Last Updated :2024/09/11
Researcher Information
Field Of Study
Career
- Jan. 2024 - Present
Hyogo Medical University, Faculty of Medicine, 准教授 - Apr. 2021 - Present
Hyogo Medical University, Faculty of Medicine, 医学教育センター兼務教員 - Jan. 2014 - Dec. 2023
Hyogo Medical University, Faculty of Medicine, 講師 - Apr. 2010 - Dec. 2013
Hyogo Medical University, Faculty of Medicine, 助教 - Apr. 2007 - Mar. 2010
松山大学薬学部医療薬学科 医薬品化学研究室, 助教
Educational Background
- Apr. 2004 - Mar. 2007, Gifu Pharmaceutical University, Graduate School Department of Pharmaceutical Science
- Apr. 2002 - Mar. 2004, Gifu Pharmaceutical University, Graduate School Department of Pharmaceutical Science
- Apr. 1998 - Mar. 2002, Gifu Pharmaceutical University, Faculty of Pharmaceutical Science, Department of Manufacturing Pharmacy
Research activity information
Paper
- Electrophilic Alkynylation and Alkenylation Using Alkynyl Hypervalent Iodine Compounds
Norihiro Tada; Hiroyoshi Esaki; Akichika Itoh
Journal of Synthetic Organic Chemistry, Japan, Dec. 2023 - Synthesis of 4-Imidazolidinones from Diamides and Ethynyl Benziodoxolones via Double Michael-Type Addition: Ethynyl Benziodoxolones as Electrophilic Ynol Synthons
Ayaka Shimizu; Atsushi Shibata; Takashi Kano; Yuuichi Kumai; Ryouhei Kawakami; Hiroyoshi Esaki; Kazuaki Fukushima; Norihiro Tada; Akichika Itoh
Organic Letters, Nov. 2022, [Reviewed]
Corresponding - Theoretical Study of the Mechanism of Ribosomal Peptide Bond Formation Using the ONIOM Method
Kazuaki Fukushima; Hiroyoshi Esaki
Chemical and Pharmaceutical Bulletin, Aug. 2021, [Reviewed] - Enantioselective Protonation of Cyclic Carbonyl Ylides by Chiral Lewis Acid Assisted Alcohols
Yasunori Toda; Takayuki Yoshida; Kaoru Arisue; Kazuaki Fukushima; Hiroyoshi Esaki; Ayaka Kikuchi; Hiroyuki Suga
Chemistry – A European Journal, Jul. 2021, [Reviewed] - Methoxy Groups Increase Reactivity of Bifunctional Tetraarylphosphonium Salt Catalysts for Carbon Dioxide Fixation: A Mechanistic Study
Yasunori Toda; Yutaka Komiyama; Hiroyoshi Esaki; Kazuaki Fukushima; Hiroyuki Suga
The Journal of Organic Chemistry, Dec. 2019, [Reviewed] - Enantioselective Cycloadditions between Aliphatic Nitrile Oxides And 2-Hydroxystyrenes Catalyzed by Chiral Amine-urea
Yasunori Toda; Masato Koyama; Hiroyoshi Esaki; Kazuaki Fukushima; Hiroyuki Suga
Heterocycles, 2018, [Reviewed] - Amine-Urea-Mediated Asymmetric Cycloadditions between Nitrile Oxides and o-Hydroxystyrenes by Dual Activation
Hiroyuki Suga; Yohei Hashimoto; Yasunori Toda; Kazuaki Fukushima; Hiroyoshi Esaki; Ayaka Kikuchi
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Sep. 2017, [Reviewed] - Human colonic thiamin pyrophosphate transporter
Kazuto Nosaka; Hiroyoshi Esaki
VITAMINS, 2015, [Reviewed] - Highly chemoselective hydrogenation method using Pd on spherical carbon
Esaki Hiroyoshi; Hattori Tomohiro; Tsubone Aya; Mibayashi Satoko; Sakata Takao; Sawama Yoshinari; Monguchi Yasunari; Yasuda Hidehiro; Nosaka Kazuto; Sajiki Hironao
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2014, [Reviewed] - Enzymatic and structural characterization of an archaeal thiamin phosphate synthase
Maria Hayashi; Kazuya Kobayashi; Hiroyoshi Esaki; Hiroyuki Konno; Kenichi Akaji; Keiko Tazuya; Kazuko Yamada; Toshikatsu Nakabayashi; Kazuto Nosaka
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, Apr. 2014, [Reviewed] - SYNTHESIS OF 4-ARYLPIPERIDIN-4-OL DERIVATIVES OF LOPERAMIDE AS AGENTS WITH POTENT ANTIPROLIFERATIVE EFFECTS AGAINST HCT-116 AND HL-60 CELLS
Noriyuki Hatae; Tomoyuki Nagayama; Hiroyoshi Esaki; Eiko Kujime; Masabumi Minami; Minoru Ishikura; Tominari Choshi; Satoshi Hibino; Chiaki Okada; Eiko Toyota; Hideko Nagasawa; Tatsunori Iwamura
HETEROCYCLES, Jan. 2014, [Reviewed] - Chemoselective Hydrogenation Catalyzed by Pd on Spherical Carbon
Hiroyoshi Esaki; Tomohiro Hattori; Aya Tsubone; Satoko Mibayashi; Takao Sakata; Yoshinari Sawama; Yasunari Monguchi; Hidehiro Yasuda; Kazuto Nosaka; Hironao Sajiki
CHEMCATCHEM, Dec. 2013, [Reviewed] - トランスケトラーゼ様タンパク質はトランスケトラーゼ活性を持たない
野坂和人; 江嵜啓祥
ビタミン, 2013, [Reviewed] - Facilitated recruitment of Pdc2p, a yeast transcriptional activator, in response to thiamin starvation
Kazuto Nosaka; Hiroyoshi Esaki; Mari Onozuka; Hiroyuki Konno; Yasunao Hattori; Kenichi Akaji
FEMS MICROBIOLOGY LETTERS, May 2012, [Reviewed] - Development of antimicrobial drugs targeting riboswitches
Kazuto Nosaka; Hiroyoshi Esaki
VITAMINS, 2012, [Reviewed] - Thiamin-dependent transcriptional induction by Pdc2 in saccharomyces cerevisiae
Nosaka Kazuto; Esaki Hiroyoshi; Onozuka Mari; Konno Hiroyuki; Hattori Yasunao; Akaji Kenichi
VITAMINS, 2011, [Reviewed] - Efficient and selective Pt/C-catalyzed H-D exchange reaction of aromatic rings
Nobuhiro Ito; Hiroyoshi Esaki; Tsuneaki Maesawa; Eikoh Imamiya; Tomohiro Maegawa; Hironao Sajiki
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Feb. 2008, [Reviewed] - Mild and efficient H/D exchange of alkanes based on C-H activation catalyzed by rhodium on charcoal
Tomohiro Maegawa; Yuta Fujiwara; Yuya Inagaki; Hiroyoshi Esaki; Yasunari Monguchi; Hironao Sajlki
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, [Reviewed] - Facile and convenient method of deuterium gas generation using a Pd/C-catalyzed H-2-D-2 exchange reaction and its application to synthesis of deuterium-labeled compounds
Takanori Kurita; Fumiyo Aoki; Takuto Mizumoto; Toshihide Maejima; Hiroyoshi Esaki; Tomohiro Maegawa; Yasunari Monguchi; Hironao Sajiki
CHEMISTRY-A EUROPEAN JOURNAL, 2008, [Reviewed] - Novel Pd/C-catalyzed redox reactions between aliphatic secondary alcohols and ketones under hydrogenation conditions: Application to H-D exchange reaction and the mechanistic study
Hiroyoshi Esaki; Rumi Ohtaki; Tomohiro Maegawa; Yasunari Monguchi; Hironao Sajiki
JOURNAL OF ORGANIC CHEMISTRY, Mar. 2007, [Reviewed] - 不均一系白金族触媒を用いた重水素標識化反応
江嵜啓祥; 栗田貴教; 藤原佑太; 前川智弘; 門口泰也; 佐治木弘尚
有機合成化学協会誌, 2007, [Reviewed] - Efficient H/D exchange reactions of alkyl-substituted benzene derivatives by means of the Pd/C-H-2-D2O system
Hiroyoshi Esaki; Fumiyo Aoki; Miho Umemura; Masatsugu Kato; Tomohiro Maegawa; Yasunari Monguchi; Hironao Sajiki
CHEMISTRY-A EUROPEAN JOURNAL, 2007, [Reviewed] - General method of obtaining deuterium-labeled heterocyclic compounds using neutral D2O with heterogeneous Pd/C
Hiroyoshi Esaki; Nobuhiro Ito; Shino Sakai; Tomohiro Maegawa; Yasunari Monguchi; Hironao Sajiki
TETRAHEDRON, Nov. 2006, [Reviewed] - Synthesis of base-selectively deuterium-labelled nucleosides by the Pd/C-catalyzed H-D exchange reaction in deuterium oxide
H Esaki; F Aoki; T Maegawa; K Hirota; H Sajiki
HETEROCYCLES, Dec. 2005, [Reviewed] - Aromatic ring favorable and efficient H-D exchange reaction catalyzed by Pt/C
H Sajiki; N Ito; H Esaki; T Maesawa; T Maegawa; K Hirota
TETRAHEDRON LETTERS, Oct. 2005, [Reviewed] - Palladium-catalyzed base-selective H-D exchange reaction of nucleosides in deuterium oxide
H Sajiki; H Esaki; F Aoki; T Maegawa; K Hirota
SYNLETT, Jun. 2005, [Reviewed] - Efficient and selective deuteration of phenylalanine derivatives catalyzed by Pd/C
T Maegawa; A Akashi; H Esaki; F Aoki; H Sajiki; K Hirota
SYNLETT, Mar. 2005, [Reviewed] - Complete replacement of H-2 by D-2 via Pd/C-catalyzed H/D exchange reaction
H Sajiki; T Kurita; H Esaki; F Aoki; T Maegawa; K Hirota
ORGANIC LETTERS, Sep. 2004, [Reviewed] - Efficient C-H/C-D exchange reaction on the alkyl side chain of aromatic compounds using heterogeneous Pd/C in D2O
H Sajiki; F Aoki; H Esaki; T Maegawa; K Hirota
ORGANIC LETTERS, Apr. 2004, [Reviewed]
MISC
- Multiple/regioselective H-D exchange reaction of aliphatic alkanes and alcohols
Yuta Fujiwara; Hiroyoshi Esaki; Tomohiro Maegawa; Yasunari Monguchi; Hironao Sajiki
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2009 - Synthesis of naphto[1,8-bc]furan ring system via intramolecular Diels-Alder reaction
波多江典之; 江嵜啓祥; 兼松顯; 岩村樹憲
複素環化学討論会講演要旨集, 2008
Books and other publications
Affiliated academic society
Research Themes
- 中分子創薬に資するトリアゾール人工生命鎖の開発
2023年度 武田科学振興財団 薬学系研究助成
岐阜薬科大学
Mar. 2028 - 計算化学的スクリーニングを利用した有機分子触媒反応の設計および開発
基盤研究(C)
信州大学
Jul. 2017 - Mar. 2020 - 新規パラジウム触媒Pd@iO-braneTMを利用した鈴木－宮浦反応の開発
2014 - 2015 - 新規パラジウム触媒の機能性開発研究
2012 - 2014 - ロペラミドをリード化合物とした新規抗腫瘍薬の開発研究
2010 - 2011 - パラジウム触媒を用いた新規重水素標識化法に関する研究
2005 - 2006 - Efficient deuterium labeling method of biologically active compounds
2004
