Last Updated :2026/03/13
Research activity information
Paper
- Oral Administration of Itraconazole Induces M1 Polarization of Tumor-associated Macrophages in Gynecological Cancer.
Tomoko Ueda; Hiroshi Tsubamoto; Roze Taniguchi; Yumi Takimoto; Kazuko Sakata; Sachiyo Narita; Maiko Iwamoto; Momoko Nakabayashi; Y U Wakimoto; Tomoyuki Sasano; Satoko Mibayashi; Chisato Ohe; Seiji Mabuchi
In vivo (Athens, Greece), 2026 - Potential Benefit of Intravenous Iron Monotherapy for Grade 2-3 Chemotherapy-Induced Anemia Irrespective of Transferrin Saturation Levels.
Tomoko Ueda; Hiroshi Tsubamoto; Haruka Honda; Sachiyo Narita; Yumi Takimoto; Maiko Iwamoto; Maiko Korosue; Yu Wakimoto; Tomoyuki Sasano; Seiji Mabuchi
Cureus, Dec. 2025 - Roles of C-reactive protein and LOX-1 on cancer and myeloid-derived suppressor cells in the progression of uterine cervical cancer.
Michihide Maeda; Seiji Mabuchi; Takashi Akazawa; Yu Mizote; Tomoyuki Sasano; Naoko Komura; Mina Sakata; Tsuyoshi Takiuchi; Shinya Matsuzaki; Tsuyoshi Hisa; Harumi Nakamura; Tomoya Ekawa; Shoji Kamiura; Tadashi Kimura; Hideaki Tahara
Scientific reports, Mar. 2025 - Trends in incidence and hormonal management of endometrial cancer during potentially reproductive age in Japan: a population-based study.
Tomoyuki Sasano; Seiji Mabuchi; Naoko Komura; Mina Sakata; Shoji Kamiura; Toshitaka Morishima; Isao Miyashiro
International journal of clinical oncology, Jul. 2024 - Population-Based Survival Analysis of Stage IVB Small-Cell Neuroendocrine Carcinoma in Comparison to Major Histological Subtypes of Cervical Cancer.
Seiji Mabuchi; Naoko Komura; Tomoyuki Sasano; Mina Sakata; Shinya Matsuzaki; Tsuyoshi Hisa; Shoji Kamiura; Toshitaka Morishima; Isao Miyashiro
Current oncology (Toronto, Ont.), Oct. 2023 - Evaluation of survival outcomes between minimally invasive and open surgery in the treatment of early-stage endometrial cancer: a population-based study in Osaka Japan.
Tomoyuki Sasano; Seiji Mabuchi; Naoko Komura; Michihide Maeda; Shoji Kamiura; Toshitaka Morishima; Isao Miyashiro
Japanese journal of clinical oncology, Aug. 2023 - Comparison of the Survival Outcomes of Minimally Invasive Surgery with Open Surgery in Patients with Uterine-Confined and Node-Negative Cervical Cancer: A Population-Based Study.
Seiji Mabuchi; Tomoyuki Sasano; Naoko Komura; Michihide Maeda; Shinya Matsuzaki; Tsuyoshi Hisa; Shoji Kamiura; Toshitaka Morishima; Isao Miyashiro
Cancers, May 2023 - Laboratory Findings of Benign Convulsions With Mild Gastroenteritis: A Meta-Analysis.
Yoshifumi Miyagi; Tomoyuki Sasano; Kentoku Kin
Cureus, Mar. 2023 - Twenty-five-year mortality trends of four major histological subtypes of cervical cancer: a population-based study using the Osaka cancer registry data.
Naoko Komura; Seiji Mabuchi; Tomoyuki Sasano; Shoji Kamiura; Toshitaka Morishima; Isao Miyashiro
Frontiers in oncology, 2023 - Platelets Increase the Expression of PD-L1 in Ovarian Cancer.
Min Soon Cho; Hani Lee; Ricardo Gonzalez-Delgado; Dan Li; Tomoyuki Sasano; Wendolyn Carlos-Alcalde; Qing Ma; Jinsong Liu; Anil K Sood; Vahid Afshar-Kharghan
Cancers, May 2022 - Hyponatremia and Recurrent Febrile Seizures During Febrile Episodes: A Meta-Analysis.
Yoshifumi Miyagi; Tomoyuki Sasano; Hiroyuki Kato; Kentoku Kin
Cureus, Apr. 2022 - Podoplanin promotes tumor growth, platelet aggregation, and venous thrombosis in murine models of ovarian cancer.
Tomoyuki Sasano; Ricardo Gonzalez-Delgado; Nina M Muñoz; Wendolyn Carlos-Alcade; Min Soon Cho; Rahul A Sheth; Anil K Sood; Vahid Afshar-Kharghan
Journal of thrombosis and haemostasis : JTH, Jan. 2022 - Myeloid-Derived Suppressor Cells as Therapeutic Targets in Uterine Cervical and Endometrial Cancers.
Seiji Mabuchi; Tomoyuki Sasano
Cells, Apr. 2021 - The effect of platelet G proteins on platelet extravasation and tumor growth in the murine model of ovarian cancer.
Min Soon Cho; Jiasong Li; Ricardo Gonzalez-Delgado; Hani Lee; Matthew Vasquez; Tiancheng He; Yunjie He; Kai Liu; Tomoyuki Sasano; Bernd Nürnberg; Anil K Sood; Stephen T C Wong; Vahid Afshar-Kharghan
Blood advances, Apr. 2021 - Targeting Myeloid-Derived Suppressor Cells in Ovarian Cancer.
Seiji Mabuchi; Tomoyuki Sasano; Naoko Komura
Cells, Feb. 2021 - Prognostic significance of bone marrow FDG uptake in patients with gynecological cancer.
Kotaro Shimura; Seiji Mabuchi; Naoko Komura; Eriko Yokoi; Katsumi Kozasa; Tomoyuki Sasano; Mahiru Kawano; Yuri Matsumoto; Tadashi Watabe; Michiko Kodama; Kae Hashimoto; Kenjiro Sawada; Jun Hatazawa; Tadashi Kimura
Scientific reports, Jan. 2021 - Role of tissue-factor bearing extracellular vesicles released from ovarian cancer cells in platelet aggregation in vitro and venous thrombosis in mice
Tomoyuki Sasano; Min Soon Cho; Cristian Rodriguez-Aguayo; Emine Bayraktar; Mana Taki; Vahid Afshar-Kharghan; Anil K. Sood
Thrombosis Update, 2021 - The role of myeloid-derived suppressor cells in increasing cancer stem-like cells and promoting PD-L1 expression in epithelial ovarian cancer.
Naoko Komura; Seiji Mabuchi; Kotaro Shimura; Eriko Yokoi; Katsumi Kozasa; Hiromasa Kuroda; Ryoko Takahashi; Tomoyuki Sasano; Mahiru Kawano; Yuri Matsumoto; Michiko Kodama; Kae Hashimoto; Kenjiro Sawada; Tadashi Kimura
Cancer immunology, immunotherapy : CII, Dec. 2020 - Pretreatment tumor-related leukocytosis misleads positron emission tomography-computed tomography during lymph node staging in gynecological malignancies.
Seiji Mabuchi; Naoko Komura; Tomoyuki Sasano; Kotaro Shimura; Eriko Yokoi; Katsumi Kozasa; Hiromasa Kuroda; Ryoko Takahashi; Mahiru Kawano; Yuri Matsumoto; Hiroki Kato; Jun Hatazawa; Tadashi Kimura
Nature communications, Mar. 2020 - Lurbinectedin (PM01183), a selective inhibitor of active transcription, effectively eliminates both cancer cells and cancer stem cells in preclinical models of uterine cervical cancer.
Eriko Yokoi; Seiji Mabuchi; Kotaro Shimura; Naoko Komura; Katsumi Kozasa; Hiromasa Kuroda; Ryoko Takahashi; Tomoyuki Sasano; Mahiru Kawano; Yuri Matsumoto; Michiko Kodama; Kae Hashimoto; Kenjiro Sawada; Tadashi Kimura
Investigational new drugs, Oct. 2019 - Estrogen stimulates female cancer progression by inducing myeloid-derived suppressive cells: investigations on pregnant and non-pregnant experimental models.
Katsumi Kozasa; Seiji Mabuchi; Yuri Matsumoto; Hiromasa Kuroda; Eriko Yokoi; Naoko Komura; Mahiru Kawano; Ryoko Takahashi; Tomoyuki Sasano; Kotaro Shimura; Michiko Kodama; Kae Hashimoto; Kenjiro Sawada; Kazunori Nagasaka; Tadashi Kimura
Oncotarget, Mar. 2019 - The role of myeloid-derived suppressor cells in endometrial cancer displaying systemic inflammatory response: clinical and preclinical investigations.
Eriko Yokoi; Seiji Mabuchi; Naoko Komura; Kotaro Shimura; Hiromasa Kuroda; Katsumi Kozasa; Ryoko Takahashi; Tomoyuki Sasano; Mahiru Kawano; Yuri Matsumoto; Michiko Kodama; Kae Hashimoto; Kenjiro Sawada; Tadashi Kimura
Oncoimmunology, 2019 - Premetastatic niche and tumor-related leukocytosis: a close relationship that cannot be ignored in uterine cancer patients.
Seiji Mabuchi; Tomoyuki Sasano; Naoko Komura
Oncotarget, Dec. 2018 - Prostaglandin E2 produced by myeloid-derived suppressive cells induces cancer stem cells in uterine cervical cancer.
Hiromasa Kuroda; Seiji Mabuchi; Eriko Yokoi; Naoko Komura; Katsumi Kozasa; Yuri Matsumoto; Mahiru Kawano; Ryoko Takahashi; Tomoyuki Sasano; Kotaro Shimura; Michiko Kodama; Kae Hashimoto; Kenjiro Sawada; Eiichi Morii; Tadashi Kimura
Oncotarget, Nov. 2018 - The Highly Metastatic Nature of Uterine Cervical/Endometrial Cancer Displaying Tumor-Related Leukocytosis: Clinical and Preclinical Investigations.
Tomoyuki Sasano; Seiji Mabuchi; Katsumi Kozasa; Hiromasa Kuroda; Mahiru Kawano; Ryoko Takahashi; Naoko Komura; Eriko Yokoi; Yuri Matsumoto; Kae Hashimoto; Kenjiro Sawada; Eiichi Morii; Tadashi Kimura
Clinical cancer research : an official journal of the American Association for Cancer Research, Aug. 2018 - Comparison of clinical utility between neutrophil count and neutrophil-lymphocyte ratio in patients with ovarian cancer: a single institutional experience and a literature review.
Naoko Komura; Seiji Mabuchi; Eriko Yokoi; Katsumi Kozasa; Hiromasa Kuroda; Tomoyuki Sasano; Yuri Matsumoto; Tadashi Kimura
International journal of clinical oncology, Feb. 2018 - Effect of Japanese Kampo Medicine Therapy for Menopausal Symptoms after Treatment of Gynecological Malignancy.
Akihiko Yoshimura; Kenjiro Sawada; Tomoyuki Sasano; Hiromasa Kuroda; Katsumi Kozasa; Erika Nakatsuka; Koji Nakamura; Kae Hashimoto; Seiji Mabuchi; Tadashi Kimura
Obstetrics and gynecology international, 2018 - Comparison of clinical utilities of the platelet count and platelet-lymphocyte ratio for predicting survival in patients with cervical cancer: a single institutional study and literature review.
Katsumi Kozasa; Seiji Mabuchi; Naoko Komura; Eriko Yokoi; Kuroda Hiromasa; Tomoyuki Sasano; Mahiru Kawano; Yuri Matsumoto; Eiji Kobayashi; Tadashi Kimura
Oncotarget, Aug. 2017 - Predictors of Survival in Patients With FIGO Stage IVB Cervical Cancer.
Tomoyuki Sasano; Seiji Mabuchi; Hiromasa Kuroda; Ryoko Takahashi; Katsumi Kozasa; Fumiaki Isohashi; Yasuo Yoshioka; Kazuhiko Ogawa; Tadashi Kimura
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, Mar. 2016 - Preclinical Investigations of PM01183 (Lurbinectedin) as a Single Agent or in Combination with Other Anticancer Agents for Clear Cell Carcinoma of the Ovary.
Ryoko Takahashi; Seiji Mabuchi; Mahiru Kawano; Tomoyuki Sasano; Yuri Matsumoto; Hiromasa Kuroda; Katsumi Kozasa; Kae Hashimoto; Kenjiro Sawada; Tadashi Kimura
PloS one, 2016 - Efficacies of uterine artery embolization for symptomatic uterine fibroids using gelatin sponge: a single-center experience and literature review.
Aska Toda; Kenjiro Sawada; Keigo Osuga; Noboru Maeda; Hiroki Higashihara; Tomoyuki Sasano; Noriyuki Tomiyama; Tadashi Kimura
International journal of women's health, 2016 - The significance of G-CSF expression and myeloid-derived suppressor cells in the chemoresistance of uterine cervical cancer.
Mahiru Kawano; Seiji Mabuchi; Yuri Matsumoto; Tomoyuki Sasano; Ryoko Takahashi; Hiromasa Kuroda; Katsumi Kozasa; Kae Hashimoto; Aki Isobe; Kenjiro Sawada; Toshimitsu Hamasaki; Eiichi Morii; Tadashi Kimura
Scientific reports, Dec. 2015 - The significance of lymphatic space invasion and its association with vascular endothelial growth factor-C expression in ovarian cancer.
Takeshi Hisamatsu; Seiji Mabuchi; Tomoyuki Sasano; Hiromasa Kuroda; Ryoko Takahashi; Yuri Matsumoto; Mahiru Kawano; Katsumi Kozasa; Kei Takahashi; Kenjiro Sawada; Koji Matsuo; Yutaka Tamada; Eiichi Morii; Yasuhiko Kitadai; Tadashi Kimura
Clinical & experimental metastasis, Dec. 2015 - Prognostic Significance of Pretreatment Thrombocytosis in Cervical Cancer Patients Treated With Definitive Radiotherapy.
Mahiru Kawano; Seiji Mabuchi; Yuri Matsumoto; Tomoyuki Sasano; Ryoko Takahashi; Hiromasa Kuroda; Katsumi Kozasa; Fumiaki Isohashi; Kazuhiko Ogawa; Tadashi Kimura
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, Nov. 2015 - Real-time tissue sonoelastography for early response monitoring in cervical cancer patients treated with definitive chemoradiotherapy: preliminary results.
Seiji Mabuchi; Tomoyuki Sasano; Hiromasa Kuroda; Ryoko Takahashi; Satoshi Nakagawa; Tadashi Kimura
Journal of medical ultrasonics (2001), Jul. 2015 - Preclinical Efficacy for AKT Targeting in Clear Cell Carcinoma of the Ovary.
Tomoyuki Sasano; Seiji Mabuchi; Hiromasa Kuroda; Mahiru Kawano; Yuri Matsumoto; Ryoko Takahashi; Takeshi Hisamatsu; Kenjiro Sawada; Kae Hashimoto; Aki Isobe; Joseph R Testa; Tadashi Kimura
Molecular cancer research : MCR, Apr. 2015 - Prognostic significance of systemic neutrophil and leukocyte alterations in surgically treated endometrial cancer patients: a monoinstitutional study.
Ryoko Takahashi; Seiji Mabuchi; Mahiru Kawano; Tomoyuki Sasano; Yuri Matsumoto; Hiromasa Kuroda; Takeshi Hisamatsu; Katsumi Kozasa; Kenjiro Sawada; Toshimitsu Hamasaki; Tadashi Kimura
Gynecologic oncology, Apr. 2015 - Uterine cervical cancer displaying tumor-related leukocytosis: a distinct clinical entity with radioresistant feature.
Seiji Mabuchi; Yuri Matsumoto; Mahiru Kawano; Kazumasa Minami; Yuji Seo; Tomoyuki Sasano; Ryoko Takahashi; Hiromasa Kuroda; Takeshi Hisamatsu; Aiko Kakigano; Masami Hayashi; Kenjiro Sawada; Toshimitsu Hamasaki; Eiichi Morii; Hirohisa Kurachi; Nariaki Matsuura; Tadashi Kimura
Journal of the National Cancer Institute, Jul. 2014 - Combination treatment with trabectedin and irinotecan or topotecan has synergistic effects against ovarian clear cell carcinoma cells.
Mahiru Kawano; Seiji Mabuchi; Toshiko Kishimoto; Takeshi Hisamatsu; Yuri Matsumoto; Tomoyuki Sasano; Ryoko Takahashi; Kenjiro Sawada; Kazuhiro Takahashi; Toshifumi Takahashi; Toshimitsu Hamasaki; Tadashi Kimura
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, Jun. 2014 - Reirradiation using high-dose-rate interstitial brachytherapy for locally recurrent cervical cancer: a single institutional experience.
Seiji Mabuchi; Ryoko Takahashi; Fumiaki Isohashi; Takeshi Yokoi; Mika Okazawa; Tomoyuki Sasano; Shintaroh Maruoka; Makoto Anzai; Yasuo Yoshioka; Kazuhiko Ogawa; Tadashi Kimura
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, Jan. 2014 - Utility of serum squamous cell carcinoma antigen levels at the time of recurrent cervical cancer diagnosis in determining the optimal treatment choice.
Kotaro Shimura; Seiji Mabuchi; Takeshi Yokoi; Tomoyuki Sasano; Kenjirou Sawada; Toshimitsu Hamasaki; Tadashi Kimura
Journal of gynecologic oncology, Oct. 2013 - Potential role of mTORC2 as a therapeutic target in clear cell carcinoma of the ovary.
Takeshi Hisamatsu; Seiji Mabuchi; Yuri Matsumoto; Mahiru Kawano; Tomoyuki Sasano; Ryoko Takahashi; Kenjiro Sawada; Kimihiko Ito; Hirohisa Kurachi; Russell J Schilder; Joseph R Testa; Tadashi Kimura
Molecular cancer therapeutics, Jul. 2013 - Impact of the addition of concurrent chemotherapy to pelvic radiotherapy in surgically treated stage IB1-IIB cervical cancer patients with intermediate-risk or high-risk factors: a 13-year experience.
Mika Okazawa; Seiji Mabuchi; Fumiaki Isohashi; Osamu Suzuki; Yasuo Yoshioka; Tomoyuki Sasano; Yukinobu Ohta; Shoji Kamiura; Kazuhiko Ogawa; Tadashi Kimura
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, Mar. 2013
MISC
- 外観が非典型的であり診断に苦慮した妊娠後期の腟内尖圭コンジローマの1例
服部 瑞貴; 笹野 智之; 宇田 元; 粕谷 香南子; 松山 達也; 尾崎 公章; 富家 真理; 宮城 佳美; 江川 形平; 森山 明宏
日本女性医学学会雑誌, Apr. 2025, [Reviewed]
Corresponding - Torsion of Metastatic Ovarian Tumor Originating From Sigmoid Colon Cancer.
Maika Uenae; Tomoyuki Sasano; Mari Tomiie; Yoshimi Miyagi; Akihiro Moriyama
Cureus, Apr. 2025 - レボノルゲストレル放出子宮内システムの留置前に子宮内膜検査が実施されず,留置8ヵ月後に進行子宮内膜癌が判明した1例
富家 真理; 笹野 智之; 服部 瑞貴; 粕谷 香南子; 宇田 元; 高岡 幸; 尾崎 公章; 森山 明宏
日本女性医学学会雑誌, Jan. 2025
Corresponding - 妊娠18週に巨大絨毛膜下血腫を形成したが抗凝固療法を継続し、正期産に至った抗リン脂質抗体症候群合併妊娠の1例
髙岡幸; 服部瑞貴; 宇田元; 松山達也; 笹野智之; 富家真理; 尾崎公章; 森山明宏
産婦人科の進歩, 2024 - Management of early-stage and locally advanced cervical cancer.
Mabuchi S.; Kawano M.; Sasano T.; Kuroda H.
In: Shoupe, D. (eds) Handbook of Gynecology, 2017 - 子宮頸癌の化学療法と分子標的治療
馬淵誠士; 高橋良子; 黒田浩正; 笹野智之; 小笹勝巳; 松本有里; 木村正
産科と婦人科, 2016 - 第3章-1．からだとこころの変化に悩む中高年女性のミカタ
笹野智之; 澤田健二郎; 木村正
産婦人科へつなぐ日常診療での女性のミカタ, 2016 - Two consecutive pregnancies in a patient with paroxysmal nocturnal haemoglobinuria treated with anticoagulant therapy at different doses.
Tomoyuki Sasano; Takuji Tomimatsu; Jun-Ichi Nishimura; Itaru Matsumura; Yuzuru Kanakura; Tadashi Kimura
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, Jan. 2016 - The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer.
Seiji Mabuchi; Hiromasa Kuroda; Ryoko Takahashi; Tomoyuki Sasano
Gynecologic oncology, Apr. 2015 - [Treatment of ovarian clear cell carcinoma].
Seiji Mabuchi; Ryoko Takahashi; Tomoyuki Sasano; Hiromasa Kuroda; Tadashi Kimura
Gan to kagaku ryoho. Cancer & chemotherapy, Feb. 2015 - 5 画像検査ではここを診よう！産婦人科疾患の画像と実際
笹野智之; 松本有里; 熊澤恵一; 馬淵誠士
もう困らない！プライマリ・ケアでの女性の診かた, 2015 - First two cases of primary carcinoma of the vagina successfully treated with concurrent weekly carboplatin plus paclitaxel, external beam radiotherapy and high-dose-rate interstitial brachytherapy: a case report and published work review.
Seiji Mabuchi; Mahiru Kawano; Fumiaki Isohashi; Hiromasa Kuroda; Tomoyuki Sasano; Tadashi Kimura
The journal of obstetrics and gynaecology research, Jan. 2015 - [IV. Targeted therapies for epithelial ovarian cancer].
Seiji Mabuchi; Tomoyuki Sasano; Mahiru Kawano; Tadashi Kimura
Gan to kagaku ryoho. Cancer & chemotherapy, Feb. 2014 - 帝王切開術1ヵ月後に大量性器出血を認めた子宮仮性動脈瘤破裂の1症例
笹野智之; 久本浩司; 松田万里子; 塚原稚香子; 柏原宏美; 國重一郎; 西尾幸浩
産婦人科の進歩, 2014 - 5女性の腹痛: 画像検査ではここを診よう! 産婦人科疾患の画像と実際
笹野智之; 松本有里; 馬淵誠士
レジデントノート, 2013
Lectures, oral presentations, etc.
- 全腹腔鏡下子宮全摘術中に実施した膀胱鏡検査で偶発的に膀胱癌を早期発見した一例
笹野 智之; 服部 瑞貴; 松山 達也; 粕谷 香南子; 富家 真理; 尾崎 公章; 森山 明宏
第65回日本産科婦人科内視鏡学会, 2025 - 子宮筋腫の術前診断で全腹腔鏡下子宮全摘術後に低異型度子宮内膜間質肉腫と判明した1例
笹野 智之; 尾崎 公章; 松山 達也; 宇田 元; 富家 真理; 森山 明宏
第65回日本産科婦人科内視鏡学会, 2025 - ロボット支援下ステージング手術および卵巣組織凍結を施行した卵巣明細胞癌IA期の一例
脇本 裕; 成田 幸代; 上田 友子; 笹野 智之; 鍔本 浩志; 馬淵 誠士
第65回日本産科婦人科内視鏡学会, 2025 - Bevacizumab投与中にS状結腸癌の転移性卵巣腫瘍が茎捻転した1例
植苗 舞果; 笹野 智之; 富家 真理; 服部 瑞貴; 宇田 元; 粕谷 香南子; 松山 達也; 尾崎 公章; 森山 明宏
第77回日本産科婦人科学会学術講演会, 2025 - 閉経後の性器出血を契機に卵巣類内膜腺線維腫から発生した卵巣類内膜腺癌が判明した1例
笹野 智之; 植苗 舞果; 服部 瑞貴; 宇田 元; 粕谷 香南子; 松山 達也; 富家 真理; 尾崎 公章; 森山 明宏
第77回日本産科婦人科学会学術講演会, 2025
Research Themes
- Investigation of the role myeloid-derived suppressor cells (MDSC) in the maternal-fetal tolerance and pregnancy-complicated female cancer progression.
Grant-in-Aid for Scientific Research (A)
Osaka University
01 Apr. 2015 - 31 Mar. 2018
