Last Updated :2024/12/13
Researcher Information
Research activity information
Paper
- Oncogenic transformation of NIH/3T3 cells by the overexpression of L-type amino acid transporter 1, a promising anti-cancer target
Natsumi Hayashi; Akitaka Yamasaki; Shiho Ueda; Shogo Okazaki; Yoshiya Ohno; Toshiyuki Tanaka; Yuichi Endo; Yoshihisa Tomioka; Kazue Masuko; Takashi Masuko; Reiko Sugiura
Oncotarget, Jun. 2021 - Reduced lifespan of erythrocytes in Dahl/Salt sensitive rats is the cause of the renal proximal tubule damage
Eri Manabe; Satoyasu Ito; Yoshiya Ohno; Toshiyuki Tanaka; Yoshiro Naito; Naoko Sasaki; Masanori Asakura; Tohru Masuyama; Masaharu Ishihara; Takeshi Tsujino
Scientific Reports, Dec. 2020 - Neutrophil/lymphocyte ratio elevation in renal dysfunction is caused by distortion of leukocyte hematopoiesis in bone marrow.
Ito Satoyasu; Ohno Yoshiya; Tanaka Toshiyuki; Kobuchi Shuhei; Ayajiki Kazuhide; Manabe Eri; Masuyama Tohru; Jun-Ichi Sakamoto; Tsujino Takeshi
Renal failure, Nov. 2019, [Reviewed] - Differential regulation of the sphere formation and maintenance of cancer-initiating cells of malignant mesothelioma via CD44 and ALK4 signaling pathways.
Ohno Yoshiya; Shingyoku Serina; Miyake Sakina; Tanaka Aya; Fudesaka Sena; Shimizu Yuta; Yoshifuji Ai; Yamawaki Yuki; Yoshida Sachiyo; Tanaka Saya; Sakura Kazuma; Tanaka Toshiyuki
Oncogene, Dec. 2018, [Reviewed] - Inhibition of tumor formation and metastasis by a monoclonal antibody against lymphatic vessel endothelial hyaluronan receptor 1.
Yuta Hara; Ryota Torii; Shiho Ueda; Erina Kurimoto; Eri Ueda; Hiroshi Okura; Yutaka Tatano; Hideki Yagi; Yoshiya Ohno; Toshiyuki Tanaka; Kazue Masuko; Takashi Masuko
Cancer science, Oct. 2018, [Reviewed] - Inhibition of tumor formation and metastasis by a monoclonal antibody against lymphatic vessel endothelial hyaluronan receptor 1.
Hara Yuta; Torii Ryota; Ueda Shiho; Kurimoto Erina; Ueda Eri; Okura Hiroshi; Tatano Yutaka; Yagi Hideki; Ohno Yoshiya; Tanaka Toshiyuki; Masuko Kazue; Masuko Takashi
Cancer science, Oct. 2018, [Reviewed] - Differential regulation of the sphere formation and maintenance of cancer-initiating cells of malignant mesothelioma via CD44 and ALK4 signaling pathways.
Ohno Y; Shingyoku S; Miyake S; Tanaka A; Fudesaka S; Shimizu Y; Yoshifuji A; Yamawaki Y; Yoshida S; Tanaka S; Sakura K; Tanaka T
Oncogene, Jul. 2018, [Reviewed] - NIH3T3 cells overexpressing CD98 heavy chain resist early G1 arrest and apoptosis induced by serum starvation
Kaori Hara; Shiho Ueda; Yoshiya Ohno; Toshiyuki Tanaka; Hideki Yagi; Shogo Okazaki; Rieko Kawahara; Takechi Masayuki; Takemi Enomoto; Yoshiyuki Hashimoto; Kazue Masuko; Takashi Masuko
CANCER SCIENCE, Aug. 2012, [Reviewed] - Anti-Tumor Effect against Human Cancer Xenografts by a Fully Human Monoclonal Antibody to a Variant 8-Epitope of CD44R1 Expressed on Cancer Stem Cells
Kazue Masuko; Shogo Okazaki; Mayumi Satoh; Goh Tanaka; Tatsuya Ikeda; Ryota Torii; Eri Ueda; Takashi Nakano; Masaaki Danbayashi; Tomoyo Tsuruoka; Yoshiya Ohno; Hideki Yagi; Noritsugu Yabe; Hideaki Yoshida; Tomoyuki Tahara; Shiro Kataoka; Taichi Oshino; Takayuki Shindo; Shin-ichiro Niwa; Takatsugu Ishimoto; Hideo Baba; Yoshiyuki Hashimoto; Hideyuki Saya; Takashi Masuko
PLOS ONE, Jan. 2012, [Reviewed] - Oncogenicity of L-type amino-acid transporter 1 (LAT1) revealed by targeted gene disruption in chicken DT40 cells: LAT1 is a promising molecular target for human cancer therapy.
Ohkawa M; Ohno Y; Masuko K; Takeuchi A; Suda K; Kubo A; Kawahara R; Okazaki S; Tanaka T; Saya H; Seki M; Enomoto T; Yagi H; Hashimoto Y; Masuko T
Biochem Biophys Res Commun., May 2011, [Reviewed] - Towards therapeutic antibodies to membrane oncoproteins by a robust strategy using rats immunized with transfectants expressing target molecules fused to green fluorescent protein
Takashi Masuko; Yoshiya Ohno; Kazue Masuko; Hideki Yagi; Shinya Uejima; Masayuki Takechi; Yoshiyuki Hashimoto
CANCER SCIENCE, Jan. 2011 - Simultaneous induction of apoptotic, autophagic, and necrosis-like cell death by monoclonal antibodies recognizing chicken transfferin receptor.
Ohno Y; Yagi H; Nakamura M; Masuko K; Hashimoto Y; Masuko T
Biochem Biophys Res Commun., May 2008, [Reviewed] - Production and characterization of highly tumor-specific rat monoclonal antibodies recognizing the extracellular domain of human L-type amino-acid transporter 1
Yoshiya Ohno; Kentaro Suda; Kazue Masuko; Hideki Yagi; Yoshiyuki Hashimoto; Takashi Masuko
CANCER SCIENCE, May 2008 - Cell-death-inducing monoclonal antibodies raised against DT40 tumor cells: Identification of chicken transferrin receptor as a novel cell-death receptor
Yoshiya Ohno; Hideki Yagi; Masanori Nakamura; Kazue Masuko; Yoshiyuki Hashimoto; Takashi Masuko
CANCER SCIENCE, May 2008
MISC
Lectures, oral presentations, etc.
- マウス大腸癌細胞における mIFNGR1 シグナルの役割
二宮友可; 大野喜也; 田中稔之
第67回日本薬学会近畿支部総会・大会, Oct. 2017 - マウスがん細胞の in vivo 増殖における PD-L1 の役割
河野真紀; 檜垣里沙; 久世彩名; 二宮友可; 大野喜也; 田中稔之
第67回日本薬学会近畿支部総会・大会, Oct. 2017 - IL-18 による免疫チェックポイント阻害剤の作用増強における CD122 陽性細胞の関与
加戸祥揮; 大野喜也; 田中稔之
第67回日本薬学会近畿支部総会・大会, Oct. 2017 - Activin-Aとヒアルロン酸を介するALDH陽性悪性中皮腫細胞の維持機構
大野喜也; 新玉紗理奈; 三宅咲奈; 田中亜弥; 筆坂世奈; 清水雄太; 山脇優輝; 田中稔之
第67回日本薬学会近畿支部総会・大会, Oct. 2017 - Jurkat を用いた T 細胞遊走に関する研究
板垣駿輔; 大野喜也; 田中稔之
第66回 日本薬学会近畿支部総会・大会, Oct. 2016 - Hypoxia contributes to maintenance of highly tumorigenic CD133 + malignant mesothelioma cells in vitro.
Yoshiya Ohno; Toshiyuki Tanaka
第７４回日本癌学会, Sep. 2015 - THP-1 macrophage-like cells were induced to differentiate towards an M2-like phenotype by human malignant mesothelioma cells and enhanced the expression of stem cell-associated markers in the tumor cells.
Yoshiya Ohno; Toshiyuki Tanaka
がん免疫療法・マクロファージ国際会議2015, Jul. 2015 - Activin-ALK4 axisは悪性中皮腫細胞株MSTOのALDH high 細胞を維持し、造腫瘍性を高める
大野喜也; 田中稔之
第24回日本がん転移学会, Jul. 2015 - CD44依存的なスフェロイド形成はactivin産生を介してALDH発現を亢進させる
大野喜也; 田中稔之
第23回 日本がん転移学会学術集会/総会, Jul. 2014 - CD44-dependent signals and pro- and anti-inflammatory cytokines differentially regulate spheroid formation and maintenance of cancer stem-like cells in malignant mesothelioma cells
Ohno Y; Tanaka T
第22回 マクロファージ分子細胞生物学国際シンポジウム, Jun. 2014 - 悪性中皮腫のスフェロイド形成とALDH陽性癌幹細胞様細胞におけるActivinの役割
清水雄太; 大野喜也; 田中稔之
第63回 日本薬学会近畿支部総会・大会, Oct. 2013 - HA-CD44 axis was required for formation of malignant mesothelioma spheroids and maintenance of CSC-like ALDHhigh cells
Yoshiya Ohno; Toshiyuki Tanaka
第72回 日本癌学会学術総会, Oct. 2013 - TGFシグナルによる悪性中皮腫スフェロイドの形成とALDH陽性癌幹細胞様細胞の制御
大野喜也; 田中稔之
第22回 日本がん転移学会学術集会/総会, Jul. 2013 - Spheroid forming malignant mesothelioma cells showed cancer stem cell-like properties and spontaneously produced proinflammatory cytokines
Ohno Y; Ushio A; Tanaka A; Fudesaka S; Shingyoku S; Miyake S; Ueda H; Tanaka T
第21回 マクロファージ分子細胞生物学国際シンポジウム, May 2013 - Stem cell-like properties in CD133+ cells isolated from xenografted human malignant mesothelioma in immunodeficient mice
Ohno Y; Tanaka T
第71回 日本癌学会学術総会, Sep. 2012 - In vivo増殖モデルとスフェア培養を用いた悪性中皮腫における癌幹細胞の解析
大野喜也; 上田晴康; 田中稔之
第21回 日本がん転移学会学術集会/総会, Jul. 2012 - サイトカインによる血管内皮細胞の細胞動員分子発現制御
大野喜也; 上田晴康; 田中稔之
第60回 日本薬学会近畿支部総会・大会, Oct. 2010 - 新規分子標的の探索と新規モノクローナル抗体の作製
大野喜也
第8回 次世代を担う若手ファーマ・バイオフォーラム, Nov. 2009 - 悪性中皮腫によるヒアルロン酸産生とその細胞遊走・増殖制御における意義
上田 晴康; 李 千萬; 宮坂 昌之; 田中 稔之
第18回 日本がん転移学会学術集会・総会, Jul. 2009 - 新規モノクローナル抗体を用いたマウスLYVE-1の機能解析
鳥居良太; 大野喜也; 八木秀樹; 益子高
日本免疫学会, Dec. 2008 - 新規モノクローナル抗体を用いたマウス細胞株におけるLYVE-1の発現解析
鳥居良太; 大野喜也; 須田健太郎; 八木秀樹; 益子高
日本癌学会, Oct. 2008 - ヒトCD98lcアミノ酸トランスポーターに対するラットおよびキメラ化モノクローナル抗体の性状解析
須田健太郎; 大野喜也; 池田達哉; 八木秀樹; 橋本嘉幸; 益子高
日本癌学会, Oct. 2008
Research Themes
- Overcoming immune-related adverse events (irAE) induced by immune checkpoint inhibitors
Grant-in-Aid for Scientific Research (C)
Hyogo University of Health Sciences
01 Apr. 2019 - 31 Mar. 2022 - Regulation of immune-checkpoint by IL-18 and its application to cancer immunotherapy
Grant-in-Aid for Scientific Research (C)
Hyogo University of Health Sciences
01 Apr. 2018 - 31 Mar. 2021 - Tissue-specific trafficking of immune-competent cells mediated by lymph node-associated cell trafficking signals and regulation of immune-responses towards self components.
Grant-in-Aid for Scientific Research (C)
Hyogo University of Health Sciences
01 Apr. 2013 - 31 Mar. 2016 - Trafficking of immune-competent cells mediated by high endothelial venule-associated cell trafficking signals and regulation of innate and acquired immune responses.
Grant-in-Aid for Scientific Research (C)
Hyogo University of Health Sciences
2010 - 2012 - Elucidation of the mechanism in cisplatin-induced renal failure anddevelopment of drug therapy aimed at the mitigation of the renal toxicity of cisplatin.
Grant-in-Aid for Scientific Research (C)
Hyogo University of Health Sciences
2010 - 2012 - The role of Hyaluronan-triggering epithelial to mesenchymal transition on multidrug resistance in malignant mesohtlioma cells.
Grant-in-Aid for Young Scientists (B)
Hyogo University of Health Sciences
2010 - 2011
