山本 悟史
| 生物系薬学分野 | 教授 |
| 病態モデル研究センター |
Last Updated :2025/08/16
研究者情報
経歴
研究活動情報
論文
- 発酵オタネニンジンの抗ストレス効果 ランダム化二重盲検プラセボ対照並行群間比較試験
小暮 洋子; 神田 浩里; 池田 真海; 白川 由佳子; 桃崎 祐実; 乾 さやか; 越田 真由; 中村 悠希; 森上 愛弓; 諸見里 奈央; 伊藤 久富; 宮崎 寿次; 位上 健太郎; 岩岡 恵実子; 青木 俊二; 山本 悟史; 戴 毅
薬理と治療, 2022年11月 - Reactive Oxygen Species Cause Exercise-Induced Angina in a Myocardial Ischaemia-Reperfusion Injury Model
Xiaohang Wang; Hirosato; Takeshi Tsujino; Yoko Kogure; Feng Zhu; Satoshi Yamamoto; Taichi Sakaguchi; Koichi Noguchi; Yi Dai
International Journal of Molecular Sciences, 2022年03月 - Atractylodin Produces Antinociceptive Effect through a Long-Lasting TRPA1 Channel Activation.
Hirosato Kanda; Yanjing Yang; Shaoqi Duan; Yoko Kogure; Shenglan Wang; Emiko Iwaoka; Miku Ishikawa; Saki Takeda; Hidemi Sonoda; Kyoka Mizuta; Shunji Aoki; Satoshi Yamamoto; Koichi Noguchi; Yi Dai
International journal of molecular sciences, 2021年03月 - The ubiquitin E3 ligase Nedd4-2 relieves mechanical allodynia through the ubiquitination of TRPA1 channel in db/db mice.
Shenglan Wang; Simin Qi; Yoko Kogure; Hirosato Kanda; Lin Tian; Satoshi Yamamoto; Koichi Noguchi; Yi Dai
The European journal of neuroscience, 2021年03月 - Eosinophil-associated microinflammation in the gastroduodenal tract contributes to gastric hypersensitivity in a rat model of early-life adversity.
Shaoqi Duan; Takashi Kondo; Hiroto Miwa; Yanjing Yang; Shenglan Wang; Hirosato Kanda; Yoko Kogure; Nobuko Imamura; Tadahiro Fujimura; Tomoaki Kono; Masashi Fukushima; Katsuyuki Tozawa; Toshihiko Tomita; Tadayuki Oshima; Hirokazu Fukui; Satoshi Yamamoto; Koichi Noguchi; Yi Dai
American journal of physiology. Gastrointestinal and liver physiology, 2021年02月 - Daikenchuto attenuates visceral pain and suppresses eosinophil infiltration in inflammatory bowel disease in murine models.
Yoko Kogure; Hirosato Kanda; Shenglan Wang; Yongbiao Hao; Junxiang Li; Satoshi Yamamoto; Koichi Noguchi; Yi Dai
JGH open : an open access journal of gastroenterology and hepatology, 2020年12月 - TRPA1-expressing lamina propria mesenchymal cells regulate colonic motility.
Yanjing Yang; Shenglan Wang; Kimiko Kobayashi; Yongbiao Hao; Hirosato Kanda; Takashi Kondo; Yoko Kogure; Hiroki Yamanaka; Satoshi Yamamoto; Junxiang Li; Hiroto Miwa; Koichi Noguchi; Yi Dai
JCI insight, 2019年05月 - Negative Regulation of TRPA1 by AMPK in Primary Sensory Neurons as a Potential Mechanism of Painful Diabetic Neuropathy.
Shenglan Wang; Kimiko Kobayashi; Yoko Kogure; Hiroki Yamanaka; Satoshi Yamamoto; Hideshi Yagi; Koichi Noguchi; Yi Dai
Diabetes, 2018年01月 - Elevated H2O2 levels in trinitrobenzene sulfate-induced colitis rats contributes to visceral hyperalgesia through interaction with the transient receptor potential ankyrin 1 cation channel
Yoko Kogure; Shenglan Wang; Koh-ichi Tanaka; Yongbiao Hao; Satoshi Yamamoto; Nobuyoshi Nishiyama; Koichi Noguchi; Yi Dai
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2016年06月, ［査読有り］ - Partial Activation and Inhibition of TRPV1 Channels by Evodiamine and Rutaecarpine, Two Major Components of the Fruits of Evodia rutaecarpa
Shenglan Wang; Satoshi Yamamoto; Yoko Kogure; Wensheng Zhang; Koichi Noguchi; Yi Dai
JOURNAL OF NATURAL PRODUCTS, 2016年05月, ［査読有り］ - Evodiamine suppresses capsaicin-induced thermal hyperalgesia through activation and subsequent desensitization of the transient receptor potential V1 channels
Emiko Iwaoka; Shenglan Wang; Nobuyuki Matsuyoshi; Yoko Kogure; Shunji Aoki; Satoshi Yamamoto; Koichi Noguchi; Yi Dai
JOURNAL OF NATURAL MEDICINES, 2016年01月, ［査読有り］ - Xilei San Ameliorates Experimental Colitis in Rats by Selectively Degrading Proinflammatory Mediators and Promoting Mucosal Repair
Yongbiao Hao; Kazuko Nagase; Kazutoshi Hori; Shenglan Wang; Yoko Kogure; Ken Fukunaga; Shinichiro Kashiwamura; Satoshi Yamamoto; Shiro Nakamura; Junxiang Li; Hiroto Miwa; Koichi Noguchi; Yi Dai
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2014年, ［査読有り］ - Etodolac Activates and Desensitizes Transient Receptor Potential Ankyrin 1
Shenglan Wang; Yi Dai; Yoko Kogure; Satoshi Yamamoto; Wensheng Zhang; Koichi Noguchi
JOURNAL OF NEUROSCIENCE RESEARCH, 2013年12月, ［査読有り］ - Modulation of TRP channels by resveratrol and other stilbenoids
Lina Yu; Shenglan Wang; Yoko Kogure; Satoshi Yamamoto; Koichi Noguchi; Yi Dai
MOLECULAR PAIN, 2013年02月, ［査読有り］ - Evodiamine activates TRPV1 in primary sensory neurons
Emiko Iwaoka; Nobuyuki Matsuyoshi; Yoko Kogure; Shunji Aoki; Satoshi Yamamoto; Koichi Noguchi; Yi Dai
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012年 - Inhibition of TRPA1 channel activity in sensory neurons by the glial cell line-derived neurotrophic factor family member, artemin
Naoki Yoshida; Kimiko Kobayashi; Lina Yu; Shenglan Wang; Rengaowa Na; Satoshi Yamamoto; Koichi Noguchi; Yi Dai
MOLECULAR PAIN, 2011年05月, ［査読有り］ - Dual regulation of heat-activated K+ channel in rat DRG neurons via alpha(1) and beta adrenergic receptors
Satoshi Yamamoto; Takeshi Kanno; Kosaku Yamada; Yoshiyuki Yasuda; Tomoyuki Nishizaki
LIFE SCIENCES, 2009年07月 - Sensitization of TRPAl by PAR2 contributes to the sensation of inflammatory pain (vol 117, pg 1979, 2007)
Yi Dai; Shenglan Wang; Makoto Tominaga; Satoshi Yamamoto; Tetsuo Fukuoka; Tomohiro Higashi; Kimiko Kobayashi; Koichi Obata; Hiroki Yamanaka; Koichi Noguchi
JOURNAL OF CLINICAL INVESTIGATION, 2007年10月 - Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain
Yi Dai; Shenglan Wang; Makoto Tominaga; Satoshi Yamamoto; Tetsuo Fukuoka; Tomohiro Higashi; Kimiko Kobayashi; Koichi Obata; Hiroki Yamanaka; Koichi Noguchi
JOURNAL OF CLINICAL INVESTIGATION, 2007年07月 - The linoleic acid derivative DCP-LA ameliorates impairment of learning and memory
Takahiro Yaguchi; Hideyuki Yamamoto; Hirokazu Fujikawa; Tetsu Nagata; Satoshi Yamamoto; Tomoyuki Nishizaki
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007年 - Beneficial effect of intracellular free high-mannose oligosaccharides on cryopreservation of mammalian cells and proteins
Kanako Watanabe; Takahiro Yaguchi; Dongqin Yang; Takeshi Kanno; Kaoru Nagai; Satoshi Yamamoto; Hirokazu Fujikawa; Hideyuki Yamamoto; Tetsu Nagata; Chikara Tashiro; Tomoyuki Nishizaki
CRYOBIOLOGY, 2006年12月 - A(1) adenosine receptor signal and AMPK involving caspase-9/-3 activation are responsible for adenosine-induced RCR-1 astrocytoma cell death
Katsunari Sai; Dongqin Yang; Hideyuki Yamamoto; Hirokazu Fujikawa; Satoshi Yamamoto; Tetsu Nagata; Masaru Saito; Takehira Yamamura; Tomoyuki Nishizaki
NEUROTOXICOLOGY, 2006年07月 - The linoleic acid derivative DCP-LA selectively activates PKC-epsilon, possibly binding to the phosphatidylserine binding site
T Kanno; H Yamamoto; T Yaguchi; R Hi; T Mukasa; H Fujikawa; T Nagata; S Yamamoto; A Tanaka; T Nishizaki
JOURNAL OF LIPID RESEARCH, 2006年06月 - Tunicamycin decreases the probability of single-channel openings for N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
K Maruo; S Yamamoto; T Kanno; T Yaguchi; S Maruo; S Yashiya; T Nishizaki
NEUROREPORT, 2006年02月 - Linoleic acid derivative DCP-LA improves learning impairment in SAMP8
T Yaguchi; T Nagata; T Mukasa; H Fujikawa; H Yamamoto; S Yamamoto; H Iso; A Tanaka; T Nishizaki
NEUROREPORT, 2006年01月 - Modulation of P2X receptors via adrenergic pathways in rat dorsal root ganglion neurons after sciatic nerve injury
K Maruo; H Yamamoto; S Yamamoto; T Nagata; H Fujikawa; T Kanno; T Yaguchi; S Maruo; S Yoshiya; T Nishizaki
PAIN, 2006年01月 - Bidirectional regulations for glutamate and GABA release in the hippocampus by alpha 7 and non-alpha 7 ACh receptors
T Kanno; T Yaguchi; S Yamamoto; T Nagata; H Yamamoto; H Fujikawa; T Nishizaki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005年12月 - 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid stimulates GABA release from interneurons projecting to CA1 pyramidal neurons in the rat hippocampus via pre-synaptic alpha 7 acetylcholine receptors
T Kanno; T Yaguchi; S Yamamoto; H Yamamoto; H Fujikawa; T Nagata; A Tanaka; T Nishizaki
JOURNAL OF NEUROCHEMISTRY, 2005年11月 - Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinase (vol 67, pg 2005, 2004)
M Saitoh; K Nagai; K Nakagawa; T Yamamura; S Yamamoto; T Nishizaki
BIOCHEMICAL PHARMACOLOGY, 2005年09月 - Effects of cis-unsaturated free fatty acids on PKC-epsilon activation and nicotinic ACh receptor responses
T Yaguchi; S Yamamoto; T Nagata; T Kanno; A Tanaka; T Nishizaki
MOLECULAR BRAIN RESEARCH, 2005年02月 - The newly synthesized linoleic acid derivative DCP-LA ameliorates memory deficits in animal models treated with amyloid-β peptide and scopolamine
Tetsu Nagata; Satoshi Yamamoto; Takahiro Yaguchi; Hiroyuki Iso; Akito Tanaka; Tomoyuki Nishizaki
Psychogeriatrics, 2005年 - The linoleic acid derivative FR236924 facilitates hippocampal synaptic transmission by enhancing activity of presynaptic alpha 7 acetylcholine receptors on the glutamatergic terminals
S Yamamoto; T Kanno; T Nagata; T Yaguchi; A Tanaka; T Nishizaki
NEUROSCIENCE, 2005年 - Interleukin-18 stimulates synaptically released glutamate and enhances postsynaptic AMPA receptor responses in the CA1 region of mouse hippocampal slices
T Kanno; T Nagata; S Yamamoto; H Okamura; T Nishizaki
BRAIN RESEARCH, 2004年06月 - Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinase
M Saitoh; K Nagai; K Nakagawa; T Yamamura; S Yamamoto; T Nishizaki
BIOCHEMICAL PHARMACOLOGY, 2004年05月 - Stearic acid facilitates hippocampal neurotransmission by enhancing nicotinic ACh receptor responses via a PKC pathway
K Ohta; H Miyamoto; T Yaguchi; K Nagai; S Yamamoto; T Nomura; A Tanaka; T Nishizaki
MOLECULAR BRAIN RESEARCH, 2003年11月 - Arachidonic acid peroxides induce apoptotic Neuro-2A cell death in association with intracellular Ca2+ rise and mitochondrial damage independently of caspase-3 activation
M Saitoh; K Nagai; T Yaguchi; Y Fujikawa; K Ikejiri; S Yamamoto; K Nakagawa; T Yamamura; T Nishizaki
BRAIN RESEARCH, 2003年11月 - 2-pyrrolidinone induces a long-lasting facilitation of hippocampal synaptic transmission by enhancing alpha 7 ACh receptor responses via a PKC pathway
H Miyamoto; T Yaguchi; K Ohta; K Nagai; T Nagata; S Yamamoto; T Nishizaki
MOLECULAR BRAIN RESEARCH, 2003年09月 - Pipecolic acid induces apoptosis in neuronal cells
S Matsumoto; S Yamamoto; K Sai; K Maruo; M Adachi; M Saitoh; T Nishizaki
BRAIN RESEARCH, 2003年08月 - Tunicamycin inhibits NMDA and AMPA receptor responses independently of N-glycosylation
K Maruo; T Nagata; S Yamamoto; K Nagai; Y Yajima; S Maruo; T Nishizaki
BRAIN RESEARCH, 2003年07月 - (-)-Epigallocatechin gallate protects against NO stress-induced neuronal damage after ischemia by acting as an anti-oxidant
K Nagai; MH Jiang; J Hada; T Nagata; Y Yajima; S Yamamoto; T Nishizaki
BRAIN RESEARCH, 2002年11月 - L-trans-PDC enhances hippocampal neuronal activity by stimulating glial glutamate release independently of blocking transporters
K Ohta; T Nomura; T Kanno; K Nagai; S Yamamoto; Y Yajima; T Kondoh; E Kohmura; N Saito; T Nishizaki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002年07月 - The inhibitory and facilitatory actions of amyloid-beta peptides on nicotinic ACh receptors and AMPA receptors
H Tozaki; A Matsumoto; T Kanno; K Nagai; T Nagata; S Yamamoto; T Nishizaki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002年05月 - Bupivacaine, but not tetracaine, protects against the in vitro ischemic insult of rat hippocampal CA1 neurons
S Niiyama; E Tanaka; S Yamamoto; S Yasumoto; T Kano; H Higashi
NEUROSCIENCE RESEARCH, 2002年03月 - Na+/Ca2+ exchanger activity induces a slow DC potential after in vitro ischemia in rat hippocampal CA1 region
H Uchikado; E Tanaka; S Yamamoto; T Isagai; M Shigemori; H Higashi
NEUROSCIENCE RESEARCH, 2000年02月 - Differential regulation of inotropy and lusitropy in overexpressed Gsalfa myocytes through cAMP and Ca2+ channel pathways.
Song-Jung Kim, Atsuko Yatani, Dorothy E. Vatner, Satoshi Yamamoto, Yoshihiro Ishikawa, Thomas E. Wagner, Richard P. Shannon, Young-Kwon Kim, Gen Takagi, Kuniya Asai, Charles J. Homcy, and Stephen F. Vatner
J Clin Invest, 1999年04月 - Membrane dysfunction induced by in vitro ischemia in immature rat hippocampal CA1 neurons
T Isagai; N Fujimura; E Tanaka; S Yamamoto; H Higashi
JOURNAL OF NEUROPHYSIOLOGY, 1999年04月 - Membrane dysfunction induced by in vitro ischemia in rat hippocampal CA1 pyramidal neurons
E. Tanaka; S. Yamamoto; H. Inokuchi; T. Isagai; H. Higashi
Journal of Neurophysiology, 1999年 - Mechanisms underlying the enhancement of excitatory synaptic transmission in basolateral amygdala neurons of the kindling rat
Y Shoji; E Tanaka; S Yamamoto; H Maeda; H Higashi
JOURNAL OF NEUROPHYSIOLOGY, 1998年08月 - Nitric oxide contributes to irreversible membrane dysfunction caused by experimental ischemia in rat hippocampal CA1 neurons
Meiko Onitsuka; Satoshi Mihara; Satoshi Yamamoto; Minoru Shigemori; Hideho Higashi
Neuroscience Research, 1998年01月 - Factors that reverse the persistent depolarization produced by deprivation of oxygen and glucose in rat hippocampal CA1 neurons in vitro
S Yamamoto; E Tanaka; Y Shoji; Y Kudo; H Inokuchi; H Higashi
JOURNAL OF NEUROPHYSIOLOGY, 1997年08月 - Mechanisms underlying the rapid depolarization produced by deprivation of oxygen and glucose in rat hippocampal CA1 neurons in vitro
E Tanaka; S Yamamoto; Y Kudo; S Mihara; H Higashi
JOURNAL OF NEUROPHYSIOLOGY, 1997年08月 - Charged amino acids near the pore entrance influence ion-conduction of a human L-type cardiac calcium channel
A Bahinski; A Yatani; G Mikala; SQ Tang; S Yamamoto; A Schwartz
MOLECULAR AND CELLULAR BIOCHEMISTRY, 1997年01月 - Mediation by intracellular calcium-dependent signals of hypoxic hyperpolarization in rat hippocampal CA1 neurons in vitro
S Yamamoto; E Tanaka; H Higashi
JOURNAL OF NEUROPHYSIOLOGY, 1997年01月 - Contribution of ATP-sensitive potassium channels to hypoxic hyperpolarization in rat hippocampal CA1 neurons in vitro
N Fujimura; E Tanaka; S Yamamoto; M Shigemori; H Higashi
JOURNAL OF NEUROPHYSIOLOGY, 1997年01月 - Amino acid substitutions in the rat Na+,K+-ATPase alpha 2-subunit alter the cation regulation of pump current expressed in HeLa cells
S Yamamoto; TA Kuntzweiler; ET Wallick; N Sperelakis; A Yatani
JOURNAL OF PHYSIOLOGY-LONDON, 1996年09月 - Modulation of pump function by mutations in the first transmembrane region of Na+-K+-ATPase alpha(1)-subunit
S Yamamoto; GR Askew; J Heiny; H Masaki; A Yatani
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1996年02月 - STABLE EXPRESSION AND COUPLING OF CARDIAC L-TYPE CA2+ CHANNELS WITH BETA(1)-ADRENOCEPTORS
A YATANI; M WAKAMORI; T NIIDOME; S YAMAMOTO; TANAKA, I; Y MORI; K KATAYAMA; S GREEN
CIRCULATION RESEARCH, 1995年03月 - SINGLE AMINO-ACID SUBSTITUTIONS WITHIN THE ION PERMEATION PATHWAY ALTER SINGLE-CHANNEL CONDUCTANCE OF THE HUMAN L-TYPE CARDIAC CA2+ CHANNEL
A YATANI; A BAHINSKI; G MIKALA; S YAMAMOTO; A SCHWARTZ
CIRCULATION RESEARCH, 1994年08月
MISC
- マスタードオイル誘発性疼痛に対する発酵及び非発酵オタネニンジンの鎮痛効果
小川栞里; 藤川弘平; 山本奈緒; 小暮洋子; 神田浩里; 神田浩里; 伊藤久富; 宮崎寿次; 位上健太郎; 山本悟史; YI Dai; YI Dai; YI Dai
日本薬学会年会要旨集(CD-ROM), 2020年 - カプサイシン誘発性疼痛に対する発酵及び非発酵オタネニンジンの鎮痛効果
藤川弘平; 小川栞里; 山本奈緒; 小暮洋子; 神田浩里; 神田浩里; 伊藤久富; 宮崎寿次; 位上健太郎; 山本悟史; YI Dai; YI Dai; YI Dai
日本薬学会年会要旨集(CD-ROM), 2020年 - 一次知覚ニューロンに対する発酵オタネニンジンおよび含有成分compound Kの薬理作用
下農 修司; 松井 帝斗; 王 勝蘭; 小暮 洋子; 岩岡 恵実子; 位上 健太郎; 伊藤 久富; 宮崎 寿次; 青木 俊二; 山本 悟史; 戴 毅
日本薬学会年会要旨集, 2019年03月 - 一次知覚神経におけるAMPキナーゼによるTRPA1膜発現の制御
王 勝蘭; 小林 希実子; 小暮 洋子; 山中 博樹; 山本 悟史; 八木 秀司; 野口 光一; 戴 毅
PAIN RESEARCH, 2017年06月 - エボジアミンのTransient receptor potential(TPR)V1チャネル脱感作を介したカプサイシン誘発熱性痛覚過敏抑制作用について
岩岡恵実子; WANG Shenglan; WANG Shenglan; 松吉延之; 小暮洋子; 小暮洋子; 山本悟史; 野口光一; DAI Yi; DAI Yi; 青木俊二
食品薬学シンポジウム講演要旨集, 2017年 - 物理療法は神経障害性疼痛発症を予防できるか？―ラット神経障害性疼痛モデルに寒冷療法を用いて―
川口 浩太郎; 猪俣 陽一; 藤岡 宏幸; 坂口 顕; 山本 悟史; 小暮 洋子; 王 勝蘭; 戴 毅
兵庫医療大学紀要 = Journal of Hyogo University of Health Sciences, 2016年06月 - TNBS誘発性大腸炎モデルラットの内臓痛発症メカニズムにおける過酸化水素の役割
小暮 洋子; 王 勝蘭; 田中 康一; 山本 悟史; 西山 信好; 野口 光一; 戴 毅
日本薬学会年会要旨集, 2014年03月
書籍等出版物
- 薬学生・薬剤師のための処方解析トレーニング帳
化学同人, 2010年
9784759812978 - 脳虚血とNa,K-pump
脳機能の解明-２１世紀に向けて-（赤池紀扶、東 英穂、藤原道弘、小暮久也編）, 1998年 - Effect of glutamate agonists and antagonists on ischemicdamage of hippocampal neurons. In: Molecular Neurobiology and Brain Ischemia, Eds. Shimoji, K.
Springer-Verlag, Tokyo, 1996年 - Effect of glutamate agonists and antagonists on ischemicdamage of hippocampal neurons. In: Molecular Neurobiology and Brain Ischemia, Eds. Shimoji, K.
Springer-Verlag, Tokyo, 1996年
