Last Updated :2024/09/13
Researcher Information
Career
- Jun. 2016 - Present
Hyogo College of Medicine, 主任教授 - Apr. 2013 - Present
理化学研究所生命医科学研究センター, 客員研究員 - Apr. 2012 - May 2016
Showa Pharmaceutical University, Faculty of Pharmaceutical Sciences, 教授 - Apr. 2004 - Mar. 2013
理化学研究所 免疫・アレルギー科学総合研究 センター, チームリーダー - Apr. 2001 - Mar. 2004
神戸大学大学院医学系研究科, 助教授 - Dec. 2000 - Mar. 2001
Kobe University, School of Medicine, 助手 - Dec. 1998 - Dec. 2000
Harvard University, ポストドクトラルフェロー - Apr. 1995 - Dec. 1998
Kobe University, School of Medicine, 助手
Research activity information
Paper
- Dysfunctional Sars-CoV-2-M protein-specific cytotoxic T lymphocytes in patients recovering from severe COVID-19.
Hideki Ogura; Jin Gohda; Xiuyuan Lu; Mizuki Yamamoto; Yoshio Takesue; Aoi Son; Sadayuki Doi; Kazuyuki Matsushita; Fumitaka Isobe; Yoshihiro Fukuda; Tai-Ping Huang; Takamasa Ueno; Naomi Mambo; Hiromoto Murakami; Yasushi Kawaguchi; Jun-Ichiro Inoue; Kunihiro Shirai; Sho Yamasaki; Jun-Ichi Hirata; Satoshi Ishido
Nature communications, Dec. 2022 - Importance of accessibility to the extracellular juxtamembrane stalk region of membrane protein for substrate recognition by viral ubiquitin ligase K5.
Mizuho Kajikawa; Mizuki Hata; Maho Ishimura; Nanae Imaizumi; Minako Kimura; Kei Miyano; Toyoyuki Ose; Daisuke Asai; Satoshi Ishido; Taisei Kanamoto
The Biochemical journal, Oct. 2022, [Reviewed] - Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation.
Takeshi Tokuyama; Hideki Uosaki; Ayumu Sugiura; Gen Nishitai; Keisuke Takeda; Shun Nagashima; Isshin Shiiba; Naoki Ito; Taku Amo; Satoshi Mohri; Akiyuki Nishimura; Motohiro Nishida; Ayumu Konno; Hirokazu Hirai; Satoshi Ishido; Takahiro Yoshizawa; Takayuki Shindo; Shingo Takada; Shintaro Kinugawa; Ryoko Inatome; Shigeru Yanagi
iScience, Jul. 2022, [Reviewed] - Kaposi's sarcoma-associated herpesvirus ubiquitin ligases downregulate cell surface expression of l-selectin.
Mizuho Kajikawa; Nanae Imaizumi; Shiho Machii; Tomoka Nakamura; Nana Harigane; Minako Kimura; Kei Miyano; Satoshi Ishido; Taisei Kanamoto
The Journal of general virology, Nov. 2021 - MITOL/MARCH5 determines the susceptibility of cardiomyocytes to doxorubicin-induced ferroptosis by regulating GSH homeostasis.
Hiroki Kitakata; Jin Endo; Hirokazu Matsushima; Shoichi Yamamoto; Hidehiko Ikura; Akeo Hirai; Seien Koh; Genki Ichihara; Takahiro Hiraide; Hidenori Moriyama; Kohsuke Shirakawa; Shinichi Goto; Yoshinori Katsumata; Atsushi Anzai; Masaharu Kataoka; Takeshi Tokuyama; Satoshi Ishido; Shigeru Yanagi; Keiichi Fukuda; Motoaki Sano
Journal of molecular and cellular cardiology, Aug. 2021 - Identification of highest neurotoxic amyloid-β plaque type showing reduced contact with astrocytes.
Mikihiro Mitsubori; Keisuke Takeda; Shun Nagashima; Satoshi Ishido; Masaaki Matsuoka; Ryoko Inatome; Shigeru Yanagi
Biochemical and biophysical research communications, Apr. 2021 - Mitochondrial ubiquitin ligase alleviates Alzheimer's disease pathology via blocking the toxic amyloid-β oligomer generation.
Keisuke Takeda; Aoi Uda; Mikihiro Mitsubori; Shun Nagashima; Hiroko Iwasaki; Naoki Ito; Isshin Shiiba; Satoshi Ishido; Masaaki Matsuoka; Ryoko Inatome; Shigeru Yanagi
Communications biology, Feb. 2021 - MITOL dysfunction causes dwarfism with anterior pituitary hypoplasia.
Keigo Matsuno; Shun Nagashima; Isshin Shiiba; Keito Taniwaka; Keisuke Takeda; Takeshi Tokuyama; Naoki Ito; Nobuko Matsushita; Toshifumi Fukuda; Satoshi Ishido; Ryoko Inatome; Shigeru Yanagi
Journal of biochemistry, Apr. 2020, [Reviewed] - Membrane-Associated RING-CH (MARCH) proteins down-regulate cell surface expression of the interleukin-6 receptor alpha chain (IL6Ra).
Babon JJ; Stockwell D; DiRago L; Zhang JG; Laktyushin A; Villadangos J; Ching A; Ishido S; Hilton DJ; Alexander WS; Nicola NA
The Biochemical journal, Sep. 2019, [Reviewed] - MITOL prevents ER stress-induced apoptosis by IRE1α ubiquitylation at ER-mitochondria contact sites.
Keisuke Takeda; Shun Nagashima; Isshin Shiiba; Aoi Uda; Takeshi Tokuyama; Naoki Ito; Toshifumi Fukuda; Nobuko Matsushita; Satoshi Ishido; Takao Iwawaki; Takashi Uehara; Ryoko Inatome; Shigeru Yanagi
The EMBO journal, Aug. 2019, [Reviewed] - MITOL deletion in the brain impairs mitochondrial structure and ER tethering leading to oxidative stress.
Nagashima S; Takeda K; Ohno N; Ishido S; Aoki M; Saitoh Y; Takada T; Tokuyama T; Sugiura A; Fukuda T; Matsushita N; Inatome R; Yanagi S
Life science alliance, Aug. 2019, [Reviewed] - MITOL prevents ER stress-induced apoptosis by IRE1α ubiquitylation at ER-mitochondria contact sites.
Takeda K; Nagashima S; Shiiba I; Uda A; Tokuyama T; Ito N; Fukuda T; Matsushita N; Ishido S; Iwawaki T; Uehara T; Inatome R; Yanagi S
The EMBO journal, Jun. 2019, [Reviewed] - MHC class II fine tuning by ubiquitination: lesson from MARCHs.
Ishido S; Kajikawa M
Immunogenetics, Mar. 2019, [Reviewed] - March1-dependent modulation of donor MHC II on CD103+ dendritic cells mitigates alloimmunity.
Borges TJ; Murakami N; Machado FD; Murshid A; Lang BJ; Lopes RL; Bellan LM; Uehara M; Antunes KH; Pérez-Saéz MJ; Birrane G; Vianna P; Gonçalves JIB; Zanin RF; Azzi J; Abdi R; Ishido S; Shin JS; Souza APD; Calderwood SK; Riella LV; Bonorino C
Nature communications, Aug. 2018, [Reviewed] - MAR CH1 protects the lipid raft and tetraspanin web from MHC II proteotoxicity in dendritic cells
Jaehak Oh; Justin S.A. Perry; Heather Pua; Nicole Irgens-Möller; Satoshi Ishido; Chyi-Song Hsieh; Jeoung-Sook Shin
Journal of Cell Biology, Apr. 2018, [Reviewed] - March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation.
Kishta OA; Sabourin A; Simon L; McGovern T; Raymond M; Galbas T; Majdoubi A; Ishido S; Martin JG; Thibodeau J
Journal of immunology research, 2018, [Reviewed] - MARCH1-mediated ubiquitination of MHC II impacts the MHC I antigen presentation pathway.
Wilson KR; Liu H; Healey G; Vuong V; Ishido S; Herold MJ; Villadangos JA; Mintern JD
PloS one, 2018, [Reviewed] - The E3 ubiquitin ligase MARCH1 regulates glucose-tolerance and lipid storage in a sex-specific manner.
Bhagwandin C; Ashbeck EL; Whalen M; Bandola-Simon J; Roche PA; Szajman A; Truong SM; Wertheim BC; Klimentidis YC; Ishido S; Renquist BJ; Lybarger L
PloS one, 2018, [Reviewed] - Inflammasome and Fas-Mediated IL-1 beta Contributes to Th17/Th1 Cell Induction in Pathogenic Bacterial Infection In Vivo
Ryosuke Uchiyama; Shin Yonehara; Shun'ichiro Taniguchi; Satoshi Ishido; Ken J. Ishii; Hiroko Tsutsui
JOURNAL OF IMMUNOLOGY, Aug. 2017, [Reviewed] - MARCH1 E3 Ubiquitin Ligase Dampens the Innate Inflammatory Response by Modulating Monocyte Functions in Mice
Tristan Galbas; Maxime Raymond; Antoine Sabourin; Marie-Claude Bourgeois-Daigneault; Fanny Guimont-Desrochers; Tae Jin Yun; Jean-Francois Cailhier; Satoshi Ishido; Sylvie Lesage; Cheolho Cheong; Jacques Thibodeau
JOURNAL OF IMMUNOLOGY, Jan. 2017, [Reviewed] - The K48-K63 Branched Ubiquitin Chain Regulates NF-kappa B Signaling
Fumiaki Ohtake; Yasushi Saeki; Satoshi Ishido; Jun Kanno; Keiji Tanaka
MOLECULAR CELL, Oct. 2016, [Reviewed] - Ubiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection
Haiyin Liu; Reema Jain; Jing Guan; Vivian Vuong; Satoshi Ishido; Nicole L. La Gruta; Daniel H. Gray; Jose A. Villadangos; Justine D. Mintern
JOURNAL OF EXPERIMENTAL MEDICINE, Aug. 2016, [Reviewed] - Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83
Julia von Rohrscheidt; Elisabetta Petrozziello; Jelena Nedjic; Christine Federle; Lena Krzyzak; Hidde L. Ploegh; Satoshi Ishido; Alexander Steinkasserer; Ludger Klein
JOURNAL OF EXPERIMENTAL MEDICINE, Aug. 2016, [Reviewed] - Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses
Oliver Bannard; Simon J. McGowan; Jonatan Ersching; Satoshi Ishido; Gabriel D. Victora; Jeoung-Sook Shin; Jason G. Cyster
JOURNAL OF EXPERIMENTAL MEDICINE, May 2016, [Reviewed] - Interleukin 10 (IL-10)-mediated Immunosuppression: MARCH-I INDUCTION REGULATES ANTIGEN PRESENTATION BY MACROPHAGES BUT NOT DENDRITIC CELLS
Sharad K. Mittal; Kyung-Jin Cho; Satoshi Ishido; Paul A. Roche
JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2015, [Reviewed] - Ubiquitination by March-I prevents MHC class II recycling and promotes MHC class II turnover in antigen-presenting cells
Kyung-Jin Cho; Even Walseng; Satoshi Ishido; Paul A. Roche
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Aug. 2015, [Reviewed] - Loss of MHC II ubiquitination inhibits the activation and differentiation of CD4 T cells
Rikiya Ishikawa; Mizuho Kajikawa; Satoshi Ishido
INTERNATIONAL IMMUNOLOGY, May 2014, [Reviewed] - Multidimensional Umbrella Sampling and Replica-Exchange Molecular Dynamics Simulations for Structure Prediction of Transmembrane Helix Dimers
Pai-Chi Li; Naoyuki Miyashita; Wonpil Im; Satoshi Ishido; Yuji Sugita
JOURNAL OF COMPUTATIONAL CHEMISTRY, Feb. 2014, [Reviewed] - MITOL Regulates Endoplasmic Reticulum-Mitochondria Contacts via Mitofusin2
Ayumu Sugiura; Shun Nagashima; Takeshi Tokuyama; Taku Amo; Yohei Matsuki; Satoshi Ishido; Yoshihisa Kudo; Heidi M. McBride; Toshifumi Fukuda; Nobuko Matsushita; Ryoko Inatome; Shigeru Yanagi
MOLECULAR CELL, Jul. 2013, [Reviewed] - MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells
Jaehak Oh; Nan Wu; Guenther Baravalle; Benjamin Cohn; Jessica Ma; Bryan Lo; Ira Mellman; Satoshi Ishido; Mark Anderson; Jeoung-Sook Shin
JOURNAL OF EXPERIMENTAL MEDICINE, Jun. 2013, [Reviewed] - Tollip-induced down-regulation of MARCH1
Marie-Claude Bourgeois-Daigneault; Abdul Mohammad Pezeshki; Tristan Galbas; Mathieu Houde; Martin Baril; Klaus Früh; Abdelaziz Amrani; Satoshi Ishido; Daniel Lamarre; Jacques Thibodeau
Results in Immunology, 2013, [Reviewed] - HSP90 alpha deficiency does not affect immunoglobulin gene hypermutation and class switch but causes enhanced MHC class II antigen presentation
Yingqian Li; Shuyin Li; Mari Hoshino; Rikiya Ishikawa; Chiaki Kajiwara; Xiang Gao; Yaofeng Zhao; Satoshi Ishido; Heiichiro Udono; Ji-Yang Wang
INTERNATIONAL IMMUNOLOGY, Dec. 2012, [Reviewed] - Encounter with antigen-specific primed CD4 T cells promotes MHC class II degradation in dendritic cells
Kazuyuki Furuta; Satoshi Ishido; Paul A. Roche
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Nov. 2012, [Reviewed] - Spermatogenesis arrest caused by conditional deletion of Hsp90 alpha in adult mice
Chiaki Kajiwara; Shiho Kondo; Shizuha Uda; Lei Dai; Tomoko Ichiyanagi; Tomoki Chiba; Satoshi Ishido; Takehiko Koji; Heiichiro Udono
BIOLOGY OPEN, Oct. 2012, [Reviewed] - MARCH1 down-regulation in IL-10-activated B cells increases MHC class II expression
Tristan Galbas; Viktor Steimle; Rejean Lapointe; Satoshi Ishido; Jacques Thibodeau
CYTOKINE, Jul. 2012, [Reviewed] - The Intertransmembrane Region of Kaposi's Sarcoma-Associated Herpesvirus Modulator of Immune Recognition 2 Contributes to B7-2 Downregulation
Mizuho Kajikawa; Pai-Chi Li; Eiji Goto; Naoyuki Miyashita; Masami Aoki-Kawasumi; Mari Mito-Yoshida; Mika Ikegaya; Yuji Sugita; Satoshi Ishido
JOURNAL OF VIROLOGY, May 2012, [Reviewed] - Francisella tularensis Elicits IL-10 via a PGE2-Inducible Factor, to Drive Macrophage MARCH1 Expression and Class II Down-Regulation
Danielle Hunt; Justin E. Wilson; Karis A. Weih; Satoshi Ishido; Jonathan A. Harton; Paul A. Roche; James R. Drake
PLOS ONE, May 2012, [Reviewed] - The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane
Hidetaka Tanno; Teppei Yamaguchi; Eiji Goto; Satoshi Ishido; Masayuki Komada
MOLECULAR BIOLOGY OF THE CELL, Apr. 2012, [Reviewed] - 3B1022 A computational Investigation into the MHC-I Recognition Mechanism of MIR2 from Kaposi's Sarcoma-Associated Herpesvirus(Proteins:Structure & Function III:Dynamics and Circadian Rhythm,Oral Presentation,The 50th Annual Meeting of the Biophysical Society of Japan)
Li Pai-Chi; Miyashita Naoyuki; Ishido Satoshi; Sugita Yuji
Seibutsu Butsuri, 2012 - Ubiquitination of CD86 Is a Key Mechanism in Regulating Antigen Presentation by Dendritic Cells
Guenther Baravalle; Hyesuk Park; Megan McSweeney; Mari Ohmura-Hoshino; Yohei Matsuki; Satoshi Ishido; Jeoung-Sook Shin
JOURNAL OF IMMUNOLOGY, Sep. 2011, [Reviewed] - Anti-arthritic effect of E3 ubiquitin ligase, c-MIR, expression in the joints
Masayasu Toyomoto; Satoshi Ishido; Nobuyuki Miyasaka; Hachiro Sugimoto; Hitoshi Kohsaka
INTERNATIONAL IMMUNOLOGY, Mar. 2011, [Reviewed] - 3G1534 A multi-dimensional umbrella sampling approach for structure prediction of transmembrane helical dimer(3G Protein: Structure 4,The 49th Annual Meeting of the Biophysical Society of Japan)
Li Pai-Chi; Miyashita Naoyuki; Ishido Satoshi; Sugita Yuji
Seibutsu Butsuri, 2011 - CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation
Lina E. Tze; Keisuke Horikawa; Heather Domaschenz; Debbie R. Howard; Carla M. Roots; Robert J. Rigby; David A. Way; Mari Ohmura-Hoshino; Satoshi Ishido; Christopher E. Andoniou; Mariapia A. Degli-Esposti; Christopher C. Goodnow
JOURNAL OF EXPERIMENTAL MEDICINE, Jan. 2011, [Reviewed] - Contribution of Lysine 11-linked Ubiquitination to MIR2-mediated Major Histocompatibility Complex Class I Internalization
Eiji Goto; Yuko Yamanaka; Akiyo Ishikawa; Masami Aoki-Kawasumi; Mari Mito-Yoshida; Mari Ohmura-Hoshino; Yohei Matsuki; Mizuho Kajikawa; Hisashi Hirano; Satoshi Ishido
JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2010, [Reviewed] - Ubiquitination regulates MHC class II-peptide complex retention and degradation in dendritic cells
Even Walseng; Kazuyuki Furuta; Berta Bosch; Karis A. Weih; Yohei Matsuki; Oddmund Bakke; Satoshi Ishido; Paul A. Roche
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Nov. 2010, [Reviewed] - MARCH-I: A new regulator of dendritic cell function
Satoshi Ishido; Yohei Matsuki; Eiji Goto; Mizuho Kajikawa; Mari Ohmura-Hoshino
MOLECULES AND CELLS, Mar. 2010, [Reviewed] - 2P042 Molecular dynamics study of transmembrane segments of MIRs(The 48th Annual Meeting of the Biophysical Society of Japan)
Li Pai-Chi; Miyashita Naoyuki; Ishido Satoshi; Sugita Yuji
Seibutsu Butsuri, 2010 - Cutting Edge: Requirement of MARCH-I-Mediated MHC II Ubiquitination for the Maintenance of Conventional Dendritic Cells
Mari Ohmura-Hoshino; Yohei Matsuki; Mari Mito-Yoshida; Eiji Goto; Masami Aoki-Kawasumi; Manabu Nakayama; Osamu Ohara; Satoshi Ishido
JOURNAL OF IMMUNOLOGY, Dec. 2009, [Reviewed] - E3 ubiquitin ligases for MHC molecules
Satoshi Ishido; Eiji Goto; Yohei Matsuki; Mari Ohmura-Hoshino
CURRENT OPINION IN IMMUNOLOGY, Feb. 2009, [Reviewed] - [Novel immune regulation by ubiquitination].
Ishido S; Hoshino M; Matsuki Y; Goto E; Mito M; Aoki M
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Dec. 2008, [Reviewed] - Hepatitis C Virus Infection Induces Apoptosis through a Bax-Triggered, Mitochondrion-Mediated, Caspase 3-Dependent Pathway
Lin Deng; Tetsuya Adachi; Kikumi Kitayama; Yasuaki Bungyoku; Sohei Kitazawa; Satoshi Ishido; Ikuo Shoji; Hak Hotta
JOURNAL OF VIROLOGY, Nov. 2008, [Reviewed] - Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells
Louise J. Young; Nicholas S. Wilson; Petra Schnorrer; Anna Proietto; Toine ten Broeke; Yohei Matsuki; Adele M. Mount; Gabrielle T. Belz; Meredith O'Keeffe; Mari Ohmura-Hoshino; Satoshi Ishido; Willem Stoorvogel; William R. Heath; Ken Shortman; Jose A. Villadangos
NATURE IMMUNOLOGY, Nov. 2008, [Reviewed] - An Excellent Monitoring System for Surface Ubiquitination-Induced Internalization in Mammals
Eiji Goto; Mari Mito-Yoshida; Mika Uematsu; Masami Aoki; Yohei Matsuki; Mari Ohmura-Hoshino; Hak Hotta; Makoto Miyagishi; Satoshi Ishido
PLOS ONE, Jan. 2008, [Reviewed] - Novel regulation of MHC class II function in B cells
Yohei Matsuki; Mari Ohmura-Hoshino; Eiji Goto; Masami Aoki; Mari Mito-Yoshida; Mika Uematsu; Takanori Hasegawa; Haruhiko Koseki; Osamu Ohara; Manabu Nakayama; Kiminori Toyooka; Ken Matsuoka; Hak Hotta; Akitsugu Yamamoto; Satoshi Ishido
EMBO JOURNAL, Feb. 2007, [Reviewed] - Difference in production of infectious wild-type measles and vaccine viruses in monocyte-derived dendritic cells
Kaori Ohgimoto; Shinji Ohgimoto; Toshiaki Ihara; Hiroyuki Mizuta; Satoshi Ishido; Minoru Ayata; Hisashi Ogura; Hak Hotta
VIRUS RESEARCH, Jan. 2007, [Reviewed] - A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics
Ryo Yonashiro; Satoshi Ishido; Shinkou Kyo; Toshifumi Fukuda; Eiji Goto; Yohei Matsuki; Mari Ohmura-Hoshino; Kiyonao Sada; Hak Hotta; Hirohei Yamamura; Ryoko Inatome; Shigeru Yanagi
EMBO JOURNAL, Aug. 2006, [Reviewed] - A novel family of membrane-bound E3 ubiquitin ligases
Mari Ohmura-Hoshino; Eiji Goto; Yohei Matsuki; Masami Aoki; Mari Mito; Mika Uematsu; Hak Hotta; Satoshi Ishido
JOURNAL OF BIOCHEMISTRY, Aug. 2006, [Reviewed] - Non-structural protein 4A of Hepatitis C virus accumulates on mitochondria and renders the cells prone to undergoing mitochondria-mediated apoptosis
Y Nomura-Takigawa; M Nagano-Fujii; L Deng; S Kitazawa; S Ishido; K Sada; H Hotta
JOURNAL OF GENERAL VIROLOGY, Jul. 2006, [Reviewed] - Inhibition of MHC class II expression and immune responses by c-MIR
M Ohmura-Hoshino; Y Matsuki; M Aoki; E Goto; M Mito; M Uematsu; T Kakiuchi; H Hotta; S Ishido
JOURNAL OF IMMUNOLOGY, Jul. 2006, [Reviewed] - [Immune modulation by KSHV].
Goto E; Hoshino M; Matsuki Y; Mito M; Ishido S
Nihon rinsho. Japanese journal of clinical medicine, Mar. 2006, [Reviewed] - Single-point mutations of hepatitis C virus NS3 that impair p53 interaction and anti-apoptotic activity of NS3
M Tanaka; M Nagano-Fujii; L Deng; S Ishido; K Sada; H Hotta
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 2006, [Reviewed] - Hepatitis C virus NS5A protein interacts with 2 ',5 '-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner
T Taguchi; M Nagano-Fujii; M Akutsu; H Kadoya; S Ohgimoto; S Ishido; H Hotta
JOURNAL OF GENERAL VIROLOGY, Apr. 2004, [Reviewed] - AIRE functions as an E3 ubiquitin ligase
D Uchida; S Hatakeyama; A Matsushima; HW Han; S Ishido; H Hotta; J Kudoh; N Shimizu; Doucas, V; KI Nakayama; N Kuroda; M Matsumoto
JOURNAL OF EXPERIMENTAL MEDICINE, Jan. 2004, [Reviewed] - C-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity
E Goto; S Ishido; Y Sato; S Ohgimoto; K Ohgimoto; M Nagano-Fujii; H Hotta
JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2003, [Reviewed] - [Viral strategies of interference with MHC functions].
Ishido S; Goto E; Sato Y; Hotta H
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Dec. 2002, [Reviewed] - Multiple endocytic trafficking pathways of MHC class I molecules induced by a Herpesvirus protein
RE Means; S Ishido; Alvarez, X; JU Jung
EMBO JOURNAL, Apr. 2002, [Reviewed] - Regulation of tyrosine phosphorylation of PYK2 in vascular endothelial cells by lysophosphatidylcholine
Y Rikitake; S Kawashima; T Takahashi; T Ueyama; S Ishido; N Inoue; K Hirata; M Yokoyama
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Jul. 2001, [Reviewed] - Inhibition of p21/Waf1/Cip1/Sdi1 expression by hepatitis C virus core protein
Yoshida, I; K Oka; R Hidajat; M Nagano-Fujii; S Ishido; H Hotta
MICROBIOLOGY AND IMMUNOLOGY, 2001, [Reviewed] - The collagen repeat sequence is a determinant of the degree of herpesvirus saimiri STP transforming activity
JK Choi; S Ishido; JU Jung
JOURNAL OF VIROLOGY, Sep. 2000, [Reviewed] - Nuclear localization and intramolecular cleavage of N-terminally deleted NS5A protein of hepatitis C virus
J Song; M Nagano-Fujii; F Wang; R Florese; T Fujita; S Ishido; H Hotta
VIRUS RESEARCH, Sep. 2000, [Reviewed] - Inhibition of natural killer cell-mediated cytotoxicity by kaposi's sarcoma-associated herpesvirus K5 protein
S Ishido; JK Choi; BS Lee; CY Wang; M DeMaria; RP Johnson; GB Cohen; JU Jung
IMMUNITY, Sep. 2000, [Reviewed] - Complex formation between hepatitis C virus core protein and p21Waf1/Cip1/Sdi1
F Wang; Yoshida, I; M Takamatsu; S Ishido; T Fujita; K Oka; H Hotta
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jul. 2000, [Reviewed] - Inhibition of intracellular transport of B cell antigen receptor complexes by Kaposi's sarcoma-associated herpesvirus K1
BS Lee; Alvarez, X; S Ishido; AA Lackner; JU Jung
JOURNAL OF EXPERIMENTAL MEDICINE, Jul. 2000, [Reviewed] - Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins
S Ishido; CY Wang; BS Lee; GB Cohen; JU Jung
JOURNAL OF VIROLOGY, Jun. 2000, [Reviewed] - Requirement of activation of the extracellular signal-regulated kinase cascade in myocardial cell hypertrophy
T Ueyama; S Kawashima; T Sakoda; Y Rikitake; T Ishida; M Kawai; T Yamashita; S Ishido; H Hotta; M Yokoyama
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Jun. 2000, [Reviewed] - Lysophosphatidylcholine inhibits endothelial cell migration and proliferation via inhibition of the extracellular signal-regulated kinase pathway
Y Rikitake; S Kawashima; T Yamashita; T Ueyama; S Ishido; H Hotta; K Hirata; M Yokoyama
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Apr. 2000, [Reviewed] - Viral load in Indonesian patients with chronic liver disease and in blood donors infected with different subtypes of hepatitis C virus
MI Lusida; Soetjipto; R Handajani; CA Nidom; Soemarto; S Darmadi; P Adi; M Fujii; T Fujita; S Ishido; H Hotta
JAPANESE JOURNAL OF INFECTIOUS DISEASES, Apr. 2000, [Reviewed] - Possible Involvement of the NS3 Protein of Hepatitis C Virus in Hepatocarcinogenesis : Its Interaction with the p53 Tumor Suppressor.
Ishido S; Fujita T; Hotta H
Methods in molecular medicine, 2000, [Reviewed] - Complex formation of the nonstructural protein 3 of hepatitis C virus with the p53 tumor suppressor
S Ishido; H Hotta
FEBS LETTERS, Nov. 1998, [Reviewed] - Complex formation of NS5B with NS3 and NS4A proteins of hepatitis C virus
S Ishido; T Fujita; H Hotta
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 1998, [Reviewed] - Follow-up study of hypervariable region sequences of the hepatitis C virus (HCV) genome in an infant with delayed anti-HCV antibody responses
Y Katayama; H Tajiri; K Tada; S Okada; WY Tong; S Ishido; H Hotta
MICROBIOLOGY AND IMMUNOLOGY, 1998, [Reviewed] - Nuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization
S Muramatsu; S Ishido; T Fujita; M Itoh; H Hotta
JOURNAL OF VIROLOGY, Jul. 1997, [Reviewed] - GB virus C hepatitis G virus (GBV-C/HGV) infection in Chiang Mai, Thailand, and identification of variants on the basis of 5 '-untranslated region sequences
Y Katayama; C Apichartpiyakul; R Handajani; S Ishido; H Hotta
ARCHIVES OF VIROLOGY, 1997, [Reviewed] - Wild-type, but not mutant-type, p53 enhances nuclear accumulation of the NS3 protein of hepatitis C virus
S Ishido; S Muramatsu; T Fujita; Y Iwanaga; WY Tong; Y Katayama; M Itoh; H Hotta
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 1997, [Reviewed] - Differential prevalence of hepatitis C virus subtypes in healthy blood donors, patients on maintenance hemodialysis, and patients with hepatocellular carcinoma in Surabaya, Indonesia
Soetjipto; R Handajani; MI Lusida; S Darmadi; P Adi; Soemarto; S Ishido; Y Katayama; H Hotta
JOURNAL OF CLINICAL MICROBIOLOGY, Dec. 1996, [Reviewed] - Suppression of actinomycin D-induced apoptosis by the NS3 protein of hepatitis C virus
T Fujita; S Ishido; S Muramatsu; M Itoh; H Hotta
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 1996, [Reviewed] - Hepatitis C virus infection-associated markers in sera from blood donors in Surabaya, Indonesia
S Darmadi; Soetjipto; R Handajani; MI Lusida; Soemarto; H Sakugawa; S Ishido; H Hotta
MICROBIOLOGY AND IMMUNOLOGY, 1996, [Reviewed] - Genotype analysis of hepatitis C virus among blood donors and inmates in Metro Manila, the Philippines
Y Katayama; NG Barzaga; A Alipio; Soetjipto; H Doi; S Ishido; H Hotta
MICROBIOLOGY AND IMMUNOLOGY, 1996, [Reviewed] - SIGNIFICANCE OF DETECTION OF ENTEROVIRUS RNA IN MYOCARDIAL TISSUES BY REVERSE TRANSCRIPTION-POLYMERASE CHAIN-REACTION
H UENO; Y YOKOTA; H SHIOTANI; M YOKOYAMA; H ITOH; S ISHIDO; S MAEDA; Y KATAYAMA; H HOTTA
INTERNATIONAL JOURNAL OF CARDIOLOGY, Sep. 1995, [Reviewed] - DETECTION OF TRANSFORMING GROWTH-FACTOR-BETA-1 IN COXSACKIE B3 VIRUS-INDUCED MURINE MYOCARDITIS
S ISHIDO; M SAKAUE; K ASAKA; S MAEDA
ACTA HISTOCHEMICA ET CYTOCHEMICA, 1995, [Reviewed] - DNA resynthesis and binucleated metamorphosis in cardiac muscle cells after isoproterenol-induced injury: bromodeoxyuridine immunohistochemistry.
Ishido S; Yokoyama M; Kitazawa S; Maeda S
The American journal of cardiovascular pathology, 1995, [Reviewed] - FENTANYL FOR SEDATION DURING UPPER GASTROINTESTINAL ENDOSCOPY
S ISHIDO; Y KINOSHITA; N KITAJIMA; T ITOH; K NISHIYAMA; M TOJO; T YANO; T INATOME; H FUKUZAKI; T CHIBA
GASTROINTESTINAL ENDOSCOPY, Nov. 1992, [Reviewed] - GASTROESOPHAGEAL REFLUX AFTER ENDOSCOPIC INJECTION SCLEROTHERAPY
Y KINOSHITA; N KITAJIMA; T ITOH; S ISHIDO; K NISHIYAMA; C KAWANAMI; K KISHI; T INATOME; H FUKUZAKI; T CHIBA
AMERICAN JOURNAL OF GASTROENTEROLOGY, Mar. 1992, [Reviewed] - ARTERIAL OXYGEN-SATURATION, BLOOD-PRESSURE, AND PULSE-RATE DURING UPPER GASTROINTESTINAL ENDOSCOPY - INFLUENCE OF SEDATION AND AGE
Y KINOSHITA; S ISHIDO; K NISHIYAMA; N KITAJIMA; T ITOH; T INATOME; T INOH; H FUKUZAKI; T CHIBA
JOURNAL OF CLINICAL GASTROENTEROLOGY, Dec. 1991, [Reviewed]
MISC
- Immune regulation by MARCH family members
石戸 聡
臨床免疫・アレルギー科 = Clinical immunology & allergology, Oct. 2016 - MHC class II恒常的ユビキチン化モデルマウスの解析
小泉龍士; 嶋秀明; 梶川瑞穂; 井上能博; 石戸聡; 石戸聡
Pharmaco-Hematologyシンポジウム講演要旨集, 03 Sep. 2016 - MARCH E3 ligases and ubiquitination events that shape immunity
J. D. Mintern; H. Liu; A. Ching; P. Huang; S. Ishido; J. A. Villadangos
EUROPEAN JOURNAL OF IMMUNOLOGY, Aug. 2016 - The ubiquitin ligase MARCH 1 regulates complement C3 deposition on professional antigen presenting cells
J. Villadangos; A. Ching; G. Infusini; J. Moffat; S. Ishido; J. Mintern
EUROPEAN JOURNAL OF IMMUNOLOGY, Aug. 2016 - Loss of MHC II ubiquitination induces negative consequence to dendritic cells
Satoshi Ishido; Mizuho Kajikawa
MOLECULAR IMMUNOLOGY, Dec. 2015 - Examining a potential link between antigen presentation and metabolic dysregulation
Candida Bhagwandin; Michael Whalen; Satoshi Ishido; Adam Szajman; Sarah Truong; Tsu-Shuen Tsao; Lonnie Lybarger
JOURNAL OF IMMUNOLOGY, May 2014 - 膜貫通型E3ユビキチンリガーゼMIRファミリーによる基質認識
KAJIKAWA MIZUHO; LI PAI-CHI; KIMURA MINAKO; AOKI(KAWASUMI) MASAMI; MITO MARI; MIYASHITA NAOYUKI; SUGITA YUJI; ISHIDO SATOSHI
日本分子生物学会年会プログラム・要旨集(Web), 2014 - KSHV免疫回避分子MIRによる免疫受容体の認識機構
KAJIKAWA MIZUHO; AOKI MASAMI; LI PAI-CHI; MITO MARI; MIYASHITA NAOYUKI; SUGITA YUJI; ISHIDO SATOSHI
日本ウイルス学会学術集会プログラム・抄録集, 31 Oct. 2012 - Encounter with antigen-specific CD4 T cells promotes down-regulation of MHC-II in Dendritic cells
Kazuyuki Furuta; Satoshi Ishido; Paul Roche
JOURNAL OF IMMUNOLOGY, May 2012 - MHC-II crosslinking promotes lipid-raft dependent MHC-II clustering, endocytosis, and degradation in dendritic cells
Paul Roche; Kazuyuki Furuta; Satoshi Ishido
MOLECULAR IMMUNOLOGY, May 2012 - カポジ肉腫関連ヘルペスウイルス免疫回避分子MIR2によるB7‐2認識の分子基盤
KAJIKAWA MIZUHO; GOTO EIJI; LI PAI-CHI; MIYASHITA NAOYUKI; AOKI(KAWASUMI) MASAMI; MITO(YOSHIDA) MARI; SUGITA YUJI; ISHIDO SATOSHI
日本蛋白質科学会年会プログラム・要旨集, 27 May 2011 - MIRファミリーによるK11/K63混合型ポリユビキチン鎖を介した免疫関連分子の制御機構
GOTO EIJI; MITO MARI; AOKI MASAMI; MATSUKI YOHEI; HOSHINO MARI; KAJIKAWA MIZUHO; ISHIDO SATOSHI
日本ウイルス学会学術集会プログラム・抄録集, 15 Oct. 2010 - A novel E3 ubiquitin ligase down-regulates MHC class 2
星野 真理; 石戸 聡
Clinical immunology & allergology, Feb. 2007 - Inhibition of MHC class II expression and immune responses by c-MIR (vol 177, pg 341, 2006)
M. Ohmura-Hoshino; Y. Matsuki; M. Aoki; E. Goto; M. Mito; M. Uematsu; T. Kakiuchi; H. Hotta; S. Ishido
JOURNAL OF IMMUNOLOGY, Sep. 2006 - 【免疫2004】 病気と免疫 新たな免疫抑制性E3ユビキチンリガーゼファミリー
ISHIDO,Satoshi; 後藤栄治; 松木洋平; 佐藤祐也; HOTTA, Haku
Molecular Medicine, Dec. 2003 - AIRE(autoimmune regulator)はPHDドメインを介してUbiquitin E3 ligase活性を発揮する
黒田範行; 内田大亮; 畠山鎮次; 松島明美; 石戸聡; 工藤純; 清水信義; 中山敬一; 松本満
日本分子生物学会年会プログラム・講演要旨集, 25 Nov. 2003 - ウイルスによる抗原提示抑制機構 (免疫研究の最前線--高次複雑系免疫システムの包括的理解をめざして) -- (樹状細胞・抗原プロセシングと免疫応答)
石戸 聰; 後藤 栄治; 佐藤 祐也
蛋白質核酸酵素, Dec. 2002 - Immune evasion strategies of Kaposi's sarcoma-associated herpesvirus
RE Means; JK Choi; H Nakamura; YH Chung; S Ishido; JU Jung
VIRAL PROTEINS COUNTERACTING HOST DEFENSES, 2002 - E-P30 心筋炎における Transforming Growth Factor-β1の発現および局在
石戸 聡; 片山 友子; 堀田 博; 本間 守男; 横山 光宏; 前田 盛
日本組織細胞化学会総会プログラムおよび抄録集, 1993 - SIGNIFICANCE OF DETECTION OF ENTEROVIRUS RNA IN MYOCARDIAL TISSUES BY PCR
H UENO; Y YOKOTA; H ITOH; S ISHIDO; S KITAZAWA; S MAEDA; Y KATAYAMA; H HOTTA; M HOMMA
CIRCULATION, Oct. 1992
Research Themes
- Molecular mechanisms of regulation of abdominal adhesion formation by anti-IL-6 antibody.
Grant-in-Aid for Scientific Research (B)
Hyogo Medical University
01 Apr. 2018 - 31 Mar. 2021 - Exploration of diseases caused by MARCH dysregulation
Grant-in-Aid for Challenging Research (Exploratory)
Hyogo Medical University
29 Jun. 2018 - 31 Mar. 2020 - Regulation of endocytosis and lysosomal traffic by the ubiquitin conjugation system
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Tokyo Institute of Technology
28 Jun. 2012 - 31 Mar. 2017 - Novel immune regulation through regulated MHC II ubiquitination
Grant-in-Aid for Scientific Research (B)
Showa Pharmaceutical University
01 Apr. 2012 - 31 Mar. 2015 - Exploration into MHC class II-mediated immune regulation
Grant-in-Aid for Scientific Research (B)
The Institute of Physical and Chemical Research
2009 - 2011 - Immunological disorder in a novel E3 ubiquitin ligase, c-MIR2 deficient mice
Grant-in-Aid for Scientific Research (C)
The Institute of Physical and Chemical Research
2007 - 2008 - Functional analysis of a novel E3 ubiquitin ligase family.
Grant-in-Aid for Scientific Research (C)
The Institute of Physical and Chemical Research
2006 - 2007 - Functional analysis of a novel E3 ubiquitin ligase, c-MIR
Grant-in-Aid for Scientific Research (C)
RIKEN
2004 - 2005 - Viral factors that determine viremia titers of hepatitis C virus in Indonesia
Grant-in-Aid for Scientific Research (B)
Kobe University
2001 - 2002 - Inhibition of apoptosis by the NS3 protein of hepatitis C virus and its interaction with the p53 tumor suppressor protein.
Grant-in-Aid for Scientific Research (C)
Kobe University
1997 - 1998
