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遺伝性難病・難治性癌に対し遺伝子細胞治療やウイルス療法の研究を行なっている。
Last Updated :2024/12/13
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Research activity information
Paper
- Human-Brain-Derived Ischemia-Induced Stem Cell Transplantation Is Associated with a Greater Neurological Functional Improvement Compared with Human-Bone Marrow-Derived Mesenchymal Stem Cell Transplantation in Mice After Stroke.
Shuichi Tanada; Takayuki Nakagomi; Akiko Nakano-Doi; Toshinori Sawano; Shuji Kubo; Yoji Kuramoto; Kazutaka Uchida; Kenichi Yamahara; Nobutaka Doe; Shinichi Yoshimura
International journal of molecular sciences, Nov. 2024 - Administration of Human-Derived Mesenchymal Stem Cells Activates Locally Stimulated Endogenous Neural Progenitors and Reduces Neurological Dysfunction in Mice after Ischemic Stroke.
Shuichi Fujiwara; Akiko Nakano-Doi; Toshinori Sawano; Shuji Kubo; Nobutaka Doe; Takayuki Nakagomi
Cells, May 2024 - Targeted Suicide Gene Therapy with Retroviral Replicating Vectors for Experimental Canine Cancers
Emiko Sonoda-Fukuda; Yuya Takeuchi; Nao Ogawa; Shunsuke Noguchi; Toru Takarada; Noriyuki Kasahara; Shuji Kubo
International Journal of Molecular Sciences, Feb. 2024, [Reviewed]
Last - Therapeutic Efficacy of Prodrug Activator Gene Therapy Using Retroviral Replicating Vectors for Human Ovarian Cancer.
Lisa Isoda; Emiko Sonoda-Fukuda; Hiroaki Fujino; Toru Takarada; Kosei Hasegawa; Noriyuki Kasahara; Shuji Kubo
Anticancer research, Dec. 2023, [Reviewed]
Last - ミクログリアがマウス脳梗塞巣由来傷害/虚血誘発性神経幹細胞に及ぼす影響
平野 佳伸; 中込 隆之; 土居 亜紀子; 久保 秀司; 湊 雄介; 澤野 俊憲; 都築 建三; 阪上 雅史
脳循環代謝, Nov. 2023 - Retroviral Replicating Vectors Mediated Prodrug Activator Gene Therapy in a Gastric Cancer Model.
Hiroaki Fujino; Emiko Sonoda-Fukuda; Lisa Isoda; Ayane Kawabe; Toru Takarada; Noriyuki Kasahara; Shuji Kubo
International journal of molecular sciences, Oct. 2023, [Reviewed]
Last - Microglia Negatively Regulate the Proliferation and Neuronal Differentiation of Neural Stem/Progenitor Cells Isolated from Poststroke Mouse Brains.
Yoshinobu Hirano; Takayuki Nakagomi; Akiko Nakano-Doi; Shuji Kubo; Yusuke Minato; Toshinori Sawano; Masafumi Sakagami; Kenzo Tsuzuki
Cells, Aug. 2023, [Reviewed] - Transplantation of Human Brain-Derived Ischemia-Induced Multipotent Stem Cells Ameliorates Neurological Dysfunction in Mice After Stroke.
Takayuki Nakagomi; Akiko Nakano-Doi; Shuji Kubo; Toshinori Sawano; Yoji Kuramoto; Kenichi Yamahara; Tomohiro Matsuyama; Toshinori Takagi; Nobutaka Doe; Shinichi Yoshimura
Stem cells translational medicine, Jun. 2023, [Reviewed] - Different Contacted Cell Types Contribute to Acquiring Different Properties in Brain Microglial Cells upon Intercellular Interaction.
Akiko Nakano-Doi; Shuji Kubo; Emiko Sonoda; Akihiko Taguchi; Takayuki Nakagomi
International journal of molecular sciences, Jan. 2023, [Reviewed] - BAP1 depletion in human B-lymphoblast cells affects the production of innate immune cytokines and chemokines.
Misato Takagi-Kimura; Akio Tada; Takashi Kijima; Shuji Kubo; Masaki Ohmuraya; Yoshie Yoshikawa
Genes to cells : devoted to molecular & cellular mechanisms, Oct. 2022, [Reviewed] - Assessment of circulating microRNA specific for patients with familial adenomatous polyposis.
Tomoki Yamano; Shuji Kubo; Emiko Sonoda; Tomoko Kominato; Kei Kimura; Michiko Yasuhara; Kozo Kataoka; Jihyung Son; Akihito Babaya; Yuya Takenaka; Takaaki Matsubara; Naohito Beppu; Masataka Ikeda
PloS one, 2021, [Reviewed] - A patient‐derived xenograft and a cell line derived from it form a useful preclinical model for small bowel adenocarcinoma
Tomoki Yamano; Shuji Kubo; Naohiro Tomita
Cancer Medicine, May 2020, [Reviewed] - Splicing modulator FR901464 is a potential agent for colorectal cancer in combination therapy.
Yamano T; Kubo S; Yano A; Kominato T; Tanaka S; Ikeda M; Tomita N
Oncotarget, Jan. 2019, [Reviewed] - Dual-vector prodrug activator gene therapy using retroviral replicating vectors.
Kubo S; Takagi-Kimura M; Tagawa M; Kasahara N
Cancer gene therapy, Oct. 2018, [Reviewed]
Lead - Efficient tumor transduction and antitumor efficacy in experimental human osteosarcoma using retroviral replicating vectors.
Kubo S; Takagi-Kimura M; Kasahara N
Cancer gene therapy, Jul. 2018, [Reviewed]
Lead - Cytotoxicity of replication-competent adenoviruses powered by an exogenous regulatory region is not linearly correlated with the viral infectivity/gene expression or with the E1A-activating ability but is associated with the p53 genotypes
Suguru Yamauchi; Boya Zhong; Kiyoko Kawamura; Shan Yang; Shuji Kubo; Masato Shingyoji; Ikuo Sekine; Yuji Tada; Koichiro Tatsumi; Hideaki Shimada; Kenzo Hiroshima; Masatoshi Tagawa
BMC CANCER, Sep. 2017, [Reviewed] - Whole cell vaccination using immunogenic cell death by an oncolytic adenovirus is effective against a colorectal cancer model
Tomoki Yamano; Shuji Kubo; Miki Fukumoto; Aya Yano; Yuki Mawatari-Furukawa; Haruki Okamura; Naohiro Tomita
MOLECULAR THERAPY-ONCOLYTICS, Dec. 2016, [Reviewed] - Replication-competent adenoviruses with the type 35-derived fiber-knob region achieve reactive oxygen species-dependent cytotoxicity and produce greater toxicity than those with the type 5-derived region in pancreatic carcinoma
Suguru Yamauchi; Kiyoko Kawamura; Shinya Okamoto; Takao Morinaga; Yuanyuan Jiang; Masato Shingyoji; Ikuo Sekine; Shuji Kubo; Yuji Tada; Koichiro Tatsumi; Hideaki Shimada; Kenzo Hiroshima; Masatoshi Tagawa
APOPTOSIS, Dec. 2015, [Reviewed] - Expression of p53 synergistically augments caspases-mediated apoptosis induced by replication-competent adenoviruses in pancreatic carcinoma cells
Y. Takei; S. Okamoto; K. Kawamura; Y. Jiang; T. Morinaga; M. Shingyoji; I. Sekine; S. Kubo; Y. Tada; K. Tatsumi; H. Shimada; K. Hiroshima; N. Yamaguchi; M. Tagawa
CANCER GENE THERAPY, Sep. 2015, [Reviewed] - Exogenous expression of FIR demonstrated TP53-independent cell-killing effect and enhanced anti-tumor activity of carbon-ion beams.
Kano M; Matsushita K; Rahmutulla B; Yamada S; Shimada H; Kubo S; Hiwasa T; Matsubara H; Nomura F
Gene therapy, Aug. 2015, [Reviewed] - Combinatorial anti-angiogenic gene therapy in a human malignant mesothelioma model
Shuji Kubo; Misato Takagi-Kimura; Noriyuki Kasahara
ONCOLOGY REPORTS, Aug. 2015, [Reviewed]
Lead - Brain Vascular Pericytes Following Ischemia Have Multipotential Stem Cell Activity to Differentiate Into Neural and Vascular Lineage Cells
Takayuki Nakagomi; Shuji Kubo; Akiko Nakano-Doi; Rika Sakuma; Shan Lu; Aya Narita; Maiko Kawahara; Akihiko Taguchi; Tomohiro Matsuyama
STEM CELLS, Jun. 2015, [Reviewed] - Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1.
Matsushita K; Kitamura K; Rahmutulla B; Tanaka N; Ishige T; Satoh M; Hoshino T; Miyagi S; Mori T; Itoga S; Shimada H; Tomonaga T; Kito M; Nakajima-Takagi Y; Kubo S; Nakaseko C; Hatano M; Miki T; Matsuo M; Fukuyo M; Kaneda A; Iwama A; Nomura F
Oncotarget, Mar. 2015, [Reviewed] - 悪性中皮腫細胞では複数の転写制御遺伝子に稀な多型が検出される(Rare germline variants of transcription regulator genes in malignant mesothelioma)
吉川 良恵; 大搗 泰一郎; 久保 秀司; 佐藤 鮎子; 辻村 亨; 江見 充; 中野 孝司; 玉置 知子[橋本]
日本癌学会総会記事, Sep. 2014 - Oncolytic virotherapy for osteosarcoma using midkine promoter-regulated adenoviruses
M. Takagi-Kimura; T. Yamano; M. Tagawa; S. Kubo
CANCER GENE THERAPY, Mar. 2014, [Reviewed]
Last - Alternative splicing of FBP-interacting repressor coordinates c-Myc, P27Kip1/cyclinE and Ku86/XRCC5 expression as a molecular sensor for bleomycin-induced DNA damage pathway
Bahityar Rahmutulla; Kazuyuki Matsushita; Mamoru Satoh; Masanori Seimiya; Sachio Tsuchida; Shuji Kubo; Hideaki Shimada; Masayuki Ohtsuka; Masaru Miyazaki; Fumio Nomura
Oncotarget, 2014, [Reviewed] - Highly efficient tumor transduction and antitumor efficacy in experimental human malignant mesothelioma using replicating gibbon ape leukemia virus
S. Kubo; M. Takagi-Kimura; C. R. Logg; N. Kasahara
CANCER GENE THERAPY, Dec. 2013, [Reviewed]
Lead - Enhanced antitumor efficacy of fiber-modified, midkine promoter-regulated oncolytic adenovirus in human malignant mesothelioma
Misato Takagi-Kimura; Tomoki Yamano; Atsuko Tamamoto; Nobutaka Okamura; Haruki Okamura; Tomoko Hashimoto-Tamaoki; Masatoshi Tagawa; Noriyuki Kasahara; Shuji Kubo
Cancer Science, Nov. 2013, [Reviewed]
Last - FK506 induces endothelial dysfunction through attenuation of Akt and ERK1/2 independently of calcineurin inhibition and the caspase pathway
Ryoji Eguchi; Shuji Kubo; Toshiro Ohta; Kazuhiro Kunimasa; Masaya Okada; Hiroya Tamaki; Kazuhiko Kaji; Ichiro Wakabayashi; Yoshihiro Fujimori; Hiroyasu Ogawa
Cellular Signalling, Sep. 2013, [Reviewed] - Molecular targeting of hepatocyte growth factor by an antagonist, NK4, in the treatment of rheumatoid arthritis
Sachi Tsunemi; Tsuyoshi Iwasaki; Sachie Kitano; Kunio Matsumoto; Misato Takagi-Kimura; Shuji Kubo; Tomoko Tamaoki; Hajime Sano
Arthritis Research and Therapy, Jul. 2013, [Reviewed] - Hybrid Vectors as Trojan Horses; Adventure with Adenovirus for Successful Gene Therapy.
Shuji Kubo
Acta Med Hyogo, Sep. 2012, [Reviewed]
Lead - 悪性中皮腫におけるBAP1遺伝子欠失のMLPA法での詳細解析(Fine structural analysis of BAP 1 gene deletion in malignant mesothelioma by MLPA method)
江見 充; 佐藤 秀則; 吉川 良恵; 森永 伴法; 久保 秀司; 佐藤 鮎子; 辻村 亨; 長谷川 誠紀; 中野 孝司; 玉置 知子[橋本]
日本癌学会総会記事, Aug. 2012 - BAP1遺伝子の上皮型悪性中皮腫での高頻度欠失(Frequent inactivation of BAP1 gene in epithelioid-type malignant mesothelioma)
吉川 良恵; 江見 充; 森永 伴法; 久保 秀司; 佐藤 鮎子; 辻村 亨; 長谷川 誠紀; 中野 孝司; 玉置 知子[橋本]
日本癌学会総会記事, Aug. 2012 - SAP155-Mediated Splicing of FUSE-Binding Protein-Interacting Repressor Serves as a Molecular Switch for c-myc Gene Expression
Kazuyuki Matsushita; Toshiko Kajiwara; Mai Tamura; Mamoru Satoh; Nobuko Tanaka; Takeshi Tomonaga; Hisahiro Matsubara; Hideaki Shimada; Rei Yoshimoto; Akihiro Ito; Shuji Kubo; Tohru Natsume; David Levens; Minoru Yoshida; Fumio Nomura
MOLECULAR CANCER RESEARCH, Jun. 2012, [Reviewed] - Deficiency of Fyn protein is prerequisite for apoptosis induced by Src family kinase inhibitors in human mesothelioma cells
Ryoji Eguchi; Shuji Kubo; Hiromi Takeda; Toshiro Ohta; Chiharu Tabata; Hiroyasu Ogawa; Takashi Nakano; Yoshihiro Fujimori
CARCINOGENESIS, May 2012, [Reviewed] - Ischemia-Induced Neural Stem/Progenitor Cells in the Pia Mater Following Cortical Infarction
Takayuki Nakagomi; Zoltan Molnar; Akiko Nakano-Doi; Akihiko Taguchi; Orie Saino; Shuji Kubo; Martijn Clausen; Hiroo Yoshikawa; Nami Nakagomi; Tomohiro Matsuyama
STEM CELLS AND DEVELOPMENT, Dec. 2011, [Reviewed] - Replication-competent retrovirus vector-mediated prodrug activator gene therapy in experimental models of human malignant mesothelioma
Y. Kawasaki; A. Tamamoto; M. Takagi-Kimura; Y. Maeyama; N. Yamaoka; N. Terada; H. Okamura; N. Kasahara; S. Kubo
CANCER GENE THERAPY, Aug. 2011
Last - Intracellular estrogen receptor-binding fragment-associated antigen 9 exerts in vivo tumor-promoting effects via its coiled-coil region
Yoshihiro Maeyama; Makoto Otsu; Shuji Kubo; Tomoki Yamano; Yasuaki Iimura; Masafumi Onodera; Satoshi Kondo; Yukio Sakiyama; Tadashi Ariga
INTERNATIONAL JOURNAL OF ONCOLOGY, Jul. 2011, [Reviewed] - Mitochondria Determine the Efficacy of Anticancer Agents that Interact with DNA but Not the Cytoskeleton
Kenjirou Hara; Emiko Kasahara; Nozomi Takahashi; Masami Konishi; June Inoue; Mika Jikumaru; Shuji Kubo; Haruki Okamura; Eisuke Sato; Masayasu Inoue
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Jun. 2011, [Reviewed] - Involvement of CD56(bright)CD11c(+) Cells in IL-18-Mediated Expansion of Human gamma delta T Cells
Junko Tsuda; Wen Li; Hiromichi Yamanishi; Hideyuki Yamamoto; Akico Okuda; Shuji Kubo; Zhifeng Ma; Nobuyuki Terada; Yoshimasa Tanaka; Haruki Okamura
JOURNAL OF IMMUNOLOGY, Feb. 2011, [Reviewed] - Adenovirus-Retrovirus Hybrid Vectors Achieve Highly Enhanced Tumor Transduction and Antitumor Efficacy In Vivo
Shuji Kubo; Kazunori Haga; Atsuko Tamamoto; Donna J. Palmer; Philip Ng; Haruki Okamura; Noriyuki Kasahara
MOLECULAR THERAPY, Jan. 2011, [Reviewed]
Lead - Immobilization of 293 cells using porous support particles for adenovirus vector production
Naoya Morishita; Tomohisa Katsuda; Shuji Kubo; Akinobu Gotoh; Hideki Yamaji
CYTOTECHNOLOGY, Aug. 2010, [Reviewed] - Establishment of in vivo fluorescence imaging in mouse models of malignant mesothelioma
Norie Yamaoka; Yoshiko Kawasaki; Yunfeng Xu; Hideyuki Yamamoto; Nobuyuki Terada; Haruki Okamura; Shuji Kubo
INTERNATIONAL JOURNAL OF ONCOLOGY, Aug. 2010, [Reviewed]
Last - Complete regression of human malignant mesothelioma xenografts following local injection of midkine promoter-driven oncolytic adenovirus
Shuji Kubo; Yoshiko Kawasaki; Norie Yamaoka; Masatoshi Tagawa; Noriyuki Kasahara; Nobuyuki Terada; Haruki Okamura
JOURNAL OF GENE MEDICINE, Aug. 2010, [Reviewed]
Lead - Bone Marrow Mononuclear Cells Promote Proliferation of Endogenous Neural Stem Cells Through Vascular Niches After Cerebral Infarction
Akiko Nakano-Doi; Takayuki Nakagomi; Masatoshi Fujikawa; Nami Nakagomi; Shuji Kubo; Shan Lu; Hiroo Yoshikawa; Toshihiro Soma; Akihiko Taguchi; Tomohiro Matsuyama
STEM CELLS, Jul. 2010, [Reviewed] - Separation of antileukemic effects from graft-versus-host disease in MHC-haploidentical murine bone marrow transplantation: participation of host immune cells
Atsushi Satake; Takayuki Inoue; Shuji Kubo; Yuki Taniguchi; Takehito Imado; Tatsuya Fujioka; Marika Horiuchi; Yunfeng Xu; Kazuhiro Ikegame; Satoshi Yoshihara; Katsuji Kaida; Hiroya Tamaki; Masaya Okada; Haruki Okamura; Hiroyasu Ogawa
INTERNATIONAL JOURNAL OF HEMATOLOGY, Apr. 2010, [Reviewed] - Effect of IL-18 on Expansion of gamma delta T Cells Stimulated by Zoledronate and IL-2
Wen Li; Shuji Kubo; Akico Okuda; Hideyuki Yamamoto; Haruyasu Ueda; Toshiyuki Tanaka; Hideji Nakamura; Hiromichi Yamanishi; Nobuyuki Terada; Haruki Okamura
JOURNAL OF IMMUNOTHERAPY, Apr. 2010, [Reviewed] - In Vivo Stable Transduction of Humanized Liver Tissue in Chimeric Mice via High-Capacity Adenovirus-Lentivirus Hybrid Vector
Shuji Kubo; Miho Kataoka; Chise Tateno; Katsutoshi Yoshizato; Yoshiko Kawasaki; Takahiro Kimura; Emmanuelle Faure-Kumar; Donna J. Palmer; Philip Ng; Haruki Okamura; Noriyuki Kasahara
HUMAN GENE THERAPY, Jan. 2010, [Reviewed]
Lead - Modulation of innate immunity by IL-18
Wen Li; Hideyuki Yamamoto; Shuji Kubo; Haruki Okamura
JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Dec. 2009, [Reviewed] - Isolation and characterization of neural stem/progenitor cells from post-stroke cerebral cortex in mice
Takayuki Nakagomi; Akihiko Taguchi; Yoshihiro Fujimori; Orie Saino; Akiko Nakano-Doi; Shuji Kubo; Akinobu Gotoh; Toshihiro Soma; Hiroo Yoshikawa; Tomoyuki Nishizaki; Nami Nakagomi; David M. Stern; Tomohiro Matsuyama
EUROPEAN JOURNAL OF NEUROSCIENCE, May 2009, [Reviewed] - Adenovirus vector production using low-multiplicity infection of 293 cells
Kentaro Yamada; Naoya Morishita; Tomohisa Katsuda; Shuji Kubo; Akinobu Gotoh; Hideki Yamaji
CYTOTECHNOLOGY, Apr. 2009, [Reviewed] - c-myc suppressor FBP-interacting repressor for cancer diagnosis and therapy
Kazuyuki Matsushita; Takeshi Tomonaga; Toshiko Kajiwara; Hideaki Shimada; Sakae Itoga; Takaki Hiwasa; Shuji Kubo; Takenori Ochiai; Hisahiro Matsubara; Fumio Nomura
FRONTIERS IN BIOSCIENCE, Jan. 2009, [Reviewed] - Endothelial Cells Support Survival, Proliferation, and Neuronal Differentiation of Transplanted Adult Ischemia-Induced Neural Stem/Progenitor Cells After Cerebral Infarction
Nami Nakagomi; Takayuki Nakagomi; Shuji Kubo; Akiko Nakano-Doi; Orie Saino; Masashi Takata; Hiroo Yoshikawa; David M. Stern; Tomohiro Matsuyama; Akihiko Taguchi
STEM CELLS, 2009, [Reviewed] - Midkine promoter-based conditionally replicative adenovirus for targeting midkine-expressing human bladder cancer model
Shuji Terao; Toshiro Shirakawa; Shuji Kubo; Acharya Bishunu; Sang-Jin Lee; Kazumasa Goda; Mamoru Tsukuda; Katsuyuk Hamada; Masatoshi Tagawa; Atsushi Takenaka; Masato Fujisawa; Akinobu Gotoh
UROLOGY, Nov. 2007, [Reviewed] - PP-329 マウス前立腺癌モデルに対するPETを用いたAd-OC-TK/VAL遺伝子治療効果および遺伝子導入効率の評価に関する有用性の検討(第95回日本泌尿器科学会総会)
寺尾 秀治; 白川 利朗; 久保 秀司; 田沢 周作; 富永 英之; 千田 道雄; 武中 篤; 藤澤 正人; 後藤 章暢
日本泌尿器科学会雑誌, 2007 - 内分泌療法抵抗性前立腺癌に対するAd-OC-TK plus Valacyclovir遺伝子治療臨床研究におけるquality of lifeの評価
寺尾 秀治; 白川 利朗; 日向 信行; 和田 義孝; 宮田 賢宏; 久保 秀司; 田中 一志; 武中 篤; 荒川 創一; 原 勲; 藤澤 正人; 後藤 章暢
西日本泌尿器科, Oct. 2006 - L1 retrotransposition in nondividing and primary human somatic cells
S Kubo; MD Seleme; HS Soifer; JLG Perez; JV Moran; HH Kazazian; N Kasahara
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, May 2006, [Reviewed]
Lead - Infantile Chlamydia trachomatis pneumonia in siblings
Kei Numazaki; Shuji Kubo
Clinical Microbiology Newsletter, Oct. 2004
Last - An HSV amplicon-based helper system for helper-dependent adenoviral vectors
S Kubo; Y Saeki; EA Chiocca; K Mitani
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2003, [Reviewed]
Lead - A new hybrid system capable of efficient lentiviral vector production and stable gene transfer mediated by a single helper-dependent adenoviral vector
S Kubo; K Mitani
JOURNAL OF VIROLOGY, Mar. 2003, [Reviewed]
Lead - Replication and packaging of helper-dependent adenoviral vectors
M Sato; S Suzuki; S Kubo; K Mitani
GENE THERAPY, Apr. 2002 - Adenovirus as an integrating vector.
Mitani K; Kubo S
Curr Gene Ther, 2002
Last - A mouse model of renal tubular injury of tyrosinemia type 1: Development of de Toni Fanconi syndrome and apoptosis of renal tubular cells in Fah/Hpd double mutant mice
MS Sun; S Hattori; S Kubo; H Awata; Matsuda, I; F Endo
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Feb. 2000 - Hepatocyte injury in tyrosinemia type 1 is induced by fumarylacetoacetate and is inhibited by caspase inhibitors
S Kubo; MS Sun; M Miyahara; K Umeyama; K Urakami; T Yamamoto; C Jakobs; Matsuda, I; F Endo
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Aug. 1998, [Reviewed]
Lead - Complete rescue of lethal albino c(14CoS) mice by null mutation of 4-hydroxyphenylpyruvate dioxygenase and induction of apoptosis of hepatocytes in these mice by in vivo retrieval of the tyrosine catabolic pathway
F Endo; S Kubo; H Awata; K Kiwaki; H Katoh; Y Kanegae; Saito, I; J Miyazaki; T Yamamoto; C Jakobs; S Hattori; Matsuda, I
JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 1997 - In vivo correction with recombinant adenovirus of 4-hydroxyphenylpyruvic acid dioxygenase deficiencies in strain III mice
S Kubo; K Kiwaki; H Awata; H Katoh; Y Kanegae; Saito, I; T Yamamoto; J Miyazaki; Matsuda, I; F Endo
HUMAN GENE THERAPY, Jan. 1997, [Reviewed]
Lead - A neonatal case of hydranencephaly caused by atheromatous plaque obstruction of aortic arch: possible association with a congenital cytomegalovirus infection?
Kubo S; Kishino T; Satake N; Okano M; Mikawa M; Ishikawa N
J Perinatol, 1994, [Reviewed]
Lead - A CASE OF FULMINANT ECTHYMA GANGRENOSUM ASSOCIATED WITH PSEUDOMONAS-AERUGINOSA INFECTION IN A PATIENT WITH METHYLMALONIC ACIDEMIA
M OKANO; K KISHIYAMA; N SATAKE; S KUBO; N ISHIKAWA
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 1994, [Reviewed] - CAN HIGH-DOSE IMMUNOGLOBULIN THERAPY BY INDICATED IN NEONATAL RHESUS HEMOLYSIS - A SUCCESSFUL CASE OF HEMOLYTIC-DISEASE DUE TO RHESUS (C+E) INCOMPATIBILITY
S KUBO; T ARIGA; H TSUNETA; T ISHII
EUROPEAN JOURNAL OF PEDIATRICS, May 1991, [Reviewed]
Lead
MISC
- Retroviral replicating vector-mediated prodrug activator gene therapy in an experimental model of human osteosarcoma
S. Kubo; M. Takagi-Kimura; N. Kasahara
HUMAN GENE THERAPY, Dec. 2017 - An Inhibitor for the MDM2-p53 Interaction Produces Synergistic Cytotoxicity with Oncolytic Adenoviruses on Mesothelioma with Wild-Type p53 Genotype
Masatoshi Tagawa; Thao T. T. Nguyen; Takao Morinaga; Boya Zhong; Michiko Hanazono; Shuji Kubo; Masato Shingyoji; Yuji Tada; Koichiro Tatsumi; Hideaki Shimada; Kenzo Hiroshima
MOLECULAR THERAPY, May 2017 - Prodrug Activator Gene Therapy Using Retroviral Replicating Vectors in an Experimental Model of Human Osteosarcoma
Shuji Kubo; Misato Takagi-Kimura; Noriyuki Kasahara
MOLECULAR THERAPY, May 2017 - E1B-55kDa-defective adenoviruses produced cytotoxicity in combination with MDM2 inhibitors on INK4A/ARF-defective mesothelioma
Y. Tada; T. T. Nguyen; S. Kubo; M. Shingyoji; I. Sekine; K. Tatsumi; H. Shimada; K. Hiroshima; M. Tagawa
HUMAN GENE THERAPY, Nov. 2016 - Customization of virotherapy with retroviral replicating vectors on the basis of cellular receptor expression profiles
S. Kubo; Y. Mawatari-Furukawa; N. Kasahara
HUMAN GENE THERAPY, Nov. 2016 - Combinatorial Anti-Angiogenic Gene Therapy in a Human Malignant Mesothelioma Model
Shuji Kubo; Yuki Mawatari-Furukawa; Noriyuki Kasahara
MOLECULAR THERAPY, May 2016 - Combination of Forced Transduction of P53 and an Agent That Blocks MDM2-p53 Interactions Produces Synergistic Cytotoxicity on Mesothelioma Defective of the INK4A/ARF Region
Masatoshi Tagawa; Takao Morinaga; Zhihan Li; Thao T. T. Nguyen; Boya Zhong; Shuji Kubo; Ikuo Sekine; Yuji Tada; Koichiro Tatsumi; Hideaki Shimada; Kenzo Hiroshima
MOLECULAR THERAPY, May 2016 - Inhibited interaction between p53 and Mdm2 enhances p53-mediated cytotoxic activities on INK4A/ARF-defective mesothelioma
M. Tagawa; T. Morinaga; K. Kawamura; S. Okamoto; S. Kubo; M. Shingyoji; I. Sekine; Y. Tada; K. Tatsumi; H. Shimada; K. Hiroshima
HUMAN GENE THERAPY, Oct. 2015 - Dual-vector prodrug activator gene therapy using two different retroviral replicating vectors
S. Kubo; M. Takagi-Kimura; C. R. Logg; K. Hermann; N. Kasahara
HUMAN GENE THERAPY, Oct. 2015 - Different mechanism of Oxaliplatin resistance in human colorectal cancer cell lines
Tomoki Yamano; Shuji Kubo; Aya Yano; Naohiro Tomita
CANCER RESEARCH, Aug. 2015 - Cytotoxicity by Adenovirus Replications is Associated with DNA Damages and the Activated P53 Pathways and Is Dependent on Reactive Oxygen Species
Masatoshi Tagawa; Kiyoko Kawamura; Shinya Okamoto; Yuanyuan Jiang; Zhihan Li; Takao Morinaga; Shuji Kubo; Masato Shingyoji; Ikuo Sekine; Yuji Tada; Koichiro Tatsumi; Hideaki Shimada; Kenzo Hiroshima
MOLECULAR THERAPY, May 2015 - Dual-Vector Prodrug Activator Gene Therapy Using Retroviral Replicating Vectors Derived from Amphotropic Murine Leukemia Virus and Gibbon Ape Leukemia Virus
Shuji Kubo; Misato Takagi-Kimura; Christopher R. Logg; Kip Hermann; Noriyuki Kasahara
MOLECULAR THERAPY, May 2015 - Influence of SF3B1 gene mutation is different from that of Sf3B1 inhibitor in colorectal cancer
Tomoki Yamano; Shuji Kubo; Nagahide Matsubara; Aya Yano; Naohiro Tomita
CANCER RESEARCH, Oct. 2014 - FIRのスプライシング変化はブレオマイシンによるDNA損傷のセンサーとして機能している(FIR splicing as a molecular sensor for bleomycin-induced DNA damage response pathway)
ラヒムトラ・バハテヤリ; 松下 一之; 佐藤 守; 清宮 正徳; 土田 祥央; 久保 秀司; 島田 英昭; 大塚 将之; 宮崎 勝; 野村 文夫
日本癌学会総会記事, Sep. 2014 - 急性T細胞性白血病発症におけるc-myc遺伝子転写抑制因子FIRのスプライシングの意義(Alternative splicing of c-myc transcriptional repressor, FIR, contributes T-ALL by c-Myc activation)
松下 一之; 北村 浩一; バハテヤリ・ラヒムトラ; 星野 忠次; 岩間 厚志; 島田 英昭; 朝長 毅; 久保 秀司; 野村 文夫
日本癌学会総会記事, Sep. 2014 - Replication-competent retrovirus vector-mediated prodrug activator gene therapy in experimental models of human malignant mesothelioma
Shuji Kubo; Atsuko Tamamoto; Tomoko Tamaoki; Nobuyuki Terada; Yoshihiro Maeyama; Haruki Okamura; Noriyuki Kasahara
JOURNAL OF GENE MEDICINE, Jul. 2014 - A Small Molecule That Inhibits p53 Degradation Influences Cytotoxicity of Ad-p53 in INK4A/ARF-Defective Mesothelioma with Wild-Type p53 Gene
Masatoshi Tagawa; Kiyoko Kawamura; Shinya Okamoto; Yuanyuan Jiang; Zhihan Li; Shuji Kubo; Masato Shingyoji; Yuji Tada; Yuichi Takiguchi; Koichiro Tatsumi; Hideaki Shimada; Kenzo Hiroshima
MOLECULAR THERAPY, May 2014 - Highly Efficient Tumor Transduction and Antitumor Efficacy in Experimental Human Malignant Mesothelioma Using Replicating Gibbon Ape Leukemia Virus
Shuji Kubo; Misato Takagi-Kimura; Christopher R. Logg; Noriyuki Kasahara
MOLECULAR THERAPY, May 2014 - Cytotoxicity of replication-competent adenoviruses are enhanced by co-transduced p53 gene
M. Tagawa; S. Yang; K. Kawamura; S. Okamoto; S. Kubo; Y. Tada; K. Hiroshima; H. Shimada
HUMAN GENE THERAPY, Dec. 2013 - 悪性中皮腫におけるBAP1とPBRM1遺伝子の複合欠失と癌化における役割(Biological roles of deletion of PBRM1 and BAP1 in malignant mesotheliomas)
吉川 良恵; 佐藤 鮎子; 辻村 亨; 久保 秀司; 江見 充; 長谷川 誠紀; 中野 孝司; 玉置 知子[橋本]
日本癌学会総会記事, Oct. 2013 - Anti-Tumor Effects of Ad-p53 on INK4A/ARF-Defective Mesothelioma Are Influenced Positively by Small G Protein Inhibitors but Negatively by Heat Shock Protein 90 Inhibitors
Masatoshi Tagawa; Kuan Chai; Yuanyuan Jiang; Kiyoko Kawamura; Shan Yang; Atsushi Ogino; Naoto Yamaguchi; Kazunori Kato; Yuji Tada; Yuichi Takiguchi; Koichiro Tatsumi; Hideaki Shimada; Kenzo Hiroshima; Shuji Kubo
MOLECULAR THERAPY, Jun. 2013 - Comparative Evaluation of the Antitumor Activity of Anti-Angiogenic Proteins Delivered by Lentivirus Vector in Human Malignant Mesothelioma Model
Misato Takagi-Kimura; Tomoko Hashimoto-Tamaoki; Noriyuki Kasahara; Shuji Kubo
MOLECULAR THERAPY, Jun. 2013 - Development of Dual Targeted Oncolytic Adenovirus for Human Malignant Mesothelioma
Shuji Kubo; Misato Takagi-Kimura; Atsuko Tamamoto; Tomoko Hashimoto-Tamaoki; Noriyuki Kasahara; Masatoshi Tagawa
MOLECULAR THERAPY, Jun. 2013 - Low frequencies of SF3B1 mutations indicate SF3B1 inhibitor as a novel moleculartargeted drug for colorectal cancer.
Tomoki Yamano; Hidenori Nakajima; Satoshi Tsuda; Shuji Kubo; Mie Hamanaka; Masayoshi Kobayashi; Daisuke Yamagishi; Takashi Kuno; Kiyoshi Tsukamoto; Astuko Tamamoto; Masafumi Noda; Nagahide Matsubara; Dave S. B. Hoon; Naohiro Tomita
CANCER RESEARCH, Apr. 2013 - c-myc遺伝子転写抑制因子FIRとスプライシング因子SAP155の結合による新規がん化メカニズムについて(SAP155-mediated splicing of FIR serves as a molecular switch for c-myc gene expression)
松下 一之; 石塚 寿子; 佐藤 守; 松原 久裕; 島田 英昭; 朝長 毅; 久保 秀司; 吉田 稔; 野村 文夫
日本癌学会総会記事, Aug. 2012 - Midkine Promoter-Driven Oncolytic Adenovirus with Ad35 Fiber Modification Achieves Enhanced Transduction of Human Malignant Mesothelioma Cells In Vitro and In Vivo
Shuji Kubo; Misato Takagi-Kimura; Atsuko Tamamoto; Nobutaka Okamura; Yoshihiro Maeyama; Nobuyuki Terada; Masatoshi Tagawa; Noriyuki Kasahara; Haruki Okamura; Tomoko Hashimoto-Tamaoki
MOLECULAR THERAPY, May 2012 - Adenoviruses-Mediated Up-Regulation of p53 Expression Produces Cytotoxic Effects on INK4A/ARF-Defective Mesothelioma and Increases the Susceptibility to Chemotherapeutic Agents and Small G Protein Inhibitors
Masatoshi Tagawa; Shinya Okamoto; Yuanyuan Jiang; Kiyoko Kawamura; Shan Yang; Suguru Yamauchi; Yuji Tada; Yuichi Takiguchi; Koichiro Tatsumi; Hideaki Shimada; Kenzo Hiroshima; Shuji Kubo; Quanhai Li; Hiroshi Kobayashi
MOLECULAR THERAPY, May 2012 - c-myc遺伝子転写抑制因子FIRはSAP155によりスプライシング変化を受けc-Mycの発現スイッチとして機能する(SAP1 55-mediated splicing of FBP-interacting repressor (FIR) serves as a molecular switch for c-myc expression)
松下 一之; 梶原 寿子; 朝長 毅; 松原 久裕; 島田 英昭; 久保 秀司; 吉田 稔; 野村 文夫
日本癌学会総会記事, Sep. 2011 - MIDKINE PROMOTER-DRIVEN ONCOLYTIC ADENOVIRUS ACHIEVES EFFECTIVE TARGETING OF HUMAN MALIGNANT MESOTHELIOMA CELLS IN VITRO AND IN VIVO
Shuji Kubo; Yoshiko Kawasaki; Hideyuki Yamamoto; Masatoshi Tagawa; Noriyuki Kasahara; Haruki Okamura
JOURNAL OF GENE MEDICINE, Dec. 2010 - Midkine Promoter-Driven Oncolytic Adenovirus Achieves Effective Targeting of Human Malignant Mesothelioma Cells In Vitro and In Vivo
Shuji Kubo; Yoshiko Kawasaki; Hideyuki Yamamoto; Masatoshi Tagawa; Noriyuki Kasahara; Haruki Okamura
MOLECULAR THERAPY, May 2009 - Enhancement of transduction with replication-competent retrovirus vectors using helper-dependent adenovirus
Shuji Kubo; Kazunori Haga; Noriyuki Kasahara
JOURNAL OF GENE MEDICINE, Dec. 2006 - Improvement of quality of life of patients with metastatic or local recurrent prostate cancer after phase I/II clinical trial of Ad-OC-TK plus valacyclovir
Shuji Terao; Toshiro Shirakawa; Masahiro Miyata; Shuji Kubo; Masato Fujisawa; Akinobu Gotoh
JOURNAL OF GENE MEDICINE, Dec. 2006 - In Vivo Stable Transduction of Humanized Liver Tissue in Chimeric Mice Via High-Capacity Adenovirus-Lentivirus Hybrid Vector
Shuji Kubo; Miho Kataoka; Chise Tateno; Donna J. Palmer; Philip Ng; Katsutoshi Yoshizato; Noriyuki Kasahara
MOLECULAR THERAPY, May 2006 - L1 retrotransposition in quiescent and primary human somatic cells and in the mouse liver parenchyma after efficient transduction with an adenovirus-retrotransposon hybrid
S Kubo; HS Soifer; MD Seleme; JV Moran; HH Kazazian; N Kasahara
JOURNAL OF GENE MEDICINE, Mar. 2006 - High-capacity adenovirus/retrotransposon hybrid vectors for efficient and stable gene transfer
S Kubo; H Soifer; JV Moran; HH Kazazian; N Kasahara
MOLECULAR THERAPY, May 2004 - A lentiviral/adenoviral hybrid vector; Efficient lentiviral vector production and stable gene transfer mediated by a single helper-dependent adenoviral vector
S Kubo; K Mitani
MOLECULAR THERAPY, May 2003
Research Themes
- Development of virotherapy for osteosarcoma pulmonary metastases using stem cells as carriers
Grant-in-Aid for Challenging Research (Exploratory)
Hyogo Medical University
28 Jun. 2019 - 31 Mar. 2022 - Development of cell transplantation therapy using human injury/ischemia-induced neural stem/progenitor cells
Grant-in-Aid for Scientific Research (C)
Hyogo Medical University
01 Apr. 2018 - 31 Mar. 2021 - Development of retroviral replicating vector-mediated suicide gene therapy for malignant mesothelioma
Grant-in-Aid for Scientific Research (C)
Hyogo Medical University
01 Apr. 2016 - 31 Mar. 2019 - Development of molecular marker and novel therapy for FAP
Grant-in-Aid for Scientific Research (C)
Hyogo Medical University
01 Apr. 2015 - 31 Mar. 2018 - Potential role of IL-1 family cytokines in periodontal diseases
Grant-in-Aid for Scientific Research (C)
01 Apr. 2014 - 31 Mar. 2017 - Effect of combination of IL-18 and immune checkpoint inhibitors on peritoneal dissemination of tumor cells
Grant-in-Aid for Scientific Research (B)
Hyogo Medical University
01 Apr. 2012 - 31 Mar. 2017 - Intestinal surfactant protein in the intestinal failure of low birth weight children
Grant-in-Aid for Scientific Research (C)
01 Apr. 2013 - 31 Mar. 2016 - Development of oncolytic adenovirus as a new therapeutic agent for treating disseminated cancers
Grant-in-Aid for Scientific Research (C)
Hyogo Medical University
01 Apr. 2013 - 31 Mar. 2016 - Deletion of the 3p region in malignant mesothelioma cells derived from Japanese patients
Grant-in-Aid for Scientific Research (C)
Hyogo Medical University
01 Apr. 2012 - 31 Mar. 2015 - Role of Src-family kinase in the progression of malignant tumor cells and its clinical implication
Grant-in-Aid for Scientific Research (C)
Hyogo Medical University
01 Apr. 2012 - 31 Mar. 2015 - The role of glucocorticoid in mitochondria-dependent resistance to anticancer therapy
Grant-in-Aid for Scientific Research (C)
Osaka City University
01 Apr. 2012 - 31 Mar. 2015 - Analysis of Functional Bowel Disorder and Development of Vew Treatments
Grant-in-Aid for Challenging Exploratory Research
Hyogo Medical University
01 Apr. 2012 - 31 Mar. 2014 - Development of a novel cancer vaccine using chemokine CCL21 and oncolytic adenovirus
Grant-in-Aid for Scientific Research (C)
Hyogo Medical University
2011 - 2013 - Molecular pathogenesis of myotonic dystrophy in the central nervous system
Grant-in-Aid for Scientific Research (C)
Hyogo Medical University
2011 - 2013 - The elucidation of central chemosensitive respiratory regulation by TRP channels expressed in glial cell.
Grant-in-Aid for Scientific Research (C)
Hyogo Medical University
2011 - 2013 - Development of oncolytic adenovirus as a new therapeutic agent for treating human malignant mesothelioma
Grant-in-Aid for Scientific Research (C)
Hyogo Medical University
2010 - 2012 - The assessment using Positron Emission Tomography in conditionally replicating adenovirus therapy.
Grant-in-Aid for Scientific Research (B)
Hyogo College of Medicine
2007 - 2009 - 遺伝子治療、細胞治療、遺伝子導入法の開発
2008 - Gene therapy, Cell therapy, Development of novel viral vectors
