Last Updated :2026/10/28
Research activity information
Paper
- Jun N-terminal kinase's role in neuropathic pain: C-fiber remodeling and growth-associated protein-43 phosphorylation.
Hiroki Yamanaka; Kimiko Kobayashi; Hirosato Kanda; Koichi Noguchi
Pain reports, Dec. 2025 - Expression of platelet–derived growth factor receptors in primary afferents and their effect on pain behaviors
Masamichi Okubo; Miyuna Nagai; Hirosato Kanda; Hiroki Yamanaka; Kimiko Kobayashi; Koichi Noguchi; Yi Dai
PAIN RESEARCH, Sep. 2025 - The neuronal and glial cell diversity in the celiac ganglion revealed by single-nucleus RNA sequencing
Hirosato Kanda; Hiroki Yamanaka; Yi Dai; Koichi Noguchi
Scientific Reports, Feb. 2025 - COX2 expression plays a role in spinal cord injury-induced neuropathic pain.
Masakazu Toi; Tachibana Toshiya; Koichi Noguchi; Hiroki Yamanaka; Kimiko Kobayashi; Masamichi Okubo; Kazuya Kishima; Yi Dai
Neuroscience letters, Jan. 2024 - The Anterior Cingulate Cortex is Critical for Acute Stress-induced Hypersensitivity in Mice.
Ryo Kawabata; Hiroki Yamanaka; Kimiko Kobayashi; Yoshihiko Oke; Ayumi Fujita; Yoshitaka Oku; Ikuko Yao; Kohei Koga
Neuroscience, Jul. 2023 - Morphology of Schwann Cell Processes Supports Renal Sympathetic Nerve Terminals With Local Distribution of Adrenoceptors.
Seishi Maeda; Yusuke Minato; Sachi Kuwahara-Otani; Hiroki Yamanaka; Mitsuyo Maeda; Yosky Kataoka; Hideshi Yagi
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Jul. 2022 - Analgesic effect of gastrin-releasing peptide in the dorsal horn.
Ayano Saeki; Hiroki Yamanaka; Kimiko Kobayashi; Masamichi Okubo; Koichi Noguchi
Molecular pain, Apr. 2022 - Acid increases PGE2 in the duodenal mucosa in rats.
Tadahiro Fujimura; Takashi Kondo; Kimiko Kobayashi; Shaoqi Duan; Hirosato Kanda; Tomoaki Kono; Masashi Fukushima; Toshihiko Tomita; Tadayuki Oshima; Hirokazu Fukui; Yoshihito Fujii; Takashi Konemura; Hiroki Okada; Hiroki Yamanaka; Yi Dai; Koichi Noguchi; Hiroto Miwa
Journal of clinical biochemistry and nutrition, Jan. 2022 - Aberrant axo-axonic synaptic reorganization in the phosphorylated l1-cam/calcium channel subunit α2δ 1-containing central terminals of injured c-fibers in the spinal cord of a neuropathic pain model
Hiroki Yamanaka; Masamichi Okubo; Kimiko Kobayashi; Koichi Noguchi
eNeuro, 2021 - Localization of prostaglandin E2 synthases and E-prostanoid receptors in the spinal cord in a rat model of neuropathic pain.
Hirosato Kanda; Kimiko Kobayashi; Hiroki Yamanaka; Masamichi Okubo; Yi Dai; Koichi Noguchi
Brain research, Jan. 2021 - Role of Rho-associated coiled-coil containing protein kinase in the spinal cord injury induced neuropathic pain.
Kazuya Kishima; Toshiya Tachibana; Hiroki Yamanaka; Kimiko Kobayashi; Masamichi Okubo; Keishi Maruo; Koichi Noguchi
The spine journal : official journal of the North American Spine Society, Aug. 2020, [Reviewed] - Hippocalcin-like 4, a neural calcium sensor, has a limited contribution to pain and itch processing.
Christopher G Alvaro; João M Braz; Mollie Bernstein; Katherine A Hamel; Veronica Craik; Hiroki Yamanaka; Allan I Basbaum
PloS one, 2020, [Reviewed] - TRPA1-expressing lamina propria mesenchymal cells regulate colonic motility.
Yanjing Yang; Shenglan Wang; Kimiko Kobayashi; Yongbiao Hao; Hirosato Kanda; Takashi Kondo; Yoko Kogure; Hiroki Yamanaka; Satoshi Yamamoto; Junxiang Li; Hiroto Miwa; Koichi Noguchi; Yi Dai
JCI insight, May 2019, [Reviewed] - Differential expression of mGluRs in rat spinal dorsal horns and their modulatory effects on nocifensive behaviors
Masamichi Okubo; Hiroki Yamanaka; Kimiko Kobayashi; Koichi Noguchi
Molecular Pain, 2019 - Recombinant interleukin-4 alleviates mechanical allodynia via injury-induced interleukin-4 receptor alpha in spinal microglia in a rat model of neuropathic pain.
Hiroai Okutani; Hiroki Yamanaka; Kimiko Kobayashi; Masamichi Okubo; Koichi Noguchi
Glia, Aug. 2018, [Reviewed] - Upregulation of calcium channel alpha-2-delta-1 subunit in dorsal horn contributes to spinal cord injury-induced tactile allodynia.
Kazuki Kusuyama; Toshiya Tachibana; Hiroki Yamanaka; Masamichi Okubo; Shinichi Yoshiya; Koichi Noguchi
The spine journal : official journal of the North American Spine Society, Jun. 2018, [Reviewed] - Negative Regulation of TRPA1 by AMPK in Primary Sensory Neurons as a Potential Mechanism of Painful Diabetic Neuropathy.
Shenglan Wang; Kimiko Kobayashi; Yoko Kogure; Hiroki Yamanaka; Satoshi Yamamoto; Hideshi Yagi; Koichi Noguchi; Yi Dai
Diabetes, Jan. 2018, [Reviewed] - Microglial TNFα induces COX2 and PGI2 synthase expression in spinal endothelial cells during neuropathic pain
Hirosato Kanda; Kimiko Kobayashi; Hiroki Yamanaka; Masamichi Okubo; Koichi Noguchi
eNeuro, 2017 - Annexin A2 in primary afferents contributes to neuropathic pain associated with tissue type plasminogen activator.
H Yamanaka; K Kobayashi; M Okubo; K Noguchi
Neuroscience, Feb. 2016 - Macrophage-Colony Stimulating Factor Derived from Injured Primary Afferent Induces Proliferation of Spinal Microglia and Neuropathic Pain in Rats.
Masamichi Okubo; Hiroki Yamanaka; Kimiko Kobayashi; Yi Dai; Hirosato Kanda; Hideshi Yagi; Koichi Noguchi
PloS one, 2016, [Reviewed] - Changes in transient receptor potential channels in the rat geniculate ganglion after chorda tympani nerve injury.
Emiko Tatsumi; Hirokazu Katsura; Kimiko Kobayashi; Hiroki Yamanaka; Kenzo Tsuzuki; Koichi Noguchi; Masafumi Sakagami
Neuroreport, Sep. 2015, [Reviewed] - Leukotriene enhances NMDA-induced inward currents in dorsal horn neurons of the rat spinal cord after peripheral nerve injury.
Yasukuni Kiyoyuki; Wataru Taniguchi; Masamichi Okubo; Hiroki Yamanaka; Kimiko Kobayashi; Naoko Nishio; Terumasa Nakatsuka; Koichi Noguchi
Molecular pain, Sep. 2015 - Peripherally increased artemin is a key regulator of TRPA1/V1 expression in primary afferent neurons.
Yasuko Ikeda-Miyagawa; Kimiko Kobayashi; Hiroki Yamanaka; Masamichi Okubo; Shenglan Wang; Yi Dai; Hideshi Yagi; Munetaka Hirose; Koichi Noguchi
Molecular pain, Mar. 2015, [Reviewed] - RhoA/ROCK pathway mediates p38 MAPK activation and morphological changes downstream of P2Y12/13 receptors in spinal microglia in neuropathic pain.
Emiko Tatsumi; Hiroki Yamanaka; Kimiko Kobayashi; Hideshi Yagi; Masafumi Sakagami; Koichi Noguchi
Glia, Feb. 2015, [Reviewed] - Upregulated glial cell line-derived neurotrophic factor through cyclooxygenase-2 activation in the muscle is required for mechanical hyperalgesia after exercise in rats.
Shiori Murase; Etsuji Terazawa; Kenji Hirate; Hiroki Yamanaka; Hirosato Kanda; Koichi Noguchi; Hiroki Ota; Fernando Queme; Toru Taguchi; Kazue Mizumura
The Journal of physiology, Jun. 2013, [Reviewed] - COX-1-dependent prostaglandin D2 in microglia contributes to neuropathic pain via DP2 receptor in spinal neurons.
Hirosato Kanda; Kimiko Kobayashi; Hiroki Yamanaka; Koichi Noguchi
Glia, Jun. 2013, [Reviewed] - Excitatory superficial dorsal horn interneurons are functionally heterogeneous and required for the full behavioral expression of pain and itch.
Xidao Wang; Jie Zhang; Derek Eberhart; Rochelle Urban; Karuna Meda; Carlos Solorzano; Hiroki Yamanaka; Dennis Rice; Allan I Basbaum
Neuron, Apr. 2013, [Reviewed] - Phosphorylation of ezrin/radixin/moesin (ERM) protein in spinal microglia following peripheral nerve injury and lysophosphatidic acid administration
Ryosuke Kashimoto; Hiroki Yamanaka; Kimiko Kobayashi; Masamichi Okubo; Hideshi Yagi; Osamu Mimura; Koichi Noguchi
GLIA, Mar. 2013, [Reviewed] - Expression of ATP receptors in the rat dorsal root ganglion and spinal cord.
Kimiko Kobayashi; Hiroki Yamanaka; Koichi Noguchi
Anatomical science international, Jan. 2013, [Reviewed] - [Pathophysiology of neuropathic pain: molecular mechanisms underlying central sensitization in the dorsal horn in neuropathic pain].
Hiroki Yamanaka; Koichi Noguchi
Brain and nerve = Shinkei kenkyu no shinpo, Nov. 2012, [Reviewed] - Multiple P2Y subtypes in spinal microglia are involved in neuropathic pain after peripheral nerve injury.
Kimiko Kobayashi; Hiroki Yamanaka; Fujio Yanamoto; Masamichi Okubo; Koichi Noguchi
Glia, Oct. 2012, [Reviewed] - Potentiation of the P2X3 ATP receptor by PAR-2 in rat dorsal root ganglia neurons, through protein kinase-dependent mechanisms, contributes to inflammatory pain.
Shenglan Wang; Yi Dai; Kimiko Kobayashi; Wanjun Zhu; Yoko Kogure; Hiroki Yamanaka; You Wan; Wensheng Zhang; Koichi Noguchi
The European journal of neuroscience, Aug. 2012, [Reviewed] - Up-regulation of platelet-activating factor synthases and its receptor in spinal cord contribute to development of neuropathic pain following peripheral nerve injury.
Masamichi Okubo; Hiroki Yamanaka; Kimiko Kobayashi; Hirosato Kanda; Yi Dai; Koichi Noguchi
Molecular pain, Feb. 2012, [Reviewed] - Re-evaluation of the phenotypic changes in L4 dorsal root ganglion neurons after L5 spinal nerve ligation.
Tetsuo Fukuoka; Hiroki Yamanaka; Kimiko Kobayashi; Masamichi Okubo; Kan Miyoshi; Yi Dai; Koichi Noguchi
Pain, Jan. 2012, [Reviewed] - Induction of the P2X7 receptor in spinal microglia in a neuropathic pain model.
Kimiko Kobayashi; Emiko Takahashi; Yasuko Miyagawa; Hiroki Yamanaka; Koichi Noguchi
Neuroscience letters, Oct. 2011, [Reviewed] - Increase of close homolog of cell adhesion molecule L1 in primary afferent by nerve injury and the contribution to neuropathic pain.
Hiroki Yamanaka; Kimiko Kobayashi; Masamichi Okubo; Tetsuo Fukuoka; Koichi Noguchi
The Journal of comparative neurology, Jun. 2011, [Reviewed] - Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells.
Daniel J Cavanaugh; Alexander T Chesler; Alexander C Jackson; Yaron M Sigal; Hiroki Yamanaka; Rebecca Grant; Dajan O'Donnell; Roger A Nicoll; Nirao M Shah; David Julius; Allan I Basbaum
The Journal of neuroscience : the official journal of the Society for Neuroscience, Mar. 2011, [Reviewed] - Expression of COX1, COX2, PGD(2) and thromboxane A(2) synthases mRNAs in spinal cord following peripheral nerve injury
Hirosato Kanda; Kimiko Kobayashi; Hiroki Yamanaka; Koichi Noguchi
NEUROSCIENCE RESEARCH, 2011 - VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity.
Grégory Scherrer; Sarah A Low; Xidao Wang; Jie Zhang; Hiroki Yamanaka; Rochelle Urban; Carlos Solorzano; Blaine Harper; Thomas S Hnasko; Robert H Edwards; Allan I Basbaum
Proceedings of the National Academy of Sciences of the United States of America, Dec. 2010, [Reviewed] - Expression of leukotriene receptors in the rat dorsal root ganglion and the effects on pain behaviors.
Masamichi Okubo; Hiroki Yamanaka; Kimiko Kobayashi; Tetsuo Fukuoka; Yi Dai; Koichi Noguchi
Molecular pain, Sep. 2010, [Reviewed] - Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain.
Masamichi Okubo; Hiroki Yamanaka; Kimiko Kobayashi; Koichi Noguchi
Glia, Apr. 2010, [Reviewed] - Expression and phosphorylation of ERM family proteins in rat spinal dorsal horn with spared nerve injury (SNI) model
Ryosuke Kashimoto; Hiroki Yamanaka; Kimiko Kobayashi; Masamichi Okubo; Osamu Mimura; Koichi Noguchi
NEUROSCIENCE RESEARCH, 2009 - Platelet-activating factor biosynthesis in spinal cord contributes to neuropathic pain following peripheral nerve injury
Masamichi Okubo; Hiroki Yamanaka; Kimiko Kobayashi; Koichi Noguchi
NEUROSCIENCE RESEARCH, 2009 - Induction of P2 receptors in the spinal microglia following peripheral nerve injury
Kimiko Kobayashi; Hiroki Yamanaka; Masamichi Okubo; Koichi Noguchi
NEUROSCIENCE RESEARCH, 2009 - 3P-192 Induction of P2Y receptors in the spinal cord following peripheral nerve injury.(Neuroscience & Sensory systems,The 47th Annual Meeting of the Biophysical Society of Japan)
Kobayashi Kimiko; Yamanaka Hiroki; Noguchi Koichi
Seibutsu Butsuri, 2009 - Comparative study of the distribution of the alpha-subunits of voltage-gated sodium channels in normal and axotomized rat dorsal root ganglion neurons.
Tetsuo Fukuoka; Kimiko Kobayashi; Hiroki Yamanaka; Koichi Obata; Yi Dai; Koichi Noguchi
The Journal of comparative neurology, Sep. 2008, [Reviewed] - Transforming growth factor-activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injury.
Hirokazu Katsura; Koichi Obata; Kan Miyoshi; Takashi Kondo; Hiroki Yamanaka; Kimiko Kobayashi; Yi Dai; Tetsuo Fukuoka; Masafumi Sakagami; Koichi Noguchi
Glia, May 2008, [Reviewed] - Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain.
Shenglan Wang; Yi Dai; Tetsuo Fukuoka; Hiroki Yamanaka; Kimiko Kobayashi; Koichi Obata; Xiuyu Cui; Makoto Tominaga; Koichi Noguchi
Brain : a journal of neurology, May 2008, [Reviewed] - Differential activation of p38 and extracellular signal-regulated kinase in spinal cord in a model of bee venom-induced inflammation and hyperalgesia.
Xiu-Yu Cui; Yi Dai; Sheng-Lan Wang; Hiroki Yamanaka; Kimiko Kobayashi; Koichi Obata; Jun Chen; Koichi Noguchi
Molecular pain, Apr. 2008, [Reviewed] - Activation of extracellular signal-regulated protein kinase in sensory neurons after noxious gastric distention and its involvement in acute visceral pain in rats.
Jun Sakurai; Koichi Obata; Noriyuki Ozaki; Atsushi Tokunaga; Kimiko Kobayashi; Hiroki Yamanaka; Yi Dai; Takashi Kondo; Kan Miyoshi; Yasuo Sugiura; Takayuki Matsumoto; Hiroto Miwa; Koichi Noguchi
Gastroenterology, Apr. 2008, [Reviewed] - P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain.
Kimiko Kobayashi; Hiroki Yamanaka; Tetsuo Fukuoka; Yi Dai; Koichi Obata; Koichi Noguchi
The Journal of neuroscience : the official journal of the Society for Neuroscience, Mar. 2008, [Reviewed] - Expression of leukotriene synthases and leukotriene receptors in the skin and dorsal root ganglion
Masamichi Okubo; Yamanaka Hiroki; Kobayashi Kimiko; Noguchi Koichi
NEUROSCIENCE RESEARCH, 2008 - Activation of fibroblast growth factor receptor by axotomy, through downstream p38 in dorsal root ganglion, contributes to neuropathic pain.
Yamanaka H; Obata K; Kobayashi K; Dai Y; Fukuoka T; Noguchi K
Neuroscience, Nov. 2007, [Reviewed] - Sensitization of TRPAl by PAR2 contributes to the sensation of inflammatory pain (vol 117, pg 1979, 2007)
Yi Dai; Shenglan Wang; Makoto Tominaga; Satoshi Yamamoto; Tetsuo Fukuoka; Tomohiro Higashi; Kimiko Kobayashi; Koichi Obata; Hiroki Yamanaka; Koichi Noguchi
JOURNAL OF CLINICAL INVESTIGATION, Oct. 2007 - Roles of extracellular signal-regulated protein kinases 5 in spinal microglia and primary sensory neurons for neuropathic pain.
Koichi Obata; Hirokazu Katsura; Toshiyuki Mizushima; Jun Sakurai; Kimiko Kobayashi; Hiroki Yamanaka; Yi Dai; Tetsuo Fukuoka; Koichi Noguchi
Journal of neurochemistry, Sep. 2007, [Reviewed] - Activation of extracellular signal-regulated protein kinases 5 in primary afferent neurons contributes to heat and cold hyperalgesia after inflammation.
Hirokazu Katsura; Koichi Obata; Toshiyuki Mizushima; Jun Sakurai; Kimiko Kobayashi; Hiroki Yamanaka; Yi Dai; Tetsuo Fukuoka; Masafumi Sakagami; Koichi Noguchi
Journal of neurochemistry, Sep. 2007, [Reviewed] - Frequency-dependent ERK phosphorylation in spinal neurons by electric stimulation of the sciatic nerve and the role in electrophysiological activity.
Tomokazu Fukui; Yi Dai; Koichi Iwata; Hiroshi Kamo; Hiroki Yamanaka; Koichi Obata; Kimiko Kobayashi; Shenglan Wang; Xiuyu Cui; Shinichi Yoshiya; Koichi Noguchi
Molecular pain, Jul. 2007, [Reviewed] - Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain.
Yi Dai; Shenglan Wang; Makoto Tominaga; Satoshi Yamamoto; Tetsuo Fukuoka; Tomohiro Higashi; Kimiko Kobayashi; Koichi Obata; Hiroki Yamanaka; Koichi Noguchi
The Journal of clinical investigation, Jul. 2007, [Reviewed] - Tissue type plasminogen activator induced in rat dorsal horn astrocytes contributes to mechanical hypersensitivity following dorsal root injury.
Toyoko Kozai; Hiroki Yamanaka; Yi Dai; Koichi Obata; Kimiko Kobayashi; Takashi Mashimo; Koichi Noguchi
Glia, Apr. 2007, [Reviewed] - Two types of GABAergic miniature inhibitory postsynaptic currents in mouse substantia gelatinosa neurons (vol 553, pg 120, 2006)
Ayako Takahashi; Atsushi Tokunaga; Hiroki Yamanaka; Takashi Mashimo; Koichi Noguchi; Ichiro Uchida
EUROPEAN JOURNAL OF PHARMACOLOGY, Apr. 2007 - Intensity-dependent activation of extracellular signal-regulated protein kinase 5 in sensory neurons contributes to pain hypersensitivity.
Toshiyuki Mizushima; Koichi Obata; Hirokazu Katsura; Jun Sakurai; Kimiko Kobayashi; Hiroki Yamanaka; Yi Dai; Tetsuo Fukuoka; Takashi Mashimo; Koichi Noguchi
The Journal of pharmacology and experimental therapeutics, Apr. 2007, [Reviewed] - Alteration of the cell adhesion molecule L1 expression in a specific subset of primary afferent neurons contributes to neuropathic pain.
Hiroki Yamanaka; Koichi Obata; Kimiko Kobayashi; Yi Dai; Tetsuo Fukuoka; Koichi Noguchi
The European journal of neuroscience, Feb. 2007, [Reviewed] - Axotomy increases plasma membrane Ca2+ pump isoform4 in primary afferent neurons.
Hiroyuki Ogura; Toshiya Tachibana; Hiroki Yamanaka; Kimiko Kobayashi; Koichi Obata; Yi Dai; Shinichi Yoshiya; Koichi Noguchi
Neuroreport, Jan. 2007, [Reviewed] - Alteration of the cell adhesion molecule CHL1 expression in a specific subset of primary afferent neurons and dorsal horn following nerve injury
Hiroki Yamanaka; Masamichi Okubo; Koichi Noguchi
NEUROSCIENCE RESEARCH, 2007 - P2Y12 receptor expressed in spinal microglia contributes to neuropathic pain
Kimiko Kobayashi; Tetsuo Fukuoka; Hiroki Yamanaka; Koichi Noguchi
NEUROSCIENCE RESEARCH, 2007 - Two types of GABAergic miniature inhibitory postsynaptic currents in mouse substantia gelatinosa neurons.
Ayako Takahashi; Atsushi Tokunaga; Hiroki Yamanaka; Takashi Mashimo; Koichi Noguchi; Ichiro Uchida
European journal of pharmacology, Dec. 2006, [Reviewed] - Suppression of the p75 neurotrophin receptor in uninjured sensory neurons reduces neuropathic pain after nerve injury.
Koichi Obata; Hirokazu Katsura; Jun Sakurai; Kimiko Kobayashi; Hiroki Yamanaka; Yi Dai; Tetsuo Fukuoka; Koichi Noguchi
The Journal of neuroscience : the official journal of the Society for Neuroscience, Nov. 2006, [Reviewed] - Neurons and glial cells differentially express P2Y receptor mRNAs in the rat dorsal root ganglion and spinal cord. (vol 498. pg 443, 2006)
Kimiko Kobayashi; Tetsuo Fukuoka; Hiroki Yamanaka; Yi Dai; Koichi Obata; Atsushi Tokunaga; Koichi Noguchi
JOURNAL OF COMPARATIVE NEUROLOGY, Nov. 2006 - Neurons and glial cells differentially express P2Y receptor mRNAs in the rat dorsal root ganglion and spinal cord.
Kimiko Kobayashi; Tetsuo Fukuoka; Hiroki Yamanaka; Yi Dai; Koichi Obata; Atsushi Tokunaga; Koichi Noguchi
The Journal of comparative neurology, Oct. 2006, [Reviewed] - Activation of Src-family kinases in spinal microglia contributes to mechanical hypersensitivity after nerve injury.
Hirokazu Katsura; Koichi Obata; Toshiyuki Mizushima; Jun Sakurai; Kimiko Kobayashi; Hiroki Yamanaka; Yi Dai; Tetsuo Fukuoka; Masafumi Sakagami; Koichi Noguchi
The Journal of neuroscience : the official journal of the Society for Neuroscience, Aug. 2006, [Reviewed] - Agonist of proteinase-activated receptor 2 increases painful behavior produced by alpha, beta-methylene adenosine 5'-triphosphate.
Wan-Jun Zhu; Yi Dai; Tetsuo Fukuoka; Hiroki Yamanaka; Kimiko Kobayashi; Koichi Obata; Shenglan Wang; Koichi Noguchi
Neuroreport, Aug. 2006, [Reviewed] - Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats.
Hirokazu Katsura; Koichi Obata; Toshiyuki Mizushima; Hiroki Yamanaka; Kimiko Kobayashi; Yi Dai; Tetsuo Fukuoka; Atsushi Tokunaga; Masafumi Sakagami; Koichi Noguchi
Experimental neurology, Jul. 2006, [Reviewed] - The role of ERK signaling and the P2X receptor on mechanical pain evoked by movement of inflamed knee joint.
Daisuke Seino; Atsushi Tokunaga; Toshiya Tachibana; Shinichi Yoshiya; Yi Dai; Koichi Obata; Hiroki Yamanaka; Kimiko Kobayashi; Koichi Noguchi
Pain, Jul. 2006, [Reviewed] - The effect of site and type of nerve injury on the expression of brain-derived neurotrophic factor in the dorsal root ganglion and on neuropathic pain behavior
K Obata; H Yamanaka; K Kobayashi; Y Dai; T Mizushima; H Katsura; T Fukuoka; A Tokunaga; K Noguchi
NEUROSCIENCE, 2006, [Reviewed] - Noxious cold stimulation induces mitogen-activated protein kinase activation in transient receptor potential (TRP) channels TRPA1- and TRPM8-containing small sensory neurons
T. Mizushima; K. Obata; H. Katsura; H. Yamanaka; K. Kobayashi; Y. Dai; T. Fukuoka; A. Tokunaga; T. Mashimo; K. Noguchi
NEUROSCIENCE, 2006, [Reviewed] - Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors.
Kimiko Kobayashi; Tetsuo Fukuoka; Koichi Obata; Hiroki Yamanaka; Yi Dai; Atsushi Tokunaga; Koichi Noguchi
The Journal of comparative neurology, Dec. 2005, [Reviewed] - The tonic inhibition mediated by GABAA receptor in substantia gelatinosa neurons
Ayako Takahashi; Hiroki Yamanaka; Atsushi Tokunaga; Koichi Noguchi; Takashi Mashimo; Ichiro Uchida
International Congress Series, Nov. 2005, [Reviewed] - TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury.
Koichi Obata; Hirokazu Katsura; Toshiyuki Mizushima; Hiroki Yamanaka; Kimiko Kobayashi; Yi Dai; Tetsuo Fukuoka; Atsushi Tokunaga; Makoto Tominaga; Koichi Noguchi
The Journal of clinical investigation, Sep. 2005, [Reviewed] - Ca2+/calmodulin-dependent protein kinase II in the spinal cord contributes to neuropathic pain in a rat model of mononeuropathy.
Yi Dai; Hu Wang; Akiko Ogawa; Hiroki Yamanaka; Koichi Obata; Atsushi Tokunaga; Koichi Noguchi
The European journal of neuroscience, May 2005, [Reviewed] - Expression of mRNA for four subtypes of the proteinase-activated receptor in rat dorsal root ganglia.
Wan-Jun Zhu; Hiroki Yamanaka; Koichi Obata; Yi Dai; Kimiko Kobayashi; Toyoko Kozai; Atsushi Tokunaga; Koichi Noguchi
Brain research, Apr. 2005, [Reviewed] - Ca(2+)/calmodulin-protein kinase IIalpha in the trigeminal subnucleus caudalis contributes to neuropathic pain following inferior alveolar nerve transection.
Akiko Ogawa; Yi Dai; Hiroki Yamanaka; Koichi Iwata; Hitoshi Niwa; Koichi Noguchi
Experimental neurology, Apr. 2005, [Reviewed] - Distribution of L1cam mRNA in the adult mouse brain: In situ hybridization and Northern blot analyses.
Kazuhiro Horinouchi; Yukiko Nakamura; Hiroki Yamanaka; Takashi Watabe; Sadao Shiosaka
The Journal of comparative neurology, Feb. 2005, [Reviewed] - Differential expression patterns of mRNAs for P2X receptor subunits in neurochemically characterized dorsal root ganglion neurons in the rat.
Kimiko Kobayashi; Tetsuo Fukuoka; Hiroki Yamanaka; Yi Dai; Koichi Obata; Atsushi Tokunaga; Koichi Noguchi
The Journal of comparative neurology, Jan. 2005, [Reviewed] - Induction of plasminogen activator inhibitor-1 and-2 in dorsal root ganglion neurons after peripheral nerve injury
H Yamanaka; K Obata; T Fukuoka; Y Dai; K Kobayashi; A Tokunaga; K Noguchi
NEUROSCIENCE, 2005, [Reviewed] - Activation of p38 MAPK in primary afferent neurons by noxious stimulation and its involvement in the development of thermal hyperalgesia.
Toshiyuki Mizushima; Koichi Obata; Hiroki Yamanaka; Yi Dai; Tetsuo Fukuoka; Atsushi Tokunaga; Takashi Mashimo; Koichi Noguchi
Pain, Jan. 2005, [Reviewed] - Differential activation of MAPK in injured and uninjured DRG neurons following chronic constriction injury of the sciatic nerve in rats.
Koichi Obata; Hiroki Yamanaka; Yi Dai; Toshiyuki Mizushima; Tetsuo Fukuoka; Atsushi Tokunaga; Koichi Noguchi
The European journal of neuroscience, Dec. 2004, [Reviewed] - Plasma membrane calcium ATPase expression in the rat spinal cord.
Toshiya Tachibana; Hiroyuki Ogura; Atsushi Tokunaga; Yi Dai; Hiroki Yamanaka; Daisuke Seino; Koichi Noguchi
Brain research. Molecular brain research, Nov. 2004, [Reviewed] - Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation.
Koichi Obata; Hiroki Yamanaka; Kimiko Kobayashi; Yi Dai; Toshiyuki Mizushima; Hirokazu Katsura; Tetsuo Fukuoka; Atsushi Tokunaga; Koichi Noguchi
The Journal of neuroscience : the official journal of the Society for Neuroscience, Nov. 2004, [Reviewed] - Contribution of degeneration of motor and sensory fibers to pain behavior and the changes in neurotrophic factors in rat dorsal root ganglion.
Koichi Obata; Hiroki Yamanaka; Yi Dai; Toshiyuki Mizushima; Tetsuo Fukuoka; Atsushi Tokunaga; Hideki Yoshikawa; Koichi Noguchi
Experimental neurology, Jul. 2004, [Reviewed] - Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain.
Yi Dai; Tomoko Moriyama; Tomohiro Higashi; Kazuya Togashi; Kimiko Kobayashi; Hiroki Yamanaka; Makoto Tominaga; Koichi Noguchi
The Journal of neuroscience : the official journal of the Society for Neuroscience, May 2004, [Reviewed] - Activation of extracellular signal-regulated protein kinase in dorsal horn neurons in the rat neuropathic intermittent claudication model.
Yi Liu; Koichi Obata; Hiroki Yamanaka; Yi Dai; Tetsuo Fukuoka; Atsushi Tokunaga; Koichi Noguchi
Pain, May 2004, [Reviewed] - Contribution of sensitized P2X receptors in inflamed tissue to the mechanical hypersensitivity revealed by phosphorylated ERK in DRG neurons.
Yi Dai; Tetsuo Fukuoka; Hu Wang; Hiroki Yamanaka; Koichi Obata; Atsushi Tokunaga; Koichi Noguchi
Pain, Apr. 2004, [Reviewed] - Enhancement of stimulation-induced ERK activation in the spinal dorsal horn and gracile nucleus neurons in rats with peripheral nerve injury.
Hu Wang; Yi Dai; Tetsuo Fukuoka; Hiroki Yamanaka; Koichi Obata; Atsushi Tokunaga; Koichi Noguchi
The European journal of neuroscience, Feb. 2004, [Reviewed] - Activation of extracellular signal-regulated protein kinase in the dorsal root ganglion following inflammation near the nerve cell body
K Obata; H Yamanaka; Y Dai; T Mizushima; T Fukuoka; A Tokunaga; K Noguchi
NEUROSCIENCE, 2004, [Reviewed] - Tissue plasminogen activator in primary afferents induces dorsal horn excitability and pain response after peripheral nerve injury.
Hiroki Yamanaka; Koichi Obata; Tetsuo Fukuoka; Yi Dai; Kimiko Kobayashi; Atsushi Tokunaga; Koichi Noguchi
The European journal of neuroscience, Jan. 2004, [Reviewed] - Differential activation of extracellular signal-regulated protein kinase in primary afferent neurons regulates brain-derived neurotrophic factor expression after peripheral inflammation and nerve injury.
Koichi Obata; Hiroki Yamanaka; Yi Dai; Toshiya Tachibana; Tetsuo Fukuoka; Atsushi Tokunaga; Hideki Yoshikawa; Koichi Noguchi
The Journal of neuroscience : the official journal of the Society for Neuroscience, May 2003, [Reviewed] - Increased expression of 3 beta-hydroxysteroid dehydrogenase mRNA in dorsal root ganglion neurons of adult rats following peripheral nerve injury.
Norio Hashimoto; Hiroki Yamanaka; Toshiyuki Mizushima; Koichi Noguchi
Neuroscience letters, Apr. 2003, [Reviewed] - Induction of neuronal nitric oxide synthase by sympathetic denervation is mediated via alpha 2-adrenoceptors in the jejunal myenteric plexus.
Kazushi Nishizaki; Koji Nakao; Hiromitsu Ishii; Hiroki Yamanaka; Atsushi Tokunaga; Kazuhiko Nakagawa; Takehira Yamamura; Koichi Noguchi
Brain research, Mar. 2003, [Reviewed] - Contribution of injured and uninjured dorsal root ganglion neurons to pain behavior and the changes in gene expression following chronic constriction injury of the sciatic nerve in rats.
Koichi Obata; Hiroki Yamanaka; Tetsuo Fukuoka; Dai Yi; Atsushi Tokunaga; Norio Hashimoto; Hideki Yoshikawa; Koichi Noguchi
Pain, Jan. 2003, [Reviewed] - Phosphorylation of extracellular signal-regulated kinase in primary afferent neurons by noxious stimuli and its involvement in peripheral sensitization.
Yi Dai; Koichi Iwata; Tetsuo Fukuoka; Eiji Kondo; Atsushi Tokunaga; Hiroki Yamanaka; Toshiya Tachibana; Yi Liu; Koichi Noguchi
The Journal of neuroscience : the official journal of the Society for Neuroscience, Sep. 2002, [Reviewed] - VR1, but not P2X(3), increases in the spared L4 DRG in rats with L5 spinal nerve ligation.
Tetsuo Fukuoka; Atsushi Tokunaga; Toshiya Tachibana; Yi Dai; Hiroki Yamanaka; Koichi Noguchi
Pain, Sep. 2002, [Reviewed] - Expression of neurotrophic factors in the dorsal root ganglion in a rat model of lumbar disc herniation.
Koichi Obata; Hiroaki Tsujino; Hiroki Yamanaka; Dai Yi; Tetsuo Fukuoka; Norio Hashimoto; Kazuo Yonenobu; Hideki Yoshikawa; Koichi Noguchi
Pain, Sep. 2002, [Reviewed] - Heme oxygenase-1 expression after spinal cord injury: the induction in activated neutrophils.
Yi Liu; Toshiya Tachibana; Yi Dai; Eiji Kondo; Tetsuo Fukuoka; Hiroki Yamanaka; Koichi Noguchi
Journal of neurotrauma, Apr. 2002, [Reviewed] - Involvement of glutamate receptors on hyperexcitability of wide dynamic range neurons in the gracile nucleus of the rats with experimental mononeuropathy.
Eiji Kondo; Koichi Iwata; Akiko Ogawa; Akimasa Tashiro; Yoshiyuki Tsuboi; Tetsuo Fukuoka; Hiroki Yamanaka; Yi Dai; Toshifumi Morimoto; Koichi Noguchi
Pain, Jan. 2002, [Reviewed] - 〔Major achievements〕Expression of Apc2 during mouse development.
Hiroki Yamanaka; Norio Hashimoto; Kumiko Koyama; Hidewaki Nakagawa; Yusuke Nakamura; Koichi Noguchi
Brain research. Gene expression patterns, Jan. 2002, [Reviewed] - Expression of hepatocyte growth factor in primary sensory neurons of adult rats
N Hashimoto; H Yamanaka; T Fukuoka; K Obata; T Mashimo; K Noguchi
MOLECULAR BRAIN RESEARCH, Dec. 2001, [Reviewed] - 〔Major achievements〕Protease M/neurosin mRNA is expressed in mature oligodendrocytes.
H Yamanaka; X He; K Matsumoto; S Shiosaka; S Yoshida
Brain research. Molecular brain research, Aug. 1999, [Reviewed] - Injury induces neuropsin mRNA in the central nervous system.
K Tomizawa; X He; H Yamanaka; S Shiosaka; S Yoshida
Brain research, Apr. 1999, [Reviewed]
MISC
- Characterization of VGAT-expressing cells in the celiac ganglion of VGAT-Cre rats
伊藤三厳; 神田浩里; 小暮洋子; 山本悟史; 山中博樹
日本薬学会年会要旨集(Web), 2025 - 脊髄損傷による神経障害性疼痛におけるCOX2の発現に関する研究
都井 政和; 橘 俊哉; 山中 博樹; 小林 希実子; 大久保 正道; 野口 光一
Journal of Spine Research, Apr. 2023 - 後根神経節における血小板由来増殖因子受容体の発現と疼痛行動への影響
大久保正道; 永井みゆな; 山中博樹; 小林希実子; 神田浩里; 神田浩里; 野口光一; 戴毅; 戴毅
日本解剖学会総会・全国学術集会抄録集(CD-ROM), 2023 - 脊髄損傷による神経障害性疼痛におけるCOX2の発現に関する研究
都井 政和; 橘 俊哉; 野口 光一; 山中 博樹; 小林 希実子; 大久保 正道; 木島 和也; 戴 毅
PAIN RESEARCH, Dec. 2022 - 慢性痛のメカニズム 神経障害性疼痛を例として
山中 博樹
全日本鍼灸学会学術大会抄録集, May 2018 - 末梢神経 脊髄ネットワークにおける痛覚伝達メカニズム 神経傷害性疼痛モデル動物の脊髄後角における損傷C線維の形態的可塑性
山中 博樹; 小林 希実子; 大久保 正道; 野口 光一
PAIN RESEARCH, Jun. 2017 - 一次知覚神経におけるAMPキナーゼによるTRPA1膜発現の制御
王 勝蘭; 小林 希実子; 小暮 洋子; 山中 博樹; 山本 悟史; 八木 秀司; 野口 光一; 戴 毅
PAIN RESEARCH, Jun. 2017 - 神経障害性疼痛モデルラットの脊髄後角におけるIL-4およびIL-4受容体の発現変化
奥谷 博愛; 小林 希実子; 山中 博樹; 大久保 正道; 廣瀬 宗孝; 野口 光一
PAIN RESEARCH, Jun. 2016 - 脊椎関連難治性疼痛に対する診療アプローチの現状と課題 脊髄障害性疼痛に対するカルシウムチャネルα2δ-1サブユニット作動薬の効果と作用機序
橘 俊哉; 楠山 一樹; 圓尾 圭史; 井上 真一; 有住 文博; 山中 博樹; 野口 光一; 吉矢 晋一
Journal of Spine Research, Mar. 2015 - 脊髄損傷モデルにおけるカルシウムチャネルα2δ-1サブユニットの発現
楠山 一樹; 橘 俊哉; 山中 博樹; 野口 光一; 吉矢 晋一
Journal of Musculoskeletal Pain Research, Sep. 2014 - 骨格筋は持続性の機械痛覚過敏を引き起こす神経栄養因子を産生する
村瀬 詩織; 山中 博樹; 神田 浩里; 水村 和枝
Journal of Musculoskeletal Pain Research, Aug. 2014 - 骨格筋細胞は持続する筋機械痛覚過敏を引き起こす神経成長因子(NGF)およびグリア細胞由来神経栄養因子(GDNF)を産生する
村瀬 詩織; 山中 博樹; 神田 浩里; 水村 和枝
Journal of Musculoskeletal Pain Research, Nov. 2013 - ロイコトリエンは末梢神経損傷後に脊髄後角ニューロンのNMDA受容体の反応性を増加させる
清行 康邦; 山中 博樹; 小林 希実子; 谷口 亘; 大久保 正道; 中塚 映政; 野口 光一
Journal of Musculoskeletal Pain Research, Nov. 2013 - 末梢神経損傷後の脊髄および後根神経節におけるColony-stimulating factorとそれら受容体mRNAの発現
大久保 正道; 山中 博樹; 小林 希実子; 神田 浩里; 戴 毅; 野口 光一
Journal of Musculoskeletal Pain Research, Nov. 2013 - ロイコトリエンは末梢神経損傷後に脊髄後角ニューロンのNMDA受容体の反応性を増加させる
清行 康邦; 山中 博樹; 小林 希実子; 谷口 亘; 西尾 尚子; 大久保 正道; 中塚 映政; 野口 光一
PAIN RESEARCH, Jul. 2013 - 脊髄マイクログリアにおけるPGD2とTXA2合成酵素および受容体発現と神経障害疼痛行動への関与
山中博樹; 神田浩里; 小林希実子; 野口光一
日本解剖学会総会・全国学術集会講演プログラム・抄録集, 2013 - 末梢神経障害後の脊髄におけるPGI2合成酵素および受容体の発現と疼痛行動への関与
神田 浩里; 小林 希実子; 山中 博樹; 野口 光一
Journal of Musculoskeletal Pain Research, Oct. 2012 - 一次知覚ニューロンにおける電位依存性ナトリウムチャネルサブタイプの発現比較
福岡 哲男; 小林 希実子; 山中 博樹; 戴 毅; 小畑 浩一; 野口 光一
PAIN RESEARCH, Jul. 2008 - ラット後根神経節におけるロイコトリエン受容体の発現
大久保 正道; 山中 博樹; 野口 光一
全日本鍼灸学会雑誌, May 2008 - ラット後根神経節におけるロイコトリエン受容体の発現
大久保 正道; 山中 博樹; 小林 希実子; 野口 光一
解剖学雑誌, Mar. 2008 - ラット後根神経節・脊髄におけるAdenosine受容体mRNAの発現と坐骨神経切断後の変化
小林 希実子; 福岡 哲男; 山中 博樹; 野口 光一
解剖学雑誌, Mar. 2007 - 末梢神経損傷後の接着因子L1-CAMの発現変化と神経因性疼痛への関与
山中 博樹; 野口 光一
解剖学雑誌, Mar. 2007 - 後根神経節ニューロンでのATP受容体発現及び炎症組織における痛覚過敏
野口 光一; 小林 希実子; 福岡 哲男; 山中 博樹; 戴 毅; 清野 大輔; 徳永 敦
PAIN RESEARCH, Jul. 2005 - 後根損傷後の脊髄後角における組織型プラスミノーゲン活性化因子(tPA)による細胞外タンパク分解
香西 都容子; 山中 博樹; 真下 節; 野口 光一
PAIN RESEARCH, Jul. 2005 - ラット一次感覚ニューロンにおける冷覚受容体TRPA1,TRPM8の局在
小林 希実子; 福岡 哲男; 山中 博樹; 野口 光一
PAIN RESEARCH, Jul. 2005 - 末梢神経損傷後の後根神経節におけるFibroblast growth factor receptor1(FGFR1)の活性化
山中 博樹; 野口 光一
PAIN RESEARCH, Jul. 2005 - Proteinase activated receptorsの後根神経節における発現
朱 万君; 山中 博樹; 野口 光一
解剖学雑誌, Sep. 2004 - 疼痛メカニズム探求の新展開 ニューロパチックペインの新規メカニズムとしてのセリンプロテアーゼ及び細胞接着因子の変化(The frontier of research on pain mechanisms: Changes in serine protease and cell adhesion molecule in nociceptive pathway as novel pathomechanisms of neuropathic pain)
野口 光一; 山中 博樹
神経化学, Aug. 2004 - 脊髄後角第2層における持続性GABA,A受容体持続的抑制性電流(The tonic inhibition mediated by γ Aminobutyric AcidA receptor in substantia gelatinosa neurons)
高橋 亜矢子; 内田 一郎; 真下 節; 山中 博樹; 徳永 敦; 野口 光一
神経化学, Aug. 2004 - 末梢神経損傷による接着因子L1-CAMの発現変化と疼痛発現への関与(Expression of L1-CAM in rat dorsal root ganglia and spinal cord following nerve injury)
山中 博樹; 野口 光一
神経化学, Aug. 2004 - Protease-activated receptor 2によるTRPV1活性の増強
戴 毅; 森山 朋子; 冨樫 和也; 東 智広; 山中 博樹; 富永 真琴; 野口 光一
PAIN RESEARCH, Dec. 2003 - 末梢神経損傷に伴うplasminogen activatorの発現とその疼痛発現への影響
山中 博樹; 野口 光一
解剖学雑誌, Apr. 2003 - 末梢神経損傷後のPlasminogen activatorの後根神経節と脊髄後角における発現
山中 博樹; 野口 光一
PAIN RESEARCH, Dec. 2001 - 末梢神経損傷時の後根神経節・脊髄後角におけるPlasminogen activatorとinhibitorの発現
山中 博樹; 橋本 典夫; 野口 光一
神経化学, Sep. 2001 - Expression of HGF and cMet in the peripheral nervous system of adult rats following sciatic nerve injury
N Hashimoto; H Yamanaka; T Fukuoka; Y Dai; K Obata; T Mashimo; K Noguchi
NEUROREPORT, May 2001 - オリゴデンドロサイトに発現するセリンプロテアーゼ,プロテアーゼM
吉田 成孝; 尾辻 真紀子; 土屋 喜永; 山中 博樹; 塩坂 貞夫
解剖学雑誌, Feb. 2001 - マウス個体発生におけるAPCL mRNAの発現
山中 博樹; 金銅 英二; 野口 光一; 中川 英刀; 小山 久美子; 中村 祐輔
解剖学雑誌, Feb. 2000 - マウス個体発生におけるプロテアーゼM/ニューロシンmRNAの発現
山中 博樹; 吉田 成孝; 塩坂 貞夫
解剖学雑誌, Apr. 1999
Research Themes
- Aberrant axo-axonic synaptic reorganization in the calcium channel subunit alpha2 delta-1/L1-CAM-containing central terminals of injured c-fibers in the spinal cord of a neuropathic pain model
Grant-in-Aid for Scientific Research (B)
Hyogo Medical University
01 Apr. 2017 - 31 Mar. 2020 - Expression of neurotrypsin in dorsal root ganglia and dorsal horn following peripheral nerve injury
Grant-in-Aid for Scientific Research (C)
Hyogo Medical University
01 Apr. 2017 - 31 Mar. 2020 - Alpha2 delta-1 mediated synaptic plasticity in the dorsal horn of peripheral nerve injury model rats
Grant-in-Aid for Scientific Research (C)
Hyogo College of Medicine
01 Apr. 2014 - 31 Mar. 2017 - Molecular basis of spinal glia/endothelium/neurons interaction as the mechanisms of development and maintenance of chronic pain
Grant-in-Aid for Scientific Research (B)
Hyogo College of Medicine
01 Apr. 2013 - 31 Mar. 2016 - RhoA/ROCK pathway mediates morphological changes downstream of P2Y12/13 receptors in spinal microglia following peripheral nerve injury
Grant-in-Aid for Scientific Research (C)
Hyogo College of Medicine
01 Apr. 2012 - 31 Mar. 2015 - Involvement of phosphorylated L1-CAM in the plastic changes of nociecptive circuit following peripheral nerve injury
Grant-in-Aid for Scientific Research (C)
Hyogo College of Medicine
2011 - 2013 - A cell adhesion molecule close homologue of L1 increased in primary afferent terminal contributes to the development and maintenance of neuropathic pain
Grant-in-Aid for Young Scientists (B)
Hyogo College of Medicine
2008 - 2009 - Alteration of the cell adhesion molecule L1 expression in a specific subset of primary afferent neurons contributes to neuropathic pain
Grant-in-Aid for Scientific Research (C)
Hyogo College of Medicine
2006 - 2007 - Role of inflammation on neuropathic pain in trigeminal nerve
Grant-in-Aid for Scientific Research (C)
Hyogo College of Medicine
2005 - 2006
