Last Updated :2024/12/19
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- Two cases with Hb Andrew-Minneapolis showing high or low-normal HbA1c levels depending on the measurement method.
Noriko Kuramoto; Masakazu Koshibu; Midori Ishibashi; Ayako Miyazaki; Satoru Sumitani; Soji Kasayama; Tsutomu Hirano; Masafumi Koga
Clinica chimica acta; international journal of clinical chemistry, Feb. 2020 - Usefulness of Plasma Glucose Adjusted #C (labile HbA1c fraction) Levels for the Screening of Variant Hemoglobin with Diabetes Mellitus.
Masafumi Koga; Shinya Inada; Hiroko Ijima; Hideaki Jinnouchi; Ayako Miyazaki
Annals of clinical and laboratory science, Jan. 2020 - IFCC-HbA1c May Be More Useful than NGSP-HbA1c in the Comparison between HbA1c Values in Variant Hemoglobin with a Mutation on α Chain and β Chain.
Masafumi Koga; Shinya Inada; Kei Yoshino; Ayako Miyazaki
Annals of clinical and laboratory science, Sep. 2019 - Identification of the Presence of Variant Hemoglobin Using a Measurement of the Labile HbA1c (#C) Fraction.
Masafumi Koga; Shinya Inada; Ayako Miyazaki
Annals of clinical and laboratory science, Jul. 2016 - Degree of discrepancy between HbA1c and glycemia in variant hemoglobin is smaller when HbA1c is measured by new-type Arkray HPLC compared with old-type HPLC.
Masafumi Koga; Shogo Kurebayashi; Jun Murai; Hiroshi Saito; Ayako Miyazaki
Clinical biochemistry, Jan. 2014 - Classification of variant forms of haemoglobin according to the ratio of glycated haemoglobin to glycated albumin.
Ayako Miyazaki; Takuji Kohzuma; Soji Kasayama; Masafumi Koga
Annals of clinical biochemistry, Sep. 2012 - Identification of the First Japanese Family Harboring a Novel Hemoglobin Variant "Perpignan", Which Caused Low HbA1c Measurement During Diabetic Follow-Up.
Mami Nakamura; Ayako Miyazaki; Takayuki Takubo; Yoko Matsuzawa; Jun Saito; Masao Omura; Tetsuo Nishikawa
Japanese clinical medicine, 2011 - Detection and characterization of variant and modified structures of proteins in blood and tissues by mass spectrometry
SHIMIZU A
Mass Spectrom Rev, Sep. 2006, [Reviewed] - Hb Bristol-Alesha presenting thalassemia-type hyperunstable hemoglobinopathy.
Gen Kano; Akira Morimoto; Shigeyoshi Hibi; Chika Tokuda; Shinjiro Todo; Tohru Sugimoto; Teruo Harano; Ayako Miyazaki; Akira Shimizu; Shinsaku Imashuku
International journal of hematology, Dec. 2004 - Development of an isotope dilution mass spectrometry assay for HbA1c based on enzyme-cleaved peptide analysis
IGUCHI Ken; NAKANISHI Toyofumi; MIYAZAKI Ayako; SHIMIZU Akira; OTA Akira
J Chromatogr B, Jun. 2004, [Reviewed] - 安定同位体希釈法による糖化ヘモグロビン定量
井口 健; 中西 豊文; 宮崎 彩子; 清水 章
日本医用マススペクトル学会年会プログラム・抄録集, Sep. 2003 - A Variant Hemoglobin Found by Dissociation of Blood Glucose from HbA_(1c) on Routine Physical Examination
OGAWA Koichi; BANDO Tomoko; OGAWA Maki; MIYAZAKI Ayako; NAKANISHI Toyofumi; SHIMIZU Akira
Rinsho byori. The Japanese journal of clinical pathology, Jun. 2003, [Reviewed] - HbA1c測定値に及ぼす異常Hbの影響 質量分析法による36症例の検討
宮崎 彩子; 中西 豊文; 井口 健; 清水 章
臨床化学, Sep. 2000 - Detection and quantification of variant proteins by electrospray ionization mass spectrometry.
A Shimizu; T Nakanishi; M Kishikawa; A Miyazaki
AMYLOID AND AMYLOIDOSIS 1998, 1999, [Reviewed] - Characterization of transthyretin variants by multidimensional liquid chromatography coupled to electrospray ionization mass spectrometry.
M Kishikawa; T Nakanishi; A Miyazaki; A Shimizu
AMYLOID AND AMYLOIDOSIS 1998, 1999, [Reviewed] - Detection and Characterization of Aberrant Blood Proteins by Mass Spectrometry, introduction of new strategy for life science
Akira Shimizu; Toyofumi Nakanishi; Masahiko Kishikawa; Ayako Miyazaki; Ikuo Koyama
Skin Research, 1998, [Reviewed]
MISC
- Hb Kochi [beta 141(H19)Leu -> Val (g.1404 C -> G); 144-146(HC1-3)Lys-Tyr-His -> 0 (g.1413 A -> T)]: A new variant with increased oxygen affinity
A Miyazaki; T Nakanishi; A Shimizu; M Mizobuchi; Y Yamada; K Imai
HEMOGLOBIN, 2005 - Hb Kochi [beta 141(H19)Leu -> Val (g.1404 C -> G); 144-146(HC1-3)Lys-Tyr-His -> 0 (g.1413 A -> T)]: A new variant with increased oxygen affinity
A Miyazaki; T Nakanishi; A Shimizu; M Mizobuchi; Y Yamada; K Imai
HEMOGLOBIN, 2005 - Hemoglobin variant HbG-Coushatta (beta-22 Glu -> Ala) found by dissociation of blood glucose from values of HbA(1C) measured by HPLC
K Ogawa; T Bando; M Ogawa; A Miyazaki; T Nakanishi; A Shimizu
INTERNAL MEDICINE, Sep. 2003 - Hemoglobin variant HbG-Coushatta (beta-22 Glu -> Ala) found by dissociation of blood glucose from values of HbA(1C) measured by HPLC
K Ogawa; T Bando; M Ogawa; A Miyazaki; T Nakanishi; A Shimizu
INTERNAL MEDICINE, Sep. 2003 - First case of a single heterozygote of an abnormal hemoglobin, Hb Stanmore, [beta 111(G13)Val -> Ala]
A Miyazaki; T Nakanishi; A Shimizu; H Hisamitsu
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, Jul. 2003 - Hb Buzen [beta 138(H16)Ala -> Thr (g.1395 G -> A)]: A new beta chain variant
A Miyazaki; T Nakanishi; A Shimizu; K Ninomiya; S Nishimura; K Mai
HEMOGLOBIN, 2003 - Hb Buzen [beta 138(H16)Ala -> Thr (g.1395 G -> A)]: A new beta chain variant
A Miyazaki; T Nakanishi; A Shimizu; K Ninomiya; S Nishimura; K Mai
HEMOGLOBIN, 2003 - Assessment of the effect of hemoglobin variants on routine HbAlc measurements by electrospray ionization mass spectrometry
T Nakanishi; A Miyazaki; A Shimizu; A Yamaguchi; S Nishimura
CLINICA CHIMICA ACTA, Sep. 2002 - Assessment of the effect of hemoglobin variants on routine HbAlc measurements by electrospray ionization mass spectrometry
T Nakanishi; A Miyazaki; A Shimizu; A Yamaguchi; S Nishimura
CLINICA CHIMICA ACTA, Sep. 2002 - Detection and identification of protein variants and adducts in blood and tissues: an application of soft ionization mass spectrometry to clinical diagnosis
A Shimizu; T Nakanishi; M Kishikawa; A Miyazaki
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, Aug. 2002 - Detection and identification of protein variants and adducts in blood and tissues: an application of soft ionization mass spectrometry to clinical diagnosis
A Shimizu; T Nakanishi; M Kishikawa; A Miyazaki
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, Aug. 2002 - Effect of hemoglobin variants on routine glycohemoglobin measurements assessed by a mass spectrometric method
T Nakanishi; A Miyazaki; K Iguchi; A Shimizu
CLINICAL CHEMISTRY, Oct. 2000 - New Hemoglobin Variant Showing an Unexpectedly Low HbA_<1c> Value on Ion-Exchange HPLC in Comparison to Plasma Glucose Level
KISHIDA Osamu; SUMI Seiichi; SUZUKI Kouyasu; TSUBAKIO Tadahiro; NAKANISHI Toyohumi; MIYAZAKI Ayako; SHIMIZU Akira
糖尿病, 30 Aug. 2000 - HbA1c測定に及ぼす以上ヘモグロビンの影響－質量分析法による評価－（共著）
JJCLA（日本臨床検査自動化学会会誌）, 2000 - Hb Ernz [beta 123(H1)Thr -> Asn] and Hb Renert [beta 133(H11)Val -> Ala]: Two new neutral variants revealed by reversed phase high performance liquid chromatography analysis
P Groff; G Kalmes; B Golinska; A Miyazaki; J Riou; N Carte; D Prome; J Kister; F Galacteros; H Wajcman
HEMOGLOBIN, 2000 - Hb anderlecht [alpha 20(B1)His -> Pro]: a silent variant found in a congolese newborn
F Cotton; H Wajeman; Hansen, V; C Lin; K Jotzo; D Haumont; D Prome; J Riou; A Miyazaki; F Galacteros; F Vertongen; B Gulbis
HEMOGLOBIN, 2000 - Hb Ernz [beta 123(H1)Thr -> Asn] and Hb Renert [beta 133(H11)Val -> Ala]: Two new neutral variants revealed by reversed phase high performance liquid chromatography analysis
P Groff; G Kalmes; B Golinska; A Miyazaki; J Riou; N Carte; D Prome; J Kister; F Galacteros; H Wajcman
HEMOGLOBIN, 2000 - Hb anderlecht [alpha 20(B1)His -> Pro]: a silent variant found in a congolese newborn
F Cotton; H Wajeman; Hansen, V; C Lin; K Jotzo; D Haumont; D Prome; J Riou; A Miyazaki; F Galacteros; F Vertongen; B Gulbis
HEMOGLOBIN, 2000 - A new amyloidogenic transthyretin variant, [D38A], detected by electrospray ionization mass spectrometry
M Kishikawa; T Nakanishi; A Miyazaki; A Shimizu; H Kusaka; M Fukui; T Nishiue
AMYLOID-INTERNATIONAL JOURNAL OF EXPERIMENTAL AND CLINICAL INVESTIGATION, Dec. 1999 - 二つの新しいヘモグロビン変異体 Hb Sagami[β139 Asn→Thr]及びHb Nigata[β1 Val→Met-Leu](Two Novel Hemoglobin Variants: Hb Sagami[β139-Asn→Thr] and Hb Niigata[β1 Val→Met-Leu])
Miyazaki Ayako; Nakanishi Toyofumi; Shimizu Akira
Bulletin of the Osaka Medical College, Nov. 1999 - 二つの新しいヘモグロビン変異体 Hb Sagami[β139 Asn→Thr]及びHb Nigata[β1 Val→Met-Leu](Two Novel Hemoglobin Variants: Hb Sagami[β139-Asn→Thr] and Hb Niigata[β1 Val→Met-Leu])
Miyazaki Ayako; Nakanishi Toyofumi; Shimizu Akira
Bulletin of the Osaka Medical College, Nov. 1999 - Enhanced amyloidogenicity of sulfonated transthyretin in vitro, a hypothetical etiology of senile amyloidosis
M Kishikawa; T Nakanishi; A Miyazaki; A Shimizu
AMYLOID-INTERNATIONAL JOURNAL OF EXPERIMENTAL AND CLINICAL INVESTIGATION, Sep. 1999 - Compound heterozygosity for beta(+)-thalassemia [-31 (A -> G)] and a new variant with low oxygen affinity, Hb Sagami [beta 139(H17)Asn -> Thr]
A Miyazaki; T Nakanishi; M Kishikawa; T Nakagawa; A Shimizu; AHM Mawjood; K Imai; Y Aoki; M Kikuchi
HEMOGLOBIN, Aug. 1999 - Compound heterozygosity for beta(+)-thalassemia [-31 (A -> G)] and a new variant with low oxygen affinity, Hb Sagami [beta 139(H17)Asn -> Thr]
A Miyazaki; T Nakanishi; M Kishikawa; T Nakagawa; A Shimizu; AHM Mawjood; K Imai; Y Aoki; M Kikuchi
HEMOGLOBIN, Aug. 1999 - A simple and reliable method of detecting variant transthyretins by multidimensional liquid chromatography coupled to electrospray ionization mass spectrometry
M Kishikawa; T Nakanishi; A Miyazaki; A Shimizu
AMYLOID-INTERNATIONAL JOURNAL OF EXPERIMENTAL AND CLINICAL INVESTIGATION, Mar. 1999 - Validation of electrospray mass spectrometry for the analysis of glycated hemoglobin, comparison with routine HPLC, high resolution HPLC, and immunoassay.
A Shimizu; T Nakanishi; A Miyazaki; M Kishikawa; Y Kohno; Koyama, I
CLINICAL CHEMISTRY, Jun. 1998 - Hb Sagami [beta 139(H17)Asn -> Thr]: a new hemoglobin variant not detected by isoelectrofocusing and propan-2-ol test, was detected by electrospray ionization mass spectrometry
T Nakanishi; A Miyazaki; M Kishikawa; A Shimizu; Y Aoki; M Kikuchi
JOURNAL OF MASS SPECTROMETRY, Jun. 1998 - Hb Sagami [beta 139(H17)Asn -> Thr]: a new hemoglobin variant not detected by isoelectrofocusing and propan-2-ol test, was detected by electrospray ionization mass spectrometry
T Nakanishi; A Miyazaki; M Kishikawa; A Shimizu; Y Aoki; M Kikuchi
JOURNAL OF MASS SPECTROMETRY, Jun. 1998 - Simple and defined method to detect the SOD-1 mutants from patients with familial amyotrophic lateral sclerosis by mass spectrometry
T Nakanishi; M Kishikawa; A Miyazaki; A Shimizu; Y Ogawa; S Sakoda; T Ohi; H Shoji
JOURNAL OF NEUROSCIENCE METHODS, Jun. 1998 - Detection and Characterization of Aberrant Blood Proteins and Quantification of Glycated Hemoglobin by Mass Spectrometry
SHIMIZU Akira; NAKANISHI Toyofumi; KISHIKAWA Masahiko; MIYAZAKI Ayako; KOYAMA Ikuo
臨床病理, 25 May 1998 - Hb Peterborough [beta 111(G13)Val -> Phe] in Japan; Rapid identification by ESI/MS using proteolytic digests of oxidized globin
T Nakanishi; A Miyazaki; M Kishikawa; A Shimizu; Y Aoki; M Kikuchi
HEMOGLOBIN, 1998 - A new hemoglobin variant found during Hb A(1c) measurement: Hb Hokusetsu [beta 52(D3)Asp -> Gly]
T Nakanishi; A Miyazaki; M Kishikawa; A Shimizu; O Kishida; S Sumi; T Tsubakio; K Imai
HEMOGLOBIN, 1998 - A new nonamyloid transthyretin variant, [G101S], detected by electrospray ionization/mass spectrometry. (jointly worked)
Hum. Mutat. , Mutation in Brief #201 Online, 1998 - Hb Peterborough [beta 111(G13)Val -> Phe] in Japan; Rapid identification by ESI/MS using proteolytic digests of oxidized globin
T Nakanishi; A Miyazaki; M Kishikawa; A Shimizu; Y Aoki; M Kikuchi
HEMOGLOBIN, 1998 - A new hemoglobin variant found during Hb A(1c) measurement: Hb Hokusetsu [beta 52(D3)Asp -> Gly]
T Nakanishi; A Miyazaki; M Kishikawa; A Shimizu; O Kishida; S Sumi; T Tsubakio; K Imai
HEMOGLOBIN, 1998 - A new nonamyloid transthyretin variant, [G101S], detected by electrospray ionization/mass spectrometry. (jointly worked)
Hum. Mutat. , Mutation in Brief #201 Online, 1998 - Quantification of glycated hemoglobin by electrospray ionization mass spectrometry
T Nakanishi; A Miyazaki; M Kishikawa; M Yasuda; Y Tokuchi; Y Kanada; A Shimizu
JOURNAL OF MASS SPECTROMETRY, Jul. 1997 - The first Japanese case of Hb Santa Ana, an unstable abnormal hemoglobin, identified rapidly by electrospray ionization mass spectrometry
A Miyazaki; T Nakanishi; M Kishikawa; A Shimizu; K Jozaki; T Yonezawa
INTERNAL MEDICINE, May 1997 - 尿,血液中の変異タンパク質の迅速検出と臨床診断学への応用 (バイオロジカルマススペクトロメトリー) -- (応用(試料の調製法からデータの解析まで))
中西 豊文; 岸川 匡彦; 宮崎 彩子
現代化学 : 増刊, Apr. 1997 - Hb Niigata [beta 1(NA1)Val->Leu]: The fifth variant with retention of the initiator methionine and partial acetylation
Y Ohba; Y Hattori; S Sakata; Y Yamashiro; N Okayama; T Hirano; T Nakanishi; A Miyazaki; A Shimizu
HEMOGLOBIN, 1997 - Hb Niigata [beta 1(NA1)Val->Leu]: The fifth variant with retention of the initiator methionine and partial acetylation
Y Ohba; Y Hattori; S Sakata; Y Yamashiro; N Okayama; T Hirano; T Nakanishi; A Miyazaki; A Shimizu
HEMOGLOBIN, 1997 - The Characterization of Mutant Proteins in Body Fluids by Soft-Ionization Mass Spectrometry
Nakanishi Toyofumi; Kishikawa Masahiko; Miyazaki Ayako; Shimizu Akira
Ikagaku Shinpojumu, 1997 - Post-translational modification from methionine to aspartic acid residue on a variant hemoglobin, Hb Bristol, a proof by ESI-MS-MS
A Miyazaki; T Nakanishi; M Kishikawa; A Shimizu; Y Ohba; A Tanaka; H Sasaki
JOURNAL OF MASS SPECTROMETRY, Nov. 1996 - Electrospray ionization - Tandem mass spectrometry analysis of peptides derived by enzymatic digestion of oxidized globin subunits: An improved method to determine amino acid substitution in the hemoglobin ''core''
T Nakanishi; A Miyazaki; M Kishikawa; A Shimizu; T Yonezawa
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Oct. 1996 - Rapid Detection by Soft Ionization Mass Spectrometry of Variant Proteins and Its Application for Clinical Laboratory Tests
NAKANISHI Toyofumi; KISHIKAWA Masahiko; MIYAZAKI Ayako; SHIMIZU Akira
J. Mass Spectrom. Soc. Jpn., 01 Jun. 1996 - Simple detection of abnormal serum transthyretin from patients with familial amyloidotic polyneuropathy by high-performance liquid chromatography electrospray ionization mass spectrometry using material precipitated with specific antiserum
M Kishikawa; T Nakanishi; A Miyazaki; A Shimizu; M Nakazato; K Kangawa; H Matsuo
JOURNAL OF MASS SPECTROMETRY, Jan. 1996 - Simple detection of abnormal serum transthyretin from patients with familial amyloidotic polyneuropathy by high-performance liquid chromatography electrospray ionization mass spectrometry using material precipitated with specific antiserum
M Kishikawa; T Nakanishi; A Miyazaki; A Shimizu; M Nakazato; K Kangawa; H Matsuo
JOURNAL OF MASS SPECTROMETRY, Jan. 1996
Affiliated academic society
Research Themes
- Molecular study on the age-related muscle atrophy
Grant-in-Aid for Scientific Research (C)
Kansai University of Welfare Sciences
01 Apr. 2015 - 31 Mar. 2020 - Basic study for prevention of disuse muscular atrophy with multivalent cations
Grant-in-Aid for Scientific Research (C)
Kansai University of Welfare Sciences
01 Apr. 2015 - 31 Mar. 2020 - Interaction analysis of professional ethics education-A study of role play lessons in medical education
Grant-in-Aid for Scientific Research (B)
Kobe City College of Nursing
01 Apr. 2015 - 31 Mar. 2019 - Video-ethnography of practical teaching: Comparative case study in high education
Grant-in-Aid for Scientific Research (B)
The University of Tokushima
2009 - 2012 - communication analysis of university educational reform : on-the-spot examination
Grant-in-Aid for Scientific Research (B)
The University of Tokushima
2006 - 2008 - Analysis of modified structures of transthyretin, elucidation of disease etiology of amyloidosis and application to clinical laboratory tests
Grant-in-Aid for Scientific Research (C)
Osaka Medical College
2004 - 2005 - Elucidation of the fine structure and the generation process of modified proteins (sulfonate, nitroso, et al.) application to clinical laboratory test
Grant-in-Aid for Scientific Research (C)
Osaka Medical College
2002 - 2003 - The quantification of ratios between apo to holo types of metal binding protein : a new indicator of the oxidative stress in cells
Grant-in-Aid for Scientific Research (C)
Osaka Medical College
1999 - 2001 - 質量分析によるHbAlcの定量
- 質量分析による変異蛋白質の構造解析と疾患診断
- 異常Hb症診断のルーチン化
- Quantification of glycated hemoglobin by mass spectrometry
- Detection of protein variants by mass spectrometry
- Routinization of diagnosis of abnormal hemoglobin.
