012年03月 - Linoleic acid derivative DCP-LA stimulates vesicular transport of α7 ACh receptors towards surface membrane.
Takeshi Kanno; Akito Tanaka; Tomoyuki Nishizaki
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2012年 - Novel indomethacin action: selective and direct activation of protein kinase C-ε.
Takeshi Kanno; Ayako Tsuchiya; Tadashi Shimizu; Akito Tanaka; Tomoyuki Nishizaki
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2012年 - Indomethacin serves as a potential inhibitor of protein phosphatases.
Takeshi Kanno; Ayako Tsuchiya; Tadashi Shimizu; Akito Tanaka; Tomoyuki Nishizaki
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2012年 - α, β-DCP-LA selectively activates PKC-ε and stimulates neurotransmitter release with the highest potency among 4 diastereomers.
Tadashi Shimizu; Takeshi Kanno; Akito Tanaka; Tomoyuki Nishizaki
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2011年 - Selective elution of target protein from affinity resins by a simple reductant with a thiol group.
Miyuki Mabuchi; Masayuki Haramura; Tadashi Shimizu; Tomoyuki Nishizaki; Akito Tanaka
Bioorganic & medicinal chemistry letters, 2010年12月 - DCP-LA stimulates AMPA receptor exocytosis through CaMKII activation due to PP-1 inhibition.
Takeshi Kanno; Takahiro Yaguchi; Tetsu Nagata; Akito Tanaka; Tomoyuki Nishizaki
Journal of cellular physiology, 2009年10月 - [Identification of specific binding protein using affinity resins for discovery of drug target].
Akito Tanaka
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2009年09月 - Improvement of monolithic solid material by utilization of spacer for identification of the target using affinity resins.
Emiko Iwaoka; Tomoko Mori; Tadashi Shimizu; Ken Hosoya; Akito Tanaka
Bioorganic & medicinal chemistry letters, 2009年03月 - Identification of the specific binding proteins of bioactive small compound using affinity resins.
Akito Tanaka
Methods in molecular biology (Clifton, N.J.), 2009年 - Properties of flaky affinity resin with co-continuous structure.
Tomoko Mori; Akito Tanaka; Takuya Kubo; Kunimitsu Kaya; Mari Sakamoto; Ken Hosoya
Bioorganic & medicinal chemistry, 2008年02月 - [A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase].
Akito Tanaka
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2007年10月 - An easy preparation of 'monolithic type' hydrophilic solid phase: capability for affinity resin to isolate target proteins.
Tomoko Mori; Teruki Takahashi; Takaaki Shiyama; Akito Tanaka; Natsuki Hira; Nobuo Tanaka; Ken Hosoya
Bioorganic & medicinal chemistry, 2006年08月 - The linoleic acid derivative DCP-LA selectively activates PKC-epsilon, possibly binding to the phosphatidylserine binding site.
Takeshi Kanno; Hideyuki Yamamoto; Takahiro Yaguchi; Rika Hi; Takeshi Mukasa; Hirokazu Fujikawa; Tetsu Nagata; Satoshi Yamamoto; Akito Tanaka; Tomoyuki Nishizaki
Journal of lipid research, 2006年06月 - A versatile method of identifying specific binding proteins on affinity resins.
Kiyoshi Yamamoto; Akira Yamazaki; Mikio Takeuchi; Akito Tanaka
Analytical biochemistry, 2006年05月 - Isolating the whole complex of target proteins of FK506 using affinity resins from novel solid phases.
Teruki Takahashi; Takaaki Shiyama; Tomoko Mori; Ken Hosoya; Akito Tanaka
Analytical and bioanalytical chemistry, 2006年05月 - Linoleic acid derivative DCP-LA improves learning impairment in SAMP8.
Takahiro Yaguchi; Tetsu Nagata; Takeshi Mukasa; Hirokazu Fujikawa; Hideyuki Yamamoto; Satoshi Yamamoto; Hiroyuki Iso; Akito Tanaka; Tomoyuki Nishizaki
Neuroreport, 2006年01月 - Development of chemically stable solid phases for the target isolation with reduced nonspecific binding proteins.
Teruki Takahashi; Takaaki Shiyama; Ken Hosoya; Akito Tanaka
Bioorganic & medicinal chemistry letters, 2006年01月 - Reduction of nonspecific binding proteins to self-assembled monolayer on gold surface.
Minoru Furuya; Masayuki Haramura; Akito Tanaka
Bioorganic & medicinal chemistry, 2006年01月 - 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid stimulates GABA release from interneurons projecting to CA1 pyramidal neurons in the rat hippocampus via pre-synaptic alpha7 acetylcholine receptors.
Takeshi Kanno; Takahiro Yaguchi; Satoshi Yamamoto; Hideyuki Yamamoto; Hirokazu Fujikawa; Tetsu Nagata; Akito Tanaka; Tomoyuki Nishizaki
Journal of neurochemistry, 2005年11月 - Effects of cis-unsaturated free fatty acids on PKC-epsilon activation and nicotinic ACh receptor responses.
Takahiro Yaguchi; Satoshi Yamamoto; Tetsu Nagata; Takeshi Kanno; Akito Tanaka; Tomoyuki Nishizaki
Brain research. Molecular brain research, 2005年02月 - Design and synthesis of novel hydrophilic spacers for the reduction of nonspecific binding proteins on affinity resins.
Takaaki Shiyama; Minoru Furuya; Akira Yamazaki; Tomohiro Terada; Akito Tanaka
Bioorganic & medicinal chemistry, 2004年06月 - Stearic acid facilitates hippocampal neurotransmission by enhancing nicotinic ACh receptor responses via a PKC pathway.
Kohei Ohta; Hirohito Miyamoto; Takahiro Yaguchi; Kaoru Nagai; Satoshi Yamamoto; Tamotsu Nomura; Akito Tanaka; Tomoyuki Nishizaki
Brain research. Molecular brain research, 2003年11月 - The newly synthesized linoleic acid derivative FR236924 induces a long-lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors.
Akito Tanaka; Tomoyuki Nishizaki
Bioorganic & medicinal chemistry letters, 2003年03月 - A quantitative analysis and chemical approach for the reduction of nonspecific binding proteins on affinity resins.
Tsuruki Tamura; Tomohiro Terada; Akito Tanaka
Bioconjugate chemistry, 2003年 - FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases.
Ryohei Furumai; Akihisa Matsuyama; Nobuyuki Kobashi; Kun-Hyung Lee; Makoto Nishiyama; Hidenori Nakajima; Akito Tanaka; Yasuhiko Komatsu; Norikazu Nishino; Minoru Yoshida; Sueharu Horinouchi
Cancer research, 2002年09月
