宮﨑 彩子
| 病態解析学 | 准教授 |
| 遺伝子医療部 | |
| 医学教育センター | |
| 臨床検査部 |
Last Updated :2024/12/19
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研究活動情報
論文
- Two cases with Hb Andrew-Minneapolis showing high or low-normal HbA1c levels depending on the measurement method.
Noriko Kuramoto; Masakazu Koshibu; Midori Ishibashi; Ayako Miyazaki; Satoru Sumitani; Soji Kasayama; Tsutomu Hirano; Masafumi Koga
Clinica chimica acta; international journal of clinical chemistry, 2020年02月 - Usefulness of Plasma Glucose Adjusted #C (labile HbA1c fraction) Levels for the Screening of Variant Hemoglobin with Diabetes Mellitus.
Masafumi Koga; Shinya Inada; Hiroko Ijima; Hideaki Jinnouchi; Ayako Miyazaki
Annals of clinical and laboratory science, 2020年01月 - IFCC-HbA1c May Be More Useful than NGSP-HbA1c in the Comparison between HbA1c Values in Variant Hemoglobin with a Mutation on α Chain and β Chain.
Masafumi Koga; Shinya Inada; Kei Yoshino; Ayako Miyazaki
Annals of clinical and laboratory science, 2019年09月 - Identification of the Presence of Variant Hemoglobin Using a Measurement of the Labile HbA1c (#C) Fraction.
Masafumi Koga; Shinya Inada; Ayako Miyazaki
Annals of clinical and laboratory science, 2016年07月 - Degree of discrepancy between HbA1c and glycemia in variant hemoglobin is smaller when HbA1c is measured by new-type Arkray HPLC compared with old-type HPLC.
Masafumi Koga; Shogo Kurebayashi; Jun Murai; Hiroshi Saito; Ayako Miyazaki
Clinical biochemistry, 2014年01月 - Classification of variant forms of haemoglobin according to the ratio of glycated haemoglobin to glycated albumin.
Ayako Miyazaki; Takuji Kohzuma; Soji Kasayama; Masafumi Koga
Annals of clinical biochemistry, 2012年09月 - Identification of the First Japanese Family Harboring a Novel Hemoglobin Variant "Perpignan", Which Caused Low HbA1c Measurement During Diabetic Follow-Up.
Mami Nakamura; Ayako Miyazaki; Takayuki Takubo; Yoko Matsuzawa; Jun Saito; Masao Omura; Tetsuo Nishikawa
Japanese clinical medicine, 2011年 - Detection and characterization of variant and modified structures of proteins in blood and tissues by mass spectrometry
SHIMIZU A
Mass Spectrom Rev, 2006年09月, ［査読有り］ - Hb Bristol-Alesha presenting thalassemia-type hyperunstable hemoglobinopathy.
Gen Kano; Akira Morimoto; Shigeyoshi Hibi; Chika Tokuda; Shinjiro Todo; Tohru Sugimoto; Teruo Harano; Ayako Miyazaki; Akira Shimizu; Shinsaku Imashuku
International journal of hematology, 2004年12月 - Development of an isotope dilution mass spectrometry assay for HbA1c based on enzyme-cleaved peptide analysis
IGUCHI Ken; NAKANISHI Toyofumi; MIYAZAKI Ayako; SHIMIZU Akira; OTA Akira
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2004年06月, ［査読有り］ - 安定同位体希釈法による糖化ヘモグロビン定量
井口 健; 中西 豊文; 宮崎 彩子; 清水 章
日本医用マススペクトル学会年会プログラム・抄録集, 2003年09月 - HbA1c測定値に及ぼす異常Hbの影響 質量分析法による36症例の検討
宮崎 彩子; 中西 豊文; 井口 健; 清水 章
臨床化学, 2000年09月 - Detection and quantification of variant proteins by electrospray ionization mass spectrometry.
A Shimizu; T Nakanishi; M Kishikawa; A Miyazaki
AMYLOID AND AMYLOIDOSIS 1998, 1999年, ［査読有り］ - Characterization of transthyretin variants by multidimensional liquid chromatography coupled to electrospray ionization mass spectrometry.
M Kishikawa; T Nakanishi; A Miyazaki; A Shimizu
AMYLOID AND AMYLOIDOSIS 1998, 1999年, ［査読有り］ - Detection and Characterization of Aberrant Blood Proteins by Mass Spectrometry, introduction of new strategy for life science
Akira Shimizu; Toyofumi Nakanishi; Masahiko Kishikawa; Ayako Miyazaki; Ikuo Koyama
Skin Research, 1998年, ［査読有り］
MISC
- Hb KOCHI [beta141(H19)Leu→Val (g.1404 C→G); 144-146(HC1-3)Lys-Tyr-His→0 (g.1413 A→T)]: A NEW VARIANT WITH INCREASED OXYGEN AFFINITY.
A Miyazaki; T Nakanishi; A Shimizu; M Mizobuchi; Y Yamada; K Imai
hemoglbin, 2005年 - Hb Kochi [beta 141(H19)Leu -> Val (g.1404 C -> G); 144-146(HC1-3)Lys-Tyr-His -> 0 (g.1413 A -> T)]: A new variant with increased oxygen affinity
A Miyazaki; T Nakanishi; A Shimizu; M Mizobuchi; Y Yamada; K Imai
HEMOGLOBIN, 2005年 - Hemoglobin variant HbG-coushatta (beta-22 Glu --> Ala) found by dissociation of blood glucose from values of HbA1C measured by HPLC.（jointly worked）
K Ogawa; T Bando; M Ogawa; A Miyazaki; T Nakanishi; A Shimizu
Intern Med., 2003年09月 - Hemoglobin variant HbG-Coushatta (beta-22 Glu -> Ala) found by dissociation of blood glucose from values of HbA(1C) measured by HPLC
K Ogawa; T Bando; M Ogawa; A Miyazaki; T Nakanishi; A Shimizu
INTERNAL MEDICINE, 2003年09月 - First case of a single heterozygote of an abnormal hemoglobin, Hb Stanmore, [beta 111(G13)Val -> Ala]
A Miyazaki; T Nakanishi; A Shimizu; H Hisamitsu
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2003年07月 - Hb BUZEN [beta 138(H16)Ala→Thr]. A new beta variant.
A Miyazaki; T Nakanishi; A Shimizu; K Ninomiya; S Nishimura; K Mai
hemoglobin, 2003年 - Hb Buzen [beta 138(H16)Ala -> Thr (g.1395 G -> A)]: A new beta chain variant
A Miyazaki; T Nakanishi; A Shimizu; K Ninomiya; S Nishimura; K Mai
HEMOGLOBIN, 2003年 - Assessment of the effect of hemoglobin variants on routine HbAlc measurements by electrospray ionization mass spectrometry
T Nakanishi; A Miyazaki; A Shimizu; A Yamaguchi; S Nishimura
CLINICA CHIMICA ACTA, 2002年09月 - Assessment of the effect of hemoglobin variants on routine HbAlc measurements by electrospray ionization mass spectrometry
T Nakanishi; A Miyazaki; A Shimizu; A Yamaguchi; S Nishimura
CLINICA CHIMICA ACTA, 2002年09月 - Detection and identification of protein variants and adducts in blood and tissues: an application of soft ionization mass spectrometry to clinical diagnosis
A Shimizu; T Nakanishi; M Kishikawa; A Miyazaki
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2002年08月 - Detection and identification of protein variants and adducts in blood and tissues: an application of soft ionization mass spectrometry to clinical diagnosis
A Shimizu; T Nakanishi; M Kishikawa; A Miyazaki
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2002年08月 - Effect of hemoglobin variants on routine glycohemoglobin measurements assessed by a mass spectrometric method
T Nakanishi; A Miyazaki; K Iguchi; A Shimizu
CLINICAL CHEMISTRY, 2000年10月 - 血糖値とHbA_<1c>値との著しい解離により発見された新型異常ヘモグロビン症 (Hb Hokusetsu [β52 (D3) Asp→Gly])の1例
岸田 修; 鷲見 誠一; 鈴木 興康; 椿尾 忠博; 中西 豊文; 宮崎 彩子; 清水 章
糖尿病, 2000年08月30日 - HbA1c測定に及ぼす以上ヘモグロビンの影響－質量分析法による評価－（共著）
JJCLA（日本臨床検査自動化学会会誌）, 2000年 - Hb Ernz[β123(H1)Thr→Asn]and Hb Renert[β133(H11)Val→Ala] : two new neutral variants revealed by reversed phase high performance liquid chromatography analysis(jointly worked)
P Groff; G Kalmes; B Golinska; A Miyazaki; J Riou; N Carte; D Prome; J Kister; F Galacteros; H Wajcman
Hemoglobin, 2000年 - Hb Anderlecht[α20(B1)His→Pro] : a silent variant found in a Congolese Newborn(jointly worked)
F Cotton; H Wajeman; Hansen, V; C Lin; K Jotzo; D Haumont; D Prome; J Riou; A Miyazaki; F Galacteros; F Vertongen; B Gulbis
Hemoglobin, 2000年 - Hb Ernz [beta 123(H1)Thr -> Asn] and Hb Renert [beta 133(H11)Val -> Ala]: Two new neutral variants revealed by reversed phase high performance liquid chromatography analysis
P Groff; G Kalmes; B Golinska; A Miyazaki; J Riou; N Carte; D Prome; J Kister; F Galacteros; H Wajcman
HEMOGLOBIN, 2000年 - Hb anderlecht [alpha 20(B1)His -> Pro]: a silent variant found in a congolese newborn
F Cotton; H Wajeman; Hansen, V; C Lin; K Jotzo; D Haumont; D Prome; J Riou; A Miyazaki; F Galacteros; F Vertongen; B Gulbis
HEMOGLOBIN, 2000年 - A new amyloidogenic transthyretin variant, [D38A], detected by electrospray ionization mass spectrometry
M Kishikawa; T Nakanishi; A Miyazaki; A Shimizu; H Kusaka; M Fukui; T Nishiue
AMYLOID-INTERNATIONAL JOURNAL OF EXPERIMENTAL AND CLINICAL INVESTIGATION, 1999年12月 - Two novel hemoglobin variants : Hb Sagami[β139 Asn→Thr]and Hb Niigata[β1 Val→Met-Leu]
Miyazaki Ayako; Nakanishi Toyofumi; Shimizu Akira
Bulletin of the Osaka Medical College, 1999年11月 - 二つの新しいヘモグロビン変異体 Hb Sagami[β139 Asn→Thr]及びHb Nigata[β1 Val→Met-Leu](Two Novel Hemoglobin Variants: Hb Sagami[β139-Asn→Thr] and Hb Niigata[β1 Val→Met-Leu])
Miyazaki Ayako; Nakanishi Toyofumi; Shimizu Akira
Bulletin of the Osaka Medical College, 1999年11月 - Enhanced amyloidogenicity of sulfonated transthyretin in vitro, a hypothetical etiology of senile amyloidosis
M Kishikawa; T Nakanishi; A Miyazaki; A Shimizu
AMYLOID-INTERNATIONAL JOURNAL OF EXPERIMENTAL AND CLINICAL INVESTIGATION, 1999年09月 - Compound heterozygosity for β+-thalassemia[-31(A→G)]and a new variant with low oxygen affinity, Hb Sagami[β139(H17)Asn→Thr].
A Miyazaki; T Nakanishi; M Kishikawa; T Nakagawa; A Shimizu; AHM Mawjood; K Imai; Y Aoki; M Kikuchi
Hemoglobin, 1999年08月 - Compound heterozygosity for beta(+)-thalassemia [-31 (A -> G)] and a new variant with low oxygen affinity, Hb Sagami [beta 139(H17)Asn -> Thr]
A Miyazaki; T Nakanishi; M Kishikawa; T Nakagawa; A Shimizu; AHM Mawjood; K Imai; Y Aoki; M Kikuchi
HEMOGLOBIN, 1999年08月 - A simple and reliable method of detecting variant transthyretins by multidimensional liquid chromatography coupled to electrospray ionization mass spectrometry
M Kishikawa; T Nakanishi; A Miyazaki; A Shimizu
AMYLOID-INTERNATIONAL JOURNAL OF EXPERIMENTAL AND CLINICAL INVESTIGATION, 1999年03月 - Validation of electrospray mass spectrometry for the analysis of glycated hemoglobin, comparison with routine HPLC, high resolution HPLC, and immunoassay.
A Shimizu; T Nakanishi; A Miyazaki; M Kishikawa; Y Kohno; Koyama, I
CLINICAL CHEMISTRY, 1998年06月 - Hb Sagami[β139(H17)Asn→Thr] : a new hemoglobin variant not detected by isoelectrofocusing and propan-2-ol test, was detected by electrospray ionization mass spectrometry. (jointly worked)
NAKANISHI T; MIYAZAKI A; KISHIKAWA M; SHIMIZU A; AOKI Y; KIKUCHI M
J. Mass Spectrom., 1998年06月 - Hb Sagami [beta 139(H17)Asn -> Thr]: a new hemoglobin variant not detected by isoelectrofocusing and propan-2-ol test, was detected by electrospray ionization mass spectrometry
T Nakanishi; A Miyazaki; M Kishikawa; A Shimizu; Y Aoki; M Kikuchi
JOURNAL OF MASS SPECTROMETRY, 1998年06月 - Simple and defined method to detect the SOD-1 mutants from patients with familial amyotrophic lateral sclerosis by mass spectrometry
T Nakanishi; M Kishikawa; A Miyazaki; A Shimizu; Y Ogawa; S Sakoda; T Ohi; H Shoji
JOURNAL OF NEUROSCIENCE METHODS, 1998年06月 - シンポジウムS7:蛋白質異常症診断の最新技術 質量分析による異常蛋白質の検出による診断および糖化ヘモグロビンの定量
清水 章; 中西 豊文; 岸川 匡彦; 宮崎 彩子; 小山 郁夫
臨床病理, 1998年05月25日 - Hb Peterborough[B111(G13)Val→Phe]in Japan ; rapud identification by ESI/MS using Proteolytic digests of oxidized globin. (jointly worked)
T Nakanishi; A Miyazaki; M Kishikawa; A Shimizu; Y Aoki; M Kikuchi
Hemoglobin, 1998年 - A new hemoglobin variant found during Hb A1c measurement : Hb Hokusetsu[β52(D3)Asp→Gly]. (jointly worked)
T Nakanishi; A Miyazaki; M Kishikawa; A Shimizu; O Kishida; S Sumi; T Tsubakio; K Imai
Hemoglobin, 1998年 - A new nonamyloid transthyretin variant, [G101S], detected by electrospray ionization/mass spectrometry. (jointly worked)
Hum. Mutat. , Mutation in Brief #201 Online, 1998年 - Hb Peterborough [beta 111(G13)Val -> Phe] in Japan; Rapid identification by ESI/MS using proteolytic digests of oxidized globin
T Nakanishi; A Miyazaki; M Kishikawa; A Shimizu; Y Aoki; M Kikuchi
HEMOGLOBIN, 1998年 - A new hemoglobin variant found during Hb A(1c) measurement: Hb Hokusetsu [beta 52(D3)Asp -> Gly]
T Nakanishi; A Miyazaki; M Kishikawa; A Shimizu; O Kishida; S Sumi; T Tsubakio; K Imai
HEMOGLOBIN, 1998年 - A new nonamyloid transthyretin variant, [G101S], detected by electrospray ionization/mass spectrometry. (jointly worked)
Hum. Mutat. , Mutation in Brief #201 Online, 1998年 - Quantification of glycated hemoglobin by electrospray ionization mass spectrometry
T Nakanishi; A Miyazaki; M Kishikawa; M Yasuda; Y Tokuchi; Y Kanada; A Shimizu
JOURNAL OF MASS SPECTROMETRY, 1997年07月 - The first Japanese case of Hb Santa Ana, an unstable abnormal hemoglobin, identified rapidly by electrospray ionization mass spectrometry
A Miyazaki; T Nakanishi; M Kishikawa; A Shimizu; K Jozaki; T Yonezawa
INTERNAL MEDICINE, 1997年05月 - 尿,血液中の変異タンパク質の迅速検出と臨床診断学への応用 (バイオロジカルマススペクトロメトリー) -- (応用(試料の調製法からデータの解析まで))
中西 豊文; 岸川 匡彦; 宮崎 彩子
現代化学 : 増刊, 1997年04月 - Hb Niigata [βl(Nal)Val→Leu] : The Fifth Variant with Retention of the Initiator Methionine and Partial Acetylation(jointly worked)
Y Ohba; Y Hattori; S Sakata; Y Yamashiro; N Okayama; T Hirano; T Nakanishi; A Miyazaki; A Shimizu
Hemoglobin, 1997年 - Hb Niigata [beta 1(NA1)Val->Leu]: The fifth variant with retention of the initiator methionine and partial acetylation
Y Ohba; Y Hattori; S Sakata; Y Yamashiro; N Okayama; T Hirano; T Nakanishi; A Miyazaki; A Shimizu
HEMOGLOBIN, 1997年 - Post-translational modification from methionine to aspartic acid residue on a variant hemoglobin, Hb Bristol, a proof by ESI-MS-MS
A Miyazaki; T Nakanishi; M Kishikawa; A Shimizu; Y Ohba; A Tanaka; H Sasaki
JOURNAL OF MASS SPECTROMETRY, 1996年11月 - Electrospray ionization - Tandem mass spectrometry analysis of peptides derived by enzymatic digestion of oxidized globin subunits: An improved method to determine amino acid substitution in the hemoglobin ''core''
T Nakanishi; A Miyazaki; M Kishikawa; A Shimizu; T Yonezawa
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 1996年10月 - Simple Detection of Abnormal Serum Transthyretin from Patients with Familial Amyloidotic Polyneuropathy by High-performance Leguid Chromatography/Electrospray Ionization Mass Sepectrometry Using Material Precipitated with Specific Antiserum(jointly wor・・・
KISHIKAWA M; NAKANISHI T; MIYAZAKI A; SHIMIZU A; NAKAZATO M; KANGAWA K; MATSUO H
Journal of Mass Spectrometry, 1996年01月 - Simple detection of abnormal serum transthyretin from patients with familial amyloidotic polyneuropathy by high-performance liquid chromatography electrospray ionization mass spectrometry using material precipitated with specific antiserum
M Kishikawa; T Nakanishi; A Miyazaki; A Shimizu; M Nakazato; K Kangawa; H Matsuo
JOURNAL OF MASS SPECTROMETRY, 1996年01月
