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    Determination of breathing that regulates brain function and its application:


    Breathing is a fundamental action of life support in mammals. Breathing can change sensitively and intensively during different situations in daily life. Breathing oscillations couple with perception and actions. Sports and martial arts, such as boxing, and Kendo and Sumo fighting, are known to recruit breathing-associated actions. Japanese expression "Aun's breathing" indicates that people are in sync with each other or when people are attuned to each other. It is likely that breathing can be involved in a special "attunement" shared between self and others and between human and nature.


    A growing body of research proposes that breathing exercises, such as Yoga and Zen meditation, can provide stress reduction. In relation to breathing, allostasis is an feedforward action and highlights as a key concept for life support and mind principles (together with free energy principle).


    Have you heard about the reason why respiration has "dual innvervation" involuntarily and voluntarily? Is the voluntary function of breathing necessary? Are there any special role for voluntary respiration?


    To determine these roles, we use two dimensional, human and mouse approaches, both of which can compensate the merits and demerits each other. Our recent findings have brought essential roles for respiration during "online brain states", such as salience, attention, memory encoding and retrieval (see Nakamura et al., Cereb Cortex Commun, 2022; Nakamura et al., Nat Commun, 2023). These findings have been introduced with articles and video clips in 16 languages, including Japanese, English, French, Spanish, Portuguese, Italian, Russian, Estonian, Ukrainian, Arabic, and Chinese (News video clip: https://cheddar.com/media/study-how-you-breathe-can-affect-memory).

Last Updated :2024/09/15

Degree

  • Ph.D., Hokkaido University School of Medicine

Research Keyword

  • Active sensing
  • Corollary discharge
  • Interoception
  • Respiration
  • Salience network
  • Temporoparietal junction
  • Allostasis
  • Steroid hormone
  • Gene expression
  • Prefrontal cortex
  • Hippocampus
  • Inference
  • Cognitive function
  • Memory

Field Of Study

  • Life sciences, Nervous system function
  • Life sciences, Neuroscience - general
  • Life sciences, Basic brain sciences
  • Humanities & social sciences, Cognitive sciences

Career

  • Feb. 2015 - Present
    Hyogo College of Medicine, Nishinomiya, Japan, Department of Physiology, Assistant Professor
  • Apr. 2011 - Jan. 2015
    Ruhr-Universität Bochum, Bochum, Germany, Mercator Research Group Structure of Memory, Researcher
  • Sep. 2006 - Mar. 2011
    Okinawa Institute of Science and Technology, Okinawa, Japan, Researcher
  • Oct. 2001 - Aug. 2006
    Rockefeller University, New York, USA, Lab of Neuroendocrinology, Postdoctoral Associate
  • Apr. 2001 - Sep. 2001
    Kyoto Prefectural University of Medicine, 研修員

Educational Background

  • Mar. 2001, Hokkaido University, Gradulate School of Medicine

Member History

  • Apr. 2022 - Present
    西宮共同利用研究施設運営小委員会委員利用者会代表, 兵庫医科大学
  • Apr. 2022 - Present
    西宮病態モデル研究センター利用者会議世話人代表, 兵庫医科大学
  • Apr. 2021 - Present
    エディケータ認定, 日本生理学会
  • Apr. 2020 - Present
    評議員, 日本生理学会
  • Apr. 2020 - Mar. 2022
    共同利用研究施設微細形態エリア代表管理責任者, 兵庫医科大学

Paper

MISC

Books and other publications

Lectures, oral presentations, etc.

  • Brain-breath interactions: Memory improvement and deterioration modulated by medullary respiratory activity during encoding               
    Nozomu Nakamura
    Neuro2024, Fukuoka Convention center, Hakata, Jul. 2024
  • 〔Major achievements〕A crosstalk interaction between the brain and breath: Timing-dependent effects of respiration on functional brain networks and beyond               
    Nozomu H. Nakamura
    Symposium "A New Vision for Respiratory Study: Emotion-Cogntion Approaches" The 101st Annual Meeting of Physiological Society of Japan, Kita Kyushu Convention Center, Kita Kyushu, Mar. 2024, [Invited]
  • Brain-breath interactions: Memory enhancement and decline induced by central respiratory activity during encoding (PSTR501.04)               
    Nozomu H. Nakamura; Hidemasa Furue; Kenta Kobayashi; Yoshitaka Oku
    Society for Neuroscience Annual Meeting Neuroscience 2023, Wathington DC Convention Center, Washington DC, USA(現地開催), Nov. 2023
  • 脳息相関:記憶エンコーディング時の呼吸中枢活動によって促される記憶の強化と低下 (HT-1)               
    中村 望
    第76回本自律神経学会総会、ホットトピックセッション、埼玉会館(さいたま), Oct. 2023
  • Respiration timing-dependent modulation of neural substrates during cognitive processes (1P-039)
    Nakamura NH; Fukunaga M; Yamamoto T; Sadato N; Oku Y
    The 100th Anniversary Annual Meeting of The Physiological Society of Japan, Mar. 2023
  • The retrieval process coordinated by respiration via the right temporoparietal junction (081.11)
    Nakamura NH; Fukunaga M; Yamamoto T; Sadato N; Oku Y
    Society for Neuroscience Annual Meeting Neuroscience 2022, San Diego Convention Center, San Diego, CA, USA, Nov. 2022
  • 〔Major achievements〕Respiration timing-dependent modulation of neural substrates during cognitive processes
    Nozomu H. Nakamura
    The 15th Oxford Conference on Modeling and Control of Breathing (Oxford Conference 2020), Odawara, Japan, Oct. 2022, [Invited]
  • 〔Major achievements〕Memory consolidation initiated by central inspiratory signals from the PreBötzinger complex.
    Nozomu Nakamura
    Public Symposium, Mind-body interaction and mental conditioning, The Physiological Society of Japan 2022, Mar. 2022, [Invited]
  • マウス吸息活動による記憶機能の制御 (GP12-1)
    中村 望
    第74回日本自律神経学会総会(Web開催), Oct. 2021
  • Cognitive fluctuations caused by respiration through the right temporoparietal junction
    Nozomu Nakamura
    第5回ヒト脳イメージング研究会, Sep. 2021
  • Enhancement of contextual memory by cross-modal distraction of tones               
    Nozomu Nakamura
    第98回日本生理学会大会(第126回日本解剖学会総会と合同大会), Mar. 2021
  • 環境要因のクロスモダリティによる文脈記憶の増強               
    中村 望
    第91回日本衛生学会学術総会(Web開催), Mar. 2021
  • Improvement of contextual memory by cross-modal distraction of tones in mice (3P-170)               
    Nakamura NH; Beichert L; Kitsukawa T
    第43回日本神経科学大会(Web開催), Aug. 2020
  • Respiratory phase transition modulates cognitive performance during the retrieval process (O05-1)               
    Nakamura NH
    第97回日本生理学大会(新型コロナウイルス感染拡大のため、誌上開催に変更), Mar. 2020
  • 〔Major achievements〕Respiratory-dependent cognitive decline during the retrieval process
    Nozomu Nakamura
    Friday Lunch Seminar 国立研究開発法人 情報通信研究機構 脳情報通信融合研究センターCiNET(大阪大学吹田キャンパス、大阪), Dec. 2019, [Invited]
  • Respiratory fluctuations in pupil diameter are not maintained during cognitive tasks (1P-324)
    Nakamura NH; Fukunaga M; Oku Y
    Asian and Oceanian Physiological Societies Congress (FAOPS 2019), Mar. 2019
  • Respiratory modulation of cognitive performance during the retrieval process (248.24)
    Nakamura NH; Fukunaga M; Oku Y
    Society for Neuroscience Annual Meeting Neuroscience 2018, Convention Center, San Diego, CA, USA, Nov. 2018
  • Respiratory modulation of cognitive performance during the retrieval process (1O-10a1-2)               
    Nakamura NH
    第41回日本神経科学大会、神戸コンベンションセンター(神戸), Jul. 2018
  • Breathing-dependent cognitive decline during memory retrieval (1O-10AM-1)               
    Nakamura NH
    第95回日本生理学会大会、サンポートホール高松(高松), Mar. 2018
  • Recruitment of cardiac vagal tone in a short delay during cognitive processes               
    Nakamura NH; Fukunaga M; Oku Y
    The 14th Oxford Conference on Modelling and Control of Breathing (Oxford Conference 2017), Merton College, Oxford, UK, Sep. 2017
  • ストレスを記憶から消す?― 衛生学という名の下でのストレスと記憶 ―               
    中村 望
    第36回生体と金属・化学物質に関する研究会(チョークトーク2017)長良川温泉(岐阜), Aug. 2017
  • Vagal tone is predicted by involuntary exhalation immediately before a stress inducible task (1P-263)               
    Nakamura NH; Fukunaga M; Oku Y
    第40回日本神経科学大会、幕張メッセ(千葉), Jul. 2017
  • Stability of “vagal brake” to a mental stress response during a discrimination task – A role of regular extended expiration – (2P-099)               
    Nakamura NH; Fukunaga M; Oku Y
    第94回日本生理学会大会、アクトシティ浜松(浜松), Mar. 2017
  • Natural respiratory types on cognitive flexibility and recognition during human discrimination task (749.13)               
    Nakamura NH; Fukunaga M; Oku Y
    Society for Neuroscience Annual Meeting Neuroscience 2016, San Diego Convention Center, San Diego, CA, Nov. 2016
  • Dynamic pattern activity of CA3 and CA1 along the longitudinal axis for successful performance (O2-H-2-4)               
    Nakamura NH
    第39回日本神経科学大会、パシフィコ横浜(横浜), Jul. 2016
  • Natural respiratory types of deductive reasoning during human discrimination task (2P-128)               
    Nakamura NH; Fukunaga M; Oku Y
    第93回日本生理学会大会、札幌コンベンションセンター(札幌), Mar. 2016
  • 〔Major achievements〕よりよく生きていくための呼吸               
    中村 望
    第37回いのちの科学フォーラム 健康のための呼吸 コープイン京都(京都), Feb. 2016, [Invited]
  • Differential contribution of the medial and lateral entorhinal cortices, the perirhinal and postrhinal cortices and the hippocampal subfields to familiarity (91.10)               
    A. MALET-KARAS; N. NAKAMURA; T. KITSUKAWA; M. SAUVAGE
    Society for Neuroscience Annual Meeting Neuroscience 2014, Washington DC Convention Center, Washington DC, Nov. 2015
  • Functional evidence for a distal CA1-proximal subiculum-lateral entorhinal cortex network in recognition memory (750.01)               
    Nakamura NH; Sauvage MM
    Society for Neuroscience Annual Meeting Neuroscience 2014, Convention Center, Washington, DC, Nov. 2014
  • Segregation of spatial information along the proximodistal axis of CA3: Additional hints of segregated spatial and non-spatial subnetworks within the hippocampus (463.05)               
    Flasbeck V; Nakamura N; Sauvage M
    Society for Neuroscience Annual Meeting Neuroscience 2014, Convention Center, Washington DC, Nov. 2014
  • Dorsal CA1: Encoding- but retrieval-like activity correlates with memory performance: An Arc/Homer1a imaging study (863.12)               
    Nakamura NH; Sauvage MM
    Society for Neuroscience Annual Meeting Neuroscience 2013, San Diego Convention Center, San Diego, CA, Nov. 2013
  • 〔Major achievements〕海馬の機能分化:非空間情報の記憶と化学シナプスにおける潜在的役割               
    中村 望
    大阪大学大学院 生命機能研究科セミナー(大阪), Aug. 2013, [Invited]
  • Proximodistal functional segregation of CA3 in nonspatial recognition memory: preferential involvement of a proximal CA3-distal CA1 network (203.27)               
    Nakamura NH; Maingret N; Flasbeck V; Kitsukawa T; Sauvage MM
    Society for Neuroscience Annual Meeting Neuroscience 2012, New Orleans Convention Center, New Orleans, LA, Oct. 2012
  • Functional segregation of the medial temporal lobe in operant recognition memory: olfactory stimuli and immediate-early gene imaging (835.05)               
    Nakamura NH; Maingret N; Flasbeck V; Kitsukawa T; Sauvage MM
    Society for Neuroscience Annual Meeting Neuroscience 2011, Convention Center, Washington, DC, Nov. 2011
  • Genome-wide and quantitative gene-expression analyses of cerebellar Purkinje cells as a model single-type neuron               
    Nakamura NH; Akiyama K; Naito T
    第33回日本分子生物学会年会、第83回日本生化学会大会合同大会(BMB2010)、神戸ポートアイランド(神戸), Dec. 2010
  • Memory transfer from hippocampus to neocortex (398.21)               
    Wilken G; Nakamura N
    Society for Neuroscience Annual Meeting Neuroscience 2010, Convention Center, San Diego, CA, Oct. 2010
  • Suppression of cAMP-dependent gene expression in the hippocampus by cholecystokinin and extracellular regulatory machinery               
    Nakamura NH; Akiyama K; Naito T
    第33回日本神経科学・第53回日本神経化学・第20回日本神経回路合同大会(Neuro2010)、神戸コンベンションセンター(神戸), Sep. 2010
  • 〔Major achievements〕Hippocampal neurons encoded places by forming small anatomical clusters: A potential role of local neuropeptides               
    中村 望
    京都府立医科大学 神経懇話会セミナー(京都), Mar. 2010, [Invited]
  • Cholecystokinin suppresses cAMP-dependent immediate-early gene expression in the hippocampus               
    Nakamura NH; Akiyama K; Naito T
    第32回日本分子生物学会年会、パシフィコ横浜(横浜), Dec. 2009
  • Cholecystokinin suppresses cAMP-dependent immediate-early gene expression in the hippocampus               
    Nakamura NH; Akiyama K; Naito T
    第32回日本神経科学大会、名古屋国際会議場(名古屋), Sep. 2009
  • マウス海馬におけるリガンドーレセプターシステムの遺伝子発現解析               
    中村 望; 秋山清隆; 中西節子; 内藤隆之
    第31回日本分子生物学会年会、第81回日本生化学会大会合同大会(BMB2008)、神戸ポートアイランド(神戸), Dec. 2008
  • Hippocampal functional organization of immediate-early gene-expressing cells encoding for the spatial environment. (191.18)               
    Nakamura NH; Fukunaga M; Akama KT; Ogawa S; Pavlides C
    Society for Neuroscience Annual Meeting Neuroscience 2008, Convention Center, Washington, DC, Nov. 2008
  • 〔Major achievements〕Changes in interneuronal phenotypes and neuronal plasticity regulated by estradiol in the adult rat hippocampus (SY1-04-05)               
    Nozomu Nakamura
    第28回日本神経科学大会 シンポジウム「神経シナプス可塑性を変化させる脳内性ホルモンと環境ホルモン:神経内分泌学の革新」パシフィコ横浜(横浜), Jul. 2005, [Invited]
  • Estrogen effects on expression of cation-chloride cotransporters, calcium binding proteins, and neuropeptides in adult female rat hippocampus. (757.2)               
    Nakamura NH; McEwen BS
    Society for Neuroscience Annual Meeting Neuroscience 2004, Convention Center, San Diego, CA, Oct. 2004
  • Estrogen and ovariectomy regulate expression of glutamatic acid decarboxylase and cation-chloride cotransporters in adult female rat hippocampus               
    Nakamura NH; Rossel DR; Akama KT; McEwen BS
    第27回日本神経科学・第47回日本神経化学合同大会(Neuro2004)、大阪国際会議場、大阪, Sep. 2004
  • Estrogen effects on glutamic acid decarboxylase expression in adult female rat hippocampus. (395.2)               
    Nakamura NH; McEwen BS
    Society for Neuroscience Annual Meeting Neuroscience 2003, Convention Center, New Orleans, LA, Nov. 2003
  • Studies of estrogen-sensitive interneurons in the hippocampus of the adult rat. (368.6)               
    Nakamura N; Rossel DR; Akama KT; McEwen BS
    Society for Neuroscience 32th Annual Meeting Neuroscience 2002, Convention Center, Orlando, FL, Nov. 2002
  • Does testosterone affect dendritic spines and presynapses in the hippocampal CA1, CA3, and entorhinal cortex of adult male rat? (627.2)               
    Nakamura N; Xie CX; Ozawa H; Kawata M
    Society for Neuroscience 31th Annual Meeting, Convention Center, San Diego, CA, Nov. 2001
  • 成熟雄ラット海馬CA1,CA3,海馬台錐体細胞の樹状突起棘密度へのテストステロンの影響               
    中村 望; 謝 藏霞; 小澤一史; 河田光博
    第24回日本神経科学・第44回日本神経化学合同大会(Neuro2001)、国立京都国際会館、京都, Sep. 2001
  • 空間認知・記憶領域(皮質・前脳基底部・海馬)におけるにアセチルコリン・GABAニューロンに対するテストステロンの影響               
    中村 望; 小澤一史; 藤田博美; 河田光博
    第106回日本解剖学会、高知医科大学、高知, Apr. 2001
  • 空間認知に関連した成熟ラット脳領域におけるアセチルコリン・GABA作動性ニューロン機構へのテストステロンの影響               
    中村 望; 落合育雄; 小澤一史; 植野洋志; 藤田博美; 河田光博
    第76回日本解剖学会近畿支部学術集会、京都大学大学院理学研究科、京都, Dec. 2000
  • Does testosterone affect cholinergic and GABAergic neuron system associated with spatial processing in adult rat? (804.11)               
    Nakamura N; Ochiai I; Ozawa H; Fujita H; Kawata M
    Society for Neuroscience 30th Annual Meeting, Convention Center, New Orleans, LA, Nov. 2000
  • 空間認知に関連した成熟ラット脳領域におけるアセチルコリン・GABA作動性ニューロン機構へのテストステロンの影響               
    中村 望; 落合育雄; 小澤一史; 植野洋志; 藤田博美; 河田光博
    第23回日本神経科学大会、パシフィコ横浜、横浜, Sep. 2000
  • 脳内各種神経伝達物質に対するテストステロンの影響−ChAT及びGADの免疫組織化学−               
    中村 望; 小澤一史; 河田光博
    第105回日本解剖学会、パシフィコ横浜、横浜, Mar. 2000
  • 体性感覚刺激に対する反応選択の帯状皮質前部の活動−fMRIによる研究−               
    中村 望; 山本 徹; 斎藤 健; 藤田博美
    第12回臨床MR脳機能研究会、エーザイ本社、東京, Aug. 1999
  • 体性感覚刺激に対する反応選択の帯状皮質前部の活動−fMRIによる研究−               
    中村 望; 山本 徹; 斎藤 健; 藤田博美
    第3回GE横河メディカルシステムMR共同研究発表会、都市センターホテル、東京, Jul. 1999
  • Evaluation of motion correction in fMRI -Dependency of spatial resolution-               
    Kumazawa S; Yamamoto T; Nakamura N; Yamamoto T; Miyasaka K
    International Society for Magnetic Resonance in Medicine 7th Scientific Meeting, Convention Center, Pennsylvania, May 1999
  • A quantitative analysis of artifacts in fMRI               
    Yamamoto T; Kumazawa S; Nakamura N; Miyasaka K
    International Society for Magnetic Resonance in Medicine 7th Scientific Meeting, Convention Center, Pennsylvania, May 1999
  • 反応選択におけるヒト脳の帯状回皮質前部の活動:機能的磁気共鳴撮像法による研究               
    中村 望; 山本 徹; 斎藤 健; 藤田博美
    第69回日本衛生学会、千葉市文化センター、千葉, Mar. 1999
  • 体性感覚刺激の反応選択における帯状回皮質前部の活動—fMRIによる研究—               
    中村 望; 山本 徹; 斎藤 健; 藤田博美
    第1回ヒト脳機能マッピング研究会、アクトシティ浜松コングレスセンター、浜松, Mar. 1999
  • 体性感覚刺激に対する選択的注意のfMRIによる研究               
    中村 望; 山本 徹; 金山健夫; 熊澤誠志; 斎藤 健
    第11回臨床MR脳機能研究会、エーザイ本社、東京, Aug. 1998

Courses

  • Medical English               
    Faculty of Medicine, Hyogo Medical University
  • Morphological application and observation, Gradulate School of Medicine               
    Gradulate School of Medicine, Hyogo Medical University
  • Applied physiology: Crosstalk interactions between the brain and body through the body manipulation               
    Hyogo Medical University
  • Introduction to Medical Science (Academic Literacy)               
    Hyogo Medical University
  • European Campus of Excellence Summer School               
    Ruhr-Universität Bochum
  • TBL (Physiology and Pharmacology)               
    Hyogo Medical University
  • Physiology (Regulation of Neuronal Function)               
    Hyogo Medical University
  • Basic research               
    Hyogo Medical University
  • Physiology (Homeostasis)               
    Hyogo Medical University
  • Physiology Pratical               
    Hyogo Medical University

Research Themes

Media Coverage

Academic Contribution Activities

  • UW Short Course in Bioethics               
    Others
    Hyogo Medial Unviersity, Hirakata Ryoikuen, University of Washington School of Medicine, USA, Aug. 2023
  • Academic consulting               
    Supervision
    A foreign-affiliated company, Hyogo Medical University, 2021 - 2022
  • Research guidance and evaluation               
    Supervision
    Department of Medicine, Yamoguchi University, Hyogo Medical University, Jun. 2019 - Nov. 2019
  • UW Short Course in Bioethics               
    Others
    Hyogo Medial Unviersity, Hirakata Ryoikuen, University of Washington School of Medicine, USA, Aug. 2019
  • Evaluation of the PhD thesis               
    Review
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, 2019
  • Research guidance and evaluation               
    Supervision
    IFMSA (International Federation of Medical Students Associations), Hyogo Medical University, Sep. 2017 - Oct. 2017
  • Evaluation of the PhD thesis               
    Review
    Facultat de Biologiques, Universitat de Valencia, Spain, 2012
  • Research guidance and evaluation               
    Supervision
    Kyoto Prefecutual University of Medicine, Rockefeller University, USA, Jul. 2006 - Aug. 2006