Last Updated :2024/12/13
Researcher Information
Career
- Apr. 2020 - Present
Hyogo Medical University, Department of Neurophysiology, Assistant professor - Apr. 2019 - Mar. 2020
Kyushu University, Graduate school of Pharmacological Sciences, Department of Life Innovation, Temporally appointed assistant professor - Apr. 2018 - Mar. 2019
Japan Society for the Promotion of Science, JSPS reserch fellow (PD, switch from DC2) - Apr. 2017 - Mar. 2018
Japan Society for the Promotion of Science, JSPS reserch fellow (DC2)
Research activity information
Award
Paper
- Disease-relevant upregulation of P2Y1 receptor in astrocytes enhances neuronal excitability via IGFBP2
Eiji Shigetomi; Hideaki Suzuki; Yukiho J. Hirayama; Fumikazu Sano; Yuki Nagai; Kohei Yoshihara; Keisuke Koga; Toru Tateoka; Hideyuki Yoshioka; Youichi Shinozaki; Hiroyuki Kinouchi; Kenji F. Tanaka; Haruhiko Bito; Makoto Tsuda; Schuichi Koizumi
Nature Communications, Aug. 2024, [Reviewed] - 〔Major achievements〕Anterior cingulate cross-hemispheric inhibition via the claustrum resolves painful sensory conflict
Keisuke Koga; Kenta Kobayashi; Makoto Tsuda; Anthony E. Pickering; Hidemasa Furue
Communications Biology, Mar. 2024, [Reviewed]
Lead - Optogenetic inhibition of spinal inhibitory neurons facilitates mechanical responses of spinal wide dynamic range neurons and causes mechanical hypersensitivity
Yuka Fujiwara; Keisuke Koga; Nozomu H. Nakamura; Keishi Maruo; Toshiya Tachibana; Hidemasa Furue
Neuropharmacology, Jan. 2024, [Reviewed]
Corresponding - 〔Major achievements〕Voltage-gated calcium channel subunit α2δ-1 in spinal dorsal horn neurons contributes to aberrant excitatory synaptic transmission and mechanical hypersensitivity after peripheral nerve injury
Keisuke Koga; Kenta Kobayashi; Makoto Tsuda; Kazufumi Kubota; Yutaka Kitano; Hidemasa Furue
Frontiers in Molecular Neuroscience, Mar. 2023, [Reviewed]
Lead - Identification of Spinal Inhibitory Interneurons Required for Attenuating Effect of Duloxetine on Neuropathic Allodynia-like Signs in Rats.
Tadayuki Ishibashi; Daichi Sueto; Yu Yoshikawa; Keisuke Koga; Ken Yamaura; Makoto Tsuda
Cells, Dec. 2022, [Reviewed] - Selective Involvement of a Subset of Spinal Dorsal Horn Neurons Operated by a Prodynorphin Promoter in Aβ Fiber-Mediated Neuropathic Allodynia-Like Behavioral Responses in Rats
Tadayuki Ishibashi; Yu Yoshikawa; Daichi Sueto; Ryoichi Tashima; Hidetoshi Tozaki-Saitoh; Keisuke Koga; Ken Yamaura; Makoto Tsuda
Frontiers in Molecular Neuroscience, Jun. 2022, [Reviewed] - 〔Major achievements〕Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch.
Kensho Kanehisa; Keisuke Koga; Sho Maejima; Yuto Shiraishi; Konatsu Asai; Miho Shiratori-Hayashi; Mei-Fang Xiao; Hirotaka Sakamoto; Paul F Worley; Makoto Tsuda
Nature communications, May 2022, [Reviewed] - Stress-induced antinociception to noxious heat requires α1A-adrenaline receptors of spinal inhibitory neurons in mice.
Sawako Uchiyama; Kohei Yoshihara; Riku Kawanabe; Izuho Hatada; Keisuke Koga; Makoto Tsuda
Molecular brain, Jan. 2022, [Reviewed] - Long-term selective stimulation of transplanted neural stem/progenitor cells for spinal cord injury improves locomotor function.
Momotaro Kawai; Kent Imaizumi; Mitsuru Ishikawa; Shinsuke Shibata; Munehisa Shinozaki; Takahiro Shibata; Shogo Hashimoto; Takahiro Kitagawa; Kentaro Ago; Keita Kajikawa; Reo Shibata; Yasuhiro Kamata; Junichi Ushiba; Keisuke Koga; Hidemasa Furue; Morio Matsumoto; Masaya Nakamura; Narihito Nagoshi; Hideyuki Okano
Cell reports, Nov. 2021, [Reviewed] - α1A-adrenaline receptors in dorsal horn inhibitory neurons have an inhibitory role in the regulation of chloroquine-induced itch in mice.
Yuto Shiraishi; Keisuke Koga; Ryo Yamagata; Izuho Hatada; Miho Shiratori-Hayashi; Makoto Tsuda
Molecular brain, Mar. 2021, [Reviewed]
Lead - 〔Major achievements〕A subset of spinal dorsal horn interneurons crucial for gating touch-evoked pain-like behavior
Ryoichi Tashima; Keisuke Koga; Yu Yoshikawa; Misuzu Sekine; Moeka Watanabe; Hidetoshi Tozaki-Saitoh; Hidemasa Furue; Toshiharu Yasaka; Makoto Tsuda
Proceedings of the National Academy of Sciences, Jan. 2021, [Reviewed]
Lead - A discrete glycinergic neuronal population in the ventromedial medulla that induces muscle atonia during REM sleep and cataplexy in mice
Shuntaro Uchida; Shingo Soya; Yuki C. Saito; Arisa Hirano; Keisuke Koga; Makoto Tsuda; Manabu Abe; Kenji Sakimura; Takeshi Sakurai
The Journal of Neuroscience, Dec. 2020, [Reviewed] - Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity.
Yuta Kohro; Tsuyoshi Matsuda; Kohei Yoshihara; Keita Kohno; Keisuke Koga; Ryuichi Katsuragi; Takaaki Oka; Ryoichi Tashima; Sho Muneta; Takuya Yamane; Shota Okada; Kazuya Momokino; Aogu Furusho; Kenji Hamase; Takumi Oti; Hirotaka Sakamoto; Kenichiro Hayashida; Ryosuke Kobayashi; Takuro Horii; Izuho Hatada; Hidetoshi Tozaki-Saitoh; Katsuhiko Mikoshiba; Verdon Taylor; Kazuhide Inoue; Makoto Tsuda
Nature neuroscience, Nov. 2020, [Reviewed] - 〔Major achievements〕Intrinsic braking role of descending locus coeruleus noradrenergic neurons in acute and chronic itch in mice
Keisuke Koga; Yuto Shiraishi; Ryo Yamagata; Hidetoshi Tozaki-Saitoh; Miho Shiratori-Hayashi; Makoto Tsuda
Molecular Brain, Oct. 2020, [Reviewed]
Lead - 〔Major achievements〕Sensitization of spinal itch transmission neurons in a mouse model of chronic itch requires an astrocytic factor.
Keisuke Koga; Ryo Yamagata; Keita Kohno; Takuya Yamane; Miho Shiratori-Hayashi; Yuta Kohro; Hidetoshi Tozaki-Saitoh; Makoto Tsuda
The Journal of allergy and clinical immunology, Jan. 2020, [Reviewed]
Lead - Optogenetic Activation of Non-Nociceptive Aβ Fibers Induces Neuropathic Pain-Like Sensory and Emotional Behaviors after Nerve Injury in Rats
Ryoichi Tashima; Keisuke Koga; Misuzu Sekine; Kensho Kanehisa; Yuta Kohro; Keiko Tominaga; Katsuyuki Matsushita; Hidetoshi Tozaki-Saitoh; Yugo Fukazawa; Kazuhide Inoue; Hiromu Yawo; Hidemasa Furue; Makoto Tsuda
eNeuro, Feb. 2018, [Reviewed]
Lead - Specific activation of inhibitory interneurons in the spinal dorsal horn suppresses repetitive scratching in mouse models of chronic itch.
Kensho Kanehisa; Miho Shiratori-Hayashi; Keisuke Koga; Hidetoshi Tozaki-Saitoh; Yuta Kohro; Kenji Takamori; Makoto Tsuda
Journal of dermatological science, Nov. 2017, [Reviewed] - Chemogenetic silencing of GABAergic dorsal horn interneurons induces morphine-resistant spontaneous nocifensive behaviours.
Keisuke Koga; Kensho Kanehisa; Yuta Kohro; Miho Shiratori-Hayashi; Hidetoshi Tozaki-Saitoh; Kazuhide Inoue; Hidemasa Furue; Makoto Tsuda
Scientific reports, Jul. 2017, [Reviewed]
Lead - 〔Major achievements〕STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch.
Miho Shiratori-Hayashi; Keisuke Koga; Hidetoshi Tozaki-Saitoh; Yuta Kohro; Honami Toyonaga; Chiharu Yamaguchi; Ayumi Hasegawa; Takeshi Nakahara; Junichi Hachisuka; Shizuo Akira; Hideyuki Okano; Masutaka Furue; Kazuhide Inoue; Makoto Tsuda
Nature medicine, Aug. 2015, [Reviewed]
MISC
- 脊髄後角抑制性介在神経の急性的な抑制はモルヒネ抵抗性の自発的疼痛関連行動を引き起こす
古賀啓祐; 兼久賢章; 高露雄太; 齋藤秀俊; 井上和秀; 古江秀昌; 津田誠
Pain Research, Jun. 2017
Lectures, oral presentations, etc.
- The role of anterior cingulate cross-hemispheric projection to the claustrum in pain processing
Keisuke Koga; Kenta Kobayashi; Makoto Tsuda; Anthony E Pickering; Hidemasa Furue
Neuro2024, Jul. 2024 - Anterior cingulate cross-hemispheric projection to the claustrum determines prioritization in painful sensory conflict
Keisuke Koga; Kenta Kobayashi; Makoto Tsuda; Anthony E Pickering; Hidemasa Furue
FENS forum 2024, Jun. 2024 - 脊髄後角興奮性神経に発現するα2δ-1サブユニットの機械性痛覚過敏における役割解明
古賀 啓祐; 小林 憲太; 津田 誠; 窪田 一史; 北野 裕; 古江 秀昌
第101回日本生理学会大会, Mar. 2024 - 疼痛制御に関与する新たな中枢神経機構の探索と役割解明
古賀 啓祐; 古江 秀昌
痛み研究会2023, Jan. 2024, [Invited] - 光遺伝学的脊髄GABAニューロンの脱抑制による異常痛覚応答とα2δ-1リガンドによる鎮痛効果
藤原 優香; 古賀 啓祐; 橘 俊哉; 古江 秀昌
第45回日本疼痛学会, Dec. 2023 - 神経障害性疼痛における脊髄後角神経に発現するα2δ-1サブユニットの役割
古賀 啓祐; 小林 憲太; 津田 誠; 窪田 一史; 北野 裕; 古江 秀昌
第45回日本疼痛学会, Dec. 2023 - nvolvement of the voltage-gated calcium channel subunit, α2δ-1, expressed in spinal dorsal horn excitatory neurons for facilitation of excitatory synaptic transmission and mechanical hypersensitivity after peripheral nerve injury
Keisuke Koga; Kenta Kobayashi; Makoto Tsuda; Kazufumi Kubota; Yutaka Kitano; Hidemasa Furue
Neuroscience 2023, Nov. 2023 - 睡眠障害による前帯状回ニューロン活動の変化
中野 康佑; 古賀 啓祐; 角谷 学; 小山 英則; 古江 秀昌
第44回日本疼痛学会, Dec. 2022 - A subset of dorsal horn inhibitory interneurons has a critical role in mechanical allodynia after nerve injury
Keisuke Koga; Ryoichi Tashima; Yuta Kohro; Kazuhide Inoue; Hiromu Yawo; Hidemasa Furue; Makoto Tsuda
The 8th Asian Pain symposium in Korea, Dec. 2019 - Spinal dorsal horn astrogliosis facilitates itch transmission in a mouse model of contact dermatitis
Keisuke Koga; Ryo Yamagata; Miho Shiratori-Hayashi; Makoto Tsuda
The 92nd annual meeting of japanese pharmacological society, Mar. 2019 - Rapid and selective inhibition of dorsal horn inhibitory interneurons induces morphine-resistant spontaneous nocifensive behaviors
Keisuke Koga; Kensho Kanehisa; Tozaki-Saitoh Hidetoshi; Hidemasa Furue; Makoto Tsuda
The 18 th World Congress of Basic and Clinical Pharmacology, Jun. 2018 - Optogenetic activation of non-nociceptive Aβ fibers induces neuropathic pain-like sensory and emotional behaviors
Ryoichi Tashima; Keisuke Koga; Misuzu Sekine; Kensho Kanehisa; Yuta Kohro; Yugo, Fukazawa; Kazuhide Inoue; Hiromu Yawo; Hidemasa Furue; Makoto Tsuda
The 18 th World Congress of Basic and Clinical Pharmacology, Jun. 2018
Research Themes
- Investigation of serotonergic modulation of spinal dorsal horn neurons by cell-type specific genome editing.
Grant-in-Aid for Early-Career Scientists
Kyushu University
Apr. 2020 - Mar. 2022 - Investigation of spinal circuit mechanisms for itch sensitization in chronic itch conditions via activated spinal astrocytes
Grant-in-Aid for JSPS Fellows
Kyushu University
Apr. 2017 - Mar. 2019
