Last Updated :2025/07/10
Researcher Information
Career
- Jun. 2025 - Present
Stanford University, School of Medicine, Department of Psychiatry and Behavioral Sciences, Visiting Scholar - Apr. 2022 - Present
Hyogo Medical University, School of Medicine, Department of Anatomy and Cell Biology, Assistant Professor - Apr. 2019 - Mar. 2022
Kwansei Gakuin University, School of Biological and Environmental Sciences Department of Biomedical Sciences, Assistant Professor - Apr. 2016 - Mar. 2019
Hyogo College of Medicine, Institute for Advanced Medical Sciences, Posdoc
Research activity information
Paper
- Nrf2 phosphorylation contributes to acquisition of pericyte reprogramming via the PKCδ pathway
Rika Sakuma; Yusuke Minato; Seishi Maeda; Hideshi Yagi
Neurobiology of Disease, Mar. 2025, [Reviewed]
Lead - Yeast β-glucan Increases Etoposide Sensitivity in Lung Cancer Cell Line A549 by Suppressing Nuclear Factor Erythroid 2-Related Factor 2 via the Noncanonical Nuclear Factor Kappa B Pathway
Ferbian Milas Siswanto; Akiyoshi Tamura; Rika Sakuma; Susumu Imaoka
Molecular Pharmacology, Apr. 2022, [Reviewed] - Brain Pericytes Acquire Stemness via the Nrf2-Dependent Antioxidant System
Rika Sakuma; Miku Kobayashi; Rui Kobashi; Mako Onishi; Mitsuyo Maeda; Yosky Kataoka; Susumu Imaoka
Stem Cells, Mar. 2022, [Reviewed]
Lead - Chlorogenic Acid Activates Nrf2/SKN-1 and Prolongs the Lifespan of Caenorhabditis elegans via the Akt-FOXO3/DAF16a-DDB1 Pathway and Activation of DAF16f
Ferbian Milas Siswanto; Rika Sakuma; Ami Oguro; Susumu Imaoka
The Journals of Gerontology: Series A, Mar. 2022, [Reviewed] - Bisphenol A stabilizes Nrf2 via Ca2+ influx by direct activation of the IP3 receptor
Ami Oguro; Atsushi Sugitani; Yukino Kobayashi; Rika Sakuma; Susumu Imaoka
The Journal of Toxicological Sciences, 2021, [Reviewed] - Isolation and Characterization of Cerebellum-Derived Stem Cells in Poststroke Human Brain
Mikiya Beppu; Takayuki Nakagomi; Toshinori Takagi; Akiko Nakano-Doi; Rika Sakuma; Yoji Kuramoto; Kotaro Tatebayashi; Tomohiro Matsuyama; Shinichi Yoshimura
Stem Cells and Development, Apr. 2019, [Reviewed] - Comparative Characterization of Ischemia-Induced Brain Multipotent Stem Cells with Mesenchymal Stem Cells: Similarities and Differences
Rika Sakuma; Ai Takahashi; Akiko Nakano-Doi; Rikako Sawada; Saeko Kamachi; Mikiya Beppu; Toshinori Takagi; Shinichi Yoshimura; Tomohiro Matsuyama; Takayuki Nakagomi
Stem Cells and Development, Oct. 2018, [Reviewed]
Lead - Ischemic stroke activates the VE-cadherin promoter and increases VE-cadherin expression in adult mice
Nakano-Doi A.; Sakuma R.; Matsuyama T.; Nakagomi T.
Histol Histopathol, May 2018, [Reviewed] - Novel Regenerative Therapies Based on Regionally Induced Multipotent Stem Cells in Post-Stroke Brains: Their Origin, Characterization, and Perspective
Toshinori Takagi; Shinichi Yoshimura; Rika Sakuma; Akiko Nakano-Doi; Tomohiro Matsuyama; Takayuki Nakagomi
Translational Stroke Research, Jul. 2017, [Reviewed] - Identification of Multipotent Stem Cells in Human Brain Tissue Following Stroke
Kotaro Tatebayashi; Yasue Tanaka; Akiko Nakano-Doi; Rika Sakuma; Saeko Kamachi; Manabu Shirakawa; Kazutaka Uchida; Hiroto Kageyama; Toshinori Takagi; Shinichi Yoshimura; Tomohiro Matsuyama; Takayuki Nakagomi
Stem Cells and Development, Jun. 2017, [Reviewed] - Brain pericytes serve as microglia-generating multipotent vascular stem cells following ischemic stroke
Rika Sakuma; Maiko Kawahara; Akiko Nakano-Doi; Ai Takahashi; Yasue Tanaka; Aya Narita; Sachi Kuwahara-Otani; Tetsu Hayakawa; Hideshi Yagi; Tomohiro Matsuyama; Takayuki Nakagomi
Journal of Neuroinflammation, Mar. 2016, [Reviewed]
Lead - Brain Vascular Pericytes Following Ischemia Have Multipotential Stem Cell Activity to Differentiate Into Neural and Vascular Lineage Cells
Takayuki Nakagomi; Shuji Kubo; Akiko Nakano-Doi; Rika Sakuma; Shan Lu; Aya Narita; Maiko Kawahara; Akihiko Taguchi; Tomohiro Matsuyama
Stem Cells, Apr. 2015, [Reviewed] - Alkaloid constituents from flower buds and leaves of sacred lotus (Nelumbo nucifera, Nymphaeaceae) with melanogenesis inhibitory activity in B16 melanoma cells
Seikou Nakamura; Souichi Nakashima; Genzo Tanabe; Yoshimi Oda; Nami Yokota; Katsuyoshi Fujimoto; Takahiro Matsumoto; Rika Sakuma; Tomoe Ohta; Keiko Ogawa; Shino Nishida; Hisako Miki; Hisashi Matsuda; Osamu Muraoka; Masayuki Yoshikawa
Bioorganic & Medicinal Chemistry, Feb. 2013, [Reviewed]
Lectures, oral presentations, etc.
- pNrf2-induced brain pericytes via PKCδ pathway acquire neural stemness
Rika Sakuma; Yusuke Minato; Seishi Maeda; Hideshi Yagi
Neuro2024, Jul. 2024 - 脳ペリサイトはPKCによるNrf2リン酸化を介して幹細胞化する
佐久間理香; 湊雄介; 前田誠司; 八木秀司
第129回日本解剖学会総会・全国学術集会, Mar. 2024 - Induction of Nrf2 converted brain pericytes to neural stem cells
Rika Sakuma; Yusuke Minato; Seishi Maeda; Hideshi Yagi
Neuroscience 2023, Nov. 2023 - 抗酸化因子Nrf2のリン酸化によって誘導される脳ペリサイトのリプログラミング現象
佐久間理香; 湊雄介; 前田誠司; 八木秀司
ORIGIN 神経科学研究会2023, Aug. 2023 - 虚血による脳ペリサイトの幹細胞化現象には抗酸化因子Nrf2が関与する
佐久間理香; 湊雄介; 前田誠司; 八木秀司
第98回日本解剖学会近畿支部学術集会, Nov. 2022 - Nrf2-expressing pericytes acquire the traits of stemness.
Rika Sakuma; Miku Kobayashi; Rui Kobashi; Mako Onishi; Mitsuyo Maeda; Yosky Kataoka; Susumu Imaoka
第４５回日本神経科学大会, Jul. 2022
Affiliated academic society
Research Themes
- 脳ペリサイト幹細胞化現象に関わるNrf2リン酸化経路の解明
Jul. 2024 - Mar. 2029 - カルシウムイオン流入が引き金となる脳ペリサイト組織修復機構の解明と新規薬物療法の開発
Jul. 2022 - Mar. 2023 - Brain pericytes acquire stemness via the Nrf2-dependent antioxidant system.
Grant-in-Aid for Early-Career Scientists
Apr. 2020 - Mar. 2023 - 虚血によるペリサイトリプログラミング現象の分子機構を炎症に着目し解明する
Apr. 2021 - Mar. 2022 - ポリフェノール類による脳梗塞治療―自己再生幹細胞iSCsの形成促進と治療応用を目指して
Jul. 2020 - Jun. 2021 - iSCが低酸素負荷－酸化ストレスから受ける影響の検討
Apr. 2020 - Mar. 2021
