Last Updated :2026/01/01
Researcher Information
Career
- Apr. 2022 - Present
Hyogo Medical University, School of Rehabilitation Department of Occupational Therapy, Lecturer - Apr. 2014 - Mar. 2022
Hyogo University of Health Sciences, General Education Center, Lecturer - Apr. 2009 - Mar. 2014
Kouiken Co. Ltd., Section of Behavioral Science, Chief Research Officer - Apr. 2007 - Mar. 2009
SOMNOQUEST Co., Ltd., R&D, Vice-Head of R&D - Apr. 2006 - Mar. 2007
Kwansei Gakuin University, School of Humanities Department of Integrated Psychological Sciences, Assistant - Apr. 2002 - Mar. 2007
Behavioral and Medical Sciences Research Consortium, Section of Behavioral Science, Chief Research Officer
Educational Background
Research activity information
Paper
- Human-Brain-Derived Ischemia-Induced Stem Cell Transplantation Is Associated with a Greater Neurological Functional Improvement Compared with Human-Bone Marrow-Derived Mesenchymal Stem Cell Transplantation in Mice After Stroke.
Shuichi Tanada; Takayuki Nakagomi; Akiko Nakano-Doi; Toshinori Sawano; Shuji Kubo; Yoji Kuramoto; Kazutaka Uchida; Kenichi Yamahara; Nobutaka Doe; Shinichi Yoshimura
International journal of molecular sciences, Nov. 2024 - Administration of Human-Derived Mesenchymal Stem Cells Activates Locally Stimulated Endogenous Neural Progenitors and Reduces Neurological Dysfunction in Mice after Ischemic Stroke.
Shuichi Fujiwara; Akiko Nakano-Doi; Toshinori Sawano; Shuji Kubo; Nobutaka Doe; Takayuki Nakagomi
Cells, May 2024 - Transplantation of Human Brain-Derived Ischemia-Induced Multipotent Stem Cells Ameliorates Neurological Dysfunction in Mice After Stroke.
Takayuki Nakagomi; Akiko Nakano-Doi; Shuji Kubo; Toshinori Sawano; Yoji Kuramoto; Kenichi Yamahara; Tomohiro Matsuyama; Toshinori Takagi; Nobutaka Doe; Shinichi Yoshimura
Stem cells translational medicine, Jun. 2023 - Enhanced angiogenic properties of umbilical cord blood primed by OP9 stromal cells ameliorates neurological deficits in cerebral infarction mouse model.
Yasunori Yoshida; Yuki Takeda; Kenichi Yamahara; Hanae Yamamoto; Toshinori Takagi; Yoji Kuramoto; Akiko Nakano-Doi; Takayuki Nakagomi; Toshihiro Soma; Tomohiro Matsuyama; Nobutaka Doe; Shinichi Yoshimura
Scientific reports, Jan. 2023 - Acute stress induces severe neural inflammation and overactivation of glucocorticoid signaling in interleukin-18-deficient mice.
Kyosuke Yamanishi; Nobutaka Doe; Keiichiro Mukai; Takuya Hashimoto; Naomi Gamachi; Masaki Hata; Yuko Watanabe; Chiaki Yamanishi; Hideshi Yagi; Haruki Okamura; Hisato Matsunaga
Translational psychiatry, Sep. 2022 - Early-phase administration of human amnion-derived stem cells ameliorates neurobehavioral deficits of intracerebral hemorrhage by suppressing local inflammation and apoptosis.
Yoji Kuramoto; Mitsugu Fujita; Toshinori Takagi; Yuki Takeda; Nobutaka Doe; Kenichi Yamahara; Shinichi Yoshimura
Journal of neuroinflammation, Feb. 2022 - Voluntary running exercise after focal cerebral ischemia ameliorates dendritic spine loss and promotes functional recovery.
Natsumi Yamaguchi; Toshinori Sawano; Kae Fukumoto; Jin Nakatani; Shota Inoue; Nobutaka Doe; Daijiro Yanagisawa; Ikuo Tooyama; Takayuki Nakagomi; Tomohiro Matsuyama; Hidekazu Tanaka
Brain research, Sep. 2021 - Intravenous Administration of Human Amniotic Mesenchymal Stem Cells in the Subacute Phase of Cerebral Infarction in a Mouse Model Ameliorates Neurological Disturbance by Suppressing Blood Brain Barrier Disruption and Apoptosis via Immunomodulation.
Yasunori Yoshida; Toshinori Takagi; Yoji Kuramoto; Kotaro Tatebayashi; Manabu Shirakawa; Kenichi Yamahara; Nobutaka Doe; Shinichi Yoshimura
Cell transplantation, 2021 - Early Reperfusion Following Ischemic Stroke Provides Beneficial Effects, Even After Lethal Ischemia with Mature Neural Cell Death.
Yasue Tanaka; Nami Nakagomi; Nobutaka Doe; Akiko Nakano-Doi; Toshinori Sawano; Toshinori Takagi; Tomohiro Matsuyama; Shinichi Yoshimura; Takayuki Nakagomi
Cells, Jun. 2020 - Adipose-derived stem cell therapy inhibits the deterioration of cerebral infarction by altering macrophage kinetics.
Kotaro Tatebayashi; Toshinori Takagi; Mitsugu Fujita; Nobutaka Doe; Takayuki Nakagomi; Tomohiro Matsuyama; Shinichi Yoshimura
Brain research, Jun. 2019 - Interleukin-18-deficient mice develop hippocampal abnormalities related to possible depressive-like behaviors.
Kyosuke Yamanishi; Nobutaka Doe; Keiichiro Mukai; Kaoru Ikubo; Takuya Hashimoto; Noriko Uwa; Miho Sumida; Yosif El-Darawish; Naomi Gamachi; Wen Li; Sachi Kuwahara-Otani; Seishi Maeda; Yuko Watanabe; Tetsu Hayakawa; Hiromichi Yamanishi; Tomohiro Matsuyama; Hideshi Yagi; Haruki Okamura; Hisato Matsunaga
Neuroscience, Jun. 2019 - Intravenous administration of human adipose-derived stem cells ameliorates motor and cognitive function for intracerebral hemorrhage mouse model.
Yoji Kuramoto; Toshinori Takagi; Kotaro Tatebayashi; Mikiya Beppu; Nobutaka Doe; Mitsugu Fujita; Shinichi Yoshimura
Brain research, May 2019 - Molecular analysis of the mouse brain exposed to chronic mild stress: The influence of hepatocyte nuclear factor 4α on physiological homeostasis.
Kaoru Ikubo; Kyosuke Yamanishi; Nobutaka Doe; Takuya Hashimoto; Miho Sumida; Yuko Watanabe; Yosif El-Darawish; Wen Li; Haruki Okamura; Hiromichi Yamanishi; Hisato Matsunaga
Molecular medicine reports, Jul. 2017 - マウスのモリス型水迷路学習課題における実験装置の条件設定の重要性—The importance of apparatus setting on the Morris water maze learning task in mice
土江 伸誉
行動科学 = Behavioral science research / 日本行動科学学会編集委員会 編, Mar. 2017, [Reviewed] - CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis.
Kotaro Miyake; Toshio Ohta; Hisako Nakayama; Nobutaka Doe; Yuri Terao; Eiji Oiki; Izumi Nagatomo; Yui Yamashita; Takaya Abe; Kazuko Nishikura; Atsushi Kumanogoh; Kouichi Hashimoto; Yukio Kawahara
Cell reports, Nov. 2016 - Effect of Sema4D on microglial function in middle cerebral artery occlusion mice.
Toshinori Sawano; Fumiya Watanabe; Mitsuko Ishiguchi; Nobutaka Doe; Tatsuo Furuyama; Shinobu Inagaki
Glia, Dec. 2015 - Hepatocyte nuclear factor 4 alpha is a key factor related to depression and physiological homeostasis in the mouse brain.
Kyosuke Yamanishi; Nobutaka Doe; Miho Sumida; Yuko Watanabe; Momoko Yoshida; Hideyuki Yamamoto; Yunfeng Xu; Wen Li; Hiromichi Yamanishi; Haruki Okamura; Hisato Matsunaga
PloS one, 2015 - Hepatocyte growth factor overexpression in the nervous system enhances learning and memory performance in mice.
Takashi Kato; Hiroshi Funakoshi; Keiichi Kadoyama; Satsuki Noma; Masaaki Kanai; Wakana Ohya-Shimada; Shinya Mizuno; Nobutaka Doe; Taizo Taniguchi; Toshikazu Nakamura
Journal of neuroscience research, Sep. 2012 - A DKP cyclo(L-Phe-L-Phe) found in chicken essence is a dual inhibitor of the serotonin transporter and acetylcholinesterase.
Nobuo Tsuruoka; Yoshinori Beppu; Hirofumi Koda; Nobutaka Doe; Hiroshi Watanabe; Keiichi Abe
PloS one, 2012 - Genotoxicity-suppressing Effect of Aqueous Extract of Connarus ruber Cortex
Nakamura Takanori; Nakai Megumi; Ookubo Kaikou; Kitamura Yoshihisa; Doe Nobutaka; Hattori Sachiyo; Murakami Natsumi; Yamamoto Ayumi; Honda Gisho; Sasaki Yu F.
Genes and Environment, 2011 - Immunodeficiency reduces neural stem/progenitor cell apoptosis and enhances neurogenesis in the cerebral cortex after stroke.
Orie Saino; Akihiko Taguchi; Takayuki Nakagomi; Akiko Nakano-Doi; Shin-Ichiro Kashiwamura; Nobutaka Doe; Nami Nakagomi; Toshihiro Soma; Hiroo Yoshikawa; David M Stern; Haruki Okamura; Tomohiro Matsuyama
Journal of neuroscience research, Aug. 2010 - Impaired acquisition of water maze learning induced by forced swimming task in mice
DOE Nobutaka; TSURUDA Hirofumi; KAWAJIRI Yoshihiro; TAKAHASHI Tsutomu; NISHIGUCHI Megumi; KIRIYAMA Mika
実験動物技術, Jun. 2010, [Reviewed] - 行動科学的手法によるうつ動物モデルの有用性—Usefulness of behavioral animal models of depression—特集 行動科学研究の広がりと新たな展開
土江 伸誉
行動科学 = Behavioral science research / 日本行動科学学会編集委員会 編, Mar. 2010 - Behavioral despair during a water maze learning task in mice.
Nobutaka Doe; Tsutomu Takahashi; Mika Kiriyama
Experimental animals, 2010 - Timp-3 deficiency impairs cognitive function in mice.
Yoshichika Baba; Osamu Yasuda; Yukihiro Takemura; Yasuyuki Ishikawa; Mitsuru Ohishi; Jun Iwanami; Masaki Mogi; Nobutaka Doe; Masatsugu Horiuchi; Nobuyo Maeda; Keisuke Fukuo; Hiromi Rakugi
Laboratory investigation; a journal of technical methods and pathology, Dec. 2009 - マウスの水迷路学習場面を応用したうつ動物モデルのイミプラミンに対する感受性—Animal model of depression using water maze learning situation in mice and its sensitivity to imipramine
土江 伸誉; 桐山 美香
醫學と生物學 : 速報學術雜誌 / 醫學生物學速報會 編, Sep. 2009 - New antidepressant screening method using water maze learning situation in mice
DOE Nobutaka; KIRIYAMA Mika; TANIGUCHI Taizo
実験動物技術, Jun. 2006 - Transgenic mice expressing mutant (N279K) human tau show mutation dependent cognitive deficits without neurofibrillary tangle formation.
Taizo Taniguchi; Nobutaka Doe; Shogo Matsuyama; Yoshihisa Kitamura; Hiroshi Mori; Naoaki Saito; Chikako Tanaka
FEBS letters, Oct. 2005 - Spatial learning of mice lacking a neuron-specific epidermal growth factor family protein, NELL2.
Shogo Matsuyama; Nobutaka Doe; Naoki Kurihara; Katsuyuki Tanizawa; Shun'ichi Kuroda; Hiroyuki Iso; Masato Horie
Journal of pharmacological sciences, Jul. 2005 - Cross-modal transfer of conditioned suppression in rats: Effects of US intensity and extinction of the initial conditioning task
Nobutaka Doe; Sadahiko Nakajima; Noriko Tamai
Learning and Motivation, Aug. 2004 - 若齢・老齢マウスおよび痴呆モデルマウスの学習・記憶機能—特集:学習・記憶についての発達からのアプローチ
土江 伸誉; 磯 博行; 谷口 泰造
行動科学 = Behavioral science research / 日本行動科学学会編集委員会 編, Dec. 2003 - The influence of contextual cue on antinociceptive tolerance and facilitation of memory with morphine.
Mototaka Nakama-Kitamura; Nobutaka Doe
Journal of pharmacological sciences, Jul. 2003 - The effects of fixed sequence of US intensities and CS-US correlation on licking suppression in rats
DOE Nobutaka
Japanese Journal of Animal Psychology, 2000
MISC
- ハンドリング処置により誘発されるマウスの行動変化とストレス反応
土江, 伸誉; 高橋, 佑奈; 長永, 夕奈; 澤野, 俊憲
兵庫医療大学紀要 = Journal of Hyogo University of Health Sciences, 28 Dec. 2021, [Reviewed]
Lead - Interleukin-18-deficient mice develop dysfunction of hippocampus resulting in depression-like behavior
Kyosuke Yamanishi; Nobutaka Doe; Kaoru Ikubo; Miho Sumida; Sachi Kuwahara-Otani; Seishi Maeda; Yuko Watanabe; Momoko Yoshida; Wen Li; Tetsu Hayakawa; Haruki Okamura; Hiromichi Yamanishi; Hisato Matsunaga
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, Jun. 2016 - Interleukin-18-deficient mice develop dysfunction of hippocampus resulting in depression-like behavior
Kyosuke Yamanishi; Nobutaka Doe; Kaoru Ikubo; Takuya Hashimoto; Miho Sumida; Sachi Kuwahara-Otani; Seishi Maeda; Yuko Watanabe; Wen Li; Tetsu Hayakawa; Haruki Okamura; Hiromichi Yamanishi; Hisato Matsunaga
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2016 - Molecular analyses of the mouse brain exposed to chronic mild stress; the relation between depression and physiological dyshomeostasis
Kaoru Ikubo; Kyosuke Yamanishi; Nobutaka Doe; Miho Sumida; Yuko Watanabe; Momoko Yoshida; Wen Li; Haruki Okamura; Hisato Matsunaga; Hiromichi Yamanishi
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2015 - 川に投げ込まれたネズミはいつまでも泳ぎ続けるか?
土江 伸誉
ヒトと動物の関係学会誌, 2005, [Reviewed]
Lead - 地方に居住する中高年者の人生観(2) 山形県鶴岡市栄地区をフィールドとする聞き取り調査
荘厳舜哉; 古川義和; 竹内伸宜; 坂井明子; 土江伸誉; 荘厳依子; 澤田匡人; 谷口高士
大阪学院大学人文自然論叢, 47, 1-65., 2003, [Reviewed] - Conditioned licking suppression in rats : Kwansei Gakuin procedure
Doe, Nobutaka; Nakajima, Sadahiko
人文論究, 10 Dec. 2000 - 地方に居住する中高年者の人生観(1) 静岡県水窪町をフィールドとする聞き取り調査
荘厳舜哉; 古川義和; 藤村邦博; 竹内伸宜; 坂井明子; 土江伸誉; 荘厳依子; 澤田匡人; 谷口高士
大阪学院大学人文自然論叢, 2000, [Reviewed]
Books and other publications
Research Themes
- Contribution of Sema4D to microglia and oligodendrocyte development and to their interrelation
Grant-in-Aid for Scientific Research (C)
Osaka University
01 Apr. 2016 - 31 Mar. 2020 - Relationships between coping flexibility and chronic depression
Grant-in-Aid for Scientific Research (C)
Toyo University
01 Apr. 2016 - 31 Mar. 2019 - New behavioral animal model to study genetic and environmental factors in the cause of depression
Grant-in-Aid for Scientific Research (C)
Hyogo University of Health Sciences
01 Apr. 2016 - 31 Mar. 2019 - New behavioral animal model to study vulnerability factors for depression
Grant-in-Aid for Young Scientists (B)
Hyogo Medical University
01 Apr. 2012 - 31 Mar. 2014 - New animal model of depression using water maze learning situation in mice
Grant-in-Aid for Young Scientists (B)
Hyogo Medical University
2010 - 2011 - Influence of depression and mental stress on the experimental atherogenesis in mice
Grant-in-Aid for Scientific Research (C)
University of the Ryukyus
2008 - 2010
