Last Updated :2024/09/11
Researcher Information
Field Of Study
Career
- Oct. 2022 - Present
Hyogo Medical University, Department of General Internal Medicine, 助教 - Sep. 2019 - Aug. 2022
Salk Institute for Biological Studies, Gene Expression Laboratory (GEL-B), Postodoctoral Fellow - Sep. 2017 - Sep. 2019
Hashimoto Municipal Hospital, Department of General Internal Medicine, Academic Staff - Sep. 2017 - Sep. 2019
Salk Institute for Biological Studies, Gene Expression Laboratory (GEL-B), Visiting Scientist - Apr. 2015 - Mar. 2018
Graduate School of Medicine, Osaka University, Department of Molecular Biology and Biochemistry, Visiting Academic Staff - Sep. 2015 - Sep. 2017
Hashimoto Municipal Hospital, Department of General Internal Medicine, Attending Physician - Apr. 2009 - Mar. 2011
Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Department of Internal Medicine, Clinical Fellow - Apr. 2007 - Mar. 2009
Tokyo Metropolitan Komagome Hospital, Resident
Research activity information
Award
Paper
- Therapeutic strategy for spinal muscular atrophy by combining gene supplementation and genome editing.
Fumiyuki Hatanaka; Keiichiro Suzuki; Kensaku Shojima; Jingting Yu; Yuta Takahashi; Akihisa Sakamoto; Javier Prieto; Maxim Shokhirev; Estrella Nuñez Delicado; Concepcion Rodriguez Esteban; Juan Carlos Izpisua Belmonte
Nature communications, Jul. 2024 - Cigarette smoking and progression of kidney dysfunction: a longitudinal cohort study.
Ayako Matsumoto; Yasuyuki Nagasawa; Ryouhei Yamamoto; Maki Shinzawa; Hiromitsu Yamazaki; Kensaku Shojima; Ken Shinmura; Yoshitaka Isaka; Kunitoshi Iseki; Kunihiro Yamagata; Ichiei Narita; Tsuneo Konta; Masahide Kondo; Kazuhiko Tsuruya; Masato Kasahara; Yugo Shibagaki; Shouichi Fujimoto; Koichi Asahi; Tsuyoshi Watanabe; Toshiki Moriyama
Clinical and experimental nephrology, Apr. 2024, [Reviewed] - Factors contributing to subjective well-being and supporting successful aging among rural Japanese community-dwelling older adults: A cross-sectional and longitudinal study.
Kensaku Shojima; Takara Mori; Yosuke Wada; Hiroshi Kusunoki; Kayoko Tamaki; Ryota Matsuzawa; Koutatsu Nagai; Masashi Goto; Takahiro Tabuchi; Yasuyuki Nagasawa; Ken Shinmura
Geriatrics & gerontology international, Mar. 2024, [Reviewed]
Lead - 篠山コホート研究における歯周病菌の検出率の検討
長澤 康行; 野村 良太; 服部 洋一; 臼田 桃子; 亀谷 茉莉子; 秋友 達哉; 光畑 智恵子; 山崎 博充; 庄嶋 健作; 森 敬良; 楠 博; 岸本 裕充; 新村 健
日本病院総合診療医学会雑誌, Aug. 2023 - Association Between Timed Up-and-Go Test and Future Changes in the Frailty Status in a Longitudinal Study of Japanese Community-Dwelling Older Adults.
Yosuke Wada; Kensaku Shojima; Kayoko Tamaki; Takara Mori; Hiroshi Kusunoki; Masaaki Onishi; Shotaro Tsuji; Ryota Matsuzawa; Koutatsu Nagai; Kyoko Sano; Kana Hashimoto; Masashi Goto; Yasuyuki Nagasawa; Ken Shinmura
Clinical interventions in aging, Jul. 2023, [Reviewed] - Estrogen contributes to the sex difference in the occurrence of senescence-related T cells during the development of visceral adipose tissue inflammation.
Natsumi Imano; Kensaku Shojima; Kayoko Tamaki; Ken Shinmura
American journal of physiology. Heart and circulatory physiology, May 2023, [Reviewed] - Impact of COVID-19 Pandemic on the Influenza Vaccination and Predictors of Influenza Vaccination in Japan: A Cross-sectional Study.
Kensaku Shojima; Taiichiro Kobayashi; Takahiro Tabuchi
Journal of public health management and practice : JPHMP, Apr. 2023, [Reviewed]
Lead - Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice.
Yuta Takahashi; Mariana Morales Valencia; Yang Yu; Yasuo Ouchi; Kazuki Takahashi; Maxim Nikolaievich Shokhirev; Kathryn Lande; April E Williams; Chiara Fresia; Masakazu Kurita; Tomoaki Hishida; Kensaku Shojima; Fumiyuki Hatanaka; Estrella Nuñez-Delicado; Concepcion Rodriguez Esteban; Juan Carlos Izpisua Belmonte
Cell, Feb. 2023, [Reviewed] - Appropriate exercise might have some benefits for both mothers and their babies via epigenesis.
Yasuyuki Nagasawa; Hiromitsu Yamazaki; Kensaku Shojima; Ken Shinmura
Hypertension research : official journal of the Japanese Society of Hypertension, Jan. 2023 - In vivo partial cellular reprogramming enhances liver plasticity and regeneration
Tomoaki Hishida; Mako Yamamoto; Yuriko Hishida-Nozaki; Changwei Shao; Ling Huang; Chao Wang; Kensaku Shojima; Yuan Xue; Yuqing Hang; Maxim Shokhirev; Sebastian Memczak; Sanjeeb Kumar Sahu; Fumiyuki Hatanaka; Ruben Rabadan Ros; Matthew B. Maxwell; Jasmine Chavez; Yanjiao Shao; Hsin-Kai Liao; Paloma Martinez-Redondo; Isabel Guillen-Guillen; Reyna Hernandez-Benitez; Concepcion Rodriguez Esteban; Jing Qu; Michael C. Holmes; Fei Yi; Raymond D. Hickey; Pedro Guillen Garcia; Estrella Nuñez Delicado; Antoni Castells; Josep M. Campistol; Yang Yu; Diana C. Hargreaves; Akihiro Asai; Pradeep Reddy; Guang-Hui Liu; Juan Carlos Izpisua Belmonte
Cell Reports, Apr. 2022, [Reviewed] - In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice
Kristen C. Browder; Pradeep Reddy; Mako Yamamoto; Amin Haghani; Isabel Guillen Guillen; Sanjeeb Sahu; Chao Wang; Yosu Luque; Javier Prieto; Lei Shi; Kensaku Shojima; Tomoaki Hishida; Zijuan Lai; Qingling Li; Feroza K. Choudhury; Weng R. Wong; Yuxin Liang; Dewakar Sangaraju; Wendy Sandoval; Concepcion Rodriguez Esteban; Estrella Nuñez Delicado; Pedro Guillen Garcia; Michal Pawlak; Jason A. Vander Heiden; Steve Horvath; Heinrich Jasper; Juan Carlos Izpisua Belmonte
Nature Aging, Mar. 2022, [Reviewed] - Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion
Akikazu Harada; Shinji Matsumoto; Yoshiaki Yasumizu; Kensaku Shojima; Toshiyuki Akama; Hidetoshi Eguchi; Akira Kikuchi
eLife, Sep. 2021, [Reviewed] - αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model.
Paloma Martinez-Redondo; Isabel Guillen-Guillen; Noah Davidsohn; Chao Wang; Javier Prieto; Masakazu Kurita; Fumiyuki Hatanaka; Cuiqing Zhong; Reyna Hernandez-Benitez; Tomoaki Hishida; Takashi Lezaki; Akihisa Sakamoto; Amy N Nemeth; Yuriko Hishida; Concepcion Rodriguez Esteban; Kensaku Shojima; Ling Huang; Maxim Shokhirev; Estrella Nuñez-Delicado; Josep M Campistol; Isabel Guillen-Vicente; Elena Rodriguez-Iñigo; Juan Manuel Lopez-Alcorocho; Marta Guillen-Vicente; George Church; Pradeep Reddy; Pedro Guillen-Garcia; Guang-Hui Liu; Juan Carlos Izpisua Belmonte
Protein & cell, Jan. 2020, [Reviewed] - Voluntary home and car smoke-free rules in Japan: a cross-sectional study in 2015.
Kensaku Shojima; Takahiro Tabuchi
BMJ open, Mar. 2019, [Reviewed] - Postpartum Methicillin-Resistant Staphylococcus aureus Toxic Shock Syndrome Caused by a Perineal Infection
Deguchi Y; Horiuchi Y; Shojima K; Iwahashi N; Ikejima M; Ino K; Furukawa K
Case Reports in Obstetrics and Gynecology, Sep. 2018, [Reviewed] - Superior Mesenteric Artery Syndrome May Be Overlooked in Women with Functional Dyspepsia
Koki Kawanishi; Kensaku Shojima; Masayuki Nishimoto; Hiroko Abe; Tetsuhiro Kakimoto; Yuko Yasuda; Takeshi Hara; Jun Kato
INTERNAL MEDICINE, 2017, [Reviewed] - CKAP4 is a Dickkopf1 receptor and is involved in tumor progression.
Hirokazu Kimura; Katsumi Fumoto; Kensaku Shojima; Satoshi Nojima; Yoshihito Osugi; Hideo Tomihara; Hidetoshi Eguchi; Yasushi Shintani; Hiroko Endo; Masahiro Inoue; Yuichiro Doki; Meinoshin Okumura; Eiichi Morii; Akira Kikuchi
The Journal of clinical investigation, Jul. 2016, [Reviewed] - The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-gamma in colitis
Akira Sato; Hisako Kayama; Kensaku Shojima; Shinji Matsumoto; Hirofumi Koyama; Yasuhiro Minami; Satoshi Nojima; Eiichi Morii; Hiroaki Honda; Kiyoshi Takeda; Akira Kikuchi
SCIENTIFIC REPORTS, Jun. 2015, [Reviewed] - Wnt5a promotes cancer cell invasion and proliferation by receptor-mediated endocytosis-dependent and -independent mechanisms, respectively
Kensaku Shojima; Akira Sato; Hideaki Hanaki; Ikuko Tsujimoto; Masahiro Nakamura; Kazunari Hattori; Yuji Sato; Keiji Dohi; Michinari Hirata; Hideki Yamamoto; Akira Kikuchi
SCIENTIFIC REPORTS, Jan. 2015, [Reviewed] - Clinical and pathological features of Churg Strauss syndrome among a Japanese population: a case series of 18 patients
Tatsunori Shimoi; Kensaku Shojima; Atsuko Murota; Yasunobu Takizawa; Junko Maruyama; Keigo Setoguchi
ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY, Mar. 2012, [Reviewed]
MISC
- 地域在住高齢者における主観的、客観的睡眠指標とフレイルとの関連 FESTA研究における横断的解析
新村 健; 永井 宏達; 庄嶋 健作; 森 敬良; 和田 陽介; 楠 博; 玉城 香代子; 大西 政彰; 辻 翔太郎; 松沢 良太; 後藤 雅史; 長澤 康行
日本サルコペニア・フレイル学会雑誌, Oct. 2023 - Wnt5a-Ror2シグナルによる腸管炎症の増悪機構の解析
佐藤 朗; 香山 尚子; 庄嶋 健作; 松本 真司; 小山 浩史; 南 康博; 野島 聡; 森井 英一; 本田 浩章; 竹田 潔; 菊池 章
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015 - Wnt5a-Ror2シグナルによる腸管炎症の増悪機構の解析
佐藤 朗; 香山 尚子; 庄嶋 健作; 松本 真司; 小山 浩史; 南 康博; 野島 聡; 森井 英一; 本田 浩章; 竹田 潔; 菊池 章
日本生化学会大会プログラム・講演要旨集, Oct. 2014 - そこが知りたい!がん化学療法とケアQ&A―臨床現場からの100の質問に答えます―3.治療の開始や中止の意思決定のサポート Q30 がんと診断されましたが,「進行しており末期」と言われた患者さんがいます.「抗がん剤も適応にならない」と言われましたが,なぜですか?
庄嶋健作; 岡元るみ子
ナーシングケアQ&A, 13 Feb. 2011 - そこが知りたい!がん化学療法とケアQ&A―臨床現場からの100の質問に答えます―3.治療の開始や中止の意思決定のサポート Q29 医師から「効果的な治療がなくなった」と言われました.抗がん剤はたくさんあるのに,なぜですか?
庄嶋健作; 岡元るみ子
ナーシングケアQ&A, 13 Feb. 2011 - そこが知りたい!がん化学療法とケアQ&A―臨床現場からの100の質問に答えます―1.がん化学療法(抗がん剤・分子標的治療薬)の基礎知識 Q10 抗がん剤はいずれ効かなくなる時が来ると聞きました.それはなぜですか?
庄嶋健作; 岡元るみ子
ナーシングケアQ&A, 13 Feb. 2011 - Wnt5a deficiency ameliorates the dextran sulfate sodium (DSS)-induced acute colitis.
SATO Akira; SHOJIMA Kensaku; KOYAMA Hirofumi; KIKUCHI Akira
日本分子生物学会年会プログラム・要旨集(Web), 2011
Lectures, oral presentations, etc.
- Exploring factors contributing to well-being that support successful aging in the rural Japanese community-dwelling older adults
Kensaku Shojima; Kayoko Tamaki; Hiromitsu Yamazaki; Yasuyuki Nagasawa; Takara Mori; Ken Shinmura
IAGG-Asia Oceania Regional Congress2023, Jun. 2023 - ヒト膵癌におけるArl4cの発現および機能解析
庄嶋 健作; 藤井 慎介; 松本 真司; 江口 英利; 土岐 祐一郎; 菊池 章
日本癌学会総会記事, Oct. 2016 - 新規癌治療標的であるDkk1-CKAP4シグナル
木村 公一; 麓 勝己; 庄嶋 健作; 大杉 祥仁; 菊池 章
日本癌学会総会記事, Oct. 2016 - Wnt5a-Ror2シグナルによる腸管炎症の増悪機構の解析
佐藤 朗; 香山 尚子; 庄嶋 健作; 松本 真司; 小山 浩史; 南 康博; 野島 聡; 森井 英一; 本田 浩章; 竹田 潔; 菊池 章
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015 - 受容体エンドサイトーシスを介して癌の浸潤に関与するWnt5aシグナルが、エンドサイトーシス非依存性に癌の増殖を促進する
庄嶋 健作; 佐藤 朗; 花木 英明; 辻本 育子; 中村 昌弘; 服部 一成; 佐藤 勇次; 土肥 啓司; 平田 道也; 山本 英樹; 菊池 章
日本癌学会総会記事, Oct. 2015 - Wnt5a-Ror2シグナルによる腸管炎症の増悪機構の解析
佐藤 朗; 香山 尚子; 庄嶋 健作; 松本 真司; 小山 浩史; 南 康博; 野島 聡; 森井 英一; 本田 浩章; 竹田 潔; 菊池 章
日本生化学会大会プログラム・講演要旨集, Oct. 2014 - エンドサイトーシスを介さないWnt5aシグナルによる癌細胞増殖機構の解析(Wnt5a promotes cancer cell proliferation by the endocytosis-independent pathway)
庄嶋 健作; 佐藤 朗; 山本 英樹; 辻本 育子; 松本 真司; 菊池 章
日本癌学会総会記事, Sep. 2014 - Wnt5aシグナルによる癌細胞増殖機構の解析(Wnt5a regulates cancer cell proliferation)
庄嶋 健作; 佐藤 朗; 辻本 育子; 松本 真司; 菊池 章
日本癌学会総会記事, Oct. 2013 - 炎症と腫瘍の共通因子としてのWntシグナル(Wnt as a common mediater for inflammation and tumorgenesis)
菊池 章; 佐藤 朗; 庄嶋 健作; 山本 英樹
日本癌学会総会記事, Aug. 2012 - 乳癌胃転移の一例
庄嶋 健作; 下山 達; 佐々木 栄作; 小室 泰司; 岡元 るみ子; 前田 義治; 堀口 慎一郎; 比島 恒和; 荒川 丈夫; 黒井 克昌; 佐々木 常雄
日本胃癌学会総会記事, Mar. 2011 - Application of intrathecal trastuzumab for treatment of meningeal carcinomatosis in HER2-overexpressing metastatic breast cancer
Kensaku SHOJIMA
ASCO Annual Meeting 2008, Jun. 2008
Affiliated academic society
Research Themes
- 2023年度助成
Nov. 2023 - Mar. 2025 - 西宮キャンパス若手研究者研究助成
2023年度研究推進助成
Jul. 2023 - Mar. 2025 - 生体内リプログラミングにより誘導される循環物質 を介した抗加齢療法
Dec. 2023 - Dec. 2024 - Exploring Factors Contributing to Well-Being that Support Successful Aging
Nov. 2022 - Mar. 2024 - 生体内短期間リプログラミングと有尾両生類特異的遺伝子を用いた四肢再生
Mar. 2022 - Development of an innovative therapy against acute organ failure by in vivo partial reprograming
Sep. 2020 - Sep. 2021 - Development of an innovative therapy against aging by in vivo partial reprogramming
Apr. 2020 - Mar. 2021 - Development of an innovative therapy against acute organ failure by in vivo partial reprograming
Sep. 2019 - Sep. 2020 - Sep. 2017 - Sep. 2019
- Investigation of a new Wnt5a signaling target in cell proliferation
Grant-in-Aid for Research Activity start-up
Osaka University
28 Aug. 2015 - 31 Mar. 2017
Social Contribution Activities
- the 30th March of Dimes High School Science Day
organizing_member
Salk Institute for Biological Studies, 29 Feb. 2020
