青木 俊二
| 化学系薬学分野 | 教授 |
| 薬学教育センター |
Last Updated :2024/12/13
研究者情報
研究活動情報
論文
- Smenospongine, a sesquiterpene aminoquinone from a marine sponge, induces G1 arrest or apoptosis in different leukemia cells
Dexin Kong; Shunji Aoki; Yoshihiro Sowa; Toshiyuki Sakai; Motomasa Kobayashi
Marine Drugs, 2008年09月, ［査読有り］ - Structure-activity relationships study of bastadin 6, an anti-angiogenic brominated-tyrosine derived metabolite from marine sponge
Naoyuki Kotoku; Atsushi Hiramatsu; Hiroaki Tsujita; Yoichi Hirakawa; Mami Sanagawa; Shunji Aoki; Motomasa Kobayashi
ARCHIV DER PHARMAZIE, 2008年09月, ［査読有り］ - Structure-activity relationship and biological property of cortistatins, anti-angiogenic spongean steroidal alkaloids
Shunji Aoki; Yasuo Watanabe; Daiki Tanabe; Masayoshi Arai; Hideaki Suna; Katsushiro Miyamoto; Hiroshi Tsujibo; Kazutake Tsujikawa; Hiroshi Yamamoto; Motomasa Kobayashi
Bioorganic and Medicinal Chemistry, 2007年11月, ［査読有り］ - The plant alkaloid cryptolepine induces p21WAF1/CIP1 and cell cycle arrest in a human osteosarcoma cell line
Taka-Aki Matsui; Yoshihiro Sowa; Hiroaki Murata; Koichi Takagi; Ryoko Nakanishi; Shunji Aoki; Masayuki Yoshikawa; Motomasa Kobayashi; Tomoya Sakabe; Toshikazu Kubo; Toshiyuki Sakai
International Journal of Oncology, 2007年10月, ［査読有り］ - Crambescidin 800, a pentacyclic guanidine alkaloid, protects a mouse hippocampal cell line against glutamate-induced oxidative stress
Hideaki Suna; Shunji Aoki; Andi Setiawan; Motomasa Kobayashi
Journal of Natural Medicines, 2007年07月, ［査読有り］ - Novel isomarabarican triterpenes, exhibiting selective anti-proliferative activity against vascular endothelial cells, from marine sponge Rhabdastrella globostellata
Shunji Aoki; Mami Sanagawa; Yasuo Watanabe; Andi Setiawan; Masayoshi Arai; Motomasa Kobayashi
BIOORGANIC & MEDICINAL CHEMISTRY, 2007年07月, ［査読有り］ - Cortistatins J, K, L, novel abeo-9(10-19)-androstane-type steroidal alkaloids with isoquinoline unit, from marine sponge Corticium simplex
Shunji Aoki; Yasuo Watanabe; Daiki Tanabe; Andi Setiawan; Masayoshi Arai; Motomasa Kobayashi
TETRAHEDRON LETTERS, 2007年06月, ［査読有り］ - A functional role of intracellular loops of human multidrug resistance protein 1
Xiao-Qin Ren; Tatsuhiko Furukawa; Masatatsu Yamamoto; Shunji Aoki; Motomasa Kobayashi; Masayuki Nakagawa; Shin-Ichi Akiyama
Journal of Biochemistry, 2006年09月, ［査読有り］ - A novel synthetic drug, LB-18, closely related to lembehyne-A derived from a marine sponge, induces caspase-independent cell death to human neuroblastoma cells
Moriatsu Izumi; Shingo Yogosawa; Shunji Aoki; Hirotsuna Watanabe; Jun Kamiyama; Yoshinori Takahara; Yoshihiro Sowa; Motomasa Kobayashi; Hajime Hosoi; Tohru Sugimoto; Toshiyuki Sakai
International Journal of Oncology, 2006年07月, ［査読有り］ - Bastadins, cyclic tetramers of brominated-tyrosine derivatives, selectively inhibit the proliferation of endothelial cells
Shunji Aoki; Seok-Hwan Cho; Atsushi Hiramatsu; Naoyuki Kotoku; Motomasa Kobayashi
Journal of Natural Medicines, 2006年07月, ［査読有り］ - Aaptamine, a spongean alkaloid, activates p21 promoter in a p53-independent manner
Shunji Aoki; Dexin Kong; Hideaki Suna; Yoshihiro Sowa; Toshiyuki Sakai; Andi Setiawan; Motomasa Kobayashi
Biochemical and Biophysical Research Communications, 2006年03月, ［査読有り］ - Cortistatins A, B, C, and D, anti-angiogenic steroidal alkaloids, from the marine sponge Corticium simplex
S Aoki; Y Watanabe; M Sanagawa; A Setiawan; N Kotoku; M Kobayashi
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006年03月, ［査読有り］ - Synthesis of 15,20-triamide analogue with polar substituent on the phenyl ring of arenastatin A, an extremely potent cytotoxic spongean depsipeptide
Naoyuki Kotoku; Tomoya Kato; Fuminori Narumi; Emiko Ohtani; Sayo Kamada; Shunji Aoki; Naoki Okada; Shinsaku Nakagawa; Motomasa Kobayashi
Bioorg. Med. Chem., 2006年 - Komodoquinone A, a novel neuritogenic anthracycline, from marine Streptomyces sp KS3
T Itoh; M Kinoshita; S Aoki; M Kobayashi
JOURNAL OF NATURAL PRODUCTS, 2003年10月, ［査読有り］ - Reversal of the resistance to STI571 in human chronic myelogenous leukemia K562 cells
Motoi Mukai; Xiao-Fang Che; Tatsuhiko Furukawa; Tomoyuki Sumizawa; Shunji Aoki; Xioa-Qin Ren; Misako Haraguchi; Yoshikazu Sugimoto; Motomasa Kobayashi; Hideo Takamatsu; Shin-Ichi Akiyama
Cancer Science, 2003年06月, ［査読有り］ - In situ photoaffinity labeling of the target protein for lembehyne A, a neuronal differentiation inducer
S Aoki; K Matsui; T Takata; M Kobayashi
FEBS LETTERS, 2003年06月, ［査読有り］ - Pyridoacridine alkaloids inducing neuronal differentiation in a neuroblastoma cell line, from marine sponge Biemna fortis
S Aoki; H Wei; K Matsui; R Rachmat; M Kobayashi
BIOORGANIC & MEDICINAL CHEMISTRY, 2003年05月, ［査読有り］ - Localization of the GSH-dependent photolabelling site of an agosterol A analog on human MRP1
XQ Ren; T Furukawa; S Aoki; T Sumizawa; M Haraguchi; XF Che; M Kobayashi; S Akiyama
BRITISH JOURNAL OF PHARMACOLOGY, 2003年04月, ［査読有り］ - Binding Site(s) on P-Glycoprotein for a Newly Synthesized Photoaffinity Analog of Agosterol A
Masahiko Mitsuo; Tomohiro Noguchi; Yuichi Nakajima; Shunji Aoki; Xiao-Qin Ren; Tomoyuki Sumizawa; Misako Haraguchi; Motomasa Kobayashi; Masanori Baba; Yukihiro Nagata; Shin-Ichi Akiyama; Tatsuhiko Furukawa
Oncology Research, 2003年, ［査読有り］ - A positively charged amino acid proximal to the C-terminus of TM17 of MRP1 is indispensable for GSH-dependent binding of substrates and for transport of LTC4
XQ Ren; T Furukawa; S Aoki; T Sumizawa; M Haraguchi; Y Nakajima; R Ikeda; M Kobayashi; S Akiyama
BIOCHEMISTRY, 2002年12月 - Lembehsterols A and B, novel sulfated sterols inhibiting thymidine phosphorylase, from the marine sponge Petrosia strongylata
S Aoki; Y Naka; T Itoh; T Furukawa; R Rachmat; S Akiyama; M Kobayashi
CHEMICAL & PHARMACEUTICAL BULLETIN, 2002年06月, ［査読有り］ - Brianthein A, a novel briarane-type diterpene reversing multidrug resistance in human carcinoma cell line, from the gorgonian Briareum excavatum
S Aoki; M Okano; K Matsui; T Itoh; R Satari; S Akiyama; M Kobayashi
TETRAHEDRON, 2001年10月, ［査読有り］ - Reversing effect of agosterol A, a spongean sterol acetate, on multidrug resistance in human carcinoma cells
S Aoki; ZS Chen; K Higasiyama; A Setiawan; S Akiyama; M Kobayashi
JAPANESE JOURNAL OF CANCER RESEARCH, 2001年08月, ［査読有り］ - Lembehyne a, a novel neuritogenic polyacetylene, from a marine sponge of Haliclona sp.
S Aoki; K Matsui; K Tanaka; R Satari; M Kobayashi
TETRAHEDRON, 2000年12月, ［査読有り］
MISC
- Cortistatins E, F, G, and H, four novel steroidal alkaloids from marine sponge Corticium simplex
Yasuo Watanabe; Shunji Aoki; Daiki Tanabe; Andi Setiawan; Motomasa Kobayashi
TETRAHEDRON, 2007年05月 - Bastadin 6, a spongean brominated tyrosine derivative, inhibits tumor angiogenesis by inducing selective apoptosis to endothelial cells.
Shunji Aoki; Seok Hwan Cho; Mayumi Ono; Takashi Kuwano; Shintaro Nakao; Michihiko Kuwano; Shinsaku Nakagawa; Jian Qing Gao; Tadanori Mayumi; Masabumi Shibuya; Motomasa Kobayashi; Motomasa Kobayashi
Anti-Cancer Drugs, 2006年03月01日 - MRP1 mutated in the L0 region transports SN-38 but not Leukotriene C4 or estradiol-17 (-D-glucuronate).
Tomohiro Noguchi; Xiao-Qin Ren; Shunji Aoki; Yoshinobu Igarashi; Xiao-Fang Che; Yuichi Nakajima; Homare Takahashi; Ryoichi Mitsuo; Kazutake Tsujikawa; Tomoyuki Sumizawa; Misako Haraguchi; Motomasa Kobayashi; Susumu Goto; Minoru Kanehisa; Takashi Aikou; Shin-ichi Akiyama; Tatsuhiko Furukawa
Biochem. Pharmacol., 2005年10月 - Shimalactone A, a novel polyketide, from marine-derived fungus Emericella variecolor GF10
H Wei; T Itoh; M Kinoshita; N Kotoku; S Aoki; M Kobayashi
TETRAHEDRON, 2005年08月 - Absolute stereo-structure of kendarimide a, a novel MDR modulator, from a marine sponge
N Kotoku; LW Cao; S Aoki; M Kobayashi
HETEROCYCLES, 2005年03月 - GSH inhibits trypsinization of the C-terminal half of human MRP1
XQ Ren; T Furukawa; Y Nakajima; H Takahashi; S Aoki; T Sumizawa; M Haraguchi; M Kobayashi; K Chijiiwa; S Akiyama
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005年02月 - Kendarimide A, a novel peptide reversing P-glycoprotein-mediated multidrug resistance in tumor cells, from a marine sponge of Haliclona sp.
S Aoki; LW Cao; K Matsui; R Rachmat; S Akiyama; M Kobayashi
TETRAHEDRON, 2004年08月 - Sesquiterpene aminoquinones, from a marine sponge, induce erythroid differentiation in human chronic myelogenous leukemia, K562 cells
S Aoki; D Kong; K Matsui; R Rachmat; M Kobayashi
CHEMICAL & PHARMACEUTICAL BULLETIN, 2004年08月 - Erythroid differentiation in K562 chronic myelogenous cells induced by crambescidin 800, a pentacyclic guanidine alkaloid
S Aoki; DX Kong; K Matsui; M Kobayashi
ANTICANCER RESEARCH, 2004年07月 - Function of the ABC signature sequences in the human multidrug resistance protein 1
XQ Ren; T Furukawa; M Haraguchi; T Sumizawa; S Aoki; M Kobayashi; S Akiyama
MOLECULAR PHARMACOLOGY, 2004年06月 - Smenospongine, a spongean sesquiterpene aminoquinone, induces erythroid differentiation in K562 cells
S Aoki; D Kong; K Matsui; M Kobayashi
ANTI-CANCER DRUGS, 2004年04月 - Structure-activity relationship of neuritogenic spongean acetylene alcohols, lembehynes
S Aoki; K Matsui; H Wei; N Murakami; M Kobayashi
TETRAHEDRON, 2002年07月 - Identification of GSH and drug binding sites on the human multidrug resistance protein (MRP1)
XQ Ren; T Furukawa; S Aoki; T Sumizawa; M Hariguchi; ZS Chen; S Akiyama
MOLECULAR BIOLOGY OF THE CELL, 2001年11月 - Reversal of drug resistance mediated by multidrug resistance protein (MRP) 1 by dual effects of agosterol A on MRP1 function
ZS Chen; S Aoki; M Komatsu; K Ueda; T Sumizawa; T Furukawa; H Okumura; XQ Ren; MG Belinsky; K Lee; GD Kruh; M Kobayashi; S Akiyama
INTERNATIONAL JOURNAL OF CANCER, 2001年07月 - Glutathione-dependent binding of a photoaffinity analog of agosterol A to the C-terminal half of human multidrug resistance protein
XQ Ren; T Furukawa; S Aoki; T Nakajima; T Sumizawa; M Haraguchi; ZS Chen; M Kobayashi; S Akiyama
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001年06月 - Differentiation in chronic myelogenous leukemia cell K562 by spongean sesterterpene
S Aoki; K Higuchi; N Isozumi; K Matsui; Y Miyamoto; N Itoh; K Tanaka; M Kobayashi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001年03月 - Molecular modeling of 5-desacetylaltohyrtin A, a spongean cytotoxic macrolide
S Aoki; N Nemoto; Y Kobayashi; M Kobayashi; Kitagawa, I
TETRAHEDRON, 2001年03月 - Synthesis of amide analogs of arenastatin A
N Murakami; WQ Wang; N Ohyabu; T Ito; S Tamura; S Aoki; M Kobayashi; Kitagawa, I
TETRAHEDRON, 2000年11月 - Functional comparison between VCF1 and MRP1 expressed in Sf21 insect cells
XQ Ren; T Furukawa; ZS Chen; H Okumura; S Aoki; T Sumizawa; A Tani; M Komatsu; XD Mei; S Akiyama
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000年04月 - Melophlins A and B, novel tetramic acids reversing the phenotype of ras-transformed cells, from the marine sponge Melophlus sarassinorum
S Aoki; K Higuchi; Y Ye; R Satari; M Kobayashi
TETRAHEDRON, 2000年03月 - Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter
ZS Chen; T Kawabe; M Ono; S Aoki; T Sumizawa; T Furukawa; T Uchiumi; M Wada; M Kuwano; S Akiyama
MOLECULAR PHARMACOLOGY, 1999年12月 - Myrmekiosides A and B, novel mono-O-alkyl-diglycosylglycerols reversing tumor cell morphology of ras-transformed cells from a marine sponge of Myrmekioderma sp.
S Aoki; K Higuchi; A Kato; N Murakami; M Kobayashi
TETRAHEDRON, 1999年12月 - Reversal of multidrug resistance in human carcinoma cell line by agosterols, marine spongean sterols.
S Aoki; A Setiawan; Y Yoshioka; K Higuchi; R Fudetani; ZS Chen; T Sumizawa; S Akiyama; M Kobayashi
TETRAHEDRON, 1999年12月 - Agosterol A, a novel polyhydroxylated sterol acetate reversing multidrug resistance from a marine sponge of Spongia sp.
S Aoki; Y Yoshioka; Y Miyamoto; K Higuchi; A Setiawan; N Murakami; ZS Chen; T Sumizawa; S Akiyama; M Kobayashi
TETRAHEDRON LETTERS, 1998年08月 - Isomerization of dimeric 2,9-disubstituted 1-oxa-quinolizidine alkaloids and structural revision of araguspongines B and E, isolated from a marine sponge of Xestospongia sp.
M Kobayashi; Y Miyamoto; S Aoki; N Murakami; Kitagawa, I; Y In; T Ishida
HETEROCYCLES, 1998年01月 - Absolute stereostructure of callystatin A, a potent cytotoxic polyketide from the marine sponge, Callyspongia truncata
N Murakami; WQ Wang; M Aoki; Y Tsutsui; K Higuchi; S Aoki; M Kobayashi
TETRAHEDRON LETTERS, 1997年08月 - Inhibitory effects of various spasmolytics on the vagal afferent gastric excitatory response in cats
K Kurahashi; M Iwamoto; S Aoki; A Kawaguchi; H Jino; H Usui; H Nishiwaki; H Kitagawa
LIFE SCIENCES, 1997年07月 - Callystatin A, a potent cytotoxic polyketide from the marine sponge, Callyspongia truncata
M Kobayashi; K Higuchi; N Murakami; H Tajima; S Aoki
TETRAHEDRON LETTERS, 1997年04月 - Marine natural products .38. Absolute stereostructures of altohyrtins A, B, and C and 5-desacetylaltohyrtin A, potent cytotoxic macrolides, from the Okinawan marine sponge Hyrtios altum
M Kobayashi; S Aoki; K Gato; Kitagawa, I
CHEMICAL & PHARMACEUTICAL BULLETIN, 1996年11月 - Marine natural products .37. Aragusteroketals A and C, two novel cytotoxic steroids from a marine sponge of Xestospongia sp.
M Kobayashi; YJ Chen; K Higuchi; S Aoki; Kitagawa, I
CHEMICAL & PHARMACEUTICAL BULLETIN, 1996年10月 - Marine natural products .36. Biologically active polyacetylenes, adociacetylenes A, B, C, and D, from an Okinawan marine sponge of Adocia sp.
M Kobayashi; T Mahmud; H Tajima; WQ Wang; S Aoki; S Nakagawa; T Mayumi; Kitagawa, I
CHEMICAL & PHARMACEUTICAL BULLETIN, 1996年04月 - Four new β-carboline alkaloids isolated from two Okinawan marine sponges of Xestospongia sp. and Haliclona sp.)
Motomasa Kobayashi; Yin-Ju Chen; Shunji Aoki; Yasuko In; Toshimasa Ishida; Isao Kitagawa
Tetrahedron, 1995年03月27日 - ARENASTATIN-A, A POTENT CYTOTOXIC DEPSIPEPTIDE FROM THE OKINAWAN MARINE SPONGE DYSIDEA-ARENARIA
M KOBAYASHI; SJ AOKI; N OHYABU; M KUROSU; WQ WANG; KITAGAWA, I
TETRAHEDRON LETTERS, 1994年10月 - Absolute stereostructures of altohyrtin A and its congeners, potent cytotoxic macrolides from the Okinawan marine sponge hyrtios altum
Motomasa Kobayashi; Shunji Aoki; Isao Kitagawa
Tetrahedron Letters, 1994年02月21日 - Marine Natural Products. XXXIV. Trisindoline, a New Antibiotic Indole Trimer, Produced by a Bacterium of Vibrio sp. Separated from the Marine Sponge Hyrtios altum
Motomasa Kobayashi; Shunji Aoki; Katsuhiko Gato; Katsuyoshi Matsunami; Michio Kurosu; Isao Kitagawa
Chemical and Pharmaceutical Bulletin, 1994年 - TRICHOHARZIN, A NEW POLYKETIDE PRODUCED BY THE IMPERFECT FUNGUS TRICHODERMA-HARZIANUM SEPARATED FROM THE MARINE SPONGE MICALE-CECILIA
M KOBAYASHI; H UEHARA; K MATSUNAMI; S AOKI; KITAGAWA, I
TETRAHEDRON LETTERS, 1993年12月 - ALTOHYRTIN-B AND ALTOHYRTIN-C AND 5-DESACETYLALTOHYRTIN-A, POTENT CYTOTOXIC MACROLIDE CONGENERS OF ALTOHYRTIN-A, FROM THE OKINAWAN MARINE SPONGE HYRTIOS-ALTUM
M KOBAYASHI; S AOKI; H SAKAI; N KIHARA; T SASAKI; KITAGAWA, I
CHEMICAL & PHARMACEUTICAL BULLETIN, 1993年05月 - ALTOHYRTIN-A, A POTENT ANTITUMOR MACROLIDE FROM THE OKINAWAN MARINE SPONGE HYRTIOS-ALTUM
M KOBAYASHI; S AOKI; H SAKAI; K KAWAZOE; N KIHARA; T SASAKI; KITAGAWA, I
TETRAHEDRON LETTERS, 1993年04月
