戴 毅
| 解剖学（神経科学部門） | 教授 |
| 疼痛メカニズム研究講座（寄附講座） |
Last Updated :2024/09/04
研究者情報
経歴
研究活動情報
論文
- Modulation of Nicotine-Associated Behaviour in Rats By μ-Opioid Signals from the Medial Prefrontal Cortex to the Nucleus Accumbens Shell
Feng Zhu; Hirosato Kanda; Hiroyuki Neyama; Yuping Wu; Shigeki Kato; Di Hu; Shaoqi Duan; Koichi Noguchi; Yasuyoshi Watanabe; Kazuto Kobayashi; Yi Dai; Yilong Cui
Neuroscience Bulletin, 2024年06月 - COX2 expression plays a role in spinal cord injury-induced neuropathic pain.
Masakazu Toi; Tachibana Toshiya; Koichi Noguchi; Hiroki Yamanaka; Kimiko Kobayashi; Masamichi Okubo; Kazuya Kishima; Yi Dai
Neuroscience letters, 2024年01月 - 交感神経活動による大腸好酸球浸潤の誘導と内臓知覚過敏への関与(Sympathetic activation-induced colonic eosinophil infiltration contributes to visceral hypersensitivity)
段 韶き; 神田 浩里; 野口 光一; 戴 毅
PAIN RESEARCH, 2023年12月 - 交感神経活動による大腸好酸球浸潤の誘導と内臓知覚過敏への関与(Sympathetic activation-induced colonic eosinophil infiltration contributes to visceral hypersensitivity)
段 韶き; 神田 浩里; 野口 光一; 戴 毅
PAIN RESEARCH, 2023年12月 - Axonal membrane stretch suppresses neuronal excitability by activating mechanosensitive K2P channels at the node of Ranvier
Hirosato Kanda; Koichi Noguchi; Yi Dai
Molecular Brain, 2023年01月, ［査読有り］ - エビデンスに基づく漢方診療 機能性ディスペプシアモデルラットの胃知覚過敏及び好酸球関連微小炎症に対する抑肝散の効果
今村 信子; 段 韶キ; 近藤 隆; 神田 浩里; 小暮 洋子; 奥川 卓也; 富田 寿彦; 大島 忠之; 福井 広一; 戴 毅; 三輪 洋人; 新崎 信一郎
日本消化管学会雑誌, 2023年01月 - 抑肝散はFDモデルラットの胃痛覚過敏と微小炎症を抑制する(Yokukansan suppresses gastric pain hypersensitivity and micro inflammation in FD model rats)
段 韶き; 今村 信子; 近藤 隆; 神田 浩里; 三輪 洋人; 野口 光一; 戴 毅
PAIN RESEARCH, 2022年12月 - 脊髄損傷による神経障害性疼痛におけるCOX2の発現に関する研究
都井 政和; 橘 俊哉; 野口 光一; 山中 博樹; 小林 希実子; 大久保 正道; 木島 和也; 戴 毅
PAIN RESEARCH, 2022年12月 - 発酵オタネニンジンの抗ストレス効果 ランダム化二重盲検プラセボ対照並行群間比較試験
小暮 洋子; 神田 浩里; 池田 真海; 白川 由佳子; 桃崎 祐実; 乾 さやか; 越田 真由; 中村 悠希; 森上 愛弓; 諸見里 奈央; 伊藤 久富; 宮崎 寿次; 位上 健太郎; 岩岡 恵実子; 青木 俊二; 山本 悟史; 戴 毅
薬理と治療, 2022年11月 - Yokukansan Suppresses Gastric Hypersensitivity and Eosinophil-associated Microinflammation in Rats With Functional Dyspepsia.
Shaoqi Duan; Nobuko Imamura; Takashi Kondo; Hirosato Kanda; Yoko Kogure; Takuya Okugawa; Masashi Fukushima; Toshihiko Tomita; Tadayuki Oshima; Hirokazu Fukui; Koichi Noguchi; Yi Dai; Hiroto Miwa
Journal of neurogastroenterology and motility, 2022年04月 - Reactive Oxygen Species Cause Exercise-Induced Angina in a Myocardial Ischaemia-Reperfusion Injury Model
Xiaohang Wang; Hirosato; Takeshi Tsujino; Yoko Kogure; Feng Zhu; Satoshi Yamamoto; Taichi Sakaguchi; Koichi Noguchi; Yi Dai
International Journal of Molecular Sciences, 2022年03月 - Acid increases PGE2 in the duodenal mucosa in rats.
Tadahiro Fujimura; Takashi Kondo; Kimiko Kobayashi; Shaoqi Duan; Hirosato Kanda; Tomoaki Kono; Masashi Fukushima; Toshihiko Tomita; Tadayuki Oshima; Hirokazu Fukui; Yoshihito Fujii; Takashi Konemura; Hiroki Okada; Hiroki Yamanaka; Yi Dai; Koichi Noguchi; Hiroto Miwa
Journal of clinical biochemistry and nutrition, 2022年01月 - 過酸化水素によるTRPA1チャネルの活性化はPCI後狭心症の発症に関与する(The activation of TRPA1 by cardiac hydrogen peroxide is involved in angina after PCI of a rodent model)
王 暁航; 神田 浩里; 坂口 太一; 野口 光一; 戴 毅
PAIN RESEARCH, 2021年12月 - 過酸化水素によるTRPA1チャネルの活性化はPCI後狭心症の発症に関与する(The activation of TRPA1 by cardiac hydrogen peroxide is involved in angina after PCI of a rodent model)
王 暁航; 神田 浩里; 坂口 太一; 野口 光一; 戴 毅
PAIN RESEARCH, 2021年12月 - Atractylodin Produces Antinociceptive Effect through a Long-Lasting TRPA1 Channel Activation.
Hirosato Kanda; Yanjing Yang; Shaoqi Duan; Yoko Kogure; Shenglan Wang; Emiko Iwaoka; Miku Ishikawa; Saki Takeda; Hidemi Sonoda; Kyoka Mizuta; Shunji Aoki; Satoshi Yamamoto; Koichi Noguchi; Yi Dai
International journal of molecular sciences, 2021年03月 - The ubiquitin E3 ligase Nedd4-2 relieves mechanical allodynia through the ubiquitination of TRPA1 channel in db/db mice.
Shenglan Wang; Simin Qi; Yoko Kogure; Hirosato Kanda; Lin Tian; Satoshi Yamamoto; Koichi Noguchi; Yi Dai
The European journal of neuroscience, 2021年03月 - Protocol for pressure-clamped patch-clamp recording at the node of Ranvier of rat myelinated nerves
Hirosato Kanda; Sotatsu Tonomura; Yi Dai; Jianguo G. Gu
STAR Protocols, 2021年03月 - Eosinophil-associated microinflammation in the gastroduodenal tract contributes to gastric hypersensitivity in a rat model of early-life adversity.
Shaoqi Duan; Takashi Kondo; Hiroto Miwa; Yanjing Yang; Shenglan Wang; Hirosato Kanda; Yoko Kogure; Nobuko Imamura; Tadahiro Fujimura; Tomoaki Kono; Masashi Fukushima; Katsuyuki Tozawa; Toshihiko Tomita; Tadayuki Oshima; Hirokazu Fukui; Satoshi Yamamoto; Koichi Noguchi; Yi Dai
American journal of physiology. Gastrointestinal and liver physiology, 2021年02月 - Localization of prostaglandin E2 synthases and E-prostanoid receptors in the spinal cord in a rat model of neuropathic pain.
Hirosato Kanda; Kimiko Kobayashi; Hiroki Yamanaka; Masamichi Okubo; Yi Dai; Koichi Noguchi
Brain research, 2021年01月 - ラット母子分離ストレスモデルにおける胃十二指腸の微小炎症は胃の痛覚過敏に関与する(Micro-inflammation in the Gastroduodenal Tract Contributes to Gastric Pain Hypersensitivity in MS Model Rats)
段 韶き; 神田 浩里; 近藤 隆; 三輪 洋人; 野口 光一; 戴 毅
PAIN RESEARCH, 2020年12月 - 虚血性心疾患に関連する心臓痛へのTRPA1チャネルの関与(Involvement of TRPA1 channel in cardiac pain accompanied with ischemic heart disease)
王 暁航; 神田 浩里; 坂口 太一; 野口 光一; 戴 毅
PAIN RESEARCH, 2020年12月 - Daikenchuto attenuates visceral pain and suppresses eosinophil infiltration in inflammatory bowel disease in murine models.
Yoko Kogure; Hirosato Kanda; Shenglan Wang; Yongbiao Hao; Junxiang Li; Satoshi Yamamoto; Koichi Noguchi; Yi Dai
JGH open : an open access journal of gastroenterology and hepatology, 2020年12月 - Increased TRPV4 expression in non-myelinating Schwann cells is associated with demyelination after sciatic nerve injury.
Xiaona Feng; Yasunori Takayama; Nobuhiko Ohno; Hirosato Kanda; Yi Dai; Takaaki Sokabe; Makoto Tominaga
Communications biology, 2020年11月 - 十二指腸への酸刺激とプロスタグランジンE2との関連
近藤 隆; Shaoqi Duan; 藤村 忠宏; 森 すみれ; 井上 義仁; 江田 裕嗣; 中村 久美子; 原 謙; 田村 彰朗; 小川 智広; 河野 友彰; 福島 政司; 戸澤 勝之; 富田 寿彦; 大島 忠之; 福井 広一; 岡田 啓希; 戴 毅; 三輪 洋人
日本消化器病学会雑誌, 2020年10月 - 【運動器の痛み:どこから来るのか?どこへ行くのか?】(Part1)運動器の痛み どこから来るのか? 疼痛の発生メカニズム
戴 毅; 野口 光一
Bone Joint Nerve, 2020年10月 - Pain matrix shift in the rat brain following persistent colonic inflammation revealed by voxel-based statistical analysis
Tianliang Huang; Takashi Okauchi; Di Hu; Mika Shigeta; Yuping Wu; Yasuhiro Wada; Emi Hayashinaka; Shenglan Wang; Yoko Kogure; Koichi Noguchi; Yasuyoshi Watanabe; Yi Dai; Yilong Cui
MOLECULAR PAIN, 2019年11月 - TRPA1-expressing lamina propria mesenchymal cells regulate colonic motility.
Yang Y; Wang S; Kobayashi K; Hao Y; Kanda H; Kondo T; Kogure Y; Yamanaka H; Yamamoto S; Li J; Miwa H; Noguchi K; Dai Y
JCI insight, 2019年05月, ［査読有り］ - 一次知覚ニューロンに対する発酵オタネニンジンおよび含有成分compound Kの薬理作用
下農 修司; 松井 帝斗; 王 勝蘭; 小暮 洋子; 岩岡 恵実子; 位上 健太郎; 伊藤 久富; 宮崎 寿次; 青木 俊二; 山本 悟史; 戴 毅
日本薬学会年会要旨集, 2019年03月 - Negative regulation of TRPA1 by AMPK in primary sensory neurons as a potential mechanism of painful diabetic neuropathy
Shenglan Wang; Kimiko Kobayashi; Yoko Kogure; Hiroki Yamanaka; Satoshi Yamamoto; Hideshi Yagi; Koichi Noguchi; Yi Dai
Diabetes, 2018年01月, ［査読有り］ - Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor
Syuhei Nakao; Miyuki Mabuchi; Shenglan Wang; Yoko Kogure; Tadashi Shimizu; Koichi Noguchi; Akito Tanaka; Yi Dai
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017年07月, ［査読有り］ - 一次知覚神経におけるAMPキナーゼによるTRPA1膜発現の制御
王 勝蘭; 小林 希実子; 小暮 洋子; 山中 博樹; 山本 悟史; 八木 秀司; 野口 光一; 戴 毅
PAIN RESEARCH, 2017年06月 - 物理療法は神経障害性疼痛発症を予防できるか? ラット神経障害性疼痛モデルに寒冷療法を用いて
川口 浩太郎; 猪俣 陽一; 藤岡 宏幸; 坂口 顕; 山本 悟史; 小暮 洋子; 王 勝蘭; 戴 毅
兵庫医療大学紀要, 2016年06月 - Elevated H2O2 levels in trinitrobenzene sulfate-induced colitis rats contributes to visceral hyperalgesia through interaction with the transient receptor potential ankyrin 1 cation channel
Yoko Kogure; Shenglan Wang; Koh-ichi Tanaka; Yongbiao Hao; Satoshi Yamamoto; Nobuyoshi Nishiyama; Koichi Noguchi; Yi Dai
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2016年06月, ［査読有り］ - Partial Activation and Inhibition of TRPV1 Channels by Evodiamine and Rutaecarpine, Two Major Components of the Fruits of Evodia rutaecarpa
Shenglan Wang; Satoshi Yamamoto; Yoko Kogure; Wensheng Zhang; Koichi Noguchi; Yi Dai
JOURNAL OF NATURAL PRODUCTS, 2016年05月, ［査読有り］ - Macrophage-Colony Stimulating Factor Derived from Injured Primary Afferent Induces Proliferation of Spinal Microglia and Neuropathic Pain in Rats
Masamichi Okubo; Hiroki Yamanaka; Kimiko Kobayashi; Yi Dai; Hirosato Kanda; Hideshi Yagi; Koichi Noguchi
PLOS ONE, 2016年04月, ［査読有り］ - Evodiamine suppresses capsaicin-induced thermal hyperalgesia through activation and subsequent desensitization of the transient receptor potential V1 channels
Emiko Iwaoka; Shenglan Wang; Nobuyuki Matsuyoshi; Yoko Kogure; Shunji Aoki; Satoshi Yamamoto; Koichi Noguchi; Yi Dai
JOURNAL OF NATURAL MEDICINES, 2016年01月, ［査読有り］ - Peripherally increased artemin is a key regulator of TRPA1/V1 expression in primary afferent neurons
Yasuko Ikeda-Miyagawa; Kimiko Kobayashi; Hiroki Yamanaka; Masamichi Okubo; Shenglan Wang; Yi Dai; Hideshi Yagi; Munetaka Hirose; Koichi Noguchi
MOLECULAR PAIN, 2015年03月, ［査読有り］ - 【痛みのマネジメントupdate 基礎知識から緩和ケアまで】痛みの基礎知識 痛みの発生のメカニズム 痛みの受容器
戴 毅; 野口 光一
日本医師会雑誌, 2014年06月 - TNBS誘発性大腸炎モデルラットの内臓痛発症メカニズムにおける過酸化水素の役割
小暮 洋子; 王 勝蘭; 田中 康一; 山本 悟史; 西山 信好; 野口 光一; 戴 毅
日本薬学会年会要旨集, 2014年03月 - 一次知覚神経培養細胞に対する抗がん剤の影響(1)
谷村 梓; 梅川 小夜子; 小暮 洋子; 王 勝蘭; 山本 悟史; 戴 毅
日本薬学会年会要旨集, 2014年03月 - 一次知覚神経培養細胞に対する抗がん剤の影響(2)
梅川 小夜子; 谷村 梓; 小暮 洋子; 王 勝蘭; 山本 悟史; 戴 毅
日本薬学会年会要旨集, 2014年03月 - Xilei San Ameliorates Experimental Colitis in Rats by Selectively Degrading Proinflammatory Mediators and Promoting Mucosal Repair
Yongbiao Hao; Kazuko Nagase; Kazutoshi Hori; Shenglan Wang; Yoko Kogure; Ken Fukunaga; Shinichiro Kashiwamura; Satoshi Yamamoto; Shiro Nakamura; Junxiang Li; Hiroto Miwa; Koichi Noguchi; Yi Dai
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2014年, ［査読有り］ - Etodolac Activates and Desensitizes Transient Receptor Potential Ankyrin 1
Shenglan Wang; Yi Dai; Yoko Kogure; Satoshi Yamamoto; Wensheng Zhang; Koichi Noguchi
JOURNAL OF NEUROSCIENCE RESEARCH, 2013年12月, ［査読有り］ - Transient receptor potential channel A1 involved in calcitonin gene-related peptide release in neurons
Nobumasa Ushio; Yi Dai; Shenglan Wang; Tetsuo Fukuoka; Koichi Noguchi
Neural Regeneration Research, 2013年11月, ［査読有り］ - 末梢神経損傷後の脊髄および後根神経節におけるColony-stimulating factorとそれら受容体mRNAの発現
大久保 正道; 山中 博樹; 小林 希実子; 神田 浩里; 戴 毅; 野口 光一
Journal of Musculoskeletal Pain Research, 2013年11月 - EtodolacはTRPA1を活性化し脱感作する(Etodolac activates and desensitizes TRPA1)
王 勝蘭; 戴 毅; 野口 光一
Journal of Musculoskeletal Pain Research, 2013年11月 - Modulation of TRP channels by resveratrol and other stilbenoids
Lina Yu; Shenglan Wang; Yoko Kogure; Satoshi Yamamoto; Koichi Noguchi; Yi Dai
MOLECULAR PAIN, 2013年02月, ［査読有り］ - Potentiation of the P2X3 ATP receptor by PAR-2 in rat dorsal root ganglia neurons, through protein kinase-dependent mechanisms, contributes to inflammatory pain
Shenglan Wang; Yi Dai; Kimiko Kobayashi; Wanjun Zhu; Yoko Kogure; Hiroki Yamanaka; You Wan; Wensheng Zhang; Koichi Noguchi
EUROPEAN JOURNAL OF NEUROSCIENCE, 2012年08月, ［査読有り］ - Up-regulation of platelet-activating factor synthases and its receptor in spinal cord contribute to development of neuropathic pain following peripheral nerve injury
Masamichi Okubo; Hiroki Yamanaka; Kimiko Kobayashi; Hirosato Kanda; Yi Dai; Koichi Noguchi
MOLECULAR PAIN, 2012年02月, ［査読有り］ - Re-evaluation of the phenotypic changes in L4 dorsal root ganglion neurons after L5 spinal nerve ligation
Tetsuo Fukuoka; Hiroki Yamanaka; Kimiko Kobayashi; Masamichi Okubo; Kan Miyoshi; Yi Dai; Koichi Noguchi
PAIN, 2012年01月, ［査読有り］ - ゴシュユの主成分エボジアミンによる一次知覚ニューロンの活性化
岩岡 恵実子; 松吉 延之; 小暮 洋子; 青木 俊二; 野口 光一; 戴 毅
Journal of Traditional Medicines, 2011年08月 - Inhibition of TRPA1 channel activity in sensory neurons by the glial cell line-derived neurotrophic factor family member, artemin
Naoki Yoshida; Kimiko Kobayashi; Lina Yu; Shenglan Wang; Rengaowa Na; Satoshi Yamamoto; Koichi Noguchi; Yi Dai
MOLECULAR PAIN, 2011年05月, ［査読有り］ - Risk factors for interstitial cystitis/painful bladder syndrome in patients with lower urinary tract symptoms: a Chinese multi-center study.
Li GZ; Zhang N; Du P; Yang Y; Wu SL; Xiao YX; Jin R; Liu L; Shen H; Dai Y
Chinese medical journal, 2010年10月, ［査読有り］ - Expression of leukotriene receptors in the rat dorsal root ganglion and the effects on pain behaviors
Masamichi Okubo; Hiroki Yamanaka; Kimiko Kobayashi; Tetsuo Fukuoka; Yi Dai; Koichi Noguchi
MOLECULAR PAIN, 2010年09月, ［査読有り］ - Expression of Transient Receptor Potential Ankyrin 1 (TRPA1) in the Rat Trigeminal Sensory Afferents and Spinal Dorsal Horn
Yun Sook Kim; Jae Youn Son; Tae Heon Kim; Sang Kyoo Paik; Yi Dai; Koichi Noguchi; Dong Kuk Ahn; Yong Chul Bae
JOURNAL OF COMPARATIVE NEUROLOGY, 2010年03月, ［査読有り］ - 医学部4年生必修科目としての東洋医学教育導入の成果 アンケート調査からの検討
戴 毅; 夏秋 優; 野口 光一
日本東洋医学雑誌, 2009年05月 - Comparative study of the distribution of the alpha-subunits of voltage-gated sodium channels in normal and axotomized rat dorsal root ganglion neurons.
Fukuoka T; Kobayashi K; Yamanaka H; Obata K; Dai Y; Noguchi K
The Journal of comparative neurology, 2008年09月, ［査読有り］ - Toll-like receptor 3 contributes to spinal glial activation and tactile allodynia after nerve injury
K. Obata; H. Katsura; K. Miyoshi; T. Kondo; H. Yamanaka; K. Kobayashi; Y. Dai; T. Fukuoka; S. Akira; K. Noguchi
JOURNAL OF NEUROCHEMISTRY, 2008年06月, ［査読有り］ - 【痛みのメカニズムとその制御】TRPファミリー受容体と痛み(基礎)
戴 毅; 野口 光一
BIO Clinica, 2008年05月 - Transforming growth factor-activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injury
Hirokazu Katsura; Koichi Obata; Kan Miyoshi; Takashi Kondo; Hiroki Yamanaka; Kimiko Kobayashi; Yi Dai; Tetsuo Fukuoka; Masafumi Sakagami; Koichi Noguchi
GLIA, 2008年05月, ［査読有り］ - Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain
Shenglan Wang; Yi Dai; Tetsuo Fukuoka; Hiroki Yamanaka; Kimiko Kobayashi; Koichi Obata; Xiuyu Cui; Makoto Tominaga; Koichi Noguchi
BRAIN, 2008年05月, ［査読有り］ - Activation of extracellular signal-regulated protein kinase in sensory neurons after noxious gastric distention and its involvement in acute visceral pain in rats
Jun Sakurai; Koichi Obata; Noriyuki Ozako; Atsushi Tokunaga; Kimiko Kobayashi; Hiroki Yamanaka; Yi Dai; Takashi Kondo; Kan Miyoshi; Yasuo Sugiura; Takayuki Matsumoto; Hiroto Miwa; Koichi Noguchi
GASTROENTEROLOGY, 2008年04月, ［査読有り］ - Differential activation of p38 and extracellular signal-regulated kinase in spinal cord in a model of bee venom-induced inflammation and hyperalgesia
Xiu-Yu Cui; Yi Dai; Sheng-Lan Wang; Hiroki Yamanaka; Kimiko Kobayashi; Koichi Obata; Jun Chen; Koichi Noguchi
MOLECULAR PAIN, 2008年04月, ［査読有り］ - P2Y(12) receptor Upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain
Kimiko Kobayashi; Hiroki Yamanaka; Tetsuo Fukuoka; Yi Dai; Koichi Obata; Koichi Noguchi
JOURNAL OF NEUROSCIENCE, 2008年03月, ［査読有り］ - Activation of fibroblast growth factor receptor by axotomy, through downstream p38 in dorsal root ganglion, contributes to neuropathic pain.
Yamanaka H; Obata K; Kobayashi K; Dai Y; Fukuoka T; Noguchi K
Neuroscience, 2007年11月, ［査読有り］ - Roles of extracellular signal-regulated protein kinases 5 in spinal microglia and primary sensory neurons for neuropathic pain
Koichi Obata; Hirokazu Katsura; Toshiyuki Mizushima; Jun Sakurai; Kimiko Kobayashi; Hiroki Yamanaka; Yi Dai; Tetsuo Fukuoka; Koichi Noguchi
JOURNAL OF NEUROCHEMISTRY, 2007年09月, ［査読有り］ - Activation of extracellular signal-regulated protein kinases 5 in primary afferent neurons contributes to heat and cold hyperalgesia after inflammation
Hirokazu Katsura; Koichi Obata; Toshiyuki Mizushima; Jun Sakurai; Kimiko Kobayashi; Hiroki Yamanaka; Yi Dai; Tetsuo Fukuoka; Masafumi Sakagami; Koichi Noguchi
JOURNAL OF NEUROCHEMISTRY, 2007年09月, ［査読有り］ - Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain
Yi Dai; Shenglan Wang; Makoto Tominaga; Satoshi Yamamoto; Tetsuo Fukuoka; Tomohiro Higashi; Kimiko Kobayashi; Koichi Obata; Hiroki Yamanaka; Koichi Noguchi
JOURNAL OF CLINICAL INVESTIGATION, 2007年07月, ［査読有り］ - Frequency-dependent ERK phosphorylation in spinal neurons by electric stimulation of the sciatic nerve and the role in electrophysiological activity
Tomokazu Fukui; Yi Dai; Koichi Iwata; Hiroshi Kamo; Hiroki Yamanaka; Koichi Obata; Kimiko Kobayashi; Shenglan Wang; Xiuyu Cui; Shinichi Yoshiya; Koichi Noguchi
MOLECULAR PAIN, 2007年07月, ［査読有り］ - Intensity-dependent activation of extracellular signal-regulated protein kinase 5 in sensory neurons contributes to pain hypersensitivity
Toshiyuki Mizushima; Koichi Obata; Hirokazu Katsura; Jun Sakurai; Kimiko Kobayashi; Hiroki Yamanaka; Yi Dai; Tetsuo Fukuoka; Takashi Mashimo; Koichi Noguchi
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2007年04月, ［査読有り］ - Tissue type plasminogen activator induced in rat dorsal horn astrocytes contributes to mechanical hypersensitivity following dorsal root injury
Toyoko Kozai; Hiroki Yamanaka; Yi Dai; Koichi Obata; Kimiko Kobayashi; Takashi Mashimo; Koichi Noguchi
GLIA, 2007年04月, ［査読有り］ - Alteration of the cell adhesion molecule L1 expression in a specific subset of primary afferent neurons contributes to neuropathic pain
Hiroki Yamanaka; Koichi Obata; Kimiko Kobayashi; Yi Dai; Tetsuo Fukuoka; Koichi Noguchi
EUROPEAN JOURNAL OF NEUROSCIENCE, 2007年02月, ［査読有り］ - Axotomy increases plasma membrane Ca2+ pump isoform4 in primary afferent neurons.
Ogura H; Tachibana T; Yamanaka H; Kobayashi K; Obata K; Dai Y; Yoshiya S; Noguchi K
Neuroreport, 2007年01月, ［査読有り］ - Suppression of the p75 neurotrophin receptor in uninjured sensory neurons reduces neuropathic pain after nerve injury
Koichi Obata; Hirokazu Katsura; Jun Sakurai; Kimiko Kobayashi; Hiroki Yamanaka; Yi Dai; Tetsuo Fukuoka; Koichi Noguchi
JOURNAL OF NEUROSCIENCE, 2006年11月, ［査読有り］ - Neurons and glial cells differentially express P2Y receptor mRNAs in the rat dorsal root ganglion and spinal cord.
Kobayashi K; Fukuoka T; Yamanaka H; Dai Y; Obata K; Tokunaga A; Noguchi K
The Journal of comparative neurology, 2006年10月, ［査読有り］ - Activation of Src-family kinases in spinal microglia contributes to mechanical hypersensitivity after nerve injury
Hirokazu Katsura; Koichi Obata; Toshiyuki Mizushima; Jun Sakurai; Kimiko Kobayashi; Hiroki Yamanaka; Yi Dai; Tetsuo Fukuoka; Masafumi Sakagami; Koichi Noguchi
JOURNAL OF NEUROSCIENCE, 2006年08月, ［査読有り］ - Agonist of proteinase-activated receptor 2 increases painful behavior produced by alpha, beta-methylene adenosine 5 '-triphosphate
Wan-Jun Zhu; Yi Dai; Tetsuo Fukuoka; Hiroki Yamanaka; Kimiko Kobayashi; Koichi Obata; Shenglan Wang; Koichi Noguchi
NEUROREPORT, 2006年08月, ［査読有り］ - Antisense knock down of TRPA1, but not TRPM8. alleviates cold hyperalgesia after spinal nerve ligation in rats
Hirokazu Katsura; Koichi Obata; Toshiyuki Mizushima; Hiroki Yamanaka; Kimiko Kobayashi; Yi Dai; Tetsuo Fukuoka; Atsushi Tokunaga; Masafumi Sakagami; Koichi Noguchi
EXPERIMENTAL NEUROLOGY, 2006年07月, ［査読有り］ - The role of ERK signaling and the P2X receptor on mechanical pain evoked by movement of inflamed knee joint
D Seino; A Tokunaga; T Tachibana; S Yoshiya; Y Dai; K Obata; H Yamanaka; K Kobayashi; K Noguchi
PAIN, 2006年07月, ［査読有り］ - The effect of site and type of nerve injury on the expression of brain-derived neurotrophic factor in the dorsal root ganglion and on neuropathic pain behavior
K Obata; H Yamanaka; K Kobayashi; Y Dai; T Mizushima; H Katsura; T Fukuoka; A Tokunaga; K Noguchi
NEUROSCIENCE, 2006年, ［査読有り］ - Noxious cold stimulation induces mitogen-activated protein kinase activation in transient receptor potential (TRP) channels TRPA1- and TRPM8-containing small sensory neurons
T. Mizushima; K. Obata; H. Katsura; H. Yamanaka; K. Kobayashi; Y. Dai; T. Fukuoka; A. Tokunaga; T. Mashimo; K. Noguchi
NEUROSCIENCE, 2006年, ［査読有り］ - Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors.
Kobayashi K; Fukuoka T; Obata K; Yamanaka H; Dai Y; Tokunaga A; Noguchi K
The Journal of comparative neurology, 2005年12月, ［査読有り］ - TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury
K Obata; H Katsura; T Mizushima; H Yamanaka; K Kobayashi; Y Dai; T Fukuoka; A Tokunaga; M Tominaga; K Noguchi
JOURNAL OF CLINICAL INVESTIGATION, 2005年09月, ［査読有り］ - 後根神経節ニューロンでのATP受容体発現及び炎症組織における痛覚過敏
野口 光一; 小林 希実子; 福岡 哲男; 山中 博樹; 戴 毅; 清野 大輔; 徳永 敦
PAIN RESEARCH, 2005年07月 - Ca2+/calmodulin-dependent protein kinase II in the spinal cord contributes to neuropathic pain in a rat model of mononeuropathy
Y Dai; H Wang; A Ogawa; H Yamanaka; K Obata; A Tokunaga; K Noguchi
EUROPEAN JOURNAL OF NEUROSCIENCE, 2005年05月, ［査読有り］ - Expression of mRNA for four subtypes of the proteinase-activated receptor in rat dorsal root ganglia.
Zhu WJ; Yamanaka H; Obata K; Dai Y; Kobayashi K; Kozai T; Tokunaga A; Noguchi K
Brain research, 2005年04月, ［査読有り］ - Ca2+/calmodulin-protein kinase II alpha in the trigeminal subnucleus caudalis contributes to neuropathic pain following inferior alveolar nerve transection
A Ogawa; Y Dai; H Yamanaka; K Iwata; H Niwa; K Noguchi
EXPERIMENTAL NEUROLOGY, 2005年04月, ［査読有り］ - Induction of plasminogen activator inhibitor-1 and -2 in dorsal root ganglion neurons after peripheral nerve injury.
Yamanaka H; Obata K; Fukuoka T; Dai Y; Kobayashi K; Tokunaga A; Noguchi K
Neuroscience, 2005年, ［査読有り］ - Differential expression patterns of mRNAs for P2X receptor subunits in neurochemically characterized dorsal root ganglion neurons in the rat.
Kobayashi K; Fukuoka T; Yamanaka H; Dai Y; Obata K; Tokunaga A; Noguchi K
The Journal of comparative neurology, 2005年01月, ［査読有り］ - Activation of p38 MAPK in primary afferent neurons by noxious stimulation and its involvement in the development of thermal hyperalgesia
T Mizushima; K Obata; H Yamanaka; Y Dai; T Fukuoka; A Tokunaga; T Mashimo; K Noguchi
PAIN, 2005年01月, ［査読有り］ - Differential activation of MAPK in injured and uninjured DRG neurons following chronic constriction injury of the sciatic nerve in rats
K Obata; H Yamanaka; Y Dai; T Mizushima; T Fukuoka; A Tokunaga; K Noguchi
EUROPEAN JOURNAL OF NEUROSCIENCE, 2004年12月, ［査読有り］ - Plasma membrane calcium ATPase expression in the rat spinal cord
T Tachibana; H Ogura; A Tokunaga; Y Dai; H Yamanaka; D Seino; K Noguchi
MOLECULAR BRAIN RESEARCH, 2004年11月, ［査読有り］ - Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation
K Obata; H Yamanaka; K Kobayashi; Y Dai; T Mizushima; H Katsura; T Fukuoka; A Tokunaga; K Noguchi
JOURNAL OF NEUROSCIENCE, 2004年11月, ［査読有り］ - Contribution of degeneration of motor and sensory fibers to pain behavior and the changes in neurotrophic factors in rat dorsal root ganglion
K Obata; H Yamanaka; Y Dai; T Mizushima; T Fukuoka; A Tokunaga; H Yoshikawa; K Noguchi
EXPERIMENTAL NEUROLOGY, 2004年07月, ［査読有り］ - Activation of extracellular signal-regulated protein kinase in dorsal horn neurons in the rat neuropathic intermittent claudication model
Y Liu; K Obata; H Yamanaka; Y Dai; T Fukuoka; A Tokunaga; K Noguchi
PAIN, 2004年05月, ［査読有り］ - Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain
Y Dai; T Moriyama; T Higashi; K Togashi; K Kobayashi; H Yamanaka; M Tominaga; K Noguchi
JOURNAL OF NEUROSCIENCE, 2004年05月, ［査読有り］ - Contribution of sensitized P2X receptors in inflamed tissue to the mechanical hypersensitivity revealed by phosphorylated ERK in DRG neurons
Y Dai; T Fukuoka; H Wang; H Yamanaka; K Obata; A Tokunaga; K Noguchi
PAIN, 2004年04月, ［査読有り］ - Enhancement of stimulation-induced ERK activation in the spinal dorsal horn and gracile nucleus neurons in rats with peripheral nerve injury
H Wang; Y Dai; T Fukuoka; H Yamanaka; K Obata; A Tokunaga; K Noguchi
EUROPEAN JOURNAL OF NEUROSCIENCE, 2004年02月, ［査読有り］ - Activation of extracellular signal-regulated protein kinase in the dorsal root ganglion following inflammation near the nerve cell body
K Obata; H Yamanaka; Y Dai; T Mizushima; T Fukuoka; A Tokunaga; K Noguchi
NEUROSCIENCE, 2004年, ［査読有り］ - Tissue plasminogen activator in primary afferents induces dorsal horn excitability and pain response after peripheral nerve injury
H Yamanaka; K Obata; T Fukuoka; Y Dai; K Kobayashi; A Tokunaga; K Noguchi
EUROPEAN JOURNAL OF NEUROSCIENCE, 2004年01月, ［査読有り］ - Changes in DRG neurons and spinal excitability in neuropathy
Koichi Noguchi; Koichi Obata; Yi Dai; Mantyh; Devor; Dray; Belmonte; Perl
Novartis Foundation Symposium, 2004年, ［査読有り］ - Protease-activated receptor 2によるTRPV1活性の増強
戴 毅; 森山 朋子; 冨樫 和也; 東 智広; 山中 博樹; 富永 真琴; 野口 光一
PAIN RESEARCH, 2003年12月 - Differential activation of extracellular signal-regulated protein kinase in primary afferent neurons regulates brain-derived neurotrophic factor expression after peripheral inflammation and nerve injury
K Obata; H Yamanaka; Y Dai; T Tachibana; T Fukuoka; A Tokunaga; H Yoshikawa; K Noguchi
JOURNAL OF NEUROSCIENCE, 2003年05月, ［査読有り］ - Changes in phosphorylation of ERK and Fos expression in dorsal horn neurons following noxious stimulation in a rat model of neuritis of the nerve root
Y Kominato; T Tachibana; Y Dai; H Tsujino; S Maruo; K Noguchi
BRAIN RESEARCH, 2003年03月, ［査読有り］ - Expression of auxiliary beta subunits of sodium channels in primary afferent neurons and the effect of nerve injury.
Takahashi N; Kikuchi S; Dai Y; Kobayashi K; Fukuoka T; Noguchi K
Neuroscience, 2003年, ［査読有り］ - Contribution of injured and uninjured dorsal root ganglion neurons to pain behavior and the changes in gene expression following chronic constriction injury of the sciatic nerve in rats
K Obata; H Yamanaka; T Fukuoka; D Yi; A Tokunaga; N Hashimoto; H Yoshikawa; K Noguchi
PAIN, 2003年01月, ［査読有り］ - Phosphorylation of extracellular signal-regulated kinase in primary afferent neurons by noxious stimuli and its involvement in peripheral sensitization
Y Dai; K Iwata; T Fukuoka; E Kondo; A Tokunaga; H Yamanaka; T Tachibana; Y Liu; K Noguchi
JOURNAL OF NEUROSCIENCE, 2002年09月, ［査読有り］ - VR1, but not P2X(3), increases in the spared L4 DRG in rats with L5 spinal nerve ligation
T Fukuoka; A Tokunaga; T Tachibana; Y Dai; H Yamanaka; K Noguchi
PAIN, 2002年09月, ［査読有り］ - Expression of neurotrophic factors in the dorsal root ganglion in a rat model of lumbar disc herniation
K Obata; H Tsujino; H Yamanaka; D Yi; T Fukuoka; N Hashimoto; K Yonenobu; H Yoshikawa; K Noguchi
PAIN, 2002年09月, ［査読有り］ - Heme oxygenase-1 expression after spinal cord injury: the induction in activated neutrophils.
Liu Y; Tachibana T; Dai Y; Kondo E; Fukuoka T; Yamanaka H; Noguchi K
Journal of neurotrauma, 2002年04月, ［査読有り］ - Involvement of glutamate receptors on hyperexcitability of wide dynamic range neurons in the gracile nucleus of the rats with experimental mononeuropathy
E Kondo; K Iwata; A Ogawa; A Tashiro; Y Tsuboi; T Fukuoka; H Yamanaka; Y Dai; T Morimoto; K Noguchi
PAIN, 2002年01月, ［査読有り］ - Brain-derived neurotrophic factor increases in the uninjured dorsal root ganglion neurons in selective spinal nerve ligation model
T Fukuoka; E Kondo; Y Dai; N Hashimoto; K Noguchi
JOURNAL OF NEUROSCIENCE, 2001年07月, ［査読有り］ - The effect of electroacupuncture on pain behaviors and noxious stimulus-evoked fos expression in a rat model of neuropathic pain
Y Dai; E Kondo; T Fukuoka; A Tokunaga; K Miki; K Noguchi
JOURNAL OF PAIN, 2001年06月, ［査読有り］ - Expression of HGF and cMet in the peripheral nervous system of adult rats following sciatic nerve injury
N Hashimoto; H Yamanaka; T Fukuoka; Y Dai; K Obata; T Mashimo; K Noguchi
NEUROREPORT, 2001年05月, ［査読有り］ - Differential regulation of P2X(3) mRNA expression by peripheral nerve injury in intact and injured neurons in the rat sensory ganglia
K Tsuzuki; E Kondo; T Fukuoka; D Yi; H Tsujino; M Sakagami; K Noguchi
PAIN, 2001年04月, ［査読有り］ - A selective increase in Fos expression in the spinal dorsal horn neurons following quantitative thermal stimulation in rats with experimental mononeuropathy (joint worked)
Dai Y; Iwata K; Kondo E; Morimoto T; Noguchi K
Pain, 2001年02月, ［査読有り］ - A selective increase in Fos expression in spinal dorsal horn neurons following graded thermal stimulation in rats with experimental mononeuropathy
Y Dai; K Iwata; E Kondo; T Morimoto; K Noguchi
PAIN, 2001年02月, ［査読有り］ - Suppression of neuropeptides' mRNA expression by herbal medicines in a rat model of peripheral inflammation
Y Dai; K Miki; T Fukuoka; A Tokunaga; T Tachibana; E Kondo; K Noguchi
LIFE SCIENCES, 2000年11月, ［査読有り］ - Dorsal column-thalamic pathway is involved in thalamic hyperexcitability following peripheral nerve injury: a lesion study in rats with experimental mononeuropathy
K Miki; K Iwata; Y Tsuboi; T Morimoto; E Kondo; Y Dai; K Ren; K Noguchi
PAIN, 2000年03月, ［査読有り］ - Activating transcription factor 3 (ATF3) induction by axotomy in sensory and motoneurons: A novel neuronal marker of nerve injury
H Tsujino; E Kondo; T Fukuoka; Y Dai; A Tokunaga; K Miki; K Yonenobu; T Ochi; K Noguchi
MOLECULAR AND CELLULAR NEUROSCIENCE, 2000年02月, ［査読有り］ - Differential effect of brain-derived neurotrophic factor on high-threshold mechanosensitivity in a rat neuropathic pain model
K Miki; T Fukuoka; A Tokunaga; E Kondo; Y Dai; K Noguchi
NEUROSCIENCE LETTERS, 2000年01月, ［査読有り］ - Excitability of spinal cord and gracile nucleus neurons in rats with chronically injured sciatic nerve examined by c-fos expression
A Tokunaga; E Kondo; T Fukuoka; K Miki; Y Dai; H Tsujino; K Noguchi
BRAIN RESEARCH, 1999年11月, ［査読有り］
MISC
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日本消化管学会雑誌, 2021年 - ラット十二指腸での酸刺激に伴うプロスタグランジンE2とその受容体の検討
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段韶基; 段韶基; 近藤隆; 神田浩里; 河野友彰; 福島政司; 富田寿彦; 大島忠之; 福井広一; 戴毅; 戴毅; 野口光一; 三輪洋人
日本潰瘍学会プログラム・抄録集, 2021年 - 漢方薬と処方箋医薬品との併用に伴う薬物相互作用の予測シミュレーター開発のための基礎的検討
橋本佳奈; 木下淳; 神田浩里; 神田浩里; DAI Yi; DAI Yi; 天野学; 藤野秀樹
日本薬学会年会要旨集(Web), 2021年 - Infused acid in the duodenum increases Prostaglandin E2 level in rat
Tadahiro Fujimura; Takashi Kondo; Duan Shaoqi; Daisuke Morishita; Katsuyuki Tozawa; Toshihiko Tomita; Tadayuki Oshima; Hirokazu Fukui; Hiroki Okada; Yi Dai; Hiroto Miwa
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JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013年 - Toll-like receptor 3 contributes to spinal glial activation and tactile allodynia after nerve injury. (vol 105, pg 2249, 2008)
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NEUROSCIENCE RESEARCH, 2007年 - Neurons and glial cells differentially express P2Y receptor mRNAs in the rat dorsal root ganglion and spinal cord. (vol 498. pg 443, 2006)
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Pain research : the journal of the Japanese Society for the Study of Pain = 日本疼痛学会誌, 2000年12月02日 - CCIモデルラットに対する定量的温度刺激により脊髄後角ニューロンに発現するFos蛋白
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Pain research : the journal of the Japanese Society for the Study of Pain = 日本疼痛学会誌, 1998年12月05日
