古賀 浩平
| 生理学（神経生理部門） | 准教授 |
Last Updated :2024/12/13
研究者情報
経歴
- 2020年12月 - 現在
兵庫医科大学 生理学 神経生理部門, （准教授） - 2017年04月 - 2020年11月
兵庫医科大学, 生理学 神経生理部門, (講師) - 2015年06月 - 2017年03月
弘前大学, 脳神経生理学講座, （助教） - 2011年04月 - 2015年05月
Fragile X Research Foundation of Canada, (Medical Research Fellow) - 2009年04月 - 2015年05月
トロント大学, 生理学, (博士研究員) - 2008年04月 - 2009年03月
熊本保健科学大学, リハビリテーション学科, (博士研究員) - 2007年04月 - 2008年03月
九州大学, 医学研究院統合生理学, (博士研究員) - 2006年04月 - 2008年03月
日本学術振興会特別研究員, (DC2, PD)
学歴
研究活動情報
受賞
- 2018年04月
公益財団法人 ひょうご科学技術協会, ひょうご科学技術賞
古賀浩平 - 2016年07月
第11回 青森神経科学談話会, 奨励賞
慢性疼痛による前帯状回GABAシナプス伝達の可塑的変化
古賀浩平 - 2016年04月
文部科学省, H28年度 科学技術分野の文部科学大臣表彰 若手科学者賞
古賀浩平 - 2013年07月
The 8th International conference for Neuron and Brain Diseases, 1st prize
Presynaptic long term potentiation in the cingulate cortex.
古賀浩平 - 2008年10月
第59回 西日本生理学会九州支部会, 日本生理学会九州奨励賞
In vivoパッチクランプ記録法を用いたラット一次体性感覚野における痛覚応答の解析
古賀浩平 - 2005年11月
The 5th Japan-Korea Joint Symposium of Brain Sciences, and Cardiac and Smooth Muscles, Silver Prize
Aspirin inhibits noxious transmission from periphery to the spinal cord in inflamed and naïve rats.
古賀浩平
論文
- The elevated open platform stress suppresses excitatory synaptic transmission in the layer V anterior cingulate cortex
Ryo Kawabata; Ayumi Fujita; Yoshihiko Oke; Ikuko Yao; Kohei Koga
Neuroscience, 2025年01月, ［査読有り］
ラスト(シニア)オーサー - The Anterior Cingulate Cortex is Critical for Acute Stress-induced Hypersensitivity in Mice
Ryo Kawabata; Hiroki Yamanaka; Kimiko Kobayashi; Yoshihiko Oke; Ayumi Fujita; Yoshitaka Oku; Ikuko Yao; Kohei Koga
Neuroscience, 2023年07月, ［査読有り］
ラスト(シニア)オーサー - TRPA1 as a O2 sensor detects microenvironmental hypoxia in the mice anterior cingulate cortex.
Ryo Kawabata; Shuji Shimoyama; Shinya Ueno; Ikuko Yao; Akiko Arata; Kohei Koga
Scientific reports, 2023年02月, ［査読有り］
ラスト(シニア)オーサー - Nicotine Exposure during Adolescence Leads to Changes of Synaptic Plasticity and Intrinsic Excitability of Mice Insular Pyramidal Cells at Later Life
Hiroki Toyoda; Kohei Koga
International Journal of Molecular Sciences, 2021年12月
ラスト(シニア)オーサー - Acute elevated platform triggers stress induced hyperalgesia and alters glutamatergic transmission in the adult mice anterior cingulate cortex
Koki Kawakami; Kohei Koga
IBRO Neuroscience Reports, 2021年06月
ラスト(シニア)オーサー - L-bupivacaine Inhibition of Nociceptive Transmission in Rat Peripheral and Dorsal Horn Neurons
Daisuke Uta; Kohei Koga; Hidemasa Furue; Keiji Imoto; Megumu Yoshimura
Anesthesiology, 2021年01月, ［査読有り］ - Ascending noradrenergic excitation from the locus coeruleus to the anterior cingulate cortex
Kohei Koga; Akihiro Yamada; Qian Song; Xu-Hui Li; Qi-Yu Chen; Ren-Hao Liu; Jun Ge; Cheng Zhan; Hidemasa Furue; Min Zhuo; Tao Chen
Molecular Brain, 2020年12月, ［査読有り］
筆頭著者 - Anti-Epileptic Effects of FABP3 Ligand MF1 through the Benzodiazepine Recognition Site of the GABAA Receptor
Yasushi Yabuki; Jiaqi Liu; Ichiro Kawahata; Hisanao Izumi; Yasuharu Shinoda; Kohei Koga; Shinya Ueno; Norifumi Shioda; Kohji Fukunaga
International Journal of Molecular Sciences, 2020年08月, ［査読有り］ - Chronic pain models amplify transient receptor potential vanilloid 1 (TRPV1) receptor responses in adult rat spinal dorsal horn.
Uta D; Yoshimura M; Koga K
Neuropharmacology, 2019年09月, ［査読有り］
ラスト(シニア)オーサー - Muscarinic M1 receptors stimulated by intracerebroventricular administration of McN-A-343 reduces the nerve injury-induced mechanical hypersensitivity via GABAB receptors rather than GABAA receptors in mice.
Migita K; Nishimura A; Eto F; Koga K; Matsumoto T; Terada K; Hara S; Honda K
Journal of pharmacological sciences, 2019年06月, ［査読有り］ - Animal models of chronic pain increase spontaneous glutamatergic transmission in adult rat spinal dorsal horn in vitro and in vivo.
Uta D; Kato G; Doi A; Andoh T; Kume T; Yoshimura M; Koga K
Biochemical and biophysical research communications, 2019年04月, ［査読有り］
ラスト(シニア)オーサー - Lipopolysaccharide induces mouse translocator protein (18 kDa) expression via the AP-1 complex in the microglial cell line, BV-2.
Shimoyama S; Furukawa T; Ogata Y; Nikaido Y; Koga K; Sakamoto Y; Ueno S; Nakamura K
PloS one, 2019年, ［査読有り］ - Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex
Tao Chen; Wataru Taniguchi; Qi-Yu Chen; Hidetoshi Tozaki-Saitoh; Qian Song; Ren-Hao Liu; Kohei Koga; Tsuyoshi Matsuda; Yae Kaito-Sugimura; Jian Wang; Zhi-Hua Li; Ya-Cheng Lu; Kazuhide Inoue; Makoto Tsuda; Yun-Qing Li; Terumasa Nakatsuka; Min Zhuo
Nature Communications, 2018年12月, ［査読有り］ - Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice.
Qiu S; Wu Y; Lv X; Li X; Zhuo M; Koga K
Molecular brain, 2018年09月, ［査読有り］
ラスト(シニア)オーサー - Chronic inflammatory pain induced GABAergic synaptic plasticity in the adult mouse anterior cingulate cortex.
Koga K; Shimoyama S; Yamada A; Furukawa T; Nikaido Y; Furue H; Nakamura K; Ueno S
Molecular pain, 2018年01月, ［査読有り］
筆頭著者 - Involvement of GABAB receptor in the antihypersensitive effect in anterior cingulate cortex of partial sciatic nerve ligation model
Keisuke Migita; Yu Matsuzaki; Kohei Koga; Taichi Matsumoto; Kenichi Mishima; Shuji Hara; Kenji Honda
Journal of Pharmacological Sciences, 2018年, ［査読有り］ - Ethanol-induced enhancement of inhibitory synaptic transmission in the rat spinal substantia gelatinosa.
Yamada A; Koga K; Kume K; Ohsawa M; Furue H
Molecular pain, 2018年01月, ［査読有り］ - 前帯状回のムスカリン受容体はGABA作動性神経を活性化し疼痛閾値を調節する
古賀 浩平; 本多 健治; 古川 智範; 二階堂 義和; 下山 修司; 上野 伸哉
弘前医学, 2017年10月 - Propofol Anesthesia Is Reduced in Phospholipase C-Related Inactive Protein Type-1 Knockout Mice
Yoshikazu Nikaido; Tomonori Furukawa; Shuji Shimoyama; Junko Yamada; Keisuke Migita; Kohei Koga; Tetsuya Kushikata; Kazuyoshi Hirota; Takashi Kanematsu; Masato Hirata; Shinya Ueno
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2017年06月, ［査読有り］ - Neuronal and microglial mechanisms for neuropathic pain in the spinal dorsal horn and anterior cingulate cortex
Makoto Tsuda; Kohei Koga; Tao Chen; Min Zhuo
JOURNAL OF NEUROCHEMISTRY, 2017年05月, ［査読有り］ - SCRAPPER Selectively Contributes to Spontaneous Release and Presynaptic Long-Term Potentiation in the Anterior Cingulate Cortex
Kohei Koga; Ikuko Yao; Mitsutoshi Setou; Min Zhuo
JOURNAL OF NEUROSCIENCE, 2017年04月, ［査読有り］
筆頭著者 - Activations of muscarinic M-1 receptors in the anterior cingulate cortex contribute to the antinociceptive effect via GABAergic transmission
Kohei Koga; Yu Matsuzaki; Kenji Honda; Fumihiro Eto; Tomonori Furukawa; Keisuke Migita; Keiichi Irie; Kenichi Mishima; Shinya Ueno
MOLECULAR PAIN, 2017年02月, ［査読有り］
筆頭著者 - Chronic diazepam administration increases the expression of Lcn2 in the CNS
Tomonori Furukawa; Shuji Shimoyama; Yasuo Miki; Yoshikazu Nikaido; Kohei Koga; Kazuhiko Nakamura; Koichi Wakabayashi; Shinya Ueno
Pharmacology Research and Perspectives, 2017年02月, ［査読有り］ - Metabotropic Glutamate Receptor Dependent Cortical Plasticity in Chronic Pain
Kohei Koga; Shermaine Li; Min Zhuo
CURRENT NEUROPHARMACOLOGY, 2016年, ［査読有り］
筆頭著者 - Impaired Presynaptic Long-Term Potentiation in the Anterior Cingulate Cortex of Fmr1 Knock-out Mice
Kohei Koga; Ming-Gang Liu; Shuang Qiu; Qian Song; Gerile O'Den; Tao Chen; Min Zhuo
JOURNAL OF NEUROSCIENCE, 2015年02月, ［査読有り］
筆頭著者 - Coexistence of Two Forms of LTP in ACC Provides a Synaptic Mechanism for the Interactions between Anxiety and Chronic Pain
Kohei Koga; Giannina Descalzi; Tao Chen; Hyoung-Gon Ko; Jinshan Lu; Shermaine Li; Junehee Son; TaeHyun Kim; Chuljung Kwak; Richard L. Huganir; Ming-gao Zhao; Bong-Kiun Kaang; Graham L. Collingridge; Min Zhuo
NEURON, 2015年01月, ［査読有り］
筆頭著者 - Adenylyl cyclase subtype 1 is essential for late-phase long term potentiation and spatial propagation of synaptic responses in the anterior cingulate cortex of adult mice
Tao Chen; Gerile O'Den; Qian Song; Kohei Koga; Ming-Ming Zhang; Min Zhuo
MOLECULAR PAIN, 2014年10月, ［査読有り］ - Postsynaptic insertion of AMPA receptor onto cortical pyramidal neurons in the anterior cingulate cortex after peripheral nerve injury
Tao Chen; Wen Wang; Yu-Lin Dong; Ming-Ming Zhang; Jian Wang; Kohei Koga; Yong-Hui Liao; Jin-Lian Li; Timotheus Budisantoso; Ryuichi Shigemoto; Makoto Itakura; Richard L. Huganir; Yun-Qing Li; Min Zhuo
MOLECULAR BRAIN, 2014年10月, ［査読有り］ - Long-Term Temporal Imprecision of Information Coding in the Anterior Cingulate Cortex of Mice with Peripheral Inflammation or Nerve Injury
Xiang-Yao Li; Ning Wang; Yong-Jie Wang; Zhen-Xing Zuo; Kohei Koga; Fei Luo; Min Zhuo
JOURNAL OF NEUROSCIENCE, 2014年08月, ［査読有り］ - Pharmacological Rescue of Cortical Synaptic and Network Potentiation in a Mouse Model for Fragile X Syndrome
Tao Chen; Jing-Shan Lu; Qian Song; Ming-Gang Liu; Kohei Koga; Giannina Descalzi; Yun-Qing Li; Min Zhuo
NEUROPSYCHOPHARMACOLOGY, 2014年07月, ［査読有り］ - Postsynaptic potentiation of corticospinal projecting neurons in the anterior cingulate cortex after nerve injury
Tao Chen; Kohei Koga; Giannina Descalzi; Shuang Qiu; Jian Wang; Le-Shi Zhang; Zhi-Jian Zhang; Xiao-Bin He; Xin Qin; Fu-Qiang Xu; Ji Hu; Feng Wei; Richard L. Huganir; Yun-Qing Li; Min Zhuo
MOLECULAR PAIN, 2014年06月, ［査読有り］ - Effects of NB001 and gabapentin on irritable bowel syndrome-induced behavioral anxiety and spontaneous pain
Ming-Ming Zhang; Shui-Bing Liu; Tao Chen; Kohei Koga; Ting Zhang; Yun-Qing Li; Min Zhuo
MOLECULAR BRAIN, 2014年06月, ［査読有り］ - Long-term depression of synaptic transmission in the adult mouse insular cortex in vitro.
Liu MG; Koga K; Guo YY; Kang SJ; Collingridge GL; Kaang BK; Zhao MG; Zhuo M
The European journal of neuroscience, 2013年10月, ［査読有り］ - Cortical GluK1 kainate receptors modulate scratching in adult mice.
Descalzi G; Chen T; Koga K; Li XY; Yamada K; Zhuo M
Journal of neurochemistry, 2013年09月, ［査読有り］ - Long-term potentiation of synaptic transmission in the adult mouse insular cortex: multielectrode array recordings.
Liu MG; Kang SJ; Shi TY; Koga K; Zhang MM; Collingridge GL; Kaang BK; Zhuo M
Journal of neurophysiology, 2013年07月, ［査読有り］ - An increase in synaptic NMDA receptors in the insular cortex contributes to neuropathic pain.
Qiu S; Chen T; Koga K; Guo YY; Xu H; Song Q; Wang JJ; Descalzi G; Kaang BK; Luo JH; Zhuo M; Zhao MG
Science signaling, 2013年05月, ［査読有り］ - Kainate receptor-mediated synaptic transmissions in the adult rodent insular cortex
Kohei Koga; Su-Eon Sim; Tao Chen; Long-Jun Wu; Bong-Kiun Kaang; Min Zhuo
JOURNAL OF NEUROPHYSIOLOGY, 2012年10月, ［査読有り］
筆頭著者 - Characterization of neuronal intrinsic properties and synaptic transmission in layer I of anterior cingulate cortex from adult mice
Xiang-Yao Li; Tao Chen; Giannina Descalzi; Kohei Koga; Shuang Qiu; Min Zhuo
MOLECULAR PAIN, 2012年07月, ［査読有り］ - Rapid synaptic potentiation within the anterior cingulate cortex mediates trace fear learning
Giannina Descalzi; Xiang-Yao Li; Tao Chen; Valentina Mercaldo; Kohei Koga; Min Zhuo
MOLECULAR BRAIN, 2012年02月, ［査読有り］ - Glutamate acts as a neurotransmitter for gastrin releasing peptide-sensitive and insensitive itch-related synaptic transmission in mammalian spinal cord
Kohei Koga; Tao Chen; Xiang-Yao Li; Giannina Descalzi; Jennifer Ling; Jianguo Gu; Min Zhuo
MOLECULAR PAIN, 2011年06月, ［査読有り］
筆頭著者 - Identification of an Adenylyl Cyclase Inhibitor for Treating Neuropathic and Inflammatory Pain
Hansen Wang; Hui Xu; Long-Jun Wu; Susan S. Kim; Tao Chen; Kohei Koga; Giannina Descalzi; Bo Gong; Kunjumon I. Vadakkan; Xuehan Zhang; Bong-Kiun Kaang; Min Zhuo
SCIENCE TRANSLATIONAL MEDICINE, 2011年01月, ［査読有り］ - Interplay of Amygdala and Cingulate Plasticity in Emotional Fear
Hiroki Toyoda; Xiang-Yao Li; Long-Jun Wu; Ming-Gao Zhao; Giannina Descalzi; Tao Chen; Kohei Koga; Min Zhuo
NEURAL PLASTICITY, 2011年, ［査読有り］ - Alleviating Neuropathic Pain Hypersensitivity by Inhibiting PKM zeta in the Anterior Cingulate Cortex
Xiang-Yao Li; Hyoung-Gon Ko; Tao Chen; Giannina Descalzi; Kohei Koga; Hansen Wang; Susan S. Kim; Yuze Shang; Chuljung Kwak; Soo-Won Park; Jaehoon Shim; Kyungmin Lee; Graham L. Collingridge; Bong-Kiun Kaang; Min Zhuo
SCIENCE, 2010年12月, ［査読有り］ - In vivo whole-cell patch-clamp recording of sensory synaptic responses of cingulate pyramidal neurons to noxious mechanical stimuli in adult mice
Kohei Koga; Xiangyao Li; Tao Chen; Hendrik W. Steenland; Giannina Descalzi; Min Zhuo
MOLECULAR PAIN, 2010年09月, ［査読有り］
筆頭著者 - Spinal microglial motility is independent of neuronal activity and plasticity in adult mice
Tao Chen; Kohei Koga; Xiang-Yao Li; Min Zhuo
MOLECULAR PAIN, 2010年04月, ［査読有り］ - Organization of Intralaminar and Translaminar Neuronal Connectivity in the Superficial Spinal Dorsal Horn
Go Kato; Yasuhiko Kawasaki; Kohei Koga; Daisuke Uta; Masafumi Kosugi; Toshiharu Yasaka; Megumu Yoshimura; Ru-Rong Ji; Andrew M. Strassman
JOURNAL OF NEUROSCIENCE, 2009年04月, ［査読有り］ - The Spinal Muscarinic M-1 Receptors and GABA(A) Receptors Contribute to the McN-A-343-Induced Antinociceptive Effects During Thermal Stimulation of Mice
Kenji Honda; Keigo Horikawa; Suguru Ando; Kohei Koga; Satoshi Kawata; Keisuke Migita; Yukio Takano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008年12月, ［査読有り］ - Slow oscillation of membrane currents mediated by glutamatergic inputs of rat somatosensory cortical neurons: in vivo patch-clamp analysis
Atsushi Doi; Masaharu Mizuno; Toshihiko Katafuchi; Hidemasa Furue; Kohei Koga; Megumu Yoshimura
EUROPEAN JOURNAL OF NEUROSCIENCE, 2007年11月, ［査読有り］ - [Analysis of hypnotic or analgesic effect of anesthetic agents by in-vivo patch clamp recordings from somatosensory cortex in rats].
Shiokawa H; Doi A; Koga K; Takahashi S; Yoshimura M
Masui. The Japanese journal of anesthesiology, 2007年11月, ［査読有り］ - Contribution of Ca2+-dependent protein kinase C in the spinal cord to the development of mechanical allodynia in diabetic mice
Kenji Honda; Masako Koguchi; Koliel Koga; Kyoko Nakajima; Furnito Kobayashi; Keisuke Migita; Shigenori Gata; Yasutoshi Hirabara; Yukio Takano
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2007年05月, ［査読有り］ - Cadherin-8 is required for the first relay synapses to receive functional inputs from primary sensory afferents for cold sensation
Sachihiro C. Suzuki; Hidemasa Furue; Kohei Koga; Nan Jiang; Mitsuo Nohmi; Yuka Shimazaki; Yuko Katoh-Fukui; Minesuke Yokoyama; Megumu Yoshimura; Masatoshi Takeichi
JOURNAL OF NEUROSCIENCE, 2007年03月, ［査読有り］ - Impairment of afferent synaptic inputs for mechanical and cold sensation to substantia gelatinosa neurons of the rat spinal dorsal horn through cadherin-8 expressing synaptic glomeruli
Hidemasa Furue; Sachihiro S. C. Suzuki; Kohei Koga; Mitsuo Nohmi; Masatoshi Takeichi; Megumu Yoshimura
NEUROSCIENCE RESEARCH, 2007年, ［査読有り］ - Actions of brain-derived neurotrophic factor on spinal nociceptive transmission during inflammation in the rat
S Matayoshi; N Jiang; T Katafuchi; K Koga; H Furue; T Yasaka; T Nakatsuka; XF Zhou; Y Kawasaki; N Tanaka; M Yoshimura
JOURNAL OF PHYSIOLOGY-LONDON, 2005年12月, ［査読有り］ - Direct inhibition of substantia gelatinosa neurones in the rat spinal cord by activation of dopamine D2-like receptors
A Tamae; T Nakatsuka; K Koga; G Kato; H Furue; T Katafuchi; M Yoshimura
JOURNAL OF PHYSIOLOGY-LONDON, 2005年10月, ［査読有り］ - Selective activation of primary afferent fibers evaluated by sine-wave electrical stimulation
Kohei Koga; Hidemasa Furue; Md Harunor Rashid; Atsushi Takaki; Toshihiko Katafuchi; Megumu Yoshimura
MOLECULAR PAIN, 2005年03月, ［査読有り］
筆頭著者 - Functional role of postsynaptic dopamine receptors in substantia gelatinosa neurons of the spinal cord
T.Nakatsuka; A.Tamae; K.Koga; G.Kato; T.Fujita; H.Furue; E.Kumamoto; M.Yoshimura
Pain Research, 2005年 - The spinal muscarinic receptor subtypes contribute to the morphine-induced antinociceptive effects in thermal stimulation in mice
K Honda; S Ando; K Koga; Y Takano
NEUROSCIENCE LETTERS, 2004年11月, ［査読有り］ - Intrathecal clonidine inhibits mechanical allodynia via activation of the spinal muscarinic M-1 receptor in streptozotocin-induced diabetic mice
K Koga; K Honda; S Ando; Harasawa, I; H Kamiya; Y Takano
EUROPEAN JOURNAL OF PHARMACOLOGY, 2004年11月, ［査読有り］
筆頭著者 - Intrathecal alpha(2) adrenoceptor agonist clonidine inhibits mechanical transmission in mouse spinal cord via activation of muscarinic M-1 receptors
K Honda; K Koga; T Moriyama; M Koguchi; Y Takano; H Kamiya
NEUROSCIENCE LETTERS, 2002年04月, ［査読有り］
MISC
- ジアゼパム長期投与マウスにおける脳内Lcn2発現および認知機能の解析
古川 智範; 二階堂 義和; 下山 修司; 三木 康生; 古賀 浩平; 中村 和彦; 若林 孝一; 上野 伸哉
弘前医学, 2017年10月 - 脳内報酬系の包括的分子解析 ノルアドレナリンによる前帯状回賦活化作用の分子メカニズム
古江 秀昌; 古賀 浩平; 山田 彬博
日本アルコール・薬物医学会雑誌, 2017年08月
講演・口頭発表等
- 前帯状回のシナプス前終末における長期増強の形成と不安様行動
古賀浩平
第27回 神経行動薬理若手研究者の集い, 2018年06月 - Functional roles of presynaptic long-term potentiation in the anterior cingulate cortex for pain and anxiety.
Koga K
第40回 日本疼痛学会, 2018年06月 - The ubiquitin proteasome system regulates presynaptic long-term potentiation in the anterior cingulate cortex.
第95回 日本生理学会大会, 2018年03月 - Cingulate presynaptic long-term potentiation contributes to chronic pain induced anxiety
Koga K; Yamada A; Furue H; Zhuo M
第44回 日本脳科学会, 2017年10月 - Presynaptic long term plasticity in the anterior cingulate cortex for chronic pain induced anxiety
Koga K; Zhuo M
The 6th Asian Pain Symposium (APS2015), 2015年11月
