Last Updated :2026/01/28
Researcher Information
Career
Educational Background
- Apr. 1993 - Mar. 1995, Kyoto University, 人間・環境学研究科 修士課程, 人間・環境学専攻 分子・生命環境論講座
- 1995, Kyoto University, Graduate School, Division of Human and Environmental Studies
- Apr. 1989 - Mar. 1993, Kyoto University, Faculty of Agriculture, 農林生物学科
- 1993, Kyoto University, Faculty of Agriculture
- Apr. 1988 - Sep. 1988, 気象大学校
Research activity information
Paper
- Repeated Social Defeat Stress Induces HMGB1 Nuclear Export in Prefrontal Neurons, Leading to Social Avoidance in Mice.
Shiho Kitaoka; Ayaka Tomohiro; Shinya Ukeshima; Keyue Liu; Hidenori Wake; Shinya H Kimura; Yasuhiko Yamamoto; Masahiro Nishibori; Tomoyuki Furuyashiki
Cells, Jul. 2023 - Prostaglandin E2 increases the expression of cyclooxygenase-2 in cultured rat microglia.
Takayuki Nagano; Naohiko Tsuda; Kenichi Fujimura; Yuji Ikezawa; Yuki Higashi; Shinya H. Kimura
Journal of Neuroimmunology, Dec. 2021, [Reviewed]
Last - Prostaglandin E<sub>2</sub> increases expression of mRNA for cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in microglia.
Takayuki Nagano; Naohiko Tsuda; Kenichi Fujimura; Yuji Ikezawa; Yuki Higashi; Shinya H. Kimura; Motohiko Takemura
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2020 - Prostaglandin E-2 potentiates interferon -gamma -induced nitric oxide production in cultured rat microglia
Takayuki Nagano; Ryo Nishiyama; Ayaka Sanada; Yukik Mutaguchi; Anna Ioku; Hirohisa Umeki; Satoshi Kishimoto; Daisuke Yamanaka; Shinya H. Kimura; Motohiko Takemura
JOURNAL OF NEUROCHEMISTRY, Feb. 2017, [Reviewed] - Prostaglandin E-2 induces apoptosis in cultured rat microglia
Takayuki Nagano; Shinya H. Kimura; Motohiko Takemura
BRAIN RESEARCH, Jun. 2014, [Reviewed] - Prostaglandin E-2 reduces amyloid beta-induced phagocytosis in cultured rat microglia
Takayuki Nagano; Shinya H. Kimura; Motohiko Takemura
BRAIN RESEARCH, Apr. 2010, [Reviewed] - Prostaglandin E(2) reduces extracellular ATP-induced migration in cultured rat microglia
Takayuki Nagano; Shinya H. Kimura; Motohiko Takemura
BRAIN RESEARCH, Jul. 2008, [Reviewed] - RECS1 deficiency in mice induces susceptibility to cystic medial degeneration
Hanjun Zhao; Akihiko Ito; Shinya H. Kimura; Norikazu Yabuta; Naohiko Sakai; Masahito Ikawa; Masaru Okabe; Yuji Matsuzawa; Shizuya Yamashita; Hiroshi Nojima
GENES & GENETIC SYSTEMS, Feb. 2006, [Reviewed] - Lipopolysaccharide sensitizes microglia toward Ca2+-induced cell death: Mode of cell death shifts from apoptosis to necrosis
T Nagano; SH Kimura; E Takai; T Matsuda; M Takemura
GLIA, Jan. 2006, [Reviewed] - A truncated isoform of the PP2A B56 gamma regulatory subunit reduces irradiation-induced Mdm2 phosphorylation and could contribute to metastatic melanoma cell radioresistance
YI Koma; A Ito; K Watabe; SH Kimura; Y Kitamura
HISTOLOGY AND HISTOPATHOLOGY, Apr. 2004, [Reviewed] - Cyclin G1 associates with MDM2 and regulates accumulation and degradation of p53 protein
SH Kimura; H Nojima
GENES TO CELLS, Aug. 2002, [Reviewed]
Lead - Cyclin G1 is involved in G2/M arrest in response to DNA damage and in growth control after damage recovery
Shinya H. Kimura; Masahito Ikawa; Akihiko Ito; Masaru Okabe; Hiroshi Nojima
Oncogene, 2001, [Reviewed]
Lead - Expression of a mammalian DNA photolyase confers light-dependent repair activity and reduces mutations of UV-irradiated shuttle vectors in xeroderma pigmentosum cells
H Asahina; ZB Han; M Kawanishi; T Kato; H Ayaki; T Todo; T Yagi; H Takebe; M Ikenaga; SH Kimura
MUTATION RESEARCH-DNA REPAIR, Dec. 1999, [Reviewed]
Last - Genomic structure and chromosomal localization of mouse cyclin G1 gene
SH Kimura; TR Kataoka; Y Endo; H Nojima
GENOMICS, Dec. 1997, [Reviewed]
Lead - Structure, expression, and chromosomal localization of human GAK
SH Kimura; H Tsuruga; N Yabuta; Y Endo; H Nojima
GENOMICS, Sep. 1997, [Reviewed]
Lead - GAK: A cyclin G associated kinase contains a tensin/auxilin-like domain
Yoshihide Kanaoka; Shinya H. Kimura; Issey Okazaki; Masako Ikeda; Hiroshi Nojima
FEBS Letters, Feb. 1997, [Reviewed]
Lead
MISC
- ミクログリアの誘導型一酸化窒素合成酵素発現に対するPGE2受容体アゴニストとアンタゴニストの影響
西山遼; 長野貴之; 眞田彩加; 牟田口由紀子; 井奥杏奈; 楳木博久; 岸本聖; 山中大輔; 木村信也; 竹村基彦
日本薬理学会近畿部会プログラム・要旨集, 2016 - Prostaglandin E-2 induces apoptosis in cultured rat microglia
Takayuki Nagano; Shinya H. KImura; Motohiko Takemura
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013 - Microglial activation is reduced by prostaglandin E2
Takayuki Nagano; Shinya H. Kimura; Motohiko Takemura
Microglia: Biology, Functions and Roles in Disease, 01 Dec. 2012 - Prostaglandin E-2 reduces amyloid beta(1-42)-induced phagocytosis in microglia
Takayuki Nagano; Shinya H. Kimura; Motohiko Takemura
NEUROSCIENCE RESEARCH, 2010 - Prostaglandin E-2 inhibits amyloid beta(25-35)-induced phagocytosis in cultured rat microglia
Takayuki Nagano; Shinya H. Kimura; Motohiko Takemura
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009 - Prostaglandin E-2 inhibits extracellular ATP-induced migration in cultured rat microglia
Takayuki Nagano; Shinya H. Kimura; Motohiko Takemura
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008 - Expression and Cellular Localization of Histamine N-methyltransferase and Its Involvement in Signal Transduction
REN Jiping; KIMURA Shinya H; TAKEMURA Motohiko
Acta medica Hyogoensia, Dec. 2007 - Lipopolysaccharide decreases intracellular ATP level via p38 mitogen-activated protein kinase and poly(ADP-ribose) polymerase in cultured rat microglia.
Takayuki Nagano; Shinya H. Kimura; Eri Takai; Motohiko Takemura
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007 - Barbiturates inhibit apoptosis induced by reactive oxygen species in PC12
Shinya Kimura; Jiping Ren; Takayuki Nagano; Motohiko Takemura
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007 - Barbiturates inhibit apoptosis induced by reactive oxygen species in PC-12
KIMURA Shinya H; REN Jiping; NAGANO Takayuki; TAKEMURA Motohiko
The Japan Radiation Research Society Annual Meeting Abstracts, 2006 - RECS1, a novel shear stress-upregulated gene in endothelial cells, suppresses Fas-mediated apoptosis
SH Kimura; T Tsujimura; H Yoshisue; H Nojima; M Takemura
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004 - Cyclin G1 associates with MDM2 and regulates accumulation and degradation of p53 protein :
Kimura Shinya H.; Takemura Motohiko; Nojima Hiroshi
Journal of radiation research, 2002 - shear stress応答性cDNAの包括的単離と動脈硬化における役割の解明
大屋健; 山下静也; 酒井尚彦; ちょう漢軍; 吉末元; 木村信也; 野島博; 松沢佑次
動脈硬化, 15 May 2001 - shear stress 応答性cDNAの包括的単離と動脈硬化における役割の解明
大屋 健; 山下 静也; 酒井 尚彦; 趙 漢軍; 吉末 元; 木村 信也; 野島 博; 松澤 佑次
動脈硬化 = The journal of Japan Atherosclerosis Society, 15 May 2001 - Cyclin G1はDNA損傷後のG2/M期停止と,損傷回復後の増殖制御に関与している
木村信也; 伊川正人; 伊藤彰彦; 岡部勝; 野島博
日本分子生物学会年会プログラム・講演要旨集, 25 Nov. 2000 - Photorecovery of ultraviolet ray DNA lesion in the xeroderma pigmentosum cell introducing photoreactivating enzyme gene of marsupials.
朝比奈宏; 木村信也; 加藤友久; 池永満生
日本放射線影響学会大会講演要旨集, Oct. 1996
