Last Updated :2025/09/13
Researcher Information
Field Of Study
Career
- Jan. 2024 - Present
Hyogo Medical University, Faculty of Medicine, 准教授 - Apr. 2021 - Present
Hyogo Medical University, Faculty of Medicine, 医学教育センター兼務教員 - Jan. 2014 - Dec. 2023
Hyogo Medical University, Faculty of Medicine, 講師 - Apr. 2010 - Dec. 2013
Hyogo Medical University, Faculty of Medicine, 助教 - Apr. 2007 - Mar. 2010
松山大学薬学部医療薬学科 医薬品化学研究室, 助教
Educational Background
- Apr. 2004 - Mar. 2007, Gifu Pharmaceutical University, Graduate School Department of Pharmaceutical Science
- Apr. 2002 - Mar. 2004, Gifu Pharmaceutical University, Graduate School Department of Pharmaceutical Science
- Apr. 1998 - Mar. 2002, Gifu Pharmaceutical University, Faculty of Pharmaceutical Science, Department of Manufacturing Pharmacy
Research activity information
Paper
- Electrophilic Alkynylation and Alkenylation Using Alkynyl Hypervalent Iodine Compounds
Norihiro Tada; Hiroyoshi Esaki; Akichika Itoh
Journal of Synthetic Organic Chemistry, Japan, Dec. 2023 - Synthesis of 4-Imidazolidinones from Diamides and Ethynyl Benziodoxolones via Double Michael-Type Addition: Ethynyl Benziodoxolones as Electrophilic Ynol Synthons
Ayaka Shimizu; Atsushi Shibata; Takashi Kano; Yuuichi Kumai; Ryouhei Kawakami; Hiroyoshi Esaki; Kazuaki Fukushima; Norihiro Tada; Akichika Itoh
Organic Letters, Nov. 2022, [Reviewed]
Corresponding - Theoretical Study of the Mechanism of Ribosomal Peptide Bond Formation Using the ONIOM Method
Kazuaki Fukushima; Hiroyoshi Esaki
Chemical and Pharmaceutical Bulletin, Aug. 2021, [Reviewed] - Enantioselective Protonation of Cyclic Carbonyl Ylides by Chiral Lewis Acid Assisted Alcohols
Yasunori Toda; Takayuki Yoshida; Kaoru Arisue; Kazuaki Fukushima; Hiroyoshi Esaki; Ayaka Kikuchi; Hiroyuki Suga
Chemistry – A European Journal, Jul. 2021, [Reviewed] - Methoxy Groups Increase Reactivity of Bifunctional Tetraarylphosphonium Salt Catalysts for Carbon Dioxide Fixation: A Mechanistic Study
Yasunori Toda; Yutaka Komiyama; Hiroyoshi Esaki; Kazuaki Fukushima; Hiroyuki Suga
The Journal of Organic Chemistry, Dec. 2019, [Reviewed] - Enantioselective Cycloadditions between Aliphatic Nitrile Oxides And 2-Hydroxystyrenes Catalyzed by Chiral Amine-urea
Yasunori Toda; Masato Koyama; Hiroyoshi Esaki; Kazuaki Fukushima; Hiroyuki Suga
Heterocycles, 2018, [Reviewed] - Amine-Urea-Mediated Asymmetric Cycloadditions between Nitrile Oxides and o-Hydroxystyrenes by Dual Activation
Hiroyuki Suga; Yohei Hashimoto; Yasunori Toda; Kazuaki Fukushima; Hiroyoshi Esaki; Ayaka Kikuchi
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Sep. 2017, [Reviewed] - Human colonic thiamin pyrophosphate transporter
Kazuto Nosaka; Hiroyoshi Esaki
VITAMINS, 2015, [Reviewed] - Highly chemoselective hydrogenation method using Pd on spherical carbon
Esaki Hiroyoshi; Hattori Tomohiro; Tsubone Aya; Mibayashi Satoko; Sakata Takao; Sawama Yoshinari; Monguchi Yasunari; Yasuda Hidehiro; Nosaka Kazuto; Sajiki Hironao
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2014, [Reviewed] - Enzymatic and structural characterization of an archaeal thiamin phosphate synthase
Maria Hayashi; Kazuya Kobayashi; Hiroyoshi Esaki; Hiroyuki Konno; Kenichi Akaji; Keiko Tazuya; Kazuko Yamada; Toshikatsu Nakabayashi; Kazuto Nosaka
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, Apr. 2014, [Reviewed] - SYNTHESIS OF 4-ARYLPIPERIDIN-4-OL DERIVATIVES OF LOPERAMIDE AS AGENTS WITH POTENT ANTIPROLIFERATIVE EFFECTS AGAINST HCT-116 AND HL-60 CELLS
Noriyuki Hatae; Tomoyuki Nagayama; Hiroyoshi Esaki; Eiko Kujime; Masabumi Minami; Minoru Ishikura; Tominari Choshi; Satoshi Hibino; Chiaki Okada; Eiko Toyota; Hideko Nagasawa; Tatsunori Iwamura
HETEROCYCLES, Jan. 2014, [Reviewed] - Chemoselective Hydrogenation Catalyzed by Pd on Spherical Carbon
Hiroyoshi Esaki; Tomohiro Hattori; Aya Tsubone; Satoko Mibayashi; Takao Sakata; Yoshinari Sawama; Yasunari Monguchi; Hidehiro Yasuda; Kazuto Nosaka; Hironao Sajiki
CHEMCATCHEM, Dec. 2013, [Reviewed] - Facilitated recruitment of Pdc2p, a yeast transcriptional activator, in response to thiamin starvation
Kazuto Nosaka; Hiroyoshi Esaki; Mari Onozuka; Hiroyuki Konno; Yasunao Hattori; Kenichi Akaji
FEMS MICROBIOLOGY LETTERS, May 2012, [Reviewed] - Development of antimicrobial drugs targeting riboswitches
Kazuto Nosaka; Hiroyoshi Esaki
VITAMINS, 2012, [Reviewed] - Thiamin-dependent transcriptional induction by Pdc2 in saccharomyces cerevisiae
Nosaka Kazuto; Esaki Hiroyoshi; Onozuka Mari; Konno Hiroyuki; Hattori Yasunao; Akaji Kenichi
VITAMINS, 2011, [Reviewed] - Efficient and selective Pt/C-catalyzed H-D exchange reaction of aromatic rings
Nobuhiro Ito; Hiroyoshi Esaki; Tsuneaki Maesawa; Eikoh Imamiya; Tomohiro Maegawa; Hironao Sajiki
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Feb. 2008, [Reviewed] - Mild and efficient H/D exchange of alkanes based on C-H activation catalyzed by rhodium on charcoal
Tomohiro Maegawa; Yuta Fujiwara; Yuya Inagaki; Hiroyoshi Esaki; Yasunari Monguchi; Hironao Sajlki
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, [Reviewed] - Facile and convenient method of deuterium gas generation using a Pd/C-catalyzed H-2-D-2 exchange reaction and its application to synthesis of deuterium-labeled compounds
Takanori Kurita; Fumiyo Aoki; Takuto Mizumoto; Toshihide Maejima; Hiroyoshi Esaki; Tomohiro Maegawa; Yasunari Monguchi; Hironao Sajiki
CHEMISTRY-A EUROPEAN JOURNAL, 2008, [Reviewed] - Novel Pd/C-catalyzed redox reactions between aliphatic secondary alcohols and ketones under hydrogenation conditions: Application to H-D exchange reaction and the mechanistic study
Hiroyoshi Esaki; Rumi Ohtaki; Tomohiro Maegawa; Yasunari Monguchi; Hironao Sajiki
JOURNAL OF ORGANIC CHEMISTRY, Mar. 2007, [Reviewed] - An Efficient Deuteration Method Catalyzed by Heterogeneous Platinum Group Metals
江嵜啓祥; 栗田貴教; 藤原佑太; 前川智弘; 門口泰也; 佐治木弘尚
有機合成化学協会誌, 2007, [Reviewed] - Efficient H/D exchange reactions of alkyl-substituted benzene derivatives by means of the Pd/C-H-2-D2O system
Hiroyoshi Esaki; Fumiyo Aoki; Miho Umemura; Masatsugu Kato; Tomohiro Maegawa; Yasunari Monguchi; Hironao Sajiki
CHEMISTRY-A EUROPEAN JOURNAL, 2007, [Reviewed] - General method of obtaining deuterium-labeled heterocyclic compounds using neutral D2O with heterogeneous Pd/C
Hiroyoshi Esaki; Nobuhiro Ito; Shino Sakai; Tomohiro Maegawa; Yasunari Monguchi; Hironao Sajiki
TETRAHEDRON, Nov. 2006, [Reviewed] - Synthesis of base-selectively deuterium-labelled nucleosides by the Pd/C-catalyzed H-D exchange reaction in deuterium oxide
H Esaki; F Aoki; T Maegawa; K Hirota; H Sajiki
HETEROCYCLES, Dec. 2005, [Reviewed] - Aromatic ring favorable and efficient H-D exchange reaction catalyzed by Pt/C
H Sajiki; N Ito; H Esaki; T Maesawa; T Maegawa; K Hirota
TETRAHEDRON LETTERS, Oct. 2005, [Reviewed] - Palladium-catalyzed base-selective H-D exchange reaction of nucleosides in deuterium oxide
H Sajiki; H Esaki; F Aoki; T Maegawa; K Hirota
SYNLETT, Jun. 2005, [Reviewed] - Efficient and selective deuteration of phenylalanine derivatives catalyzed by Pd/C
T Maegawa; A Akashi; H Esaki; F Aoki; H Sajiki; K Hirota
SYNLETT, Mar. 2005, [Reviewed] - Complete replacement of H-2 by D-2 via Pd/C-catalyzed H/D exchange reaction
H Sajiki; T Kurita; H Esaki; F Aoki; T Maegawa; K Hirota
ORGANIC LETTERS, Sep. 2004, [Reviewed] - Efficient C-H/C-D exchange reaction on the alkyl side chain of aromatic compounds using heterogeneous Pd/C in D2O
H Sajiki; F Aoki; H Esaki; T Maegawa; K Hirota
ORGANIC LETTERS, Apr. 2004, [Reviewed]
MISC
- The time-course analysis of the orotidine decarboxylase-orotidine 5’-monophosphate complex using molecular dynamics simulations
江嵜啓祥; 中山良太; 福島和明
日本薬学会年会要旨集(Web), 2025 - Molecular Dynamics Study on Conformational Change of Human Collagen Prolyl 4-Hydroxylase.
福島和明; 江嵜啓祥
日本化学会春季年会講演予稿集(Web), 2025 - Molecular Dynamics Simulation Analysis of the Reaction Mechanism of Orotidin 5’-Monophosphate Decarboxylase
江嵜啓祥; 浜崎康太; 福島和明
日本薬学会年会要旨集(Web), 2024 - Computational study of the reaction mechanism of 4-imidazolidinones synthesis using hypervalent iodine compound
江嵜啓祥; 多田教浩; 伊藤彰近; 福島和明
日本薬学会年会要旨集(Web), 2023 - Synthesis of 4-imidazolidinones with electrophilic ynol synthons
多田教浩; 清水彩加; 柴田篤; 江嵜啓祥; 福島和明; 伊藤彰近
日本薬学会年会要旨集(Web), 2022 - キラルアミン-ウレア触媒を用いる脂肪族ニトリルオキシドと2-ヒドロキシスチレン類の不斉付加環化反応
小山將人; 江嵜啓祥; 福島和明; 戸田泰徳; 菅博幸
日本化学会春季年会講演予稿集(CD-ROM), 2018 - 芳香族ニトリルオキシドと2-ヒドロキシスチレン類の不斉付加環化反応の反応機構解析と脂肪族ニトリルオキシドへの応用
小山將人; 江嵜啓祥; 福島和明; 戸田泰徳; 菅博幸
複素環化学討論会講演要旨集, 2018 - ニトリルオキシドと2-ヒドロキシスチレン類の不斉付加環化反応を基盤とする1,3-双極子の探索
小山將人; 江嵜啓祥; 福島和明; 戸田泰徳; 菅博幸
中部化学関係学協会支部連合秋季大会講演予稿集, 2018 - ニトリルオキシドと2-ヒドロキシスチレン類の酸-塩基二官能性有機触媒不斉1,3-双極性付加環化反応
橋本陽平; 江嵜啓祥; 福島和明; 戸田泰徳; 菅博幸
中部化学関係学協会支部連合秋季大会講演予稿集, 2016 - 新規パラジウム触媒を用いた官能基選択的接触還元反応の開発
江嵜啓祥; 服部倫弘; 坪根綾; 三林聡子; 坂田孝夫; 澤間善成; 門口泰也; 保田英洋; 野坂和人; 佐治木弘尚
日本プロセス化学会サマーシンポジウム講演要旨集, 2014 - 球状成形活性炭担持型パラジウムを触媒とした官能基選択的接触還元反応の開発
江嵜啓祥; 服部倫弘; 坪根綾; 三林聡子; 坂田孝夫; 澤間善成; 門口泰也; 保田英洋; 野坂和人; 佐治木弘尚
反応と合成の進歩シンポジウム講演要旨集, 2013 - Multiple/regioselective H-D exchange reaction of aliphatic alkanes and alcohols
Yuta Fujiwara; Hiroyoshi Esaki; Tomohiro Maegawa; Yasunari Monguchi; Hironao Sajiki
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2009 - 重水素化イブプロフェンの合成及びその鎮痛作用の評価
江嵜啓祥; 江嵜啓祥; 藤原佑太; 櫻井愛; 宇津貴央; 前川智弘; 門口泰也; 原英彰; 佐治木弘尚
メディシナルケミストリーシンポジウム講演要旨集, 2008 - 不均一系白金族触媒によるアルカン類の重水素化反応とアルコール類の位置選択的重水素化反応への展開
藤原佑太; 稲垣佑也; 門口泰也; 前川智弘; 佐治木弘尚; 江嵜啓祥
反応と合成の進歩シンポジウム講演要旨集, 2008 - Synthesis of naphto[1,8-bc]furan ring system via intramolecular Diels-Alder reaction
波多江典之; 江嵜啓祥; 兼松顯; 岩村樹憲
複素環化学討論会講演要旨集, 2008
Books and other publications
Affiliated academic society
Research Themes
- ペプチドミメティック中分子合成法を基盤とする新規創薬シーズの探索
Apr. 2025 - Mar. 2026 - 中分子創薬に資するトリアゾール人工生命鎖の開発
2023年度 武田科学振興財団 薬学系研究助成
岐阜薬科大学
Apr. 2023 - Mar. 2026 - 新規パラジウム触媒Pd@iO-braneTMを利用した鈴木－宮浦反応の開発
2014 - 2015 - 新規パラジウム触媒の機能性開発研究
2012 - 2014 - ロペラミドをリード化合物とした新規抗腫瘍薬の開発研究
2010 - 2011 - Efficient deuterium labeling method of biologically active compounds
2004
