Last Updated :2025/03/27
Researcher Information
Research activity information
Paper
- Identification of HUHS190, a human naftopidil metabolite, as a novel anti-bladder cancer drug.
Tadashi Shimizu; Keiko Yamaguchi; Momoka Yamamoto; Rina Kurioka; Yukari Kino; Wataru Matsunaga; Syuhei Nakao; Hiroshi Fukuhara; Akito Tanaka; Akinobu Gotoh; Miyuki Mabuchi
Bioorganic & medicinal chemistry letters, Jan. 2020 - Novel Metabolically Stable PCA-1/ALKBH3 Inhibitor Has Potent Antiproliferative Effects on DU145 Cells In Vivo.
Masahiro Ueda; Tadashi Shimizu; Miyuki Mabuchi; Kota Horiike; Kaori Kitae; Hiroaki Hase; Yuko Ueda; Kazutake Tsujikawa; Akito Tanaka
Anticancer research, Jan. 2018 - Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor.
Syuhei Nakao; Miyuki Mabuchi; Shenglan Wang; Yoko Kogure; Tadashi Shimizu; Koichi Noguchi; Akito Tanaka; Yi Dai
Bioorganic & medicinal chemistry letters, Jul. 2017 - Selective degradation of splicing factor CAPERα by anticancer sulfonamides.
Taisuke Uehara; Yukinori Minoshima; Koji Sagane; Naoko Hata Sugi; Kaoru Ogawa Mitsuhashi; Noboru Yamamoto; Hiroshi Kamiyama; Kentaro Takahashi; Yoshihiko Kotake; Mai Uesugi; Akira Yokoi; Atsushi Inoue; Taku Yoshida; Miyuki Mabuchi; Akito Tanaka; Takashi Owa
Nature chemical biology, Jun. 2017 - Systematic Trial for Evaluating Docetaxel in a Human Prostate Cancer Cell DU145 Xenograft Model.
Miyuki Mabuchi; Masahiro Ueda; Yuri Yoshida; Kota Horiike; Kenta Yamaoka; Syuhei Nakao; Tadashi Shimizu; Yuko Ueda; Kazutake Tsujikawa; Akito Tanaka
Anticancer research, Apr. 2017 - Combination of PKCε Activation and PTP1B Inhibition Effectively Suppresses Aβ-Induced GSK-3β Activation and Tau Phosphorylation.
Takeshi Kanno; Ayako Tsuchiya; Akito Tanaka; Tomoyuki Nishizaki
Molecular neurobiology, Sep. 2016 - The phosphatidylethanolamine derivative diDCP-LA-PE mimics intracellular insulin signaling.
Tomoyuki Nishizaki; Akinobu Gotoh; Tadashi Shimizu; Akito Tanaka
Scientific reports, Jun. 2016 - HUHS1015 Suppresses Colonic Cancer Growth by Inducing Necrosis and Apoptosis in Association with Mitochondrial Damage.
Yoshiko Kaku; Ayako Tsuchiya; Tadashi Shimizu; Akito Tanaka; Tomoyuki Nishizaki
Anticancer research, Jan. 2016 - Phosphatidylinositol Derivatives Induce Gastric Cancer Cell Apoptosis by Accumulating AIF and AMID in the Nucleus.
Masato Ohyama; Ayako Tsuchiya; Yoshiko Kaku; Takeshi Kanno; Tadashi Shimizu; Akito Tanaka; Tomoyuki Nishizaki
Anticancer research, Dec. 2015 - Identification and purification of target protein using affinity resin bearing a photo-labile linker.
Miyuki Mabuchi; Tadashi Shimizu; Masayuki Haramura; Akito Tanaka
Bioorganic & medicinal chemistry letters, Aug. 2015 - Improvement of solid material for affinity resins by application of long PEG spacers to capture the whole target complex of FK506.
Miyuki Mabuchi; Tadashi Shimizu; Masahiro Ueda; Kuniko Mitamura; Shigeo Ikegawa; Akito Tanaka
Bioorganic & medicinal chemistry letters, Jul. 2015 - Linoleic acid derivative DCP-LA ameliorates stress-induced depression-related behavior by promoting cell surface 5-HT1A receptor translocation, stimulating serotonin release, and inactivating GSK-3β.
Takeshi Kanno; Akito Tanaka; Tomoyuki Nishizaki
Molecular neurobiology, Apr. 2015 - The newly synthesized anticancer drug HUHS1015 is useful for treatment of human gastric cancer.
Yoshiko Kaku; Ayako Tsuchiya; Takeshi Kanno; Shuhei Nakao; Tadashi Shimizu; Akito Tanaka; Tomoyuki Nishizaki
Cancer chemotherapy and pharmacology, Mar. 2015 - Improving the bioavailability and anticancer effect of the PCA-1/ALKBH3 inhibitor HUHS015 using sodium salt.
Miyuki Mabuchi; Tadashi Shimizu; Masahiro Ueda; Yuka Sasakawa; Syuhei Nakao; Yuko Ueda; Akio Kawamura; Kazutake Tsujikawa; Akito Tanaka
In vivo (Athens, Greece), 2015 - DCP-LA Activates Cytosolic PKCε by Interacting with the Phosphatidylserine Binding/Associating Sites Arg50 and Ile89 in the C2-Like Domain.
Takeshi Kanno; Ayako Tsuchiya; Tadashi Shimizu; Miyuki Mabuchi; Akito Tanaka; Tomoyuki Nishizaki
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2015 - 1-[2-(2-Methoxyphenylamino)ethylamino]-3-(naphthalene-1- yloxy)propan-2-ol may be a promising anticancer drug.
Tomoyuki Nishizaki; Takeshi Kanno; Ayako Tsuchiya; Yoshiko Kaku; Tadashi Shimizu; Akito Tanaka
Molecules (Basel, Switzerland), Dec. 2014 - Newly synthesized anticancer drug HUHS1015 is effective on malignant pleural mesothelioma.
Yoshiko Kaku; Hisao Nagaya; Ayako Tsuchiya; Takeshi Kanno; Akinobu Gotoh; Akito Tanaka; Tadashi Shimizu; Syuhei Nakao; Chiharu Tabata; Takashi Nakano; Tomoyuki Nishizaki
Cancer science, Jul. 2014 - A novel PP2A enhancer induces caspase-independent apoptosis of MKN28 gastric cancer cells with high MEK activity.
Ayako Tsuchiya; Takeshi Kanno; Tadashi Shimizu; Syuhei Nakao; Akito Tanaka; Chiharu Tabata; Takashi Nakano; Tomoyuki Nishizaki
Cancer letters, May 2014 - Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs.
Syuhei Nakao; Miyuki Mabuchi; Tadashi Shimizu; Yoshihiro Itoh; Yuko Takeuchi; Masahiro Ueda; Hiroaki Mizuno; Naoko Shigi; Ikumi Ohshio; Kentaro Jinguji; Yuko Ueda; Masatatsu Yamamoto; Tatsuhiko Furukawa; Shunji Aoki; Kazutake Tsujikawa; Akito Tanaka
Bioorganic & medicinal chemistry letters, Feb. 2014 - DCP-LA-phosphatidylinositol and its enantiomer exhibit different bioactivities.
Ayako Tsuchiya; Takeshi Kanno; Tadashi Shimizu; Syuhei Nakao; Akito Tanaka; Tomoyuki Nishizaki
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2014 - The linoleic acid derivative DCP-LA increases membrane surface localization of the α7 ACh receptor in a protein 4.1N-dependent manner.
Takeshi Kanno; Ayako Tsuchiya; Akito Tanaka; Tomoyuki Nishizaki
The Biochemical journal, Mar. 2013 - Regulation of GluA1 AMPA receptor through PKC phosphorylation induced by free fatty acid derivative HUHS2002.
Takaaki Nishimoto; Takeshi Kanno; Tadashi Shimizu; Akito Tanaka; Tomoyuki Nishizaki
Lipids, Jan. 2013 - Effects of newly synthesized DCP-LA-phospholipids on protein kinase C and protein phosphatases.
Takeshi Kanno; Ayako Tsuchiya; Tadashi Shimizu; Syuhei Nakao; Akito Tanaka; Tomoyuki Nishizaki
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2013 - 1-[2-(2-Methoxyphenylamino)ethylamino]-3-(naphthalene-1-yloxy)propan-2-ol as a potential anticancer drug.
Takeshi Kanno; Akito Tanaka; Tadashi Shimizu; Takashi Nakano; Tomoyuki Nishizaki
Pharmacology, 2013 - Free fatty acid derivative HUHS2002 potentiates α7 ACh receptor responses through indirect activation of CaMKII.
Takeshi Kanno; Tadashi Shimizu; Akito Tanaka; Takaaki Nishimoto; Tomoyuki Nishizaki
Lipids, Sep. 2012 - 8-[2-(2-Pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid and its diastereomers improve age-related cognitive deterioration.
Takeshi Kanno; Takahiro Yaguchi; Tadashi Shimizu; Akito Tanaka; Tomoyuki Nishizaki
Lipids, Jul. 2012 - Indomethacin enhances learning and memory potential by interacting with CaMKII.
Takeshi Kanno; Takahiro Yaguchi; Tetsu Nagata; Tadashi Shimizu; Akito Tanaka; Tomoyuki Nishizaki
Journal of cellular physiology, Mar. 2012 - Linoleic acid derivative DCP-LA stimulates vesicular transport of α7 ACh receptors towards surface membrane.
Takeshi Kanno; Akito Tanaka; Tomoyuki Nishizaki
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2012 - Novel indomethacin action: selective and direct activation of protein kinase C-ε.
Takeshi Kanno; Ayako Tsuchiya; Tadashi Shimizu; Akito Tanaka; Tomoyuki Nishizaki
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2012 - Indomethacin serves as a potential inhibitor of protein phosphatases.
Takeshi Kanno; Ayako Tsuchiya; Tadashi Shimizu; Akito Tanaka; Tomoyuki Nishizaki
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2012 - α, β-DCP-LA selectively activates PKC-ε and stimulates neurotransmitter release with the highest potency among 4 diastereomers.
Tadashi Shimizu; Takeshi Kanno; Akito Tanaka; Tomoyuki Nishizaki
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2011 - Selective elution of target protein from affinity resins by a simple reductant with a thiol group.
Miyuki Mabuchi; Masayuki Haramura; Tadashi Shimizu; Tomoyuki Nishizaki; Akito Tanaka
Bioorganic & medicinal chemistry letters, Dec. 2010 - DCP-LA stimulates AMPA receptor exocytosis through CaMKII activation due to PP-1 inhibition.
Takeshi Kanno; Takahiro Yaguchi; Tetsu Nagata; Akito Tanaka; Tomoyuki Nishizaki
Journal of cellular physiology, Oct. 2009 - [Identification of specific binding protein using affinity resins for discovery of drug target].
Akito Tanaka
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Sep. 2009 - Improvement of monolithic solid material by utilization of spacer for identification of the target using affinity resins.
Emiko Iwaoka; Tomoko Mori; Tadashi Shimizu; Ken Hosoya; Akito Tanaka
Bioorganic & medicinal chemistry letters, Mar. 2009 - Identification of the specific binding proteins of bioactive small compound using affinity resins.
Akito Tanaka
Methods in molecular biology (Clifton, N.J.), 2009 - Properties of flaky affinity resin with co-continuous structure.
Tomoko Mori; Akito Tanaka; Takuya Kubo; Kunimitsu Kaya; Mari Sakamoto; Ken Hosoya
Bioorganic & medicinal chemistry, Feb. 2008 - [A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase].
Akito Tanaka
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Oct. 2007 - An easy preparation of 'monolithic type' hydrophilic solid phase: capability for affinity resin to isolate target proteins.
Tomoko Mori; Teruki Takahashi; Takaaki Shiyama; Akito Tanaka; Natsuki Hira; Nobuo Tanaka; Ken Hosoya
Bioorganic & medicinal chemistry, Aug. 2006 - The linoleic acid derivative DCP-LA selectively activates PKC-epsilon, possibly binding to the phosphatidylserine binding site.
Takeshi Kanno; Hideyuki Yamamoto; Takahiro Yaguchi; Rika Hi; Takeshi Mukasa; Hirokazu Fujikawa; Tetsu Nagata; Satoshi Yamamoto; Akito Tanaka; Tomoyuki Nishizaki
Journal of lipid research, Jun. 2006 - A versatile method of identifying specific binding proteins on affinity resins.
Kiyoshi Yamamoto; Akira Yamazaki; Mikio Takeuchi; Akito Tanaka
Analytical biochemistry, May 2006 - Isolating the whole complex of target proteins of FK506 using affinity resins from novel solid phases.
Teruki Takahashi; Takaaki Shiyama; Tomoko Mori; Ken Hosoya; Akito Tanaka
Analytical and bioanalytical chemistry, May 2006 - Linoleic acid derivative DCP-LA improves learning impairment in SAMP8.
Takahiro Yaguchi; Tetsu Nagata; Takeshi Mukasa; Hirokazu Fujikawa; Hideyuki Yamamoto; Satoshi Yamamoto; Hiroyuki Iso; Akito Tanaka; Tomoyuki Nishizaki
Neuroreport, Jan. 2006 - Development of chemically stable solid phases for the target isolation with reduced nonspecific binding proteins.
Teruki Takahashi; Takaaki Shiyama; Ken Hosoya; Akito Tanaka
Bioorganic & medicinal chemistry letters, Jan. 2006 - Reduction of nonspecific binding proteins to self-assembled monolayer on gold surface.
Minoru Furuya; Masayuki Haramura; Akito Tanaka
Bioorganic & medicinal chemistry, Jan. 2006 - 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid stimulates GABA release from interneurons projecting to CA1 pyramidal neurons in the rat hippocampus via pre-synaptic alpha7 acetylcholine receptors.
Takeshi Kanno; Takahiro Yaguchi; Satoshi Yamamoto; Hideyuki Yamamoto; Hirokazu Fujikawa; Tetsu Nagata; Akito Tanaka; Tomoyuki Nishizaki
Journal of neurochemistry, Nov. 2005 - Effects of cis-unsaturated free fatty acids on PKC-epsilon activation and nicotinic ACh receptor responses.
Takahiro Yaguchi; Satoshi Yamamoto; Tetsu Nagata; Takeshi Kanno; Akito Tanaka; Tomoyuki Nishizaki
Brain research. Molecular brain research, Feb. 2005 - Design and synthesis of novel hydrophilic spacers for the reduction of nonspecific binding proteins on affinity resins.
Takaaki Shiyama; Minoru Furuya; Akira Yamazaki; Tomohiro Terada; Akito Tanaka
Bioorganic & medicinal chemistry, Jun. 2004 - Stearic acid facilitates hippocampal neurotransmission by enhancing nicotinic ACh receptor responses via a PKC pathway.
Kohei Ohta; Hirohito Miyamoto; Takahiro Yaguchi; Kaoru Nagai; Satoshi Yamamoto; Tamotsu Nomura; Akito Tanaka; Tomoyuki Nishizaki
Brain research. Molecular brain research, Nov. 2003 - The newly synthesized linoleic acid derivative FR236924 induces a long-lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors.
Akito Tanaka; Tomoyuki Nishizaki
Bioorganic & medicinal chemistry letters, Mar. 2003 - A quantitative analysis and chemical approach for the reduction of nonspecific binding proteins on affinity resins.
Tsuruki Tamura; Tomohiro Terada; Akito Tanaka
Bioconjugate chemistry, 2003 - FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases.
Ryohei Furumai; Akihisa Matsuyama; Nobuyuki Kobashi; Kun-Hyung Lee; Makoto Nishiyama; Hidenori Nakajima; Akito Tanaka; Yasuhiko Komatsu; Norikazu Nishino; Minoru Yoshida; Sueharu Horinouchi
Cancer research, Sep. 2002
Research Themes
- Drug discovery research for clinical application of PCA-1 inhibitors
Grant-in-Aid for Scientific Research (C)
Hyogo University of Health Sciences
01 Apr. 2015 - 31 Mar. 2018
