Last Updated :2024/12/13
Researcher Information
Research activity information
Paper
- COX2 expression plays a role in spinal cord injury-induced neuropathic pain.
Masakazu Toi; Tachibana Toshiya; Koichi Noguchi; Hiroki Yamanaka; Kimiko Kobayashi; Masamichi Okubo; Kazuya Kishima; Yi Dai
Neuroscience letters, Jan. 2024 - 脊髄損傷による神経障害性疼痛におけるCOX2の発現に関する研究
都井 政和; 橘 俊哉; 山中 博樹; 小林 希実子; 大久保 正道; 野口 光一
Journal of Spine Research, Apr. 2023 - 脊髄損傷による神経障害性疼痛におけるCOX2の発現に関する研究
都井 政和; 橘 俊哉; 野口 光一; 山中 博樹; 小林 希実子; 大久保 正道; 木島 和也; 戴 毅
PAIN RESEARCH, Dec. 2022 - Analgesic effect of gastrin-releasing peptide in the dorsal horn.
Ayano Saeki; Hiroki Yamanaka; Kimiko Kobayashi; Masamichi Okubo; Koichi Noguchi
Molecular pain, Apr. 2022 - Aberrant axo-axonic synaptic reorganization in the phosphorylated l1-cam/calcium channel subunit α2δ 1-containing central terminals of injured c-fibers in the spinal cord of a neuropathic pain model
Hiroki Yamanaka; Masamichi Okubo; Kimiko Kobayashi; Koichi Noguchi
eNeuro, 2021 - Localization of prostaglandin E2 synthases and E-prostanoid receptors in the spinal cord in a rat model of neuropathic pain.
Hirosato Kanda; Kimiko Kobayashi; Hiroki Yamanaka; Masamichi Okubo; Yi Dai; Koichi Noguchi
Brain research, Jan. 2021 - Role of Rho-associated coiled-coil containing protein kinase in the spinal cord injury induced neuropathic pain.
Kazuya Kishima; Toshiya Tachibana; Hiroki Yamanaka; Kimiko Kobayashi; Masamichi Okubo; Keishi Maruo; Koichi Noguchi
The spine journal : official journal of the North American Spine Society, Aug. 2020, [Reviewed] - Characterization of Photographic Emulsions for Autoradiography
Ken’ichi Kuge; Masamichi Okubo; Naotaka Naganawa; Hyuma Masu; Hiroyuki Suzuki
Bull. Soc. Photogr. Imag. Japan., 2020, [Reviewed] - Differential expression of mGluRs in rat spinal dorsal horns and their modulatory effects on nocifensive behaviors
Masamichi Okubo; Hiroki Yamanaka; Kimiko Kobayashi; Koichi Noguchi
Molecular Pain, Jan. 2019, [Reviewed] - Recombinant interleukin-4 alleviates mechanical allodynia via injury-induced interleukin-4 receptor alpha in spinal microglia in a rat model of neuropathic pain
Okutani H; Yamanaka H; Kobahashi K; Okubo M; Noguchi K
GLIA, Aug. 2018, [Reviewed] - Upregulation of calcium channel alpha-2-delta-1 subunit in dorsal horn contributes to spinal cord injury-induced tactile allodynia
Kazuki Kusuyama; Toshiya Tachibana; Hiroki Yamanaka; Masamichi Okubo; Shinichi Yoshiya; Koichi Noguchi
Spine Journal, Jun. 2018, [Reviewed] - Upregulation of calcium channel alpha-2-delta-1 subunit in dorsal horn contributes to spinal cord injury-induced tactlie allodynia
Kusuyama K; Tachibana T; Yamanaka H; Okubo M; Yoshiya S; Noguchi K
Spine J, 2018, [Reviewed] - Contribution of adenosine to the increase in skeletal muscle blood flow caused by manual acupuncture in rats
Hisashi Shinbara; Satomi Nagaoka; Yasuyuki Izutani; Masamichi Okubo; Keisaku Kimura; Kunio Mizunuma; Eiji Sumiya
ACUPUNCTURE IN MEDICINE, Aug. 2017, [Reviewed] - 末梢神経 脊髄ネットワークにおける痛覚伝達メカニズム 神経傷害性疼痛モデル動物の脊髄後角における損傷C線維の形態的可塑性
山中 博樹; 小林 希実子; 大久保 正道; 野口 光一
PAIN RESEARCH, Jun. 2017 - Microglial TNFα induces COX2 and PGI2 synthase expression in spinal endothelial cells during neuropathic pain
Hirosato Kanda; Kimiko Kobayashi; Hiroki Yamanaka; Masamichi Okubo; Koichi Noguchi
eNeuro, 2017, [Reviewed] - 神経障害性疼痛モデルラットの脊髄後角におけるIL-4およびIL-4受容体の発現変化
奥谷 博愛; 小林 希実子; 山中 博樹; 大久保 正道; 廣瀬 宗孝; 野口 光一
PAIN RESEARCH, Jun. 2016 - Contributions of ADP and ATP to the increase in skeletal muscle blood flow after manual acupuncture stimulation in rats
S. Nagaoka; H. Shinbara; M. Okubo; T. Kawakita; K. Hino; E. Sumiya
ACUPUNCTURE IN MEDICINE, Jun. 2016, [Reviewed] - Macrophage-Colony Stimulating Factor Derived from Injured Primary Afferent Induces Proliferation of Spinal Microglia and Neuropathic Pain in Rats
Masamichi Okubo; Hiroki Yamanaka; Kimiko Kobayashi; Yi Dai; Hirosato Kanda; Hideshi Yagi; Koichi Noguchi
PLOS ONE, Apr. 2016, [Reviewed] - ANNEXIN A2 IN PRIMARY AFFERENTS CONTRIBUTES TO NEUROPATHIC PAIN ASSOCIATED WITH TISSUE TYPE PLASMINOGEN ACTIVATOR
H. Yamanaka; K. Kobayashi; M. Okubo; K. Noguchi
NEUROSCIENCE, Feb. 2016, [Reviewed] - Leukotriene enhances NMDA-induced inward currents in dorsal horn neurons of the rat spinal cord after peripheral nerve injury
Yasukuni Kiyoyuki; Wataru Taniguchi; Masamichi Okubo; Hiroki Yamanaka; Kimiko Kobayashi; Naoko Nishio; Terumasa Nakatsuka; Koichi Noguchi
MOLECULAR PAIN, Sep. 2015, [Reviewed] - Peripherally increased artemin is a key regulator of TRPA1/V1 expression in primary afferent neurons
Yasuko Ikeda-Miyagawa; Kimiko Kobayashi; Hiroki Yamanaka; Masamichi Okubo; Shenglan Wang; Yi Dai; Hideshi Yagi; Munetaka Hirose; Koichi Noguchi
MOLECULAR PAIN, Mar. 2015, [Reviewed] - Contributions of nitric oxide and prostaglandins to the local increase in muscle blood flow following manual acupuncture in rats
Hisashi Shinbara; Masamichi Okubo; Keisaku Kimura; Kunio Mizunuma; Eiji Sumiya
ACUPUNCTURE IN MEDICINE, Feb. 2015, [Reviewed] - ロイコトリエンは末梢神経損傷後に脊髄後角ニューロンのNMDA受容体の反応性を増加させる
清行 康邦; 山中 博樹; 小林 希実子; 谷口 亘; 大久保 正道; 中塚 映政; 野口 光一
Journal of Musculoskeletal Pain Research, Nov. 2013 - 末梢神経損傷後の脊髄および後根神経節におけるColony-stimulating factorとそれら受容体mRNAの発現
大久保 正道; 山中 博樹; 小林 希実子; 神田 浩里; 戴 毅; 野口 光一
Journal of Musculoskeletal Pain Research, Nov. 2013 - ロイコトリエンは末梢神経損傷後に脊髄後角ニューロンのNMDA受容体の反応性を増加させる
清行 康邦; 山中 博樹; 小林 希実子; 谷口 亘; 西尾 尚子; 大久保 正道; 中塚 映政; 野口 光一
PAIN RESEARCH, Jul. 2013 - Phosphorylation of ezrin/radixin/moesin (ERM) protein in spinal microglia following peripheral nerve injury and lysophosphatidic acid administration
Ryosuke Kashimoto; Hiroki Yamanaka; Kimiko Kobayashi; Masamichi Okubo; Hideshi Yagi; Osamu Mimura; Koichi Noguchi
GLIA, Mar. 2013, [Reviewed] - Participation of calcitonin gene related peptide released via axon reflex in the local increase in muscle blood flow following manual acupuncture
Hisashi Shinbara; Masamichi Okubo; Keisaku Kimura; Kunio Mizunuma; Eiji Sumiya
Acupuncture in Medicine, Mar. 2013, [Reviewed] - Transition to Persistent Orofacial Pain after Nerve Injury Involves Supraspinal Serotonin Mechanisms
Masamichi Okubo; Alberto Castro; Wei Guo; Shiping Zou; Ke Ren; Feng Wei; Asaf Keller; Ronald Dubner
JOURNAL OF NEUROSCIENCE, Mar. 2013, [Reviewed] - Multiple P2Y subtypes in spinal microglia are involved in neuropathic pain after peripheral nerve injury
Kimiko Kobayashi; Hiroki Yamanaka; Fujio Yanamoto; Masamichi Okubo; Koichi Noguchi
GLIA, Oct. 2012, [Reviewed] - Up-regulation of platelet-activating factor synthases and its receptor in spinal cord contribute to development of neuropathic pain following peripheral nerve injury
Masamichi Okubo; Hiroki Yamanaka; Kimiko Kobayashi; Hirosato Kanda; Yi Dai; Koichi Noguchi
MOLECULAR PAIN, Feb. 2012, [Reviewed] - Phosphorylation of ezrin/radixin/moesin (ERM) protein in spinal microglia following peripheral nerve injury and lysophosphatidic acid administration
Kashimoto R; Yamanaka H; Kobayashi K; Okubo M; Yagi H; Mimura O; Noguchi K
GLIA, 2012, [Reviewed] - Re-evaluation of the phenotypic changes in L4 dorsal root ganglion neurons after L5 spinal nerve ligation
Tetsuo Fukuoka; Hiroki Yamanaka; Kimiko Kobayashi; Masamichi Okubo; Kan Miyoshi; Yi Dai; Koichi Noguchi
PAIN, Jan. 2012, [Reviewed] - Leukotrienes in Nociceptive Pathway and Neuropathic/Inflammatory Pain
Koichi Noguchi; Masamichi Okubo
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Aug. 2011, [Reviewed] - Increase of Close Homolog of Cell Adhesion Molecule L1 in Primary Afferent by Nerve Injury and the Contribution to Neuropathic Pain
Hiroki Yamanaka; Kimiko Kobayashi; Masamichi Okubo; Tetsuo Fukuoka; Koichi Noguchi
JOURNAL OF COMPARATIVE NEUROLOGY, Jun. 2011, [Reviewed] - Effects of manual acupuncture with the Japanese traditional needle manipulation technique on skeletal muscle blood flow and arterial blood pressure in rats - a comparison of the techniques.
Shinbara H; Okubo M; Kimura K; Mizunuma K; Sumiya E; Kitade T
JAM, 2011, [Reviewed] - Acetylcholine does not participate in the increase in local muscle blood flow following manual acupuncture in rats
Shinbara H; Okubo M; Kimura K; Mizunuma K; Sumiya E
JAM, 2011, [Reviewed] - Expression of leukotriene receptors in the rat dorsal root ganglion and the effects on pain behaviors
Masamichi Okubo; Hiroki Yamanaka; Kimiko Kobayashi; Tetsuo Fukuoka; Yi Dai; Koichi Noguchi
MOLECULAR PAIN, Sep. 2010, [Reviewed] - Leukotriene Synthases and the Receptors Induced by Peripheral Nerve Injury in the Spinal Cord Contribute to the Generation of Neuropathic Pain
Masamichi Okubo; Hiroki Yamanaka; Kimiko Kobayashi; Koichi Noguchi
GLIA, Apr. 2010, [Reviewed] - Increase of close homologue of cell adhesion molecule L1 in primary afferent by nerve injury and the contribution to neuropathic pain
Yamanaka H; Kobayashi K; Okubo M; Fukuoka T; Noguchi, K
J. Comp. Neurol, 2010, [Reviewed] - Effects of manual acupuncture with sparrow pecking on muscle blood flow of normal and denervated hindlimb in rats
Hisashi Shinbara; Masamichi Okubo; Eiji Sumiya; Fumihiko Fukuda; Tadashi Yano; Toshikatsu Kitade
ACUPUNCTURE IN MEDICINE, Sep. 2008, [Reviewed] - ラット後根神経節におけるロイコトリエン受容体の発現
大久保 正道; 山中 博樹; 野口 光一
全日本鍼灸学会雑誌, May 2008 - ラット後根神経節におけるロイコトリエン受容体の発現
大久保 正道; 山中 博樹; 小林 希実子; 野口 光一
解剖学雑誌, Mar. 2008 - ラット下腿筋群の血流量に及ぼす局所マニュアル鍼刺激の影響
大久保 正道; 新原 寿志; 泉谷 泰行; 角谷 英治; 福田 文彦; 矢野 忠
明治鍼灸医学, Dec. 2007 - マニュアル鍼刺激がラット骨格筋の血流量に及ぼす影響
新原 寿志; 大久保 正道; 泉谷 泰行; 角谷 英治; 福田 文彦; 矢野 忠
全日本鍼灸学会雑誌, May 2007 - 瞬目反射に対する「外関」穴の鍼通電の効果
泉谷 泰行; 角谷 英治; 新原 寿志; 尾崎 昭弘; 大久保 正道
全日本鍼灸学会雑誌, May 2006
MISC
- Expression and phosphorylation of ERM family proteins in rat spinal dorsal horn with spared nerve injury (SNI) model
Ryosuke Kashimoto; Hiroki Yamanaka; Kimiko Kobayashi; Masamichi Okubo; Osamu Mimura; Koichi Noguchi
NEUROSCIENCE RESEARCH, 2009 - Platelet-activating factor biosynthesis in spinal cord contributes to neuropathic pain following peripheral nerve injury
Masamichi Okubo; Hiroki Yamanaka; Kimiko Kobayashi; Koichi Noguchi
NEUROSCIENCE RESEARCH, 2009 - Induction of P2 receptors in the spinal microglia following peripheral nerve injury
Kimiko Kobayashi; Hiroki Yamanaka; Masamichi Okubo; Koichi Noguchi
NEUROSCIENCE RESEARCH, 2009 - Expression of leukotriene synthases and leukotriene receptors in the skin and dorsal root ganglion
Masamichi Okubo; Yamanaka Hiroki; Kobayashi Kimiko; Noguchi Koichi
NEUROSCIENCE RESEARCH, 2008 - ヒト瞬目反射を指標にした鍼鎮痛研究
泉谷 泰行; 角谷 英治; 大久保 正道; 新原 寿志; 矢野 忠
明治鍼灸医学, Dec. 2007 - Alteration of the cell adhesion molecule CHL1 expression in a specific subset of primary afferent neurons and dorsal horn following nerve injury
Hiroki Yamanaka; Masamichi Okubo; Koichi Noguchi
NEUROSCIENCE RESEARCH, 2007
Lectures, oral presentations, etc.
- 後根神経節における血小板由来増殖因子受容体の発現と疼痛行動への影響
大久保正道
日本解剖学会, Mar. 2023 - 脊髄後角神経回路におけるmGluRの発現解析と炎症性疼痛との関連
大久保正道、山中博樹; 小林希実子; 野口光一
第４２回日本疼痛学会 - Evaluation of photographic emulsions for autoradiography
Okubo Masamichi
画像関連学会連合会 第６回秋季大会, Oct. 2019 - Inhibitory neurons expressing mGluR4 and 8 modulate pain transmission in spinal dorsal horn
Okubo Masamichi
第42回日本神経科学大会, Jul. 2019 - 脊髄後角神経回路におけるmGluRの発現解析
大久保正道
第125回日本解剖学会総会, Mar. 2019 - Macrophage-colony stimulating factor derived from injured primary afferent induces proliferation of spinal microglia and neuropathic pain in rats
Okubo Masamichi
International Association for the Study of Pain (IASP), Sep. 2016 - 末梢神経損傷後の脊髄および脊髄神経節におけるcolony stimulating factorとそれら受容体mRNAの発現
大久保正道
第6回日本運動器疼痛学会, Dec. 2013 - Expression of colony stimulating factors and their receptors in dorsal root ganglion and spinal cord after peripheral nerve injury
Okubo Masamichi
The 43th Annual Meeting of the Society for Neuroscience, Nov. 2013 - Transition to persistent pain after injury of the infraorbital nerve involved maladaptive plasticity in trigeminal nucleus caudalis
Okubo Masamichi
The 42th Annual Meeting of the Society for Neuroscience, Oct. 2012 - Expression of leukotriene receptors in the rat dorsal root ganglion and the effect on pain behaviors
Okubo Masamichi
The 41th Annual Meeting of the Society for Neuroscience, Nov. 2011 - ラット後根神経節ロイコトリエン受容体発現と疼痛行動への関与
大久保正道
第33回日本疼痛学会, Jul. 2011 - Platelet-activating factor biosynthesis in spinal cord contributes to neuropathic pain following peripheral nerve injury
Okubo Masamichi
The 39th Annual Meeting of the Society for Neuroscience, Oct. 2009 - 末梢神経損傷後に脊髄で合成が増加した血小板活性化因子は神経因性疼痛に関与する
大久保正道
第32回日本神経科学大会, Jul. 2009 - 末梢神経損傷後に脊髄で増加したロイコトリエンは神経因性疼痛に関与する
大久保正道
第31回日本疼痛学会, Jul. 2009 - Upregulation of leukotriene synthesis in glial cells contributes to neuropathic pain following peripheral nerve injury
Okubo Masamichi
The 38th Annual Meeting of the Society for Neuroscience, Nov. 2008 - 皮膚と後根神経節におけるロイコトリエン合成酵素および受容体の発現
大久保正道
第３１回日本神経科学大会, Jul. 2008 - ラット後根神経節におけるロイコトリエン受容体の発現
大久保正道
第57回（社）全日本鍼灸学会学術大会（京都大会）, May 2008
Affiliated academic society
Research Themes
- The role of colony-stimulating factors on microglial proliferation and neuropathic pain in rats
Grant-in-Aid for Young Scientists (B)
Hyogo Medical University
2016 - 2017
