Last Updated :2026/10/03
Researcher Information
Research Keyword
Field Of Study
Career
- Sep. 2014 - Present
Hyogo College of Medicine, Department of Chemistry, Professor - Apr. 2007 - Aug. 2014
Wakayama Medical University, Faculty of Medicine, 准教授 - Apr. 2003 - Mar. 2007
Wakayama Medical University, 助教授 - Apr. 1997 - Mar. 2003
Wakayama Medical University, 講師 - Jun. 1995 - Mar. 1997
Osaka University, Graduate School of Engineering - 1995 - 1997
Osaka University, Graduate School of Engineering, Assistant
Research activity information
Paper
- The Ile 35 residue of the ALS-associated mutant SOD1 plays a crucial role in the intracellular aggregation of the molecule.
Yoshiyuki Asai; Kyoka Yano; Tomoyuki Higashino; Daisaku Yoshihara; Haruhiko Sakiyama; Hironobu Eguchi; Kazuaki Fukushima; Keiichiro Suzuki; Noriko Fujiwara
Molecular Neurobiology, Jul. 2025, [Reviewed] - Synthesis of 4-Imidazolidinones from Diamides and Ethynyl Benziodoxolones via Double Michael-Type Addition: Ethynyl Benziodoxolones as Electrophilic Ynol Synthons
Ayaka Shimizu; Atsushi Shibata; Takashi Kano; Yuuichi Kumai; Ryouhei Kawakami; Hiroyoshi Esaki; Kazuaki Fukushima; Norihiro Tada; Akichika Itoh
Organic Letters, Nov. 2022, [Reviewed] - Theoretical Study of the Mechanism of Ribosomal Peptide Bond Formation Using the ONIOM Method.
Kazuaki Fukushima; Hiroyoshi Esaki
Chemical and Pharmaceutical Bulletin, Aug. 2021, [Reviewed]
Lead - Enantioselective Protonation of Cyclic Carbonyl Ylides by Chiral Lewis Acid Assisted Alcohols
Yasunori Toda; Takayuki Yoshida; Kaoru Arisue; Kazuaki Fukushima; Hiroyoshi Esaki; Ayaka Kikuchi; Hiroyuki Suga
Chemistry – A European Journal, Jul. 2021, [Reviewed] - Methoxy Groups Increase Reactivity of Bifunctional Tetraarylphosphonium Salt Catalysts for Carbon Dioxide Fixation: A Mechanistic Study
Yasunori Toda; Yutaka Komiyama; Hiroyoshi Esaki; Kazuaki Fukushima; Hiroyuki Suga
The Journal of Organic Chemistry, Dec. 2019, [Reviewed] - Enantioselective Cycloadditions between Aliphatic Nitrile Oxides and 2-Hydroxystyrenes Catalyzed by Chiral Amine-Urea,
Yasunori Toda; Masato Koyama; Hiroyoshi Esaki; Kazuaki Fukushima; Hiroyuki Suga
Heterocycles, 2018, [Reviewed] - Amine-Urea-Mediated Asymmetric Cycloadditions between Nitrile Oxides and o-Hydroxystyrenes by Dual Activation
Hiroyuki Suga; Yohei Hashimoto; Yasunori Toda; Kazuaki Fukushima; Hiroyoshi Esaki; Ayaka Kikuchi
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Sep. 2017, [Reviewed] - ONIOM Study of a Proton Shuttle-Catalyzed Stepwise Mechanism for Peptide Bond Formation in the Ribosome
Kazuaki Fukushima; Hideo Iwahashi; Morimitsu Nishikimi
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Oct. 2012, [Reviewed]
Lead - Effect of some naturally occurring iron ion chelators on the formation of radicals in the reaction mixtures of rat liver microsomes with ADP, Fe3+ and NADPH
Katsuyuki Minakata; Kazuaki Fukushima; Masayuki Nakamura; Hideo Iwahashi
Journal of Clinical Biochemistry and Nutrition, 2011, [Reviewed] - Substituent Effects on Two Orthogonal p-Systems in Pseudopericyclcic Ring-opening Reaction s of 5-Alkoxy-2-aminooxazoles
Kazuaki Fukushima; Hideo Iwahashi
Chem. Lett., 2006, [Reviewed] - Efficient catalytic effects of Lewis acids in the 1,3-dipolar cycloaddition reactions of carbonyl ylides with imines
H Suga; Y Ebiura; K Fukushima; A Kakehi; T Baba
JOURNAL OF ORGANIC CHEMISTRY, Dec. 2005, [Reviewed] - Natural bond orbital analysis of pericyclic and pseudopericyclic 1,5-electrocyclizations of conjugated azides
K Fukushima; H Iwahashi
HETEROCYCLES, Nov. 2005, [Reviewed] - Effects of Some Naturally Occurring Iron Ion Chelators on In Vitro Superoxide Radical Formation
Tomihiro Hirai; Kazuaki Fukushima; Kazumasa Kumamoto; Hideo Iwahashi
Biological Trace Element Research, 2005, [Reviewed] - Natural bond orbital analysis of pericyclic and pseudopericyclic 1,5-electrocyclizations of conjugated nitrileimines
K Fukushima; H Iwahashi
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Sep. 2004, [Reviewed] - 1 : 1 Complex of guanine quartet with alkali metal cations detected by electrospray ionization mass spectrometry
K Fukushima; H Iwahashi
CHEMICAL COMMUNICATIONS, 2000, [Reviewed] - 2-Bromo-2,3-diphenylmethano-2,3-dihydronaphthoquinone
T. Oshima; K. Fukushima; T. Kawamoto
Acta Crystallographica Section C Crystal Structure Communications, Apr. 1999, [Reviewed] - Quinolinic acid, α-picolinic acid, fusaric acid, and 2,6-pyridinedicarboxylic acid enhance the Fenton reaction in phosphate buffer
Hideo Iwahashi; Hiroyuki Kawamori; Kazuaki Fukushima
Chemico-Biological Interactions, Apr. 1999, [Reviewed] - Selective cation binding of crown ether acetals in electrospray ionization mass spectrometry
Takumi Oshima; Fumikazu Matsuda; Kazuaki Fukushima; Hatsue Tamura; Gen-etsu Matsubayashi; Ryuichi Arakawa
Journal of the Chemical Society, Perkin Transactions 2, 1998, [Reviewed] - Formation of 5-alkoxy-2-aminooxazoles and their novel reactivity: Equilibrium with nitrile ylide
K Fukushima; YQ Lu; T Ibata
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Nov. 1996, [Reviewed] - Conversion of donor-substituted homonaphthoquinones to indenonaphthoquinones via intramolecular photoinduced electron-transfer
Hiroshi Moriwaki; Kazuaki Fukushima; Toshikazu Nagai; Takumi Oshima
Chemical Communications, 1996, [Reviewed] - REGIO-SELECTIVITY AND RELATIVE REACTIVITY OF YLIDE FORMATION IN THE REACTION OF KETOCARBENOID WITH HETERO-CUMULENES
Toshikazu Ibata; Motomu Himori; Kazuaki Fukushima; Hiroyuki Suga; Hirofumi Nakano
Heterocyclic Communications, Jan. 1996, [Reviewed] - Formation of acyl-substituted nitrile ylides by Rh-2(OAc)(4)-catalyzed decomposition of alpha-diazocarbonyl compounds in nitriles
K Fukushima; T Ibata
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Dec. 1995, [Reviewed] - Formation of 2-Alkylaminooxazoles by the Rh2(OAc)4-Catalyzed Reaction of a-Diazocarbonyl Compounds in the Presence of Cyanamides
Toshikazu Ibata; Kazuaki Fukushima
HETEROCYCLES, 1995, [Reviewed] - Thermolysis and photolysis of arylchlorodiazirines in allyl bromide
R. Bonneau; M. Grobys; M. T. H. Liu; M. Himori; K. Fukushima; T. Ibata
Research on Chemical Intermediates, Jan. 1994, [Reviewed] - FORMATION AND REACTION OF ACYL SUBSTITUTED NITRILE YLIDE THROUGH THE RH2(OAC)4-CATALYZED REACTION OF ALPHA-DIAZOCARBONYL COMPOUNDS WITH BENZONITRILE
T IBATA; K FUKUSHIMA
CHEMISTRY LETTERS, Nov. 1992, [Reviewed]
MISC
- The time-course analysis of the orotidine decarboxylase-orotidine 5’-monophosphate complex using molecular dynamics simulations
江嵜啓祥; 中山良太; 福島和明
日本薬学会年会要旨集(Web), 2025 - Molecular Dynamics Study on Conformational Change of Human Collagen Prolyl 4-Hydroxylase.
福島和明; 江嵜啓祥
日本化学会春季年会講演予稿集(Web), 2025 - Molecular Dynamics Simulation Analysis of the Reaction Mechanism of Orotidin 5’-Monophosphate Decarboxylase
江嵜啓祥; 浜崎康太; 福島和明
日本薬学会年会要旨集(Web), 2024 - Computational study of the reaction mechanism of 4-imidazolidinones synthesis using hypervalent iodine compound
江嵜啓祥; 多田教浩; 伊藤彰近; 福島和明
日本薬学会年会要旨集(Web), 2023 - Synthesis of 4-imidazolidinones with electrophilic ynol synthons
多田教浩; 清水彩加; 柴田篤; 江嵜啓祥; 福島和明; 伊藤彰近
日本薬学会年会要旨集(Web), 2022 - キラルアミン-ウレア触媒を用いる脂肪族ニトリルオキシドと2-ヒドロキシスチレン類の不斉付加環化反応
小山將人; 江嵜啓祥; 福島和明; 戸田泰徳; 菅博幸
日本化学会春季年会講演予稿集(CD-ROM), 2018 - 芳香族ニトリルオキシドと2-ヒドロキシスチレン類の不斉付加環化反応の反応機構解析と脂肪族ニトリルオキシドへの応用
小山將人; 江嵜啓祥; 福島和明; 戸田泰徳; 菅博幸
複素環化学討論会講演要旨集, 2018 - ニトリルオキシドと2-ヒドロキシスチレン類の不斉付加環化反応を基盤とする1,3-双極子の探索
小山將人; 江嵜啓祥; 福島和明; 戸田泰徳; 菅博幸
中部化学関係学協会支部連合秋季大会講演予稿集, 2018 - Molecular Orbital Calculations on Ground State Nitrilium Betaines
Kazuaki Fukushima
Bulletin of Wakayama Medical University, Liberal Arts and Sciences, 2000 - Density Functional Studies of 1, 5-Cyclization of 3-Carbonyl Nitrile Ylide.
Kazuaki Fukushima
Bulletin of Wakayama Medical University, Liberal Arts and Sciences, 1999 - Ab Initio and Density Functional Studies of Nitrile Ylide and 3-Formyl Nitrile Ylide.
Kazuaki Fukushima
Bulletin of Wakayama Medical College, Premedical School, 1998
Lead
Research Themes
- Elucidation of the molecular mechanism of ALS causative protein aggregate formation and pathogenesis
Grant-in-Aid for Scientific Research (C)
Hyogo Medical University
01 Apr. 2025 - 31 Mar. 2028 - Quantum Chemical Calculations of Mechanism for Formation of Peptide Bond on the Ribosome
Grant-in-Aid for Scientific Research (C)
01 Apr. 2013 - 31 Mar. 2016 - グアニン4量体の形成
- ニトリルイリドを経由するオキサゾールの生成
- 共役1,3-双極子の1,5-電子環状反応の機構
- Formation of Guanine Quartet
- Formation of Oxazole via Nitrile Ylide
- Mechanism of 1,5-Electrocyclization of Conjgated 1,3-Dipole
- 量子化学計算を用いた酵素反応の反応機構の解明
- 量子化学計算を用いた有機触媒反応の反応機構の解明
