Last Updated :2025/10/01
Researcher Information
Career
- Apr. 2025 - Present
The University of Osaka, Graduate School of Medicine Division of Medicine, 招へい教員 - Apr. 2025 - Present
Hyogo Medical University, 病理学 (分子病理部門) 講座, Assistant professor - Apr. 2022 - Mar. 2025
Japan Society for the Promotion of Science - Apr. 2021 - Mar. 2025
The University of Osaka, 卓越大学院プログラム (生命医科学の社会実装を推進する卓越人材の涵養), 修了 - Sep. 2021 - Mar. 2022
The University of Osaka, 学際融合を推進し社会実装を担う 次世代挑戦的研究者育成プロジェクト, 修了
Educational Background
- Apr. 2021 - Mar. 2025, The University of Osaka, Graduate School of Medicine, Division of Medicine
- Apr. 2018 - Mar. 2020, Hiroshima University, Graduate School of Biomedical Sciences, 医歯科学専攻, 修士課程
- Apr. 2014 - Mar. 2018, Kurashiki University of Science and the Arts, College of Life Science, Department of Medical Life Science
Research activity information
Paper
- 〔Major achievements〕Involvement of lncRNA MIR205HG in idiopathic pulmonary fibrosis and IL-33 regulation via Alu elements.
Takashima T; Zeng C; Murakami E; Fujiwara N; Kohara M; Nagata H; Feng Z; Sugai A; Harada Y; Ichijo R; Okuzaki D; Nojima S; Matsui T; Shintani Y; Kawai G; Hamada M; Hirose T; Nakatani K; Morii E
JCI insight, Mar. 2025, [Reviewed]
Lead - Spatial transcriptome analysis of lung squamous cell carcinoma arising from interstitial pneumonia provides insights into tumor heterogeneity
Koto Ukon; Satoshi Nojima; Daisuke Motooka; Tsuyoshi Takashima; Masaharu Kohara; Hiroki Kiyokawa; Kenji Kimura; Eriko Fukui; Shinichiro Tahara; Kansuke Kido; Takahiro Matsui; Yasushi Shintani; Daisuke Okuzaki; Eiichi Morii
Pathology - Research and Practice, Feb. 2025, [Reviewed] - Hypoxia drives the formation of lung micropapillary adenocarcinoma-like structure through hypoxia-inducible factor-1α
Daisuke Umeda; Akikazu Harada; Daisuke Motooka; Shinichiro Tahara; Masako Kurashige; Kansuke Kido; Tsuyoshi Takashima; Hiroki Kiyokawa; Koto Ukon; Takahiro Matsui; Shinji Matsumoto; Yasushi Shintani; Daisuke Okuzaki; Akira Kikuchi; Satoshi Nojima; Eiichi Morii
Scientific Reports, Dec. 2024, [Reviewed] - Mesothelin promotes the migration of endometrioid carcinoma and is associated with the MELF pattern
Shinichiro Tahara; Satoshi Nojima; Tsuyoshi Takashima; Daisuke Okuzaki; Eiichi Morii
Pathology - Research and Practice, Oct. 2024, [Reviewed] - Transcriptome analysis of an AKT inhibitor-resistant endometrial cancer cell line
Takafumi Onishi; Tsuyoshi Takashima; Kazuki Shibahara; Shoji Takagi; Shinichi Tanaka; Michihiro Mori; Hirokazu Odashima; Yukihiko Osawa; Manabu Hattori
Pharmacological Reports, Apr. 2024, [Reviewed] - Acquired AKT-inhibitor Resistance Is Mediated by ATP-binding Cassette Transporters in Endometrial Carcinoma
Shoji Takagi; Takafumi Onishi; Tsuyoshi Takashima; Kazuki Shibahara; Michihiro Mori
Anticancer Research, Jun. 2023, [Reviewed] - Ovarian high‐grade serous carcinoma cells with low SMARCA4 expression and high SMARCA2 expression contribute to platinum resistance
Kansuke Kido; Satoshi Nojima; Daisuke Motooka; Yusuke Nomura; Masaharu Kohara; Kazuaki Sato; Kenji Ohshima; Shinichiro Tahara; Masako Kurashige; Daisuke Umeda; Tsuyoshi Takashima; Hiroki Kiyokawa; Koto Ukon; Takahiro Matsui; Daisuke Okuzaki; Eiichi Morii
The Journal of Pathology, May 2023, [Reviewed] - Schlafen family member 11 indicates favorable prognosis of patients with head and neck cancer following platinum-based chemoradiotherapy
Seijiro Hamada; Satoshi Kano; Junko Murai; Takayoshi Suzuki; Nayuta Tsushima; Takatsugu Mizumachi; Masanobu Suzuki; Tsuyoshi Takashima; Daiki Taniyama; Naoya Sakamoto; Yoichiro Fujioka; Yusuke Ohba; Akihiro Homma
Frontiers in Oncology, Jan. 2023, [Reviewed] - Essential Roles of TDO2 in Gastric Cancer: TDO2 Is Associated with Cancer Progression, Patient Survival, PD-L1 Expression, and Cancer Stem Cells
Quoc Thang Pham; Daiki Taniyama; Shintaro Akabane; Tsuyoshi Takashima; Ryota Maruyama; Yohei Sekino; Kazuhiro Sentani; Wataru Yasui; Naohide Oue
Pathobiology, 2023, [Reviewed] - Mutually exclusive expression of EZH2 and H3K27me3 in non-small cell lung carcinoma
Takafumi Onishi; Tsuyoshi Takashima; Masako Kurashige; Kenji Ohshima; Eiichi Morii
Pathology - Research and Practice, Oct. 2022, [Reviewed] - Prognostic impact of Schlafen 11 in bladder cancer patients treated with platinum‐based chemotherapy
Daiki Taniyama; Naoya Sakamoto; Tsuyoshi Takashima; Masahiko Takeda; Quoc Thang Pham; Shoichi Ukai; Ryota Maruyama; Kenji Harada; Takashi Babasaki; Yohei Sekino; Tetsutaro Hayashi; Kazuhiro Sentani; Yves Pommier; Junko Murai; Wataru Yasui
Cancer Science, Feb. 2022, [Reviewed] - Establishment of oxaliplatin-resistant gastric cancer organoids: importance of myoferlin in the acquisition of oxaliplatin resistance
Kenji Harada; Naoya Sakamoto; Shoichi Ukai; Yusuke Yamamoto; Quoc Thang Pham; Daiki Taniyama; Ririno Honma; Ryota Maruyama; Tsuyoshi Takashima; Hiroshi Ota; Yuki Takemoto; Kazuaki Tanabe; Hideki Ohdan; Wataru Yasui
Gastric Cancer, Nov. 2021, [Reviewed] - 〔Major achievements〕Schlafen 11 predicts response to platinum-based chemotherapy in gastric cancers
Tsuyoshi Takashima; Daiki Taniyama; Naoya Sakamoto; Maika Yasumoto; Ryuichi Asai; Takuya Hattori; Ririno Honma; Quoc Thang Pham; Shoichi Ukai; Ryota Maruyama; Kenji Harada; Kazuya Kuraoka; Kazuaki Tanabe; Atsuo T. Sasaki; Hideki Ohdan; Eiichi Morii; Junko Murai; Wataru Yasui
British Journal of Cancer, Jul. 2021, [Reviewed]
Lead - 〔Major achievements〕Immunohistochemical analysis of SLFN11 expression uncovers potential non-responders to DNA-damaging agents overlooked by tissue RNA-seq
Tsuyoshi Takashima; Naoya Sakamoto; Junko Murai; Daiki Taniyama; Ririno Honma; Shoichi Ukai; Ryota Maruyama; Kazuya Kuraoka; Vinodh N. Rajapakse; Yves Pommier; Wataru Yasui
Virchows Archiv, Mar. 2021, [Reviewed]
Lead - Epigenetic suppression of SLFN11 in germinal center B-cells during B-cell development
Fumiya Moribe; Momoko Nishikori; Tsuyoshi Takashima; Daiki Taniyama; Nobuyuki Onishi; Hiroshi Arima; Hiroyuki Sasanuma; Remi Akagawa; Fathi Elloumi; Shunichi Takeda; Yves Pommier; Eiichi Morii; Akifumi Takaori-Kondo; Junko Murai
PLOS ONE, Jan. 2021, [Reviewed] - Molecular biological analysis of 5-FU-resistant gastric cancer organoids; KHDRBS3 contributes to the attainment of features of cancer stem cell
Shoichi Ukai; Ririno Honma; Naoya Sakamoto; Yusuke Yamamoto; Quoc Thang Pham; Kenji Harada; Tsuyoshi Takashima; Daiki Taniyama; Ryuichi Asai; Kaho Fukada; Kazuhito Naka; Kazuaki Tanabe; Hideki Ohdan; Wataru Yasui
Oncogene, Oct. 2020, [Reviewed] - Uc.63+ contributes to gastric cancer progression through regulation of NF-kB signaling
Naoya Sakamoto; Yohei Sekino; Kaho Fukada; Quoc Thang Pham; Ririno Honma; Daiki Taniyama; Shoichi Ukai; Tsuyoshi Takashima; Takuya Hattori; Kazuhito Naka; Kazuaki Tanabe; Hideki Ohdan; Wataru Yasui
Gastric Cancer, Sep. 2020, [Reviewed]
MISC
- 〔Major achievements〕Involvement of MIR205HG in idiopathic pulmonary fibrosis and regulation of IL33 via Alu elements
TAKASHIMA TSUYOSHI; MORII EIICHI
日本病理学会会誌, 2025 - Basic Research for Acquiring Advanced Pathological Information by Circularly Polarized Light Analysis of Biological Tissue
戸田晋太郎; 市川修平; 高島剛志; 森井英一
ULVAC Technical Journal, 2025 - SLFN11 regulates the sensitivity of PARP inhibitors to renal cell carcinoma
OKUDA Yohei; KATO Taigo; TAKASHIMA Tsuyoshi; YOSHIMURA Akihiro; TANI Masaru; LIU Yutong; YAMAMICHI Gaku; ISHIZUYA Yu; YAMAMOTO Yoshiyuki; HATANO Koji; KAWASHIMA Atsunari; MURAI Junko; NONOMURA Norio
日本泌尿器科学会総会(Web), 2024 - 〔Major achievements〕IncRNA MIR205HG is increased in idiopathic pulmonary fibrosis and regulates Inflammation gene
TAKASHIMA TSUYOSHI; MORII EIICHI
日本病理学会会誌, 2024 - AKT阻害剤耐性子宮内膜癌細胞株のトランスクリプトーム解析
大西崇文; 高島剛志; 芝原一樹; 高木翔士; 田中慎一; 森康浩; 小田嶋広和; 大澤幸希光; 服部学
日本臨床細胞学会雑誌(Web), 2024 - SLFN11 regulates the sensitivity to PARP inhibitors in RCC regardless of homologous recombination deficiency
奥田洋平; 加藤大悟; 高島剛志; 金城友紘; LIU Yutong; 吉村明洋; 谷優; 岡利樹; 山道岳; 石津谷祐; 林拓自; 山本致之; 波多野浩士; 河嶋厚成; 村井純子; 野々村祝夫
日本癌学会学術総会抄録集(Web), 2024 - Visible circular polarized light characteristics of human lung adenocarcinoma.
戸田晋太郎; 市川修平; 高島剛志; 森井英一
応用物理学会秋季学術講演会講演予稿集(CD-ROM), 2024 - 白金感受性再発卵巣癌維持療法におけるオラパリブ効果予測因子の解析~KCOG-G2101s
福田奈穂; 高島剛志; 森井英一; 中井英勝; 吉岡恵美; 伊藤公彦; 磯野路善; 鍔本浩志; 勝田隆博; 長野浩明; 甲斐健太郎; 藤原聡枝; 本橋卓; 荒川敦志; 坂井和子; 松村謙臣
日本婦人科腫瘍学会学術講演会プログラム・抄録集(Web), 2024 - 非小細胞肺癌におけるEZH2とH3K27me3の相互排他的な発現
大西崇文; 高島剛志; 倉重真沙子; 大島健司; 森井英一; 大西崇文; 高島剛志; 倉重真沙子; 森井英一; 大西崇文
日本臨床細胞学会雑誌(Web), 2023 - Identification of a novel biomarker and therapeutic target for oxaliplatin resistant gastric cancer
HARADA Kenji; SAKAMOTO Naoya; UKAI Shoichi; TANIYAMA Daiki; HONMA Ririno; MARUYAMA Ryota; TAKASHIMA Tsuyoshi; TANABE Kazuaki; OHDAN Hideki; YASUI Wataru
日本病理学会会誌, 2022 - 〔Major achievements〕胃癌におけるSLFN11の発現はプラチナ製剤の効果反応を予測する
高島剛志; 坂本直也; 谷山大樹; 安本舞夏; 鵜飼翔一; 丸山諒太; 原田健司; 森井英一; 村井純子; 安井弥
日本臨床細胞学会雑誌(Web), 2022 - Identification of novel biomarker Myoferlin, by dissecting oxaliplatin-resistant gastric cancer organoid
HARADA Kenji; SAKAMOTO Naoya; UKAI Shoichi; TANIYAMA Daiki; MARUYAMA Ryota; TAKASHIMA Tsuyoshi; TANABE Kazuaki; OHDAN Hideki; YASUI Wataru
組織培養研究(Web), 2021 - 〔Major achievements〕SLFN11 as a novel biomarker of platinum-based chemotherapy in gastric cancer
TAKASHIMA Tsuyoshi; SAKAMOTO Naoya; TANIYAMA Daiki; UKAI Shoichi; MORII Eiichi; MURAI Junko; YASUI Wataru
日本消化器癌発生学会総会プログラム・抄録集, 2021 - The key function of Myoferlin in L-OHP-resistant gastric cancer organoid
HARADA Kenji; SAKAMOTO Naoya; UKAI Shoichi; TAKASHIMA Tsuyoshi; MARUYAMA Ryota; TANIYAMA Daiki; TANABE Kazuaki; OHDAN Hideki; YASUI Wataru
日本消化器癌発生学会総会プログラム・抄録集, 2021 - Establishment and functional analysis of oxaliplatin resistant gastric cancer organoids
HARADA Kenji; SAKAMOTO Naoya; UKAI Shoichi; PHAM QuocThang; TAKASHIMA Tsuyoshi; MARUYAMA Ryota; HONMA Ririno; TANIYAMA Daiki; TANABE Kazuaki; OHDAN Hideki; YASUI Wataru
日本胃癌学会総会記事, 2021 - Potential role of MYOF in L-OHP-resistant gastric cancer organoids
HARADA Kenji; SAKAMOTO Naoya; UKAI Shoichi; TAKASHIMA Tsuyoshi; MARUYAMA Ryota; TANIYAMA Daiki; TANABE Kazuaki; OHDAN Hideki; OUE Naohide; YASUI Wataru
日本病理学会会誌, 2021 - L-OHP耐性胃癌オルガノイドにおけるmyoferlinの重要性
原田健司; 坂本直也; 鵜飼翔一; ファム クオックタング; 谷山大樹; 本間りりの; 丸山諒太; 高島剛志; 田邉和照; 大段秀樹; 安井弥
日本癌学会学術総会抄録集(Web), 2021 - Molecular biological analysis of 5-FU-resistant gastric cancer organoids
鵜飼翔一; 坂本直也; 本間りりの; PHAM Quoc Thang; 原田健司; 高島剛志; 谷山大樹; 仲一仁; 田邉和照; 大段秀樹; 安井弥
日本消化器癌発生学会総会プログラム・抄録集, 2020 - Generation and functional analysis of 5-FU resistant gastric cancer organoids
UKAI Shoichi; SAKAMOTO Naoya; HONMA Ririno; TANIYAMA Daiki; TAKASHIMA Tsuyoshi; SENTANI Kazuhiro; OUE Naohide; YASUI Wataru
日本病理学会会誌, 2020 - Potential role of SLFN11 in urothelial cancer patients treated with DNA-damaging agent
TANIYAMA Daiki; SAKAMOTO Naoya; MURAI Junko; TAKASHIMA Tsuyoshi; HAYASHI Tetsutaro; SENTANI Kazuhiro; OUE Naohide; YASUI Wataru
日本病理学会会誌, 2020 - Establishment and functional analysis of oxaliplatin resistant gastric cancer organoids
HARADA Kenji; SAKAMOTO Naoya; UKAI Shoichi; TAKASHIMA Tsuyoshi; MARUYAMA Ryota; HONMA Ririno; TANIYAMA Daiki; SENTANI Kazuhiro; OUE Naohide; YASUI Wataru
日本病理学会会誌, 2020 - Metabolome analysis using gastric cancer organoids with 5-FU resistance
SAKAMOTO Naoya; NAKA Kazuhito; UKAI Shoichi; HONMA Ririno; TANIYAMA Daiki; TAKASHIMA Tsuyoshi; SENTANI Kazuhiro; OUE Naohide; YASUI Wataru
日本病理学会会誌, 2020 - Establishment and molecular biological analysis of 5-FU-resistant gastric cancer organoids
鵜飼翔一; 坂本直也; 本間りりの; 谷山大樹; ファム クオックタング; 高島剛志; 原田健司; 仲一仁; 田邊和照; 大段秀樹; 安井弥
日本癌学会学術総会抄録集(Web), 2020 - Establishment and functional analysis of oxaliplatin resistant gastric cancer organoids
原田健司; 坂本直也; 鵜飼翔一; ファム クオックタング; 高島剛志; 丸山諒太; 本間りりの; 谷山大樹; 田邊和照; 大段秀樹; 安井弥
日本癌学会学術総会抄録集(Web), 2020 - Association between SLFN11 and efficiency of DNA-damaging agent in urothelial carcinoma patients
谷山大樹; 坂本直也; 村井純子; 高島剛志; 林哲太郎; 林哲太郎; 亭島淳; 松原昭郎; 松原昭郎; 安井弥
日本癌学会学術総会抄録集(Web), 2020 - Generation and functional analysis of 5-FU resistant gastric cancer organoids
UKAI Shoichi; SAKAMOTO Naoya; HONMA Ririno; TANIYAMA Daiki; TAKASHIMA Tsuyoshi; SENTANI Kazuhiro; OUE Naohide; YASUI Wataru
日本病理学会会誌, 2019 - 〔Major achievements〕Grobal expression pattern of SLFN11 in normal and cancer tissue
TAKASHIMA Tsuyoshi; SAKAMOTO Naoya; MURAI Junko; TANIYAMA Daiki; SENTANI Kazuhiro; OUE Naohide; YASUI Wataru
日本病理学会会誌, 2019 - Generation and gene expression analysis of 5-FU resistant gastric cancer organoids
UKAI Shoichi; SAKAMOTO Naoya; HONMA Ririno; FUKADA Kaho; TANIYAMA Daiki; TAKASHIMA Tsuyoshi; SENTANI Kazuhiro; OUE Naohide; YASUI Wataru
日本病理学会会誌, 2019 - Metabolome analysis using 5-FU resistant gastric cancer organoids
坂本直也; 仲一仁; 鵜飼翔一; 本間りりの; 谷山大樹; 高島剛志; 仙谷和弘; 大上直秀; 安井弥
日本癌学会学術総会抄録集(Web), 2019 - 〔Major achievements〕Significance of SLFN11 expression in gastric cancer
高島剛志; 坂本直也; 村井純子; 谷山大樹; 仙谷和弘; 大上直秀; 安井弥
日本がん転移学会学術集会・総会プログラム抄録集, 2019 - Generation and analysis of 5-FU resistant gastric cancer organoids
鵜飼翔一; 坂本直也; 本間りりの; 大島貴; 谷山大樹; 高島剛志; 仙谷和弘; 大上直秀; 安井弥
日本癌学会学術総会抄録集(Web), 2019 - 〔Major achievements〕Correlation between SLFN11 expression and DNA-damaging agent in gastric cancer
高島剛志; 坂本直也; 村井純子; 谷山大樹; 仙谷和弘; 大上直秀; 安井弥
日本癌学会学術総会抄録集(Web), 2019 - 〔Major achievements〕KIF23 expression is frequently found in gastric cancer with intestinal mucin phenotype
TAKASHIMA Tsuyoshi; ASAI Ryuichi; ASAI Ryuichi; YAMAMOTO Yuji; IMAI Takeharu; SAKAMOTO Naoya; SENTANI Kazuhiro; OUE Naohide; YOSHIDA Kazuhiro; YASUI Wataru
日本癌学会学術総会抄録集(Web), 2018 - Generation and analysis of 5-FU resistant gastric cancer organoids
UKAI Shoichi; SAKAMOTO Naoya; HONMA Ririno; FUKADA Kaho; TANIYAMA Daiki; TAKASHIMA Tsuyoshi; HATTORI Takuya; SENTANI Kazuhiro; OUE Naohide; YASUI Wataru
日本病理学会会誌, 2018
Lectures, oral presentations, etc.
- 特発性肺線維症において増加するlong non-cording RNA MIR205HGはIL33発現を制御する
髙島剛志
第21回日本病理学会カンファレンス, Jul. 2025 - Involvement of lncRNA MIR205HG in idiopathic pulmonary fibrosis and regulation of IL33 via Alu elements
髙島剛志
第114回日本病理学会総会, Apr. 2025 - 病理学的所見から切りひらく特発性肺線維症の悪性化メカニズム
髙島剛志
令和6年度日本病理学会近畿支部 夏期病理セミナー「夏の学校」, Aug. 2024, [Invited] - lncRNA MIR205HGは特発性肺線維症で増加し、炎症遺伝子を制御する
髙島剛志
第113回日本病理学会総会, Mar. 2024 - 胃癌におけるSLFN11の発現はプラチナ製剤の効果反応を予測する
髙島剛志
第63回日本臨床細胞学会総会春期大会, Jun. 2022 - 胃癌におけるSLFN11の発現はプラチナ製剤のバイオマーカーとして有用である
髙島剛志
第32回消化器癌発生学会総会, Nov. 2021 - A case of endometrioid carcinoma with mucinous differentiation diagnosed as mucinous carcinoma by endometrial cytology
Tsuyoshi Takashima
The 27th Thai-Japanese Workshop in Diagnostic Cytopathology, Jan. 2020 - 胃癌におけるSLFN11の発現とDNA障害型抗がん剤との相関
髙島剛志
第78回日本癌学会総会, Sep. 2019 - 胃癌における SLFN11発現の意義
髙島剛志
第28回日本がん転移学会学術集会・総会, Jul. 2019 - ヒト正常組織及び癌組織におけるSLFN11タンパク発現の検討
髙島剛志
第108回日本病理学会総会, Apr. 2019 - KIF23 expression is frequently found in gastric cancer with intestinal mucin phenotype
髙島剛志
第77回日本癌学会総会, Sep. 2018
Affiliated academic society
Research Themes
Media Coverage
- VIA Extractor™ tissue disaggregator for AT2 organoid prep in IPF research
Cytiva, https://www.cytivalifesciences.com/en/jp/insights/via-extractor-tissue-disaggregator-for-at2-organoid-prep-in-ipf-research, Sep. 2025, Internet - 特発性肺線維症、長鎖非コードRNAによるIL33遺伝子発現制御を解明-阪大ほか
QLifePro, https://www.qlifepro.com/news/20250326/il33.html, Mar. 2025, Internet - 指定難病「特発性肺線維症」で高発現する 長鎖非コードRNAの新たな機能を発見
ResOU, https://resou.osaka-u.ac.jp/ja/research/2025/20250311_3, Mar. 2025, Internet