Last Updated :2024/12/13
Researcher Information
Career
- Apr. 2022 - Present
兵庫医科大学大学院, 薬学研究科, 教授 - Apr. 2022 - Present
Hyogo Medical University, School of Pharmacy, 教授 - Oct. 2019 - Mar. 2022
兵庫医療大学, 薬学部, 准教授 - Apr. 2008 - Sep. 2019
兵庫医療大学, 薬学部, 講師 - Dec. 2007 - Mar. 2010
早稲田大学大学院, 先進理工学研究科 生命理工専攻, 客員准教授 - Sep. 2006 - Dec. 2007
株式会社ユーエスエンジニアリング, 研究室長 - Apr. 1992 - Aug. 2006
興和株式会社, 東京創薬研究所 薬物動態研究グループ, 主任研究員
Research activity information
Paper
- Proposal of a Utilization of Commercially Available Reagents in the Teaching and Learning of Radiation Safety
Fujino Hideki; Uramoto Sawa; Komatsu Rikako
RADIOISOTOPES, Mar. 2022 - Development of 14C Surface Sources for Imaging Plate Using an Ink-jet Printer
Fujino Hideki; Nagata Eiji
RADIOISOTOPES, Mar. 2022 - Proposal of education and training programs using commercial available chemical reagents as radiation source
藤野秀樹
KEK Proceedings (Web), 2021, [Reviewed] - 薬剤師生涯教育としての「化学構造式ワークショップ」の試みとその評価
清水 忠; 中尾 周平; 上田 昌宏; 豊山 美琴; 橋本 佳奈; 藤野 秀樹; 諸富 光裕; 天野 学
兵庫医療大学紀要, Dec. 2018 - Evaluation of 89 compounds for identification of substrates for cynomolgus monkey CYP2C76, a new bupropion/nifedipine oxidase.
Shinya Hosaka; Norie Murayama; Masahiro Satsukawa; Makiko Shimizu; Shotaro Uehara; Hideki Fujino; Kazuhide Iwasaki; Shunsuke Iwano; Yasuhiro Uno; Hiroshi Yamazaki
Drug metabolism and disposition: the biological fate of chemicals, Jan. 2015 - Monkey liver cytochrome P450 2C9 is involved in caffeine 7-N-demethylation to form theophylline.
Masahiro Utoh; Norie Murayama; Yasuhiro Uno; Yui Onose; Shinya Hosaka; Hideki Fujino; Makiko Shimizu; Kazuhide Iwasaki; Hiroshi Yamazaki
Xenobiotica; the fate of foreign compounds in biological systems, Dec. 2013 - Monkey liver cytochrome P450 2C19 is involved in R- and S-warfarin 7-hydroxylation.
Yoshio Hosoi; Yasuhiro Uno; Norie Murayama; Hideki Fujino; Mitsunori Shukuya; Kazuhide Iwasaki; Makiko Shimizu; Masahiro Utoh; Hiroshi Yamazaki
Biochemical pharmacology, Dec. 2012 - Effect of lipopolysaccharide on the xenobiotic-induced expression and activity of hepatic cytochrome P450 in mice.
Nozomu Moriya; Hiromi Kataoka; Hideki Fujino; Jun-ichi Nishikawa; Fumihiko Kugawa
Biological & pharmaceutical bulletin, 2012 - Metabolic Fate of Pitavastatin (NK-104), a New Inhibitor of 3-Hydroxy-3-methyllutaryl Coenzyme A Reductase
Hideki Fujino; Iwao Yamada; Syunsuke Shimada; Takeshi Nagao; Michiaki Yoneda
Arzneimittelforschung, Dec. 2011 - Interaction between Several Medicines and Statins
Hideki Fujino; Tsuyoshi Saito; Yoshihiko Tsunenari; Junji Kojima
Arzneimittelforschung, Dec. 2011 - Macaque CYP2C76 encodes cytochrome P450 enzyme not orthologous to any human isozymes.
Yasuhiro Uno; Hideki Fujino; Kazuhide Iwasaki; Masahiro Utoh
Current drug metabolism, Feb. 2010 - CYP2C76:薬物代謝において稀に見られるサルとヒトの種差の原因か
宇野泰広; 宇野泰広; 藤野秀樹; 鬼頭剛; 鬼頭剛; 鵜藤雅裕; 福崎好一郎; 鎌滝哲也; 永田良一; 永田良一
日本予防医学会雑誌, Apr. 2008 - オートラジオグラフィによる骨粗鬆症モデルラットの骨密度測定(Autoradiography of Lyophilized Animal Sections: Bone Density Measurement in Osteoporosis Model Rats)
藤野 秀樹; 朝原 庸光; 木全 秀樹; 立石 満; 小出 高志; 馬場 茂雄
Radioisotopes, Feb. 2008 - Effect of gamma-irradiation to the embryos growth of kenaf and roselle
松坂彰毅; 奥山直輝; 藤野秀樹; 藤野秀樹
食品照射, 2008 - CYP2C76-mediated species difference in drug metabolism: A comparison of pitavastatin metabolism between monkeys and humans
Yasuhiro Uno; Takayuki Kumano; Go Kito; Ryoichi Nagata; Tetsuya Kamataki; Hideki Fujino
Xenobiotica, Jan. 2007, [Reviewed] - CYP2C76, a novel cytochrome P450 in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone.
Yasuhiro Uno; Hideki Fujino; Go Kito; Tetsuya Kamataki; Ryoichi Nagata
Molecular pharmacology, Aug. 2006 - Effects of acid and lactone forms of eight HMG-CoA reductase inhibitors on CYP-mediated metabolism and MDR1-mediated transport.
Toshiyuki Sakaeda; Hideki Fujino; Chiho Komoto; Mikio Kakumoto; Jiang-Shu Jin; Koichi Iwaki; Kohshi Nishiguchi; Tsutomu Nakamura; Noboru Okamura; Katsuhiko Okumura
Pharmaceutical research, Mar. 2006 - Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase.
Hideki Fujino; Tsuyoshi Saito; Shin-Ichiro Ogawa; Junji Kojima
The Journal of pharmacy and pharmacology, Oct. 2005 - Metabolic properties of the acid and lactone forms of HMG-CoA reductase inhibitors
H. Fujino; T. Saito; Y. Tsunenari; J. Kojima; T. Sakaeda
Xenobiotica, Nov. 2004 - Pharmacological and pharmacokinetic features and clinical effects of pitavastatin (Livalo Tablet).
山崎裕之; 藤野秀樹; 金沢瑞穂; 玉木太郎; 佐藤文泰; 鈴木幹夫; 北原真樹
日本薬理学雑誌, May 2004 - 循環器学と生物物理学との連携 新規HMG-CoA還元酵素阻害薬ピタバスタチンの薬物動態的特徴
藤野 秀樹; 小島 順司
診療と新薬, Feb. 2004 - Effect of gemfibrozil on the metabolism of pitavastatin--determining the best animal model for human CYP and UGT activities.
Hideki Fujino; Tsuyoshi Saito; Yoshihiko Tsunenari; Junji Kojima
Drug metabolism and drug interactions, 2004 - Metabolic stability and uptake by human hepatocytes of pitavastatin, a new inhibitor of HMG-CoA reductase.
Hideki Fujino; Daisuke Nakai; Rie Nakagomi; Motoko Saito; Taro Tokui; Junji Kojima
Arzneimittel-Forschung, 2004 - Interaction between several medicines and statins.
Hideki Fujino; Tsuyoshi Saito; Yoshihiko Tsunenari; Junji Kojima
Arzneimittel-Forschung, 2003 - Studies on the interaction between fibrates and statins using human hepatic microsomes.
Hideki Fujino; Syunsuke Shimada; Iwao Yamada; Masaru Hirano; Yoshihiko Tsunenari; Junji Kojima
Arzneimittel-Forschung, 2003 - Interaction between fibrates and statins--metabolic interactions with gemfibrozil.
Hideki Fujino; Iwao Yamada; Shimada Shimada; Masaru Hirano; Yoshihiko Tsunenari; Junji Kojima
Drug metabolism and drug interactions, 2003 - Uptake mechanism of pitavastatin, a new inhibitor of HMG-CoA reductase, in rat hepatocytes.
Syunsuke Shimada; Hideki Fujino; Takashi Morikawa; Matsuko Moriyasu; Junji Kojima
Drug metabolism and pharmacokinetics, 2003 - Metabolic fate of pitavastatin (NK-104), a new inhibitor of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase. Effects on drug-metabolizing systems in rats and humans.
Hideki Fujino; Iwao Yamada; Syunsuke Shimada; Takeshi Nagao; Michiaki Yoneda
Arzneimittel-Forschung, 2002 - Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase--effect of cMOAT deficiency on hepatobiliary excretion in rats and of mdr1a/b gene disruption on tissue distribution in mice.
Hideki Fujino; Iwao Yamada; Syunsuke Shimada; Junji Kojima
Drug metabolism and pharmacokinetics, 2002 - Simultaneous determination of taxol and its metabolites in microsomal samples by a simple thin-layer chromatography radioactivity assay-inhibitory effect of NK-104, a new inhibitor of HMG-CoA reductase
FUJINO Hideki; YAMADA Iwao; SHIMADA Syunsuke; YONEDA Michiaki
Jun. 2001 - Simultaneous determination of taxol and its metabolites in microsomal samples by a simple thin-layer chromatography radioactivity assay — inhibitory effect of NK-104, a new inhibitor of HMG-CoA reductase
Hideki Fujino; Iwao Yamada; Syunsuke Shimada; Michiaki Yoneda
Journal of Chromatography B: Biomedical Sciences and Applications, Jun. 2001 - Studies on the Metabolic Fate of NK-104, a New Inhibitor of HMG-CoA Reductase. (5). In Vitro Metabolism and Plasma Protein Binding in Animals and Human.
FUJINO Hideki; YAMADA Iwao; KOJIMA Junji; HIRANO Masaru; MATSUMOTO Hiroo; YONEDA Michiaki
Drug Metabolism and Pharmacokinetics, 1999 - Identification of Metabolites of NK-104, an HMG-CoA Reductase Inhibitor, in Rat, Rabbit and Dog Bile.
KOJIMA Juniji; FUJINO Hideki; ABE Haruyasu; YOSIMURA Mitsuo; KANDA Hiroyasu; KIMATA Hideki
Biological and Pharmaceutical Bulletin, 1999 - Studies on the Metabolic Fate of NK-104, a New Inhibitor of HMG-CoA Reductase (1) : Absorption, Distribution, Metabolism and Excretion in Rats
KIMATA Hideki; FUJINO Hideki; KOIDE Takashi; YAMADA Yoichi; TSUNENARI Yoshihiko; YANAGAWA Yoshinobu
Xenobio Metabol Dispos, Oct. 1998 - Studies on the Metabolic Fate of NK-104, a New Inhibitor of HMG-CoA Reductase. (2). Absorption, Distribution, Metabolism, Excretion and Accumulation Following Repeated Oral Administration of 14C-NK-104 in Rats.
FUJINO Hideki; TSUNENARI Yoshihiko; KOIDE Takashi; YONEMITSU Masahiro; YANAGAWA Yoshinobu; KIMATA Hideki
Drug Metabolism and Pharmacokinetics, 1998 - Studies on the Metabolic Fate of NK-104, a New Inhibitor of HMG-CoA Reductase. (3). Foeto-placental Transfer and Mammary Excretion after Oral Administration in Rats.
FUJINO Hideki; MORIKAWA Shigeru; KANDA Hiroyasu; KIMATA Hideki
Drug Metabolism and Pharmacokinetics, 1998 - Regulation factor for planarian regeneration
Takao Shinozawa; Syuichi Shiozaki; Masanobu Ezaki; Hideki Fujino; Takeshi Tanaka; Toshihiko Saheki
Hydrobiologia: The International Journal of Aquatic Sciences, Jun. 1995
MISC
- Proposal of inspection method for radiation measuring instruments using commercial regents
栄井修平; 藤野秀樹
日本薬学会年会要旨集(Web), 2024 - Development a novel 40K quantification to prevent medical accident caused by potassium overdose
林泰成; 高橋美帆; 吉年勉; 栄井修平; 藤野秀樹; 藤野秀樹
日本薬学会年会要旨集(Web), 2024 - Development of drug-drug interaction simulator using physiologically-based pharmacokinetic model
林琢成; 吉年勉; 白石秀伍; 高橋美帆; 栄井修平; 藤野秀樹; 藤野秀樹
日本薬学会年会要旨集(Web), 2024 - Proposal of the physiologically-based pharmacokinetic model for quantitative prediction of drug-drug interactions.
吉年勉; 吉年勉; 林琢成; 白石秀伍; 栄井修平; 梅永真弓; 藤野秀樹; 藤野秀樹
日本薬学会年会要旨集(Web), 2024 - Radiation education for junior and senior high school students using the measuring of naturally occurring radioactive materials and gamification tool
藤野秀樹; 佐藤佳子; 白石秀伍; 林啄成; 栄井修平
日本薬学会年会要旨集(Web), 2024 - 2型糖尿病患者におけるナトリウム・グルコース共輸送体2阻害剤dapagliflozin投与後のHbA1c推移の変動要因の解明
栄井 修平; 河渕 真治; 伊藤 由佳子; 藤野 秀樹; 加藤 健一郎; 早川 哲雄; 栄田 敏之
TDM研究, Jun. 2023 - Development a novel 40K quantification to prevent medical accident caused by potassium overdose
栄井修平; 林泰成; 高橋美帆; 吉年勉; 藤野秀樹; 藤野秀樹
アイソトープ・放射線研究発表会(Web), 2023 - Proposal of radiation education using naturally occurring radioactive material in uncontrolled radiation area
吉年勉; 久保田飛翔; 田川優樹; 栄井修平; 藤野秀樹; 藤野秀樹
アイソトープ・放射線研究発表会(Web), 2023 - Proposal of a Utilization of Commercially Available Reagents in the Teaching and Learning of Radiation Safety
藤野秀樹; 浦元沙和; 小松理佳子
RADIOISOTOPES (Web), 2022 - Development of 14C Surface Sources for Imaging Plate Using an Ink-jet Printer
藤野秀樹; 永田瑛偲
RADIOISOTOPES (Web), 2022 - Proposal of educational programs using natural radioactive nuclides in the chemical reagents and atmosphere as radiation source
吉年勉; 船越司; 山本直輝; 山本拓夢; 涌水章史; 藤野秀樹; 藤野秀樹
アイソトープ・放射線研究発表会(Web), 2022 - Proposal of training programs using natural radioactive nuclides in the atmosphere after collecting with air cleaner as radiation source
船越司; 山本拓夢; 吉年勉; 藤野秀樹
アイソトープ・放射線研究発表会(Web), 2022 - Proposal of education and training programs using chemical reagents and the atmosphere after collecting with air cleaner as radiation sources
山本拓夢; 吉年勉; 船越司; 藤野秀樹
アイソトープ・放射線研究発表会(Web), 2022 - Basic Investigation for the development of interaction simulator between Kampo products and prescription drugs.
橋本佳奈; 木下淳; 神田浩里; 神田浩里; DAI Yi; DAI Yi; 天野学; 藤野秀樹
日本薬学会年会要旨集(Web), 2021 - Education and training programs using commercial available chemical reagents as radiation source
小松理佳子; 長谷川彩; 増田彩乃; 美甘里香菜; 藤野秀樹
日本薬学会年会要旨集(Web), Mar. 2020 - Educational programs for team based learning using commercial available reagents for radiation source
藤野秀樹
日本放射線安全管理学会学術大会講演予稿集, 2019 - Excel VBAを用いたグレープフルーツジュースとの薬物相互作用シミュレーターの構築及び新規利用法に関する研究
小倉摩耶; 寺田裕斗; 岡村悠希; 永田瑛偲; 藤野秀樹
日本薬学会年会要旨集(CD-ROM), Mar. 2018 - 肝及び消化管代謝過程の寄与を考慮した薬物相互作用の予測法
柏井奈緒; 武田彬伸; 辰野直樹; 藤島卓也; 堀翔太; 松井聡一郎; 九川文彦; 藤野秀樹
日本薬剤学会年会講演要旨集(CD-ROM), 2013 - HEPATIC CYP GENE EXPRESSION DEPENDS ON THE DIFFERENCE OF IMMUNOSTIMULATION PATHWAY
Moriya Nozomu; Kataoka Hiromi; Fujino Hideki; Nishikawa Jun-ichi; Kugawa Fumihiko
Abstracts of Annual meeting of Japanese Society for the Study of Xenobiotics, 2010 - INVOLVEMENT OF NFKB IN LPS INDUCED DOWNREGULATION OF NUCLEAR RECEPTOR MEDIATED HEPATIC CYP FAMILY GENE EXPRESSION
Moriya Nozomu; Kataoka Hiromi; Fujino Hideki; Nishikawa Jun-ichi; Kugawa Fumihiko
Abstracts of Annual meeting of Japanese Society for the Study of Xenobiotics, 2009 - CLASSIFICATION OF CLEARANCE ROUTES OF DRUGS BASED ON PHYSICOCHEMICAL PARAMETERS
Hirai Yuka; Kato Motohiro; Maeda Kazuya; Kitamura Yoshiaki; Ose Atsushi; Fujino Hideki; Sugiyama Yuichi
Abstracts of Annual meeting of Japanese Society for the Study of Xenobiotics, 2006 - CYP2C76-MEDIATED SPECIES DIFFERENCE IN DRUG METABOLISM: A COMPARISON OF PITAVASTATIN METABOLISM BETWEEN MONKEYS AND HUMANS
Fujino Hideki; Uno Yasuhiro; Kumano Takayuki; Kito Go; Nagata Ryoichi; Kamataki Tetsuya
Abstracts of Annual meeting of Japanese Society for the Study of Xenobiotics, 2006 - TRANSPORTER-MEDIATED INFLUX AND EFFLUX MECHANISMS OF PITAVASTATIN, A NEW INHIBITOR OF HMG-CoA REDUCTASE
Ogawa Shin-ichiro; Saito Tsuyoshi; Kojima Junji; Fujino Hideki
Abstracts of Annual meeting of Japanese Society for the Study of Xenobiotics, 2006 - HMG-CoA還元酵素阻害剤のCYPsおよびMDR1を介した薬物相互作用の評価
岩城晃一; 角本幹夫; 中村任; 岡村昇; 槙本博雄; 西口工司; 藤野秀樹; 奥村勝彦; 奥村勝彦; 奥村勝彦; 栄田敏之
日本医療薬学会年会講演要旨集, 2006 - 新規HMG-CoA還元酵素阻害薬ピタバスタチン(リバロ錠)の薬理及び薬物動態的特徴と臨床効果
山崎 裕之; 藤野 秀樹; 金澤 瑞穂; 玉木 太郎; 佐藤 文泰; 鈴木 幹夫; 北原 真樹
日本薬理学雑誌, May 2004 - Studies on metabolic fate of pitavastatin (NK-104), a new inhibitor of HMG-CoA reductase-Does glucronidation mediate the lactonization of pitavastatin?
FUJINO Hideki; YAMADA Iwao; SHIMADA Syunsuke; YONEDA Michiaki
17 Sep. 2001 - [14C]ニプラジロールのウサギにおける反復点眼後の深部網・脈絡膜中濃度の測定
小出 高志; 水野 憲; 恒成 嘉彦; 藤野 秀樹; 米田 道明; 吉村 三夫; 新家 眞
緑内障, Aug. 2000 - HMG-CoAリダクターゼの新規阻害剤であるNK-104のin vitroでの代謝作用
藤野 秀樹; 山田 巌; 高田 泰孝; 米田 道明; 木全 秀樹
薬物動態, Sep. 1999 - Simultaneous determination of NK-104 and its lactone in biological samples by column-switching high-performance liquid chromatography with ultraviolet detection
KOJIMA Junji; FUJINO Hideki; YOSIMURA Mitsuo; MORIKAWA Hiroaki; KIMATA Hideki
05 Mar. 1999 - Simultaneous determination of NK-104 and its lactone in biological samples by column-switching high-performance liquid chromatography with ultraviolet detection
Junji Kojima; Hideki Fujino; Mitsuo Yosimura; Hiroaki Morikawa; Hideki Kimata
Journal of Chromatography B: Biomedical Sciences and Applications, Mar. 1999 - Studies on the Metabolic Fate of NK-104, a New Inhibitor of HMG-CoA Reductase. (4). Interspecies Variation in Laboratory Animals and Humans.
FUJINO Hideki; KOJIMA Junji; YAMADA Youichi; KANDA Hiroyasu; KIMATA Hideki
Drug Metabolism and Pharmacokinetics, 1999 - HMG-CoA還元酵素の新抑制物質NK-104の代謝的運命についての研究(1)
木全 秀樹; 小島 順司; 藤野 秀樹; 山田 洋一; 小出 高志; 梁川 栄暢
薬物動態, Oct. 1998 - Metabolic Fate of [14C]KT-210 (Nipradilol Ophthalmic Solution) in Rabbits. (1); Absorption, Distribution, Metabolism and Excretion after Instillation, and Absorption, Excretion after Intravenous Administration to Rabbits.
小出高志; 藤野秀樹; 木全秀樹; 高尾厚志; 本多尚子; 山下久美子; 堀勝行; 石黒幸男; 折橋正浩
薬理と治療, Aug. 1996 - Development of pharmacometrical method for osteoporosis by 147Pm beta ray radiography - bone density measurement of oophorectomy rat.
藤野秀樹; 木全秀樹; 馬場茂雄; 朝原庸光
日本薬学会年会要旨集, Mar. 1996
Research Themes
- Proposal of a utilization of commercially available reagents in the teaching and learning of radiation safety
Grant-in-Aid for Scientific Research (C)
Hyogo Medical University
01 Apr. 2022 - 31 Mar. 2025 - Proposal of a utilization of commercially available reagents in the teaching and learning of radiation safety
Grant-in-Aid for Scientific Research (C)
Hyogo University of Health Sciences
01 Apr. 2019 - 31 Mar. 2022 - How do the immune disorders affect drug metabolism ?
Grant-in-Aid for Scientific Research (C)
Hyogo University of Health Sciences
01 Apr. 2010 - 31 Mar. 2015
