Last Updated :2025/09/13
Researcher Information
Research activity information
Paper
- Role of nasal polyp-derived innate lymphoid cells in staphylococcal enterotoxin-induced cellular responses.
Kengo Kanai; Aiko Oka; Shin Kariya; Tazuko Fujiwara; Takaya Higaki; Seiichiro Makihara; Takenori Haruna; Maki Akamatsu; Kazunori Nishizaki; Mizuo Ando; Mitsuhiro Okano
Allergology international : official journal of the Japanese Society of Allergology, Jul. 2024 - The add-on effect of an intranasal antihistamine with an intranasal corticosteroid in Japanese cedar pollinosis.
Takenori Haruna; Shin Kariya; Takaya Higaki; Aya Murai; Kengo Kanai; Aiko Oka; Maki Akamatsu; Mizuo Ando; Kazunori Nishizaki; Mitsuhiro Okano
Auris, nasus, larynx, Feb. 2023 - Mapping naso-ocular symptom scores to EQ-5D-5L utility values in Japanese cedar pollinosis.
Hiroshi Kumanomidou; Kengo Kanai; Aiko Oka; Takenori Haruna; Yuji Hirata; Sei-Ichiro Makihara; Takaya Higaki; Maki Akamatsu; Yoshitaka Okamoto; Shunya Ikeda; Mitsuhiro Okano
Allergology international : official journal of the Japanese Society of Allergology, Apr. 2022 - Role of salivary microbiome in IL-10 production and efficacy of sublingual immunotherapy.
Aiko Oka; Masanori Kidoguchi; Shin Kariya; Tazuko Fujiwara; Atsushi Yuta; Hiromi Miyashita; Takaya Higaki; Yukiko Ogawa; Kengo Kanai; Sei-Ichiro Makihara; Takenori Haruna; Jun Kunisawa; Naoto Adachi; Keisuke Koyama; Rieko Ii; Emiko Noguchi; Shigeharu Fujieda; Kazunori Nishizaki; Mitsuhiro Okano
Allergy, Aug. 2021 - Effect of Prostaglandin D2 on mRNA Expression of Three Isoforms of Hyaluronic Acid Synthase in Nasal Polyp Fibroblasts.
Yuji Hirata; Shin Kariya; Kengo Kanai; Tazuko Fujiwara; Sei-Ichiro Makihara; Ryotaro Omichi; Takaya Higaki; Takenori Haruna; Aiko Oka; Kazunori Nishizaki; Mitsuhiro Okano
American journal of rhinology & allergy, Jan. 2021 - Association between the NOS2 pentanucleotide repeat polymorphism and risk of postoperative recurrence of chronic rhinosinusitis with nasal polyps in a Japanese population.
Masanori Kidoguchi; Kanako Yoshida; Emiko Noguchi; Takako Nakamura; Wataru Morii; Takenori Haruna; Mitsuhiro Okano; Yukiko Yamashita; Shinichi Haruna; Masayo Hasegawa; Naohiro Yoshida; Takahiro Ninomiya; Yoshimasa Imoto; Masafumi Sakashita; Tetsuji Takabayashi; Shigeharu Fujieda
Allergology international : official journal of the Japanese Society of Allergology, Oct. 2020 - Serum IgG4 as a biomarker reflecting pathophysiology and post-operative recurrence in chronic rhinosinusitis.
Aiko Oka; Takahiro Ninomiya; Tazuko Fujiwara; Soshi Takao; Yasuharu Sato; Yuka Gion; Akira Minoura; Shin-Ichi Haruna; Naohiro Yoshida; Yasunori Sakuma; Kenji Izuhara; Junya Ono; Masami Taniguchi; Takenori Haruna; Takaya Higaki; Shin Kariya; Takahisa Koyama; Tetsuji Takabayashi; Yoshimasa Imoto; Masafumi Sakashita; Masanori Kidoguchi; Kazunori Nishizaki; Shigeharu Fujieda; Mitsuhiro Okano
Allergology international : official journal of the Japanese Society of Allergology, Jul. 2020 - Corrigendum to "Effect of prostaglandin D2 on VEGF release by nasal polyp fibroblasts" [Allergol Int 65 (2016) 414-419].
Kengo Kanai; Mitsuhiro Okano; Tazuko Fujiwara; Shin Kariya; Takenori Haruna; Ryotaro Omichi; Sei-Ichiro Makihara; Yuji Hirata; Kazunori Nishizaki
Allergology international : official journal of the Japanese Society of Allergology, Jan. 2020 - The efficacy of OK-432 sclerotherapy on thyroglossal duct cyst and the influence on a subsequent surgical procedure.
Tomoyasu Tachibana; Shin Kariya; Yorihisa Orita; Takuma Makino; Takenori Haruna; Yuko Matsuyama; Yasutoshi Komatsubara; Yuto Naoi; Michihiro Nakada; Yoji Wani; Soichiro Fushimi; Machiko Hotta; Katsuya Haruna; Tami Nagatani; Yasuharu Sato; Kazunori Nishizaki
Acta oto-laryngologica, Sep. 2019 - Spontaneous closure of traumatic tympanic membrane perforation following long-term observation.
Tomoyasu Tachibana; Shin Kariya; Yorihisa Orita; Takuma Makino; Takenori Haruna; Yuko Matsuyama; Yasutoshi Komatsubara; Yuto Naoi; Michihiro Nakada; Yohei Noda; Yasuharu Sato; Kazunori Nishizaki
Acta oto-laryngologica, Jun. 2019 - Significance of IgG4-positive cells in severe eosinophilic chronic rhinosinusitis.
Takahisa Koyama; Shin Kariya; Yasuharu Sato; Yuka Gion; Takaya Higaki; Takenori Haruna; Tazuko Fujiwara; Akira Minoura; Soshi Takao; Yorihisa Orita; Kengo Kanai; Masami Taniguchi; Kazunori Nishizaki; Mitsuhiro Okano
Allergology international : official journal of the Japanese Society of Allergology, Apr. 2019 - Determining an Appropriate Time to Start Prophylactic Treatment with Intranasal Corticosteroids in Japanese Cedar Pollinosis.
Takenori Haruna; Shin Kariya; Takaya Higaki; Sei-Ichiro Makihara; Kengo Kanai; Yasutoshi Komatsubara; Aiko Oka; Kazunori Nishizaki; Mitsuhiro Okano
Medical sciences (Basel, Switzerland), Jan. 2019 - Role of whole saliva in the efficacy of sublingual immunotherapy in seasonal allergic rhinitis.
Takenori Haruna; Shin Kariya; Tazuko Fujiwara; Atsushi Yuta; Takaya Higaki; Pengfei Zhao; Yukiko Ogawa; Kengo Kanai; Yuji Hirata; Aiko Oka; Kazunori Nishizaki; Mitsuhiro Okano
Allergology international : official journal of the Japanese Society of Allergology, Jan. 2019 - Factors that prolong the duration of recovery in acute rhinosinusitis with orbital complications.
Tomoyasu Tachibana; Shin Kariya; Yorihisa Orita; Michihiro Nakada; Takuma Makino; Takenori Haruna; Yuko Matsuyama; Yasutoshi Komatsubara; Yuto Naoi; Yasuharu Sato; Kazunori Nishizaki
Acta oto-laryngologica, Jan. 2019 - [THE EXAMINATION OF IGE AND PERIPHERAL BLOOD MONONUCLEAR CELLS RESPONSES TO FLOUR EXTRACTS IN A BAKER'S RHINITIS PATIENT].
Takenori Haruna; Mitsuhiro Okano; Tazuko Fujiwara; Takaya Higaki; Shin Kariya; Seiichiro Makihara; Kengo Kanai; Tomoyasu Tachibana; Yuko Matsuyama; Yasutoshi Komatsubara; Yuto Naoi; Kazunori Nishizaki
Arerugi = [Allergy], 2019 - Periostin as a novel biomarker for postoperative recurrence of chronic rhinosinitis with nasal polyps.
Takahiro Ninomiya; Emiko Noguchi; Takenori Haruna; Masayo Hasegawa; Takuto Yoshida; Yukiko Yamashita; Mitsuhiro Okano; Naohiro Yoshida; Shinichi Haruna; Yasunori Sakuma; Shoichiro Ohta; Junya Ono; Kenji Izuhara; Masafumi Okada; Masanori Kidoguchi; Takahiro Tokunaga; Masayuki Okamoto; Masafumi Kanno; Masafumi Sakashita; Tetsuji Takabayashi; Norihiko Narita; Shigeharu Fujieda
Scientific reports, Jul. 2018 - Association between impaired IL-10 production following exposure to Staphylococcus aureus enterotoxin B and disease severity in eosinophilic chronic rhinosinusitis.
Takenori Haruna; Shin Kariya; Tazuko Fujiwara; Takaya Higaki; Seiichiro Makihara; Kengo Kanai; Rumi Fujiwara; Satoshi Iwasaki; Yoshihiro Noguchi; Kazunori Nishizaki; Mitsuhiro Okano
Allergology international : official journal of the Japanese Society of Allergology, Jul. 2018 - Pulmonary function in patients with eosinophilic chronic rhinosinusitis.
Kensuke Uraguchi; Shin Kariya; Seiichiro Makihara; Mitsuhiro Okano; Takenori Haruna; Aiko Oka; Rumi Fujiwara; Yohei Noda; Kazunori Nishizaki
Auris, nasus, larynx, Jun. 2018 - Evaluation of a new and simple classification for endoscopic sinus surgery.
Kengo Kanai; Mitsuhiro Okano; Takenori Haruna; Takaya Higaki; Ryotaro Omichi; Sei-Ichiro Makihara; Munechika Tsumura; Shin Kariya; Yuji Hirata; Kazunori Nishizaki
Allergy & rhinology (Providence, R.I.), Oct. 2017 - The impact of chronic rhinosinusitis on long-term survival in lung transplantation recipients.
Shin Kariya; Mitsuhiro Okano; Takahiro Oto; Takaya Higaki; Takenori Haruna; Yohei Noda; Kazunori Nishizaki
Acta oto-laryngologica, May 2017 - IL-22/IL-22R1 signaling regulates the pathophysiology of chronic rhinosinusitis with nasal polyps via alteration of MUC1 expression.
Yasuyuki Noyama; Mitsuhiro Okano; Tazuko Fujiwara; Shin Kariya; Takaya Higaki; Takenori Haruna; Sei-Ichiro Makihara; Kengo Kanai; Takahisa Koyama; Masami Taniguchi; Jun-Ichi Ishitoya; Akira Kanda; Yoshiki Kobayashi; Mikiya Asako; Koichi Tomoda; Kazunori Nishizaki
Allergology international : official journal of the Japanese Society of Allergology, Jan. 2017 - Effect of prostaglandin D2 on VEGF release by nasal polyp fibroblasts.
Kengo Kanai; Mitsuhiro Okano; Tazuko Fujiwara; Shin Kariya; Takenori Haruna; Ryotaro Omichi; Sei-Ichiro Makihara; Yuji Hirata; Kazunori Nishizaki
Allergology international : official journal of the Japanese Society of Allergology, Oct. 2016 - Effect of intranasal corticosteroid on pre-onset activation of eosinophils and mast cells in experimental Japanese cedar pollinosis.
Yasuyuki Noyama; Mitsuhiro Okano; Tazuko Fujiwara; Shin Kariya; Sei-Ichiro Makihara; Takenori Haruna; Kengo Kanai; Takaya Higaki; Kazunori Nishizaki
Allergology international : official journal of the Japanese Society of Allergology, Jul. 2016 - Regulatory effect of TLR3 signaling on staphylococcal enterotoxin-induced IL-5, IL-13, IL-17A and IFN-γ production in chronic rhinosinusitis with nasal polyps.
Mitsuhiro Okano; Tazuko Fujiwara; Shin Kariya; Takaya Higaki; Sei-ichiro Makihara; Takenori Haruna; Yasuyuki Noyama; Takahisa Koyama; Ryotaro Omichi; Yorihisa Orita; Kentaro Miki; Kengo Kanai; Kazunori Nishizaki
Allergology international : official journal of the Japanese Society of Allergology, Jan. 2016 - Pulmonary function in never-smoker patients with chronic rhinosinusitis.
Shin Kariya; Mitsuhiro Okano; Takaya Higaki; Yasuyuki Noyama; Takenori Haruna; Kazunori Nishizaki
International forum of allergy & rhinology, Nov. 2015 - Staphylococcal protein A-formulated immune complexes suppress enterotoxin-induced cellular responses in nasal polyps.
Mitsuhiro Okano; Tazuko Fujiwara; Shin Kariya; Takenori Haruna; Takaya Higaki; Yasuyuki Noyama; Sei-ichiro Makihara; Kengo Kanai; Kazunori Nishizaki
The Journal of allergy and clinical immunology, Aug. 2015 - Macrophage Migration Inhibitory Factor Deficiency Causes Prolonged Hearing Loss After Acoustic Overstimulation.
Shin Kariya; Mitsuhiro Okano; Yukihide Maeda; Haruka Hirai; Takaya Higaki; Yasuyuki Noyama; Takenori Haruna; Jun Nishihira; Kazunori Nishizaki
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, Jul. 2015 - [Eosinophilic chronic rhinosinusitis].
Shigeharu Fujieda; Masafumi Sakashita; Takahiro Tokunaga; Mitsuhiro Okano; Takenori Haruna; Mamoru Yoshikawa; Nobuyoshi Ohtori; Daiya Asaka; Shinichi Haruna; Tsuguhisa Nakayama; Junichi Ishitoya; Yasunori Sakuma; Katsuhiro Hirakawa; Sachio Takeno; Tetsuo Himi; Nobuhiko Seki; Yukiko Iino; Naohiro Yoshida; Masayoshi Kobayashi; Hiroshi Sakaida; Kenji Kondo; Tatsuya Yamasoba; Takaki Miwa; Kanako Yamada; Ryo Kawata; Tetsuya Terada; Hideyuki Kawauchi; Ichiro Morikura; Katsuhisa Ikeda; Junko Murata; Hiroki Ikeda; Emiko Noguchi; Mayumi Tamari; Tomomitsu Hirota; Yoshimasa Imoto; Tetsuji Takabayashi; Kaori Tomita; Takahiro Ninomiya; Taiyo Morikawa; Mitsuyoshi Urashima
Arerugi = [Allergy], Feb. 2015 - Cellular responses to Staphylococcus aureus alpha-toxin in chronic rhinosinusitis with nasal polyps.
Mitsuhiro Okano; Tazuko Fujiwara; Shin Kariya; Takaya Higaki; Takenori Haruna; Osamu Matsushita; Yohei Noda; Seiichiro Makihara; Kengo Kanai; Yasuyuki Noyama; Masami Taniguchi; Kazunori Nishizaki
Allergology international : official journal of the Japanese Society of Allergology, Dec. 2014 - Role of macrophage migration inhibitory factor in age-related hearing loss
Shin Kariya; Mitsuhiro Okano; Yukihide Maeda; Haruka Hirai; Takaya Higaki; Yasuyuki Noyama; Takenori Haruna; Jun Nishihira; Kazunori Nishizaki
Neuroscience, Oct. 2014, [Reviewed] - Chronic rhinosinusitis patients have decreased lung function.
Shin Kariya; Mitsuhiro Okano; Takaya Higaki; Yasuyuki Noyama; Takenori Haruna; Hisashi Ishihara; Takuma Makino; Tomoo Onoda; Kazunori Nishizaki
International forum of allergy & rhinology, Oct. 2014 - Local expression of interleukin-17a is correlated with nasal eosinophilia and clinical severity in allergic rhinitis.
Seiichiro Makihara; Mitsuhiro Okano; Tazuko Fujiwara; Yohei Noda; Takaya Higaki; Tomomi Miyateke; Kengo Kanai; Takenori Haruna; Shin Kariya; Kazunori Nishizaki
Allergy & rhinology (Providence, R.I.), Apr. 2014 - Pulmonary function in patients with chronic rhinosinusitis and allergic rhinitis
Shin Kariya; Mitsuhiro Okano; Takahiro Oto; Takaya Higaki; Seiichiro Makihara; Takenori Haruna; Kazunori Nishizaki
The Journal of Laryngology & Otology, Mar. 2014, [Reviewed] - Determining minimal clinically important differences in Japanese cedar/cypress pollinosis patients.
Takaya Higaki; Mitsuhiro Okano; Shin Kariya; Tazuko Fujiwara; Takenori Haruna; Haruka Hirai; Aya Murai; Minoru Gotoh; Kimihiro Okubo; Shuji Yonekura; Yoshitaka Okamoto; Kazunori Nishizaki
Allergology international : official journal of the Japanese Society of Allergology, Dec. 2013 - Neutralizing antibody against granulocyte/macrophage colony-stimulating factor inhibits inflammatory response in experimental otitis media.
Shin Kariya; Mitsuhiro Okano; Takaya Higaki; Seiichiro Makihara; Takenori Haruna; Motoharu Eguchi; Kazunori Nishizaki
The Laryngoscope, Jun. 2013 - Characterization of IL-18 expression and release in the pathogenesis of chronic rhinosinusitis.
Mitsuhiro Okano; Tazuko Fujiwara; Seiichiro Makihara; Rumi Fujiwara; Takaya Higaki; Shin Kariya; Yohei Noda; Takenori Haruna; Kazunori Nishizaki
International archives of allergy and immunology, 2013 - Early interventional treatment with intranasal corticosteroids compared with postonset treatment in pollinosis.
Takaya Higaki; Mitsuhiro Okano; Seiichiro Makihara; Tazuko Fujiwara; Takenori Haruna; Yohei Noda; Shin Kariya; Kazunori Nishizaki
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, Dec. 2012 - Early interventional treatment with intranasal mometasone furoate in Japanese cedar/cypress pollinosis: a randomized placebo-controlled trial.
Seiichiro Makihara; Mitsuhiro Okano; Tazuko Fujiwara; Masayo Kimura; Takaya Higaki; Takenori Haruna; Yohei Noda; Kengo Kanai; Shin Kariya; Kazunori Nishizaki
Allergology international : official journal of the Japanese Society of Allergology, Jun. 2012 - Characterization of pollen antigen-induced IL-31 production by PBMCs in patients with allergic rhinitis.
Mitsuhiro Okano; Tazuko Fujiwara; Takaya Higaki; Seiichiro Makihara; Takenori Haruna; Yohei Noda; Kengo Kanai; Shin Kariya; Hiroshi Yasueda; Kazunori Nishizaki
The Journal of allergy and clinical immunology, Jan. 2011 - Prostaglandin E(2) suppresses staphylococcal enterotoxin-induced eosinophilia-associated cellular responses dominantly through an E-prostanoid 2-mediated pathway in nasal polyps.
Mitsuhiro Okano; Tazuko Fujiwara; Takenori Haruna; Shin Kariya; Seiichiro Makihara; Takaya Higaki; Kazunori Nishizaki
The Journal of allergy and clinical immunology, Apr. 2009
Research Themes
- Development of predicting factor for the efficacy of sublingual immunotherapy for Japanese cedar pollinosis using saliva
Grant-in-Aid for Scientific Research (B)
Okayama University
01 Apr. 2015 - 31 Mar. 2019 - Role of Staphylococcus aureus alpha-toxin and IL-22 in the pathogenesis of eosinophilic rhinosinusitis
Grant-in-Aid for Young Scientists (B)
Okayama University
01 Apr. 2013 - 31 Mar. 2016
