Last Updated :2024/12/13
Researcher Information
Research Keyword
Career
- Apr. 2023 - Present
Hyogo Medical University, Department of Biochemistry, chief professor - Apr. 2023 - Present
Osaka University, Graduate School of Medicine, visiting professor - Jul. 2019 - Mar. 2023
大阪大学大学院生命機能研究科・医学系研究科, 医化学講座, 准教授 - Sep. 2013 - Jun. 2019
大阪大学大学院医学系研究科, 医化学講座, 助教 - Apr. 2010 - Aug. 2013
大阪大学大学院医学系研究科, 分子心血管医学講座, 特任研究員 - Apr. 2009 - Mar. 2010
国立循環器病研究センター - Jul. 2007 - Mar. 2009
University of California, Los Angeles - Apr. 2002 - Jun. 2007
大阪大学大学院医学系研究科 - Apr. 2005 - Mar. 2007
日本学術振興会, 特別研究員 - Apr. 2001 - Mar. 2002
国立循環器病研究センター - Apr. 1997 - Mar. 2001
長崎大学附属病院
Educational Background
Research activity information
Award
- 2018
Best Reviewer of the Year 2018, Japanese Circulation Society
Osamu Tsukamoto - 2017
Best Reviewer of the Year 2017, Japanese Circulation Society
Osamu Tsukamoto - 2017
大阪大学, 先導的学際研究機構創薬サイエンス部門研究助成
塚本 蔵 - 2016
Japanese Circulation Society, Japanese Circulation Society
塚本 蔵 - 2016
公益財団法人先進医薬研究振興財団, 公益財団法人先進医薬研究振興財団医化学研究助成
塚本 蔵 - 2015
公益財団法人 鈴木謙三記念医科学応用研究財団, 鈴木謙三記念医化学応用研究財団研究助成
塚本 蔵 - 2015
持田記念医学薬学振興財団, 持田記念研究助成
塚本 蔵 - 2015
日本医師会, 日本医師会医学研究奨励賞
塚本 蔵 - 2015
大阪大学, 大阪大学総長奨励賞2015（研究部門）
塚本 蔵 - 2014
Japanese Circulation Society, Best Reviewer of the Year 2014
Osamu Tsukamoto - 2013
Japanese circulation society, Best Reviewer of the Year 2013
Osamu Tsukamoto - 2012
japanese circulation society, Best Reviewer of the Year 2012
Osamu Tsukamoto - 2011
日本心臓財団, 日本心臓財団分子循環器研究助成
塚本 蔵
Paper
- BRAF V600E-induced distinct DNA damage response defines the therapeutic potential of p53 activation for TP53 wild-type colorectal cancer.
Shinji Tokuyama; Hisakazu Kato; Hidekazu Takahashi; Kyoko Ueda; Asami Arita; Ryuta Ueda; Hiroto Seto; Yuki Sekido; Tsuyoshi Hata; Atsushi Hamabe; Takayuki Ogino; Norikatsu Miyoshi; Mamoru Uemura; Ken Matsuoka; Osamu Tsukamoto; Hirofumi Yamamoto; Yuichiro Doki; Hidetoshi Eguchi; Seiji Takashima
Carcinogenesis, Jun. 2024 - 〔Major achievements〕Relative B-Type Natriuretic Peptide Deficiency May Exist in Diastolic Dysfunction in Subclinical Population
Chisato Okamoto; Osamu Tsukamoto; Takuya Hasegawa; Ken Matsuoka; Makoto Amaki; Hideaki Kanzaki; Chisato Izumi; Seiji Takashima; Shin Ito; Masafumi Kitakaze
Circulation Reports, May 2024, [Reviewed]
Corresponding - 〔Major achievements〕Association Between B-Type Natriuretic Peptide Deficiency and Left Ventricular Concentric Hypertrophy in Subclinical Individuals
Chisato Okamoto; Osamu Tsukamoto; Takuya Hasegawa; Ken Matsuoka; Makoto Amaki; Hideaki Kanzaki; Chisato Izumi; Seiji Takashima; Shin Ito; Masafumi Kitakaze
JACC: Asia, Jan. 2024, [Reviewed]
Corresponding - 〔Major achievements〕Response by Tsukamoto and Takashima to Letter Regarding Article, "Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Super-Relaxed Myosin".
Osamu Tsukamoto; Seiji Takashima
Circulation, Dec. 2023
Lead - 〔Major achievements〕Wnt5a-YAP signaling axis mediates mechanotransduction in cardiac myocytes and contributes to contractile dysfunction induced by pressure overload
Hiroshi Kishimoto; Masayoshi Iwasaki; Kensaku Wada; Keita Horitani; Osamu Tsukamoto; Kenta Kamikubo; Seitaro Nomura; Shinji Matsumoto; Takeshi Harada; Daisuke Motooka; Daisuke Okuzaki; Seiji Takashima; Issei Komuro; Akira Kikuchi; Ichiro Shiojima
iScience, Jun. 2023, [Reviewed] - 〔Major achievements〕Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin
Tatsuro Hitsumoto; Osamu Tsukamoto; Ken Matsuoka; Junjun Li; Li Liu; Yuki Kuramoto; Shuichiro Higo; Shou Ogawa; Noboru Fujino; Shohei Yoshida; Hidetaka Kioka; Hisakazu Kato; Hideyuki Hakui; Yuki Saito; Chisato Okamoto; Hijiri Inoue; Jo Hyejin; Kyoko Ueda; Takatsugu Segawa; Shunsuke Nishimura; Yoshihiro Asano; Hiroshi Asanuma; Akiyoshi Tani; Riyo Imamura; Shinsuke Komagawa; Toshio Kanai; Masayuki Takamura; Yasushi Sakata; Masafumi Kitakaze; Jun-ichi Haruta; Seiji Takashima
Circulation, May 2023, [Reviewed]
Corresponding - 〔Major achievements〕Candidate Screening for Heart Failure With Preserved Ejection Fraction Clinic by Fib-4 Index From Subclinical Subjects
Chisato Okamoto; Osamu Tsukamoto; Takuya Hasegawa; Tatsuro Hitsumoto; Ken Matsuoka; Makoto Amaki; Hideaki Kanzaki; Chisato Izumi; Seiji Takashima; Shin Ito; Masafumi Kitakaze
Gastro Hep Advances, 2023, [Reviewed]
Corresponding - 〔Major achievements〕Gene Transfer of Skeletal Muscle-Type Myosin Light Chain Kinase via Adeno-Associated Virus 6 Improves Muscle Functions in an Amyotrophic Lateral Sclerosis Mouse Model.
Ryohei Oya; Osamu Tsukamoto; Tatsuro Hitsumoto; Naoya Nakahara; Chisato Okamoto; Ken Matsuoka; Hisakazu Kato; Hidenori Inohara; Seiji Takashima
International journal of molecular sciences, Feb. 2022, [Reviewed]
Corresponding - 〔Major achievements〕Loss-of-function mutations in the co-chaperone protein BAG5 cause dilated cardiomyopathy requiring heart transplantation.
Hideyuki Hakui; Hidetaka Kioka; Yohei Miyashita; Shunsuke Nishimura; Ken Matsuoka; Hisakazu Kato; Osamu Tsukamoto; Yuki Kuramoto; Ayako Takuwa; Yusuke Takahashi; Shigeyoshi Saito; Kunio Ohta; Hiroshi Asanuma; Hai Ying Fu; Haruki Shinomiya; Noriaki Yamada; Tomohito Ohtani; Yoshiki Sawa; Masafumi Kitakaze; Seiji Takashima; Yasushi Sakata; Yoshihiro Asano
Science translational medicine, Jan. 2022, [Reviewed] - 〔Major achievements〕Lower B-type natriuretic peptide levels predict left ventricular concentric remodelling and insulin resistance.
Chisato Okamoto; Osamu Tsukamoto; Takuya Hasegawa; Tatsuro Hitsumoto; Ken Matsuoka; Seiji Takashima; Makoto Amaki; Hideaki Kanzaki; Chisato Izumi; Shin Ito; Masafumi Kitakaze
ESC heart failure, Nov. 2021, [Reviewed]
Corresponding - 〔Major achievements〕Aberrant accumulation of TMEM43 accompanied by perturbed transmural gene expression in arrhythmogenic cardiomyopathy.
Haruki Shinomiya; Hisakazu Kato; Yuki Kuramoto; Nozomi Watanabe; Toshihiro Tsuruda; Tadaaki Arimura; Yohei Miyashita; Yoshiki Miyasaka; Tomoji Mashimo; Ayako Takuwa; Daisuke Motooka; Daisuke Okuzaki; Ken Matsuoka; Osamu Tsukamoto; Hideyuki Hakui; Noriaki Yamada; Jong-Kook Lee; Hidetaka Kioka; Masafumi Kitakaze; Seiji Takashima; Yasushi Sakata; Yoshihiro Asano
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Nov. 2021, [Reviewed] - 〔Major achievements〕Phosphorylation of MYL12 by Myosin Light Chain Kinase Regulates Cellular Shape Changes in Cochlear Hair Cells.
Ryohei Oya; Osamu Tsukamoto; Takashi Sato; Hisakazu Kato; Ken Matsuoka; Kazuo Oshima; Takefumi Kamakura; Yumi Ohta; Takao Imai; Seiji Takashima; Hidenori Inohara
Journal of the Association for Research in Otolaryngology : JARO, Apr. 2021, [Reviewed]
Corresponding - 〔Major achievements〕The CR9 element is a novel mechanical load-responsive enhancer that regulates natriuretic peptide genes expression.
Yohei Miyashita; Osamu Tsukamoto; Ken Matsuoka; Kenta Kamikubo; Yuki Kuramoto; Hai Ying Fu; Tomoya Tsubota; Hirona Hasuike; Toshio Takayama; Hiroaki Ito; Tatsuro Hitsumoto; Chisato Okamoto; Hidetaka Kioka; Ryohei Oya; Haruki Shinomiya; Hideyuki Hakui; Yasunori Shintani; Hisakazu Kato; Masafumi Kitakaze; Yasushi Sakata; Yoshihiro Asano; Seiji Takashima
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Apr. 2021, [Reviewed]
Corresponding - 〔Major achievements〕AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP-170.
Shohei Yashirogi; Takemasa Nagao; Yuya Nishida; Yusuke Takahashi; Tasneem Qaqorh; Issei Yazawa; Toru Katayama; Hidetaka Kioka; Tsubasa S Matsui; Shigeyoshi Saito; Yuki Masumura; Osamu Tsukamoto; Hisakazu Kato; Hiromichi Ueda; Osamu Yamaguchi; Kenta Yashiro; Satoru Yamazaki; Seiji Takashima; Yasunori Shintani
EMBO reports, Jan. 2021, [Reviewed] - Plasma indoxyl sulfate levels predict cardiovascular events in patients with mild chronic heart failure.
Miki Imazu; Hiroki Fukuda; Hideaki Kanzaki; Makoto Amaki; Takuya Hasegawa; Hiroyuki Takahama; Tatsuro Hitsumoto; Osamu Tsukamoto; Toshisuke Morita; Shin Ito; Masafumi Kitakaze
Scientific reports, Oct. 2020, [Reviewed] - 〔Major achievements〕Non-Radioactive In Vitro Cardiac Myosin Light Chain Kinase Assays.
Kenta Kamikubo; Osamu Tsukamoto; Yuki Uyama-Saito; Ryohei Oya; Tomoya Tsubota; Noboru Fujino; Yoshihiro Asano; Hisakazu Kato; Ken Matsuoka; Seiji Takashima
Journal of visualized experiments : JoVE, Jun. 2020, [Reviewed]
Lead - 〔Major achievements〕In vivo real-time ATP imaging in zebrafish hearts reveals G0s2 induces ischemic tolerance.
Hidetaka Kioka; Hisakazu Kato; Takeshi Fujita; Yoshihiro Asano; Yasunori Shintani; Satoru Yamazaki; Osamu Tsukamoto; Hiromi Imamura; Mikihiko Kogo; Masafumi Kitakaze; Yasushi Sakata; Seiji Takashima
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Feb. 2020, [Reviewed] - 〔Major achievements〕Higd1a improves respiratory function in the models of mitochondrial disorder.
Takemasa Nagao; Yasunori Shintani; Takaharu Hayashi; Hidetaka Kioka; Hisakazu Kato; Yuya Nishida; Satoru Yamazaki; Osamu Tsukamoto; Shohei Yashirogi; Issei Yazawa; Yoshihiro Asano; Kyoko Shinzawa-Itoh; Hiromi Imamura; Takeo Suzuki; Tsutomu Suzuki; Yu-Ichi Goto; Seiji Takashima
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Jan. 2020, [Reviewed] - 〔Major achievements〕Direct Sarcomere Modulators Are Promising New Treatments for Cardiomyopathies.
Osamu Tsukamoto
International journal of molecular sciences, Dec. 2019, [Reviewed]
Lead - 〔Major achievements〕A molecular triage process mediated by RING finger protein 126 and BCL2-associated athanogene 6 regulates degradation of G0/G1 switch gene 2.
Kenta Kamikubo; Hisakazu Kato; Hidetaka Kioka; Satoru Yamazaki; Osamu Tsukamoto; Yuya Nishida; Yoshihiro Asano; Hiromi Imamura; Hiroyuki Kawahara; Yasunori Shintani; Seiji Takashima
The Journal of biological chemistry, Oct. 2019, [Reviewed] - Endogenously released adenosine causes pulmonary vasodilation during the acute phase of pulmonary embolization in dogs.
Hiroko Takahama; Hiroshi Asanuma; Osamu Tsukamoto; Shin Ito; Masafumi Kitakaze
International journal of cardiology. Heart & vasculature, Sep. 2019, [Reviewed] - 〔Major achievements〕Impact of cardiac myosin light chain kinase gene mutation on development of dilated cardiomyopathy.
Akihiko Hodatsu; Noboru Fujino; Yuki Uyama; Osamu Tsukamoto; Atsuko Imai-Okazaki; Satoru Yamazaki; Osamu Seguchi; Tetsuo Konno; Kenshi Hayashi; Masa-Aki Kawashiri; Yoshihiro Asano; Masafumi Kitakaze; Seiji Takashima; Masakazu Yamagishi
ESC heart failure, Apr. 2019, [Reviewed] - 〔Major achievements〕Mutant KCNJ3 and KCNJ5 Potassium Channels as Novel Molecular Targets in Bradyarrhythmias and Atrial Fibrillation
Noriaki Yamada; Yoshihiro Asano; Masashi Fujita; Satoru Yamazaki; Atsushi Inanobe; Norio Matsuura; Hatasu Kobayashi; Seiko Ohno; Yusuke Ebana; Osamu Tsukamoto; Saki Ishino; Ayako Takuwa; Hidetaka Kioka; Toru Yamashita; Norio Hashimoto; Dimitar P. Zankov; Akio Shimizu; Masanori Asakura; Hiroshi Asanuma; Hisakazu Kato; Yuya Nishida; Yohei Miyashita; Haruki Shinomiya; Nobu Naiki; Kenshi Hayashi; Takeru Makiyama; Hisakazu Ogita; Katsuyuki Miura; Hirotsugu Ueshima; Issei Komuro; Masakazu Yamagishi; Minoru Horie; Koichi Kawakami; Tetsushi Furukawa; Akio Koizumi; Yoshihisa Kurachi; Yasushi Sakata; Tetsuo Minamino; Masafumi Kitakaze; Seiji Takashima
Circulation, Apr. 2019, [Reviewed] - 〔Major achievements〕Radiation-induced HFpEF model as a potential tool for the exploration of novel therapeutic targets
Osamu Tsukamoto; Masafumi Kitakaze
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Aug. 2017, [Reviewed]
Lead - Identification of the Mtus1 Splice Variant as a Novel Inhibitory Factor Against Cardiac Hypertrophy
Shin Ito; Masanori Asakura; Yulin Liao; Kyung-Duk Min; Ayako Takahashi; Kazuhiro Shindo; Satoru Yamazaki; Osamu Tsukamoto; Hiroshi Asanuma; Masaki Mogi; Masatsugu Horiuchi; Yoshihiro Asano; Shoji Sanada; Tetsuo Minamino; Seiji Takashima; Naoki Mochizuki; Masafumi Kitakaze
JOURNAL OF THE AMERICAN HEART ASSOCIATION, Jul. 2016, [Reviewed] - Btg2 is a Negative Regulator of Cardiomyocyte Hypertrophy through a Decrease in Cytosolic RNA
Yuki Masumura; Shuichiro Higo; Yoshihiro Asano; Hisakazu Kato; Yi Yan; Saki Ishino; Osamu Tsukamoto; Hidetaka Kioka; Takaharu Hayashi; Yasunori Shintani; Satoru Yamazaki; Tetsuo Minamino; Masafumi Kitakaze; Issei Komuro; Seiji Takashima; Yasushi Sakata
SCIENTIFIC REPORTS, Jun. 2016, [Reviewed] - A Development of Nucleic Chromatin Measurements as a New Prognostic Marker for Severe Chronic Heart Failure
Machiko Kanzaki; Yoshihiro Asano; Hatsue Ishibashi-Ueda; Eiji Oiki; Tomoki Nishida; Hiroshi Asanuma; Hisakazu Kato; Toru Oka; Tomohito Ohtani; Osamu Tsukamoto; Shuichiro Higo; Hidetaka Kioka; Ken Matsuoka; Yoshiki Sawa; Issei Komuro; Masafumi Kitakaze; Seiji Takashima; Yasushi Sakata
PLOS ONE, Feb. 2016, [Reviewed] - Targeting lysosomal Ca2+ to reduce reperfusion injury
Osamu Tsukamoto; Hiroshi Asanuma; Masafumi Kitakaze
CARDIOVASCULAR RESEARCH, Dec. 2015, [Reviewed]
Lead - 〔Major achievements〕Recent Progress and Next Challenges in the Treatment of Symptomatic Heart Failure in Japan
Osamu Tsukamoto; Masafumi Kitakaze
CIRCULATION JOURNAL, Nov. 2015, [Reviewed]
Lead - 〔Major achievements〕Different Implications of Functional Tricuspid Regurgitation Between Heart Failure (HF) With Reduced Ejection Fraction (EF) and HF With Preserved EF
Osamu Tsukamoto; Masafumi Kitakaze
CIRCULATION JOURNAL, Jul. 2015, [Reviewed]
Lead - 〔Major achievements〕Higd1a is a positive regulator of cytochrome c oxidase
Takaharu Hayashi; Yoshihiro Asano; Yasunori Shintani; Hiroshi Aoyama; Hidetaka Kioka; Osamu Tsukamoto; Masahide Hikita; Kyoko Shinzawa-Itoh; Kazuaki Takafuji; Shuichiro Higo; Hisakazu Kato; Satoru Yamazaki; Ken Matsuoka; Atsushi Nakano; Hiroshi Asanuma; Masanori Asakura; Tetsuo Minamino; Yu-ichi Goto; Takashi Ogura; Masafumi Kitakaze; Issei Komuro; Yasushi Sakata; Tomitake Tsukihara; Shinya Yoshikawa; Seiji Takashima
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Feb. 2015, [Reviewed] - 〔Major achievements〕Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5
Yi Yan; Osamu Tsukamoto; Atsushi Nakano; Hisakazu Kato; Hidetaka Kioka; Noriaki Ito; Shuichiro Higo; Satoru Yamazaki; Yasunori Shintani; Ken Matsuoka; Yulin Liao; Hiroshi Asanuma; Masanori Asakura; Kazuaki Takafuji; Tetsuo Minamino; Yoshihiro Asano; Masafumi Kitakaze; Seiji Takashima
NATURE COMMUNICATIONS, Jan. 2015, [Reviewed]
Lead - 〔Major achievements〕PDE5 inhibitor efficacy is estrogen dependent in female heart disease
Hideyuki Sasaki; Takahiro Nagayama; Robert M. Blanton; Kinya Seo; Manling Zhang; Guangshuo Zhu; Dong I. Lee; Djahida Bedja; Steven Hsu; Osamu Tsukamoto; Seiji Takashima; Masafumi Kitakaze; Michael E. Mendelsohn; Richard H. Karas; David A. Kass; Eiki Takimoto
JOURNAL OF CLINICAL INVESTIGATION, Jun. 2014, [Reviewed] - 〔Major achievements〕Noninvasive and quantitative live imaging reveals a potential stress-responsive enhancer in the failing heart
Ken Matsuoka; Yoshihiro Asano; Shuichiro Higo; Osamu Tsukamoto; Yi Yan; Satoru Yamazaki; Takashi Matsuzaki; Hidetaka Kioka; Hisakazu Kato; Yoshihiro Uno; Masanori Asakura; Hiroshi Asanuma; Tetsuo Minamino; Hiroyuki Aburatani; Masafumi Kitakaze; Issei Komuro; Seiji Takashima
FASEB JOURNAL, Apr. 2014, [Reviewed] - 〔Major achievements〕Evaluation of intramitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation
Hidetaka Kioka; Hisakazu Kato; Makoto Fujikawa; Osamu Tsukamoto; Toshiharu Suzuki; Hiromi Imamura; Atsushi Nakano; Shuichiro Higo; Satoru Yamazaki; Takashi Matsuzaki; Kazuaki Takafuji; Hiroshi Asanuma; Masanori Asakura; Tetsuo Minamino; Yasunori Shintani; Masasuke Yoshida; Hiroyuki Noji; Masafumi Kitakaze; Issei Komuro; Yoshihiro Asano; Seiji Takashima
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jan. 2014, [Reviewed] - Biochemical and Physiological Regulation of Cardiac Myocyte Contraction by Cardiac-Specific Myosin Light Chain Kinase
Osamu Tsukamoto; Masafumi Kitakaze
CIRCULATION JOURNAL, Sep. 2013, [Reviewed]
Lead - It is Time to Reconsider the Cardiovascular Protection Afforded by RAAS Blockade - Overview of RAAS Systems
Osamu Tsukamoto; Masafumi Kitakaze
CARDIOVASCULAR DRUGS AND THERAPY, Apr. 2013, [Reviewed]
Lead - Reserve of Coronary Flow Deserves Predictor of Cardiovascular Events
Osamu Tsukamoto; Masafumi Kitakaze
CIRCULATION JOURNAL, Aug. 2012, [Reviewed]
Lead - Repetitive transient phosphodiesterase-3 inhibition eliminates non-ischemic cardiac remodeling and failure
Shoji Sanada; Hiroshi Asanuma; Tetsuo Minamino; Osamu Tsukamoto; Kenichiro Okada; Masafumi Kitakaze; Issei Komuro
Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry, 2012, [Reviewed] - Isoform-specific Intermolecular Disulfide Bond Formation of Heterochromatin Protein 1 (HP1)
Shuichiro Higo; Yoshihiro Asano; Hisakazu Kato; Satoru Yamazaki; Atsushi Nakano; Osamu Tsukamoto; Osamu Seguchi; Mitsutoshi Asai; Masanori Asakura; Hiroshi Asanuma; Shoji Sanada; Tetsuo Minamino; Issei Komuro; Masafumi Kitakaze; Seiji Takashima
JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2010, [Reviewed] - 〔Major achievements〕Differential Regulation of Proteasome Function in Isoproterenol-Induced Cardiac Hypertrophy
Oliver Drews; Osamu Tsukamoto; David Liem; John Streicher; Yibin Wang; Peipei Ping
CIRCULATION RESEARCH, Oct. 2010, [Reviewed]
Lead - 〔Major achievements〕What Is the Role of ER Stress in the Heart? Introduction and Series Overview
Masafumi Kitakaze; Osamu Tsukamoto
CIRCULATION RESEARCH, Jul. 2010, [Reviewed]
Last - 〔Major achievements〕Ablation of C/EBP Homologous Protein Attenuates Endoplasmic Reticulum-Mediated Apoptosis and Cardiac Dysfunction Induced by Pressure Overload
Hai Ying Fu; Ken-ichiro Okada; Yulin Liao; Osamu Tsukamoto; Tadashi Isomura; Mitsutoshi Asai; Tamaki Sawada; Keiji Okuda; Yoshihiro Asano; Shoji Sanada; Hiroshi Asanuma; Masanori Asakura; Seiji Takashima; Issei Komuro; Masafumi Kitakaze; Tetsuo Minamino
CIRCULATION, Jul. 2010, [Reviewed] - X-box binding protein 1 regulates brain natriuretic peptide through a novel AP1/CRE-like element in cardiomyocytes
Tamaki Sawada; Tetsuo Minamino; Hai Ying Fu; Mitsutoshi Asai; Keiji Okuda; Tadashi Isomura; Satoru Yamazaki; Yoshihiro Asano; Ken-ichiro Okada; Osamu Tsukamoto; Shoji Sanada; Hiroshi Asanuma; Masanori Asakura; Seiji Takashima; Masafumi Kitakaze; Issei Komuro
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Jun. 2010, [Reviewed] - 〔Major achievements〕Functional alterations of cardiac proteasomes under physiological and pathological conditions
Osamu Tsukamoto; Tetsuo Minamino; Masafumi Kitakaze
CARDIOVASCULAR RESEARCH, Jan. 2010, [Reviewed]
Lead - 〔Major achievements〕Natriuretic Peptides Enhance the Production of Adiponectin in Human Adipocytes and in Patients With Chronic Heart Failure
Osamu Tsukamoto; Masashi Fujita; Mahoto Kato; Satoru Yamazaki; Yoshihiro Asano; Akiko Ogai; Hidetoshi Okazaki; Mitsutoshi Asai; Yoko Nagamachi; Norikazu Maeda; Yasunori Shintani; Tetsuo Minamino; Masanori Asakura; Ichiro Kishimoto; Tohru Funahashi; Hitonobu Tomoike; Masafumi Kitakaze
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Jun. 2009, [Reviewed]
Lead - 〔Major achievements〕PKA rapidly enhances proteasome assembly and activity in in vivo canine hearts
Mitsutoshi Asai; Osamu Tsukamoto; Tetsuo Minamino; Hiroshi Asanuma; Masashi Fujita; Yoshihiro Asano; Hiroyuki Takahama; Hideyuki Sasaki; Shuichiro Higo; Masanori Asakura; Seiji Takashima; Masatsugu Hori; Masafumi Kitakaze
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Apr. 2009, [Reviewed] - 〔Major achievements〕Overexpression of endoplasmic reticulum-resident chaperone attenuates cardiomyocyte death induced by proteasome inhibition
Hai Ying Fu; Tetsuo Minamino; Osamu Tsukamoto; Tamaki Sawada; Mitsutoshi Asai; Hisakazu Kato; Yoshihiro Asano; Masashi Fujita; Seiji Takashima; Masatsugu Hori; Masafumi Kitakaze
CARDIOVASCULAR RESEARCH, Sep. 2008, [Reviewed] - Activation of ecto-5 '-nucleotidase in the blood and hearts of patients with chronic heart failure
Masashi Fujita; Masanori Asakura; Shoji Sanada; Hiroharu Funaya; Osamu Tsukamoto; Kazuo Komamura; Hiroshi Asanuma; Satoshi Taketani; Tadashi Isomura; Kenji Nakamaru; Hidehiko Furukawa; Yoshiki Sawa; Masatsugu Hori; Masafumi Kitakaze
JOURNAL OF CARDIAC FAILURE, Jun. 2008, [Reviewed] - ER stress and cardiovascular disease
Yamamoto, H.; Tsukamoto, O.; Myoishi, M.; Kitakaze, M.; Minamino, T.; Asai, M.
Respiration and Circulation, 2008 - Impaired glucose tolerance: A possible contributor to left ventricular hypertrophy and diastolic dysfunction
Masashi Fujita; Hiroshi Asanuma; Jiyoong Kim; Yulin Liao; Akio Hirata; Osamu Tsukamoto; Tetsuo Minamino; Masatsugu Hori; Moritaka Goto; Koichi Node; Masafumi Kitakaze
INTERNATIONAL JOURNAL OF CARDIOLOGY, May 2007, [Reviewed] - Prolonged transient acidosis during early reperfusion contributes to the cardioprotective effects of postconditioning
Masashi Fujita; Hiroshi Asanuma; Akio Hirata; Masakatsu Wakeno; Hiroyuki Takahama; Hideyuki Sasaki; Jiyoong Kim; Seiji Takashima; Osamu Tsukamoto; Tetsuo Minamino; Yoshiro Shinozaki; Hitonobu Tomoike; Masatsugu Hori; Masafumi Kitakaze
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Apr. 2007, [Reviewed] - Blockade of angiotensin II receptors reduces the expression of receptors for advanced glycation end products in human endothelial cells
Masashi Fujita; Hiroko Okuda; Osamu Tsukamoto; Yoshihiro Asano; Yulin Liao; Akio Hirata; Jiyoong Kim; Takeshi Miyatsuka; Seiji Takashima; Tetsuo Minamino; Hitonobu Tomoike; Masafumi Kitakaze
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Oct. 2006, [Reviewed] - 〔Major achievements〕Long-term stimulation of adenosine A2b receptors begun after myocardial infarction prevents cardiac remodeling in rats
Masakatsu Wakeno; Tetsuo Minamino; Osamu Seguchi; Hidetoshi Okazaki; Osamu Tsukamoto; Ken-ichiro Okada; Akio Hirata; Masashi Fujita; Hiroshi Asanuma; Jiyoong Kim; Kazuo Komamura; Seiji Takashima; Naoki Mochizuki; Masafumi Kitakaze
CIRCULATION, Oct. 2006, [Reviewed] - 〔Major achievements〕Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling
Yasunori Shintani; Seiji Takashima; Yoshihiro Asano; Hisakazu Kato; Yulin Liao; Satoru Yamazaki; Osamu Tsukamoto; Osamu Seguchi; Hiroyuki Yamamoto; Tomi Fukushima; Kazuyuki Sugahara; Masafumi Kitakaze; Masatsugu Hori
EMBO JOURNAL, Jul. 2006, [Reviewed] - 〔Major achievements〕Erythropoietin enhances neovascularization of ischemic myocardium and improves left ventricular dysfunction after myocardial infarction in dogs
A Hirata; T Minammo; H Asanuma; M Fujita; M Wakeno; M Myoishi; O Tsukamoto; K Okada; H Koyama; K Komamura; S Takashima; Y Shinozaki; H Mori; M Shiraga; M Kitakaze; M Hori
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Jul. 2006, [Reviewed] - Granulocyte colony-stimulating factor mediates cardioprotection against ischemia/reperfusion injury via phosphatidylinositol-3-kinase/akt pathway in canine hearts
Hiroyuki Takahama; Tetsuo Minamino; Akio Hirata; Akiko Ogai; Hiroshi Asanuma; Masashi Fujita; Masakatsu Wakeno; Osamu Tsukamoto; Ken-ichiro Okada; Kazuo Komamura; Seiji Takashima; Yoshiro Shinozaki; Hidezo Mori; Naoki Mochizuki; Masafumi Kitakaze
CARDIOVASCULAR DRUGS AND THERAPY, Jun. 2006, [Reviewed] - Blockade of histamine H-2 receptors protects the heart against ischemia and reperfusion injury in dogs
Hiroshi Asanuma; Tetsuo Minamino; Akiko Ogai; Jiyoong Kim; Masanori Asakura; Kazuo Komamura; Shoji Sanada; Masashi Fujita; Akio Hirata; Masakatsu Wakeno; Osamu Tsukamoto; Yoshiro Shinozaki; Masafumi Myoishi; Seiji Takashima; Hitonobu Tomoike; Masafumi Kitakaze
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, May 2006, [Reviewed] - 〔Major achievements〕The antagonism of aldosterone receptor prevents the development of hypertensive heart failure induced by chronic inhibition of nitric oxide synthesis in rats
O Tsukamoto; T Minamino; S Sanada; K Okada; A Hirata; M Fujita; Y Shintani; L Yulin; Y Asano; S Takashima; S Yamasaki; H Tomoike; M Hori; M Kitakaze
CARDIOVASCULAR DRUGS AND THERAPY, Apr. 2006, [Reviewed]
Lead - Angiotensin II type 1 receptor blocker prevents atrial structural remodeling in rats with hypertension induced by chronic nitric oxide inhibition
H Okazaki; T Minamino; O Tsukamoto; J Kim; KI Okada; M Myoishi; M Wakeno; S Takashima; N Mochizuki; M Kitakaze
HYPERTENSION RESEARCH, Apr. 2006, [Reviewed] - 〔Major achievements〕Depression of proteasome activities during the progression of cardiac dysfunction in pressure-overloaded heart of mice
O Tsukamoto; T Minamino; K Okada; Y Shintani; S Takashima; H Kato; YL Liao; H Okazaki; M Asai; A Hirata; M Fujita; Y Asano; S Yamazaki; H Asanuma; M Hori; M Kitakaze
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 2006, [Reviewed]
Lead - 〔Major achievements〕A role of opening of mitochondrial ATP-sensitive potassium channels in the infarct size-limiting effect of ischemic preconditioning via activation of protein kinase C in the canine heart
O Tsukamoto; H Asanuma; J Kim; T Minamino; S Takashima; A Ogai; A Hirata; M Fujita; Y Shinozaki; H Mori; H Tomoike; M Hori; M Kitakaze
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 2005, [Reviewed] - 〔Major achievements〕A calcium channel blocker amlodipine increases coronary blood flow via both adenosine- and NO-dependent mechanisms in ischemic hearts
H Asanuma; T Minamino; S Sanada; H Ogita; J Kim; M Fujita; A Hirata; O Tsukamoto; A Ogai; K Node; M Hori; H Tomoike; M Kitakaze
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Oct. 2005, [Reviewed] - Aldosterone nongenomically worsens ischemia via protein kinase C-dependent pathways in hypoperfused canine hearts
M Fujita; T Minamino; H Asanuma; S Sanada; A Hirata; M Wakeno; M Myoishi; H Okuda; A Ogai; K Okada; O Tsukamoto; H Koyama; M Hori; M Kitakaze
HYPERTENSION, Jul. 2005, [Reviewed] - 〔Major achievements〕Ablation of MEK kinase 1 suppresses intimal hyperplasia by impairing smooth muscle cell migration and urokinase plasminogen activator expression in a mouse blood-flow cessation model
Y Li; T Minamino; O Tsukamoto; T Yujiri; Y Shintani; K Okada; Y Nagamachi; M Fujita; A Hirata; S Sanada; H Asanuma; S Takashima; M Hori; GL Johnson; M Kitakaze
CIRCULATION, Apr. 2005, [Reviewed]
Lead - Erythropoietin just before reperfusion reduces both lethal arrhythmias and infarct size via the phosphatidylinositol-3 kinase-dependent pathway in canine hearts
A Hirata; T Minamino; H Asanuma; S Sanada; M Fujita; O Tsukamoto; M Wakeno; M Myoishi; K Okada; H Koyama; K Komamura; S Takashima; Y Shinozaki; H Mori; H Tomoike; M Hori; M Kitakaze
CARDIOVASCULAR DRUGS AND THERAPY, Jan. 2005, [Reviewed] - Selective blockade of serotonin 5-HT2A receptor increases coronary blood flow via augmented cardiac nitric oxide release through 5-HT1B receptor in hypoperfused canine hearts
M Fujita; T Minamino; S Sanada; H Asanuma; A Hirata; H Ogita; K Okada; O Tsukamoto; S Takashima; H Tomoike; K Node; M Hori; M Kitakaze
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Dec. 2004, [Reviewed] - 〔Major achievements〕Prolonged endoplasmic reticulum stress in hypertrophic and failing heart after aortic constriction - Possible contribution of endoplasmic reticulum stress to cardiac myocyte apoptosis
K Okada; T Minamino; Y Tsukamoto; YL Liao; O Tsukamoto; S Takashima; A Hirata; M Fujita; Y Nagamachi; T Nakatani; C Yutani; K Ozawa; S Ogawa; H Tomoike; M Hori; M Kitakaze
CIRCULATION, Aug. 2004, [Reviewed] - 〔Major achievements〕Protein kinase A as another mediator of ischemic preconditioning independent of protein kinase C
S Sanada; H Asanuma; O Tsukamoto; T Minamino; K Node; S Takashima; T Fukushima; A Ogai; Y Shinozaki; M Fujita; A Hirata; H Okuda; H Shimokawa; H Tomoike; M Hori; M Kitakaze
CIRCULATION, Jul. 2004, [Reviewed] - Left cervical aortic arch associated with aortic aneurysm, aortic coarctation, and branch artery aneurysm - A case report and review
O Tsukamoto; S Seto; M Moriya; K Yano
ANGIOLOGY, Mar. 2003, [Reviewed]
Lead
MISC
- HepG2細胞におけるc-Metのリン酸化に対するNOの影響
江口 裕伸; 浜崎 重彰; 崎山 晴彦; 吉原 大作; 藤原 範子; 塚本 蔵; 鈴木 敬一郎
日本生化学会大会プログラム・講演要旨集, Oct. 2023 - 心不全病態特異的エンハンサークラスターによるNa利尿ペプチド遺伝子の転写制御機構
井上 聖; 松岡 研; ゾ・ヘジン; 塚本 蔵; 高島 成二
日本生化学会大会プログラム・講演要旨集, Oct. 2023 - Transcriptional regulation of the natriuretic peptide gene during fetal life and heart failure.
井上聖; 松岡研; JO Hyejin; 塚本蔵; 高島成二; 高島成二
日本分子生物学会年会プログラム・要旨集(Web), 2023 - Transcription environment imaging of newly identified cardiac-specific enhancer for regulating transcription of natriuretic peptide genes (Nppa, Nppb).
JO Hyejin; 松岡研; 井上聖; 塚本蔵; 塚本蔵; 塚本蔵; 高島成二; 高島成二
日本分子生物学会年会プログラム・要旨集(Web), 2023 - ナトリウム利尿ペプチド遺伝子を制御する心不全感受性エンハンサークラスターの解明
井上 聖; 松岡 研; ゾ・ヘジン; 塚本 蔵; 高島 成二
日本生化学会大会プログラム・講演要旨集, Nov. 2022 - ナトリウム利尿ペプチドの転写を制御するエンハンサー領域と結合する転写因子群の同定
Jo Hyejin; 松岡 研; 井上 聖; 塚本 蔵; 高島 成二
日本生化学会大会プログラム・講演要旨集, Nov. 2022 - Identification of potential enhancers and transcription factors that regulate the expression of Nppa and Nppb genes
JO Hyejin; 松岡研; 井上聖; 塚本蔵; 塚本蔵; 高島成二; 高島成二
日本分子生物学会年会プログラム・要旨集(Web), 2022 - Molecular mechanism of the heart failure-responsive enhancer cluster that regulates the dramatic induction of the natriuretic peptide gene transcription
井上聖; 松岡研; JO Hyejin; 塚本蔵; 塚本蔵; 高島成二; 高島成二
日本分子生物学会年会プログラム・要旨集(Web), 2022 - 【心不全の診療update-最新の診断と治療-】心筋ミオシンアクチベータomecamtiv mecarbil
塚本 蔵
日本臨床, Aug. 2021 - サルコメア機能の生化学的および生物物理学的制御(Biochemical and Biophysical Regulation of Sarcomere Function)
塚本 蔵
日本循環器学会学術集会抄録集, Mar. 2021 - Biochemical and Biophysical Regulation of Sarcomere Function(和訳中)
塚本 蔵
日本循環器学会学術集会抄録集, Mar. 2021 - 心臓および病態特異的エンハンサーCR9は力学的負荷で活性化されBNP発現を増加する
坪田 朋也; 松岡 研; 塚本 蔵; 高島 成二
日本生化学会大会プログラム・講演要旨集, Sep. 2020 - Clinical significance of myosin regulatory light chain phosphorylation in heart failure
塚本 蔵; 斎藤 侑希; 藤野 陽; 高島 成二; 北風 政史
循環器内科 = Cardioangiology, Apr. 2020 - 新しい心筋症治療薬 直接的サルコメア制御剤
塚本 蔵
別冊Bio Clinica: 慢性炎症と疾患, Jan. 2020 - 心臓特異的ミオシン軽鎖キナーゼの機能解明
宇山 侑希; 塚本 蔵; 高島 成二
日本生化学会大会プログラム・講演要旨集, Sep. 2019 - 心臓特異的ミオシン軽鎖キナーゼの活性制御機構の解明
宇山 侑希; 塚本 蔵; 高島 成二
生命科学系学会合同年次大会, Dec. 2017 - 心筋機能の矯正を目指したmyosin proteinを標的とする直接的サルコメア調節因子の開発(Development of Direct Sarcomere Modulators Targeting the Myosin Proteins to Correct Cardiac Muscle Function)
塚本 蔵
日本循環器学会学術集会抄録集, Mar. 2017 - 心臓特異的ミオシン軽鎖キナーゼ特異的阻害ペプチドの同定
宇山 侑希; 塚本 蔵; 菅 裕明; 高島 成二
日本生化学会大会プログラム・講演要旨集, Sep. 2016 - Direct Sarcomere Modulators Open a New Era in the Management of Heart Failure With Reduced Systolic Function
Osamu Tsukamoto
JOURNAL OF CARDIAC FAILURE, Sep. 2016 - Phosphorylation of p64, a New Substrate of AMPK, Perturbs Cell Migration
Yi Yan; Osamu Tsukamoto; Masafumi Kitakaze; Seiji Takashima
JOURNAL OF CARDIAC FAILURE, Oct. 2014 - Identification of a New Substrate of AMP-activated Protein Kinase (AMPK)
Osamu Tsukamoto; Yi Yan; Masafumi Kitakaze; Seiji Takashima
JOURNAL OF CARDIAC FAILURE, Oct. 2014 - Heart Failure Specific Enhancer Regulates the Expression of Natriuretic Peptides
Ken Matsuoka; Yoshihiro Asano; Shuichiro Higo; Osamu Tsukamoto; Hidetaka Kioka; Hisakazu Kato; Tetsuo Minamino; Masafumi Kitakaze; Issei Komuro; Seiji Takashima
JOURNAL OF CARDIAC FAILURE, Oct. 2013 - Reduced Proteasome Heterogeneity Augments Cardiac Remodeling
David Liem; Franziska Koser; Osamu Tsukamoto; Yibin Wang; Markus Hecker; Peipei Ping; Oliver Drews
CIRCULATION, Nov. 2012 - Ablation of C/EBP Homologous Protein Attenuates ER-Mediated Apoptosis and Cardiac Dysfunction Induced by Pressure Overload
Hai Ying Fu; Tetsuo Minamino; Osamu Tsukamoto; Yoshihiro Asano; Tadashi Isomura; Masafumi Kitakaze; Issei Komuro
JOURNAL OF CARDIAC FAILURE, Sep. 2010 - Diversity of proteasome complexes in the myocardium and shifts in response to the development of cardiac hypertrophy
Oliver Drews; Osamu Tsukamoto; David Liem; John Streicher; Yibin Wang; Peipei Ping
AMINO ACIDS, Oct. 2009 - Enhancement of the Production of Adiponectin by Natriuretic Peptides in Human Adipocytes and in Patients With Chronic Heart Failure
Masashi Fujita; Osamu Tsukamoto; Mahoto Kato; Masaaki Uematsu; Shinsuke Nanto; Masafumi Kitakaze
JOURNAL OF CARDIAC FAILURE, Sep. 2009 - ROLES OF INFLAMMATION AND ENDOPLASMIC RETICULUM STRESS IN THE PROGRESSION AND RAPTURE OF ATHEROSCLEROTIC PLAQUES
M. Kitakaze; M. Myoishi; O. Tsukamoto; T. Minamino; M. Fujita; H. Tomoike; N. Hashimoto
ATHEROSCLEROSIS SUPPLEMENTS, Jun. 2009 - THE ONSET OF ACUTE CORONARY SYNDROME IS ATTRIBUTABLE TO ENDOPLASMIC RETICULUM STRESS IN THE ATHEROSCLEROTIC PLAQUES
M. Kitakaze; M. Myoishi; O. Tsukamoto; N. Hashimoto; H. Tomoike
ATHEROSCLEROSIS SUPPLEMENTS, Jun. 2009 - NATRIURETIC PEPTIDES ENHANCE THE PRODUCTION OF ADIPONECTIN
Masashi Fujita; Osamu Tsukamoto; Mahoto Kato; Satoru Yamazaki; Yoshihiro Asano; Masafumi Kitakaze
JOURNAL OF VASCULAR RESEARCH, 2009 - Statin prevents structural and electrical atrial remodeling in rat hypertensive heart failure induced by chronic inhibition of NO synthesis
Hidetoshi Okazaki; Tetsuo Minamino; Masakatsu Wakeno; Osamu Tsukamoto; Jiyoong Kim; Sejji Takashima; Naoki Mochizuki; Masafumi Kitakaze
CIRCULATION, Oct. 2007 - FRS-092 Chronic Stimulation of Adenosine A2b Receptors Begun after Myocardial Infarction Prevents Cardiac Remodeling in Rats(Heart Failure, Cardiac Remodeling and Cardiomyopathy 2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
Wakeno Masakatsu; Minamino Tetsuo; Seguchi Osamu; Okazaki Hidetoshi; Tsukamoto Osamu; Fujita Masashi; Asanuma Hiroshi; Kim Jiyoong; Komamura Kazuo; Takashima Seiji; Kitakaze Masafumi
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2007 - OJ-248 Depression of Proteasome Activities During the Progression of Cardiac Dysfunction in Pressure-overloaded Heart of Mice(Heart failure, basic-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
Tsukamoto Osamu; Minamino Tetsuo; Hori Masatsugu; Kitakaze Masafumi
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2007 - PE-238 Carperitide, Human Atrial Natriuretic Peptide Modulates Plasma Adiponectin Levels in Patients With Chronic Heart Failure due to Non-ischemic Dilated Cardiomyopathy(Heart failure, clinical-08, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
Kato Mahoto; Hashimura Kazuhiko; Ogai Akiko; Tsukamoto Osamu; Komamura Kazuo; Kitakaze Masafumi
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2007 - Activation of A(1) adenosine receptors inhibits the adrenal aldosterone production and attenuates severity of heart failure
Osamu Tsukamoto; Tetsuo Minamino; Shoji Sanada; Hidetoshi Okazaki; Ichiro Hisatome; Seiji Takashima; Yasunori Shintani; Yoshihiro Asano; Masafumi Kitakaze
CIRCULATION, Oct. 2006 - Brain natriuretic peptide enhances adiponectin production in adipocytes
Osamu Tsukamoto; Masanori Asakura; Tetsuo Minamino; Jiyoong Kim; Hiroshi Asanuma; Ichiro Kishimoto; Masafumi Kitakaze
CIRCULATION, Oct. 2006 - メタボリックシンドローム:最新の診断と治療 西有田町住民コホートにおけるアディポネクチン規定因子の網羅的解析 メタボリックシンドロームとの関わり
大原 貴裕; 金 智隆; 山本 博之; 塚本 蔵; 安部 晴彦; 加藤 真帆人; 杜 徳尚; 長谷川 拓也; 山野 哲弘; 吉牟田 剛; 浅沼 博司; 朝倉 正紀; 小粥 章子; 友池 仁暢; 北風 政史
Journal of Cardiology, Sep. 2006 - OJ-020 Oxidative Stress-induced Decline of Proteasome Activity Promotes Accumulation of Proapoptotic Proteins and Contributes to Cardiomyocytes Apoptosis in Failing Heart(Heart failure, basic-2 (M) OJ4,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
Tsukamoto Osamu; Minamino Tetsuo; Okada Kenichiro; Shintani Yasunori; Takashima Seiji; Hori Masatsugu; Kitakaze Masafumi
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2006 - OJ-320 Granulocyte Colony-Stimulating Factor Mediates Cardioprotection against Ischemia/Reperfusion Injury via Phosphatidylinositol-3-Kinase/Akt Pathway : Evaluation in Vitro Cardiomyocytes and in Vivo Canine Hearts(Acute myocardial infarction, basic-2 (IHD) OJ54,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
Takahama Hiroyuki; Hirata Akio; Minamino Tetsuo; Asanuma Hiroshi; Fujita Masashi; Wakeno Masakatsu; Komamura Kazuo; Tsukamoto Osamu; Okada Kenichiro; Takashima Seiji; Mochizuki Naoki; Kitakaze Masafumi
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2006 - PJ-092 Activation of Adenosine A1 Receptors Inhibits Aldosterone Synthesis in Adrenal Glands(Metabolism/Biochemistry/Energetics-3 (M) PJ16,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
Tsukamoto Osamu; Minamino Tetsuo; Sanada Shoji; Asanuma Hiroshi; Okada Kenichiro; Takashima Seiji; Hori Masatsugu; Kitakaze Masafumi
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2006 - The pathophysiological role of endoplasmic reticulum stress in the failing hearts
KI Okada; T Minamino; H Okazaki; O Tsukamoto; T Isomura; S Takashima; M Hori; M Kitakaze
JOURNAL OF CARDIAC FAILURE, Dec. 2005 - Oxidative stress-induced deactivation of proteasome contributes apoptosis of cardiomyocyte in failing hearts
O Tsukamoto; T Minamino; K Okada; Y Shintani; A Hirata; Y Asano; H Kato; Y Nagamachi; S Takashima; M Hori; M Kitakaze
CIRCULATION, Oct. 2005 - Impaired glucose tolerance: A novel risk factor contributing to left ventricular hypertrophy and diastolic cardiac dysfunction
M Fujita; T Minamino; H Asanuma; A Hirata; Y Liao; Y Asano; KI Okada; O Tsukamoto; H Okuda; M Goto; M Hori; M Kitakaze
CIRCULATION, Oct. 2005 - Angiotensin 2 type 1 receptor antagonist prevents atrial structural remodeling in rats with hypertension induced by long-term inhibition of no synthesis
H Okazaki; T Minamino; O Tsukamoto; YL Liao; J Kim; KI Okada; H Yamamoto; M Wakeno; O Seguchi; M Myoishi; M Kitakaze
CIRCULATION, Oct. 2005 - Chronic adenosine receptors stimulation prevents deterioration of cardiac function after myocardial infarction by reducing fibrosis in non-infarct area
M Wakeno; T Minamino; O Tsukamoto; K Okada; H Okazaki; O Seguchi; H Yamamoto; M Myoishi; J Kim; M Kitakaze
CIRCULATION, Oct. 2005 - 心不全進展のメカニズムを考慮した分子レベルからの新たな心不全治療戦略 アデノシンは新しい慢性心不全治療薬となりうるか 包括的解析手法の応用
北風 政史; 金 智隆; 廖 禹林; 塚本 蔵; 友池 仁暢; 北村 惣一郎
Journal of Cardiology, Aug. 2005 - 心不全における小胞体ストレスの病態生理学的役割(The pathophysiological role of endoplasmic reticulum stress in the failing hearts)
岡田 健一郎; 南野 哲男; 塚本 蔵; 新谷 泰範; 岡崎 英俊; 磯村 正; 堀 正二; 北風 政史
Journal of Cardiology, Aug. 2005 - Endoplasmic reticulum-initiated apoptosis via CHOP/GADD153-dependent pathway contributes to the development of heart failure
T Minamino; KI Okada; O Tsukamoto; M Hori; M Kitkaze
CIRCULATION, Apr. 2005 - Neovascularization by Erythropoietin Contributes to the Preservation of Left Ventricular Function after Coronary Artery Ligation in Conscious Beagle Dogs(Angiogenesis 4 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
Hirata Akio; Minamino Tetsuo; Asanuma Hiroshi; Sanada Shoji; Fujita Masashi; Wakeno Masakatsu; Myoishi Masafumi; Tsukamoto Osamu; Okada ken-ichiro; Komamura Kazuo; Hori Masatsugu; Kitakaze Masafumi
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2005 - Cotribution of Endoplasmic Reticulum-Initiated Apoptosis to Progression from Hypertensive to Failing Hearts(Hypertension and Organ Damage, The 69th Annual Scientific Meeting of the Japanese Circulation Society)
Minamino Tetsuo; Okada Kenichiro; Tsukamoto Osamu; Hori Masatsugu; Kitakaze Masafumi
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2005 - Selective Blockade of Serotonin 5HT2A Receptor Increases Coronary Blood Flow via NO-Dependent Pathway Through 5HT1B Receptor in Hypoperfused Canine Hearts(Coronary Circulation, Basic/Clinical 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
Fujita Masashi; Minamino Tetsuo; Sanada Shoji; Asanuma Hiroshi; Hirata Akio; Okada Ken-ichiro; Tsukamoto Osamu; Takashima Seiji; Tomoike Hitonobu; Node Koichi; Hori Masatsugu; kitakaze Masafumi
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2005 - Nongenomic Deleterious Effects of Aldosterone on Ischemic Hearts via PKC-Dependent Pathway in Dogs(Coronary Circulation, Basic/Clinical 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
Fujita Masashi; Minamino Tetsuo; Asanuma Hiroshi; Sanada Shoji; Hirata Akio; Wakeno Masakatsu; Myoishi Masafumi; Okada Ken-ichiro; Tsukamoto Osamu; Okuda Hiroko; Tomoike Hitonobu; Hori Masatsugu; Kitakaze Masafumi
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2005 - Decreased Proteasome Activity by Oxidative Stress Induces Cardiac Myocytes Apoptosis via p53-mediated Pathway(Heart Failure, Basic 2 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
Tsukamoto Osamu; Minamino Tetsuo; Okada Kenichiro; Shintani Yasunori; Hirata Akio; Fujita Masashi; Asano Yoshihiro; Asanuma Hiroshi; Takashima Seiji; Hori Masatsugu; Kitakaze Masafumi
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2005 - The Pathophysiological Role of Endoplasmic Reticulum Stress in the Failing Hearts : Possibility of Brain-Type Natriuretic Peptide as its Marker (Heart Failure, Basic 6 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
Okada Kenichiro; Minamino Tetsuo; Tsukamoto Osamu; Sintani Yasunori; Takashima Seiji; Hirata Akio; Fujita Masashi; Tsukamoto Yoshitane; Isomura Tadashi; Tomoike Hitonobu; Hori Masatsugu; Kitakaze Masafumi
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2005 - How to apply genomic science for new treatment of chronic heart failure: A new finding of the involvement of ER stress
M Kitakaze; J Kim; O Tsukamoto; K Okada; T Minamino; M Hori; H Tomoike; S Kitamura
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005 - Ablation of MEW suppresses vascular remodeling by attenuation of both smooth muscle cell invasion and uPA expression in blood flow cessation model of mice
O Tsukamoto; L Yan; K Okada; Y Shintani; Y Asano; Y Liao; Y Nagamachi; A Ogai; H Asanuma; S Takashima
CIRCULATION, Oct. 2004 - Proteasome deactivation by oxidative stress induces cardiac myocytes apoptosis via p53-mediated pathway in pressure-overloaded hearts of mice
O Tsukamoto; T Minamino; KI Okada; Y Shintani; Y Asano; Y Liao; J Kim; S Takashima; M Kitakaze
CIRCULATION, Oct. 2004 - OJ-298 MEKK1 is Required in Vascular Remodeling after Injury in Carotid Ligation Model(Restenosis after Angioplasty, Basic/Clinical 2 (IHD) : OJ36)(Oral Presentation (Japanese))
Ri Ken; Minamino Tetsuo; Tsukamoto Osamu; Yujiri Toshiaki; Johnson Gary L; Kitakaze Masafumi
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2004 - OJ-324 Antagonism of Aldosterone Receptor Attenuates Severity of Cardiac Dysfunction and Inflammation Induced by Chronic Blockade of NO Synthesis in Rats(Cardiovascular Pharmacology, Basic/Clinical 2 (H) : OJ39)(Oral Presentation (Japanese))
Tsukamoto Osamu; Minamino Tetsuo; Sanada Shoji; ri ken; Okada Kenichiro; Fujita Masashi; Shintani Yasunori; Asano Yoshihiro; Hirata Akio; Asanuma Hiroshi; Liao Yulin; Takashima Seiji; Hori Masatsugu; Kitakaze Masafumi
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2004 - PJ-046 Celiprolol, a Selective β_1-Adrenoceptor Antagonist, Limits Infarct Size via NO-dependent Mechanisms(Acute Myocardial Infarction, Basic 2 (IHD) : PJ8)(Poster Session (Japanese))
Asanuma Hiroshi; Minamino Tetsuo; Sanada Shoji; Takashima Seiji; Kimu Chiyun; Liao Yulin; Fujita Masashi; Hirata Akio; Asano Yoshihiro; Shintani Yasunori; Okada Kenichiro; Tsukamoto Osamu; Hori Masatsugu; Kitakaze Masafumi
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2004 - PJ-047 The Combined Therapy of Angiotensin Converting Enzyme Inhibitor, Angiotensin II Receptor Blocker and Beta-blockers Submaximally Limits Infarct Size(Acute Myocardial Infarction, Basic 2 (IHD) : PJ8)(Poster Session (Japanese))
Asanuma Hiroshi; Minamino Tetsuo; Sanada Shoji; Takashima Seiji; Kimu Chiyun; Liao Yulin; Fujita Masashi; Hirata Akio; Asano Yoshihiro; Shintani Yasunori; Okada Kenichiro; Tsukamoto Osamu; Hori Masatsugu; Kitakaze Masafumi
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2004 - OJ-442 Gq-stimulation along with low activity of proteasome induces cardiac apoptosis : Potential mechanism of transition from hypertrophy to failure(Heart Failure, Basic 3 (M) : OJ54)(Oral Presentation (Japanese))
Tsukamoto Osamu; Minamino Tetsuo; Takashima Seiji; Okada Kenichiro; Hirata Akio; Fujita Masashi; Shintani Yasunori; Asano Yoshihiro; Sanada Shoji; Asanuma Hiroshi; Ri Ken; Liao Yulin; Takashima Seiji; Hori Masatsugu; Kitakaze Masafumi
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2004 - Protein kinase A-induced Rho-kinase inhibition as a novel mediator of ischemic preconditioning independent of protein kinase C
S Sanada; H Asanuma; O Tsukamoto; S Takashima; Y Liao; T Fukushima; Y Okuda; Y Shinozaki; K Node
CIRCULATION, Oct. 2003 - A role of deactivation of proteasome in Gq-stimulation-mediated cardiac apoptosis
O Tsukamoto; K Okada; M Fujita; A Hirata; Y Asano; Y Nagamachi; T Minamino
CIRCULATION, Oct. 2003 - Selective estrogen receptor modulator raloxifene inhibits the cardiac hypertrophy and dysfunction due to aortic banding in mice
H Ogita; K Node; H Asanuma; S Sanada; S Takashima; T Minamino; M Asakura; J Kim; Y Liao; Y Asano; Y Shintani; K Okada; M Fujita; A Hirata; O Tsukamoto; M Hori; M Kitakaze
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Mar. 2003 - VO_2 oscillation during exercise testing disappears following recovery from advanced heart failure by LVAD (Left Ventricular Assist Device) and transplantation
Tsukamoto Osamu; Ino Yasushi; Sakuragi Satoru; Takagi Shuichi; Suzuki Shoji; Satoh Nagato; Nagaya Noritoshi; Sakamaki Fumio; Yasumura Yoshio; Goto Yoichi; Takaki Hiroshi; Sunagawa Kenji; Hanatani Akihisa; Nakatani Takeshi
Circulation journal : official journal of the Japanese Circulation Society, 31 Mar. 2002 - 0464 心筋虚血を示すPTCA成功例の臨床所見
片山 敏郎; 中嶋 寛; 塚本 蔵; 本田 幸治; 鈴木 伸; 矢野 捷介
Japanese circulation journal, 01 Mar. 2000 - P094 左室壁運動障害部位の型別に見た拡張型心筋症の心機能および僧帽弁逆流の検討
塚本 蔵; 戸田 源二; 南 貴子; 河野 浩章; 川原 史生; 山近 史郎; 芦澤 直人; 早野 元信; 矢野 捷介
Japanese circulation journal, 01 Mar. 2000 - P396 急性心筋梗塞におけるマグネシウム投与の心筋保護効果
中嶋 寛; 片山 敏郎; 塚本 蔵; 本田 幸治; 鈴木 伸; 矢野 捷介
Japanese circulation journal, 01 Mar. 2000 - 19) 心筋虚血を示すPTCA成功例の臨床所見
片山 敏郎; 中嶋 寛; 塚本 蔵; 本田 幸治; 鈴木 伸; 矢野 捷介
Japanese circulation journal, 20 Oct. 1999 - 57) 腺腫の局在診断が困難であった原発性アルドステロン症の一例
塚本 蔵; 片山 敏郎; 中嶋 寛; 本田 幸治; 鈴木 伸; 矢野 捷介
Japanese circulation journal, 20 Oct. 1999 - 心筋肥厚を呈する急性心筋炎の臨床所見
塚本 蔵; 中嶋 寛; 片山 敏朗; 本田 幸治; 鈴木 伸; 片山 知之; 戸田 源二; 矢野 捷介
Journal of Cardiology, Aug. 1999 - 1053 C型肝炎ウイルス感染患者における拡張型心筋症の有病率の検討
白石 嘉憲; 於久 幸治; 塚本 蔵; 江崎 宏典; 品川 達夫; 矢野 捷介
Japanese circulation journal, 01 Mar. 1999
Affiliated academic society
Research Themes
- Development of atropine esterase formulation to improve the effect of atropine used in the anesthesiology field
Grant-in-Aid for Scientific Research (C)
National Cardiovascular Center Research Institute
01 Apr. 2019 - 31 Mar. 2022 - Identification of Novel Molecular Targets and Drug Development by Genomic and Multilayer-Omics Analysis of Hereditary Cardiomyopathies
Grant-in-Aid for Scientific Research (B)
Osaka University
01 Apr. 2019 - 31 Mar. 2022 - Elucidation of the mechanism in which mechanostress modulates cardiac microtubules dynamics
Grant-in-Aid for Scientific Research (C)
01 Apr. 2018 - 31 Mar. 2021 - Development and clinical application of low molecular chemicals that modulate myosin light chain kinase for the treatment of heart failure with preserved ejection fraction
Grant-in-Aid for Scientific Research (A)
National Cardiovascular Center Research Institute
01 Apr. 2018 - 31 Mar. 2021 - Analysis of the regulatory mechanism of the activity of cardiac specific myosin light chain kinase
Grant-in-Aid for Scientific Research (C)
Osaka University
01 Apr. 2017 - 31 Mar. 2020 - Elucidation of the irreversible mechanism of severe heart failure using biological monitoring murine heart failure model
Grant-in-Aid for Scientific Research (C)
Osaka University
01 Apr. 2015 - 31 Mar. 2018 - A novel AMPK singaling at the intercalated disc in heart
Grant-in-Aid for Scientific Research (C)
Osaka University
01 Apr. 2015 - 31 Mar. 2018 - Elucidation of the regulatory mechanism of natriuretic hormone expression for oral heart failure drug development
Grant-in-Aid for Scientific Research (B)
Osaka University
01 Apr. 2015 - 31 Mar. 2018 - anti-atherosclerotic and anti-cancer effects of AMPK activation
Grant-in-Aid for Scientific Research (C)
Osaka University
01 Apr. 2014 - 31 Mar. 2017 - Exploration for Aggravating Process of Heart Failure Induced by Specific Interaction with G-protein-coupled Receptor and Toll-like Receptor
Grant-in-Aid for Scientific Research (C)
Osaka University
01 Apr. 2013 - 31 Mar. 2016 - Development of simple and noninvasive method to assess the severity of heart failure
Grant-in-Aid for Challenging Exploratory Research
Osaka University
01 Apr. 2014 - 31 Mar. 2015 - A New Diagnostics Method for Refractory Heart Failure
Grant-in-Aid for Scientific Research (C)
Osaka University
01 Apr. 2012 - 31 Mar. 2015 - Role of ER oxidoreductin-1 in cardiovascular remodeling
Grant-in-Aid for Scientific Research (C)
Osaka University
01 Apr. 2012 - 31 Mar. 2015 - Identification of cardiomyocyte-specific transcriptional mechanism of c-myc
Grant-in-Aid for Research Activity Start-up
Osaka University
2010 - 2011 - Identification and Functional Analysis of Cardiac Specific Singling Molecules and Therapeutic Applications for Cardiovascular Disease
Grant-in-Aid for Scientific Research (B)
Osaka University
2008 - 2010
