Last Updated :2024/12/13
Researcher Information
Research activity information
Award
- Jul. 2022
JSNP Excellent Presentation Award for CINP 2022 - Jun. 2018
114th Annual Meeting of the Japanese Society of Psychiatry and Neurology., Best Presentation Award
インターロイキン18の欠損状態がうつ病など精神症状発現に及ぼす影響について～精神と免疫のクロストーク～
Kyosuke Yamanishi - Jun. 2017
113th Annual Meeting of the Japanese Society of Psychiatry and Neurology, Best Presentation Award
IL-18の欠損状態がうつ病など精神症状発現に及ぼす影響について～IL-18欠損マウスを用いた多角的検討～
Kyosuke Yamanishi
Paper
- Discovery of novel protective agents for infection-related delirium through bispectral electroencephalography.
Tsuyoshi Nishiguchi; Kyosuke Yamanishi; Shivani Patel; Johnny R Malicoat; Nathan James Phuong; Tomoteru Seki; Takaya Ishii; Bun Aoyama; Akiyoshi Shimura; Nipun Gorantla; Takehiko Yamanashi; Masaaki Iwata; Andrew A Pieper; Gen Shinozaki
Translational psychiatry, Oct. 2024 - LPS-induced delirium-like behavior and microglial activation in mice correlate with bispectral electroencephalography (BSEEG)
Tsuyoshi Nishiguchi; Kyosuke Yamanishi; Nipun Gorantla; Akiyoshi Shimura; Tomoteru Seki; Takaya Ishii; Bun Aoyama; Johnny R. Malicoat; Nathan James Phuong; Nicole Jade Dye; Takehiko Yamanashi; Masaaki Iwata; Gen Shinozaki
The journals of gerontology. Series A, Biological sciences and medical sciences, Sep. 2024 - The Genome-wide DNA methylation changes in gastrointestinal surgery patients with and without postoperative delirium: Evidence of immune process in its pathophysiology.
Yoshitaka Nishizawa; Takehiko Yamanashi; Tsuyoshi Nishiguchi; Naofumi Kajitani; Akihiko Miura; Ryoichi Matsuo; Akimitsu Tanio; Manabu Yamamoto; Teruhisa Sakamoto; Yoshiyuki Fujiwara; Kaitlyn Thompson; Johnny Malicoat; Kyosuke Yamanishi; Tomoteru Seki; Tetsufumi Kanazawa; Masaaki Iwata; Gen Shinozaki
Journal of psychiatric research, Sep. 2024 - IL-18 primes T cells with an antigen-inexperienced memory phenotype for proliferation and differentiation into effector cells through Notch signaling
Wen Li; Denan Jin; Shinji Takai; Natsuko Inoue; Kyosuke Yamanishi; Yoshimasa Tanaka; Haruki Okamura
Journal of Leukocyte Biology, Aug. 2024 - A web-based delirium detection application using bispectral electroencephalography (BSEEG).
Akiyoshi Shimura; Tomoteru Seki; Tsuyoshi Nishiguchi; Kyosuke Yamanishi; Takaya Ishii; Bun Aoyama; Hieu Dinh Nguyen; Nipun Gorantla; Takeshi Inoue; Gen Shinozaki
General hospital psychiatry, Jul. 2024 - Epigenetic signals associated with delirium replicated across four independent cohorts.
Yoshitaka Nishizawa; Kaitlyn C Thompson; Takehiko Yamanashi; Nadia E Wahba; Taku Saito; Pedro S Marra; Takaaki Nagao; Tsuyoshi Nishiguchi; Kazuki Shibata; Kyosuke Yamanishi; Christopher G Hughes; Pratik Pandharipande; Hyunkeun Cho; Matthew A Howard 3rd; Hiroto Kawasaki; Hiroyuki Toda; Tetsufumi Kanazawa; Masaaki Iwata; Gen Shinozaki
Translational psychiatry, Jul. 2024 - The bispectral electroencephalography (BSEEG) method quantifies post-operative delirium-like states in young and aged male mice after head mount implantation surgery.
Tsuyoshi Nishiguchi; Kazuki Shibata; Kyosuke Yamanishi; Mia Nicole Dittrich; Noah Yuki Islam; Shivani Patel; Nathan James Phuong; Pedro S Marra; Johnny R Malicoat; Tomoteru Seki; Yoshitaka Nishizawa; Takehiko Yamanashi; Masaaki Iwata; Gen Shinozaki
The journals of gerontology. Series A, Biological sciences and medical sciences, Jun. 2024 - Genome-wide DNA methylation analysis in female veterans with military sexual trauma and comorbid PTSD/MDD.
Pedro S Marra; Tomoteru Seki; Yoshitaka Nishizawa; Gloria Chang; Kyosuke Yamanishi; Tsuyoshi Nishiguchi; Kazuki Shibata; Patricia Braun; Gen Shinozaki
Journal of affective disorders, Apr. 2024 - Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment.
Hideo Hagihara; Hirotaka Shoji; Satoko Hattori; Giovanni Sala; Yoshihiro Takamiya; Mika Tanaka; Masafumi Ihara; Mihiro Shibutani; Izuho Hatada; Kei Hori; Mikio Hoshino; Akito Nakao; Yasuo Mori; Shigeo Okabe; Masayuki Matsushita; Anja Urbach; Yuta Katayama; Akinobu Matsumoto; Keiichi I Nakayama; Shota Katori; Takuya Sato; Takuji Iwasato; Haruko Nakamura; Yoshio Goshima; Matthieu Raveau; Tetsuya Tatsukawa; Kazuhiro Yamakawa; Noriko Takahashi; Haruo Kasai; Johji Inazawa; Ikuo Nobuhisa; Tetsushi Kagawa; Tetsuya Taga; Mohamed Darwish; Hirofumi Nishizono; Keizo Takao; Kiran Sapkota; Kazutoshi Nakazawa; Tsuyoshi Takagi; Haruki Fujisawa; Yoshihisa Sugimura; Kyosuke Yamanishi; Lakshmi Rajagopal; Nanette Deneen Hannah; Herbert Y Meltzer; Tohru Yamamoto; Shuji Wakatsuki; Toshiyuki Araki; Katsuhiko Tabuchi; Tadahiro Numakawa; Hiroshi Kunugi; Freesia L Huang; Atsuko Hayata-Takano; Hitoshi Hashimoto; Kota Tamada; Toru Takumi; Takaoki Kasahara; Tadafumi Kato; Isabella A Graef; Gerald R Crabtree; Nozomi Asaoka; Hikari Hatakama; Shuji Kaneko; Takao Kohno; Mitsuharu Hattori; Yoshio Hoshiba; Ryuhei Miyake; Kisho Obi-Nagata; Akiko Hayashi-Takagi; Léa J Becker; Ipek Yalcin; Yoko Hagino; Hiroko Kotajima-Murakami; Yuki Moriya; Kazutaka Ikeda; Hyopil Kim; Bong-Kiun Kaang; Hikari Otabi; Yuta Yoshida; Atsushi Toyoda; Noboru H Komiyama; Seth G N Grant; Michiru Ida-Eto; Masaaki Narita; Ken-Ichi Matsumoto; Emiko Okuda-Ashitaka; Iori Ohmori; Tadayuki Shimada; Kanato Yamagata; Hiroshi Ageta; Kunihiro Tsuchida; Kaoru Inokuchi; Takayuki Sassa; Akio Kihara; Motoaki Fukasawa; Nobuteru Usuda; Tayo Katano; Teruyuki Tanaka; Yoshihiro Yoshihara; Michihiro Igarashi; Takashi Hayashi; Kaori Ishikawa; Satoshi Yamamoto; Naoya Nishimura; Kazuto Nakada; Shinji Hirotsune; Kiyoshi Egawa; Kazuma Higashisaka; Yasuo Tsutsumi; Shoko Nishihara; Noriyuki Sugo; Takeshi Yagi; Naoto Ueno; Tomomi Yamamoto; Yoshihiro Kubo; Rie Ohashi; Nobuyuki Shiina; Kimiko Shimizu; Sayaka Higo-Yamamoto; Katsutaka Oishi; Hisashi Mori; Tamio Furuse; Masaru Tamura; Hisashi Shirakawa; Daiki X Sato; Yukiko U Inoue; Takayoshi Inoue; Yuriko Komine; Tetsuo Yamamori; Kenji Sakimura; Tsuyoshi Miyakawa
eLife, Mar. 2024 - Meteorin-like Protein and Zonulin in Polycystic Ovary Syndrome: Exploring Associations with Obesity, Metabolic Parameters, and Inflammation.
Plamena Kabakchieva; Antoaneta Gateva; Tsvetelina Velikova; Tsvetoslav Georgiev; Kyosuke Yamanishi; Haruki Okamura; Zdravko Kamenov
Biomedicines, Jan. 2024 - Molecular Mechanisms of IL18 in Disease.
Kyosuke Yamanishi; Masaki Hata; Naomi Gamachi; Yuko Watanabe; Chiaki Yamanishi; Haruki Okamura; Hisato Matsunaga
International journal of molecular sciences, Dec. 2023 - A prospective investigation of impacts of comorbid attention deficit hyperactivity disorder (ADHD) on clinical features and long-term treatment response in adult patients with obsessive-compulsive disorder (OCD).
Masahiro Miyauchi; Naomi Matsuura; Keiichiro Mukai; Takuya Hashimoto; Shun Ogino; Kyosuke Yamanishi; Hisashi Yamada; Kazuhisa Hayashida; Hisato Matsunaga
Comprehensive psychiatry, Aug. 2023 - NSAIDs use history: impact on the genome-wide DNA methylation profile and possible mechanisms of action.
Pedro S Marra; Yoshitaka Nishizawa; Takehiko Yamanashi; Eleanor J Sullivan; Katie R Comp; Kaitlyn J Crutchley; Nadia E Wahba; Kazuki Shibata; Tsuyoshi Nishiguchi; Kyosuke Yamanishi; Nicolas O Noiseux; Matthew D Karam; Gen Shinozaki
Clinical and experimental medicine, Jun. 2023 - Acute stress induces severe neural inflammation and overactivation of glucocorticoid signaling in interleukin-18-deficient mice.
Kyosuke Yamanishi; Nobutaka Doe; Keiichiro Mukai; Takuya Hashimoto; Naomi Gamachi; Masaki Hata; Yuko Watanabe; Chiaki Yamanishi; Hideshi Yagi; Haruki Okamura; Hisato Matsunaga
Translational psychiatry, Sep. 2022 - IL-18 Serum Levels in Patients with Obesity, Prediabetes and Newly Diagnosed Type 2 Diabetes.
Iveta Nedeva; Antoaneta Gateva; Yavor Assyov; Vera Karamfilova; Julieta Hristova; Kyosuke Yamanishi; Zdravko Kamenov; Haruki Okamura
Iranian journal of immunology : IJI, Jun. 2022 - 日本における強迫症の嗅覚特性の検討
橋本 卓也; 熊崎 博一; 向井 馨一郎; 松浦 直己; 宮内 雅弘; 荻野 俊; 山西 恭輔; 松永 寿人
精神神経学雑誌, Apr. 2022 - Elevated levels of interleukin-18 are associated with several indices of general and visceral adiposity and insulin resistance in women with polycystic ovary syndrome.
Plamena Kabakchieva; Antoaneta Gateva; Tsvetelina Velikova; Tsvetoslav Georgiev; Kyosuke Yamanishi; Haruki Okamura; Zdravko Kamenov
Archives of endocrinology and metabolism, Mar. 2022 - Exploring Molecular Mechanisms Involved in the Development of the Depression-Like Phenotype in Interleukin-18-Deficient Mice.
Kyosuke Yamanishi; Masahiro Miyauchi; Keiichiro Mukai; Takuya Hashimoto; Noriko Uwa; Hitomi Seino; Wen Li; Naomi Gamachi; Masaki Hata; Sachi Kuwahara-Otani; Seishi Maeda; Yuko Watanabe; Hiromichi Yamanishi; Hideshi Yagi; Haruki Okamura; Hisato Matsunaga
BioMed research international, Oct. 2021, [Reviewed] - Evaluation of hemodynamic changes using near-infrared spectroscopy in patients with tic-related obsessive-compulsive disorder.
Keiichiro Mukai; Naomi Matsuura; Masahiro Miyauchi; Takuya Hashimoto; Kyosuke Yamanishi; Kensei Maebayashi; Kazuhisa Hayashida; Hisato Matsunaga
Psychiatry and clinical neurosciences, Feb. 2021, [Reviewed] - Acute impact of COVID-19 pandemic on phenomenological features in fully or partially remitted patients with obsessive-compulsive disorder.
Hisato Matsunaga; Keiichiro Mukai; Kyosuke Yamanishi
Psychiatry and clinical neurosciences, Oct. 2020, [Reviewed] - IL-12 regulates the expansion, phenotype, and function of murine NK cells activated by IL-15 and IL-18.
Naoto Oka; Tzvetanka Markova; Kenzo Tsuzuki; Wen Li; Yosif El-Darawish; Magdalena Pencheva-Demireva; Kyousuke Yamanishi; Hiromichi Yamanishi; Masafumi Sakagami; Yoshimasa Tanaka; Haruki Okamura
Cancer immunology, immunotherapy : CII, Sep. 2020 - 強迫症患者の強迫症状と嗅覚特性について
橋本 卓也; 熊崎 博一; 松浦 直己; 向井 馨一郎; 宮内 雅弘; 山西 恭輔; 松永 寿人
精神神経学雑誌, Sep. 2020 - Analysis of genes linked to depressive-like behaviors in interleukin-18-deficient mice: Gene expression profiles in the brain.
Kyosuke Yamanishi; Takuya Hashimoto; Masahiro Miyauchi; Keiichiro Mukai; Kaoru Ikubo; Noriko Uwa; Yuko Watanabe; Takashi Ikawa; Daisuke Okuzaki; Haruki Okamura; Hiromichi Yamanishi; Hisato Matsunaga
Biomedical reports, Jan. 2020, [Reviewed] - Impaired function of aorta and perivascular adipose tissue in IL-18-deficient mice.
Wen Li; Denan Jin; Shinji Takai; Tetsu Hayakawa; Jun Ogata; Kyosuke Yamanishi; Hiromichi Yamanishi; Haruki Okamura
American journal of physiology. Heart and circulatory physiology, Nov. 2019, [Reviewed] - Sunny walking counts more.
Rui Zhang; Hong Chen; Yi-Xiao Liu; Wen-Hui Zhang; Qin Lu; Hiromichi Yamanishi; Chiaki Yamanishi; Kyosuke Yamanishi; Yu-Lan Qiu; Xiao-Fei Ye; Zi-Rui Huang; Bo-Yuan Zhang; Yi-Fei Chen; Yan-Qian Zheng; Yong-Fang Zhang; Zi-Zhen Guo; Dong Dong; Tie-Xin Liu; Yi-Qing Dai; Mei-Han Xu; Yu Hao; Sheng-Zhou Li; Fei-Yang Cai; Rui-Qi Wang; Xin-Yi Guo; De-Hao Zhu; Hai-Yang Zhang; Zhi-Tong Zeng; Hideaki Higashino
Acta pharmacologica Sinica, Sep. 2019, [Reviewed] - Low-intensity walking as mild medication for pressure control in prehypertensive and hypertensive subjects: how far shall we wander?
Qin Lu; Sheng-Ming Wang; Yi-Xiao Liu; Hong Chen; Rui Zhang; Wen-Hui Zhang; Yuan-Yuan Zou; Jia-Wei Zhou; Xin-Yi Guo; Ying Zhang; Teng-Li Huang; Yu-Hang Liu; Si-Qi Zhang; Kyosuke Yamanishi; Hiromichi Yamanishi; Hideaki Higashino; Haruki Okamura
Acta pharmacologica Sinica, Aug. 2019, [Reviewed] - A new approach to identifying hypertension-associated genes in the mesenteric artery of spontaneously hypertensive rats and stroke-prone spontaneously hypertensive rats.
Takashi Ikawa; Yuko Watanabe; Daisuke Okuzaki; Naohisa Goto; Nobutaka Okamura; Kyosuke Yamanishi; Toshihide Higashino; Hiromichi Yamanishi; Haruki Okamura; Hideaki Higashino
Journal of hypertension, Aug. 2019, [Reviewed] - Interleukin-18-deficient mice develop hippocampal abnormalities related to possible depressive-like behaviors.
Kyosuke Yamanishi; Nobutaka Doe; Keiichiro Mukai; Kaoru Ikubo; Takuya Hashimoto; Noriko Uwa; Miho Sumida; Yosif El-Darawish; Naomi Gamachi; Wen Li; Sachi Kuwahara-Otani; Seishi Maeda; Yuko Watanabe; Tetsu Hayakawa; Hiromichi Yamanishi; Tomohiro Matsuyama; Hideshi Yagi; Haruki Okamura; Hisato Matsunaga
Neuroscience, Jun. 2019, [Reviewed] - Deficiency in interleukin-18 promotes differentiation of brown adipose tissue resulting in fat accumulation despite dyslipidemia.
Kyosuke Yamanishi; Seishi Maeda; Sachi Kuwahara-Otani; Takuya Hashimoto; Kaoru Ikubo; Keiichiro Mukai; Keiji Nakasho; Naomi Gamachi; Yosif El-Darawish; Wen Li; Daisuke Okuzaki; Yuko Watanabe; Hiromichi Yamanishi; Haruki Okamura; Hisato Matsunaga
Journal of translational medicine, Nov. 2018, [Reviewed] - Frontline Science: IL-18 primes murine NK cells for proliferation by promoting protein synthesis, survival, and autophagy.
Yosif El-Darawish; Wen Li; Kyosuke Yamanishi; Magdalena Pencheva; Naoto Oka; Hiromichi Yamanishi; Tomohiro Matsuyama; Yoshimasa Tanaka; Nagahiro Minato; Haruki Okamura
Journal of leukocyte biology, Aug. 2018, [Reviewed] - Ten-year follow-up study of Japanese patients with obsessive-compulsive disorder.
Akihiro Nakajima; Naomi Matsuura; Keiichiro Mukai; Kyosuke Yamanishi; Hisashi Yamada; Kensei Maebayashi; Kazuhisa Hayashida; Hisato Matsunaga
Psychiatry and clinical neurosciences, Jul. 2018, [Reviewed] - Physiological and molecular effects of interleukin-18 administration on the mouse kidney.
Kyosuke Yamanishi; Keiichiro Mukai; Takuya Hashimoto; Kaoru Ikubo; Keiji Nakasho; Yosif El-Darawish; Wen Li; Daisuke Okuzaki; Yuko Watanabe; Tetsu Hayakawa; Hiroshi Nojima; Hiromichi Yamanishi; Haruki Okamura; Hisato Matsunaga
Journal of translational medicine, Mar. 2018, [Reviewed] - Molecular analysis of the mouse brain exposed to chronic mild stress: The influence of hepatocyte nuclear factor 4α on physiological homeostasis.
Kaoru Ikubo; Kyosuke Yamanishi; Nobutaka Doe; Takuya Hashimoto; Miho Sumida; Yuko Watanabe; Yosif El-Darawish; Wen Li; Haruki Okamura; Hiromichi Yamanishi; Hisato Matsunaga
Molecular medicine reports, Jul. 2017, [Reviewed] - Interleukin-18 and its receptor are expressed in gonadotropin-releasing hormone neurons of mouse and rat forebrain.
Sachi Kuwahara-Otani; Seishi Maeda; Kimiko Kobayashi; Yusuke Minato; Koichi Tanaka; Kyosuke Yamanishi; Masaki Hata; Wen Li; Tetsu Hayakawa; Koichi Noguchi; Haruki Okamura; Hideshi Yagi
Neuroscience letters, May 2017, [Reviewed] - Fine structure of interleukin 18 (IL-18) receptor-immunoreactive neurons in the retrosplenial cortex and its changes in IL18 knockout mice.
Tetsu Hayakawa; Masaki Hata; Sachi Kuwahara-Otani; Kyosuke Yamanishi; Hideshi Yagi; Haruki Okamura
Journal of chemical neuroanatomy, Dec. 2016, [Reviewed] - Dysfunction of mitochondria and deformed gap junctions in the heart of IL-18-deficient mice.
Wen Li; Denan Jin; Masaki Hata; Shinji Takai; Kyosuke Yamanishi; Weili Shen; Yosif El-Darawish; Hiromichi Yamanishi; Haruki Okamura
American journal of physiology. Heart and circulatory physiology, Aug. 2016, [Reviewed] - Interleukin-18-deficient mice develop dyslipidemia resulting in nonalcoholic fatty liver disease and steatohepatitis.
Kyosuke Yamanishi; Seishi Maeda; Sachi Kuwahara-Otani; Yuko Watanabe; Momoko Yoshida; Kaoru Ikubo; Daisuke Okuzaki; Yosif El-Darawish; Wen Li; Keiji Nakasho; Hiroshi Nojima; Hiromichi Yamanishi; Tetsu Hayakawa; Haruki Okamura; Hisato Matsunaga
Translational research : the journal of laboratory and clinical medicine, Jul. 2016, [Reviewed] - Augmentation of Immune Checkpoint Cancer Immunotherapy with IL18.
Zhifeng Ma; Wen Li; Shinichi Yoshiya; Yunfeng Xu; Masaki Hata; Yosif El-Darawish; Tzvetanka Markova; Kyosuke Yamanishi; Hiromichi Yamanishi; Hideaki Tahara; Yoshimasa Tanaka; Haruki Okamura
Clinical cancer research : an official journal of the American Association for Cancer Research, Jun. 2016, [Reviewed] - Genetic analysis of genes causing hypertension and stroke in spontaneously hypertensive rats: Gene expression profiles in the kidneys.
Yuko Watanabe; Momoko Yoshida; Kyosuke Yamanishi; Hideyuki Yamamoto; Daisuke Okuzaki; Hiroshi Nojima; Teruo Yasunaga; Haruki Okamura; Hisato Matsunaga; Hiromichi Yamanishi
International journal of molecular medicine, Sep. 2015, [Reviewed] - Clinically related or predictive factors and impacts on long-term treatment outcomes of involvement behaviors in patients with obsessive-compulsive disorder.
Yoshinobu Yanagisawa; Naomi Matsuura; Keiichiro Mukai; Akihiro Nakajima; Mikuni Motoyama; Kyosuke Yamanishi; Hisashi Yamada; Kazuhisa Hayashida; Hisato Matsunaga
Comprehensive psychiatry, Jul. 2015, [Reviewed] - Hepatocyte nuclear factor 4 alpha is a key factor related to depression and physiological homeostasis in the mouse brain.
Kyosuke Yamanishi; Nobutaka Doe; Miho Sumida; Yuko Watanabe; Momoko Yoshida; Hideyuki Yamamoto; Yunfeng Xu; Wen Li; Hiromichi Yamanishi; Haruki Okamura; Hisato Matsunaga
PloS one, 2015, [Reviewed] - [A Case with Multiple Comorbidities of Obsessive-Compulsive and Related Disorders].
Ayako Arikawa; Hironori Mito; Mikuni Motoyama; Kyosuke Yamanishi; Kazuhisa Hayashida; Kensei Maebayashi; Hisato Matsunaga
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 2015, [Reviewed] - The impacts of elevated autism spectrum disorder traits on clinical and psychosocial features and long-term treatment outcome in adult patients with obsessive-compulsive disorder
Hironori Mito; Naomi Matsuura; Keiitiro Mukai; Yoshinobu Yanagisawa; Akihiro Nakajima; Mikuni Motoyama; Ayako Arikawa; Kyosuke Yamanishi; Hisato Matsunaga
COMPREHENSIVE PSYCHIATRY, Oct. 2014, [Reviewed] - Chymase inhibition improves vascular dysfunction and survival in stroke-prone spontaneously hypertensive rats
Shinji Takai; Denan Jin; Hong Chen; Wen Li; Hideyuki Yamamoto; Kyosuke Yamanishi; Mizuo Miyazaki; Hideaki Higashino; Hiromichi Yamanishi; Haruki Okamura
JOURNAL OF HYPERTENSION, Aug. 2014, [Reviewed] - Analysis of genes causing hypertension and stroke in spontaneously hypertensive rats: Gene expression profiles in the brain
Momoko Yoshida; Yuko Watanabe; Kyosuke Yamanishi; Akifumi Yamashita; Hideyuki Yamamoto; Daisuke Okuzaki; Kazunori Shimada; Hiroshi Nojima; Teruo Yasunaga; Haruki Okamura; Hisato Matsunaga; Hiromichi Yamanishi
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, Apr. 2014, [Reviewed] - Regulation of Development of CD56(bright)CD11c(+) NK-like Cells with Helper Function by IL-18
Wen Li; Akico Okuda; Hideyuki Yamamoto; Kyosuke Yamanishi; Nobuyuki Terada; Hiromichi Yamanishi; Yoshimasa Tanaka; Haruki Okamura
PLOS ONE, Dec. 2013, [Reviewed] - Genetic analysis of genes causing hypertension and stroke in spontaneously hypertensive rats
Hideyuki Yamamoto; Daisuke Okuzaki; Kyosuke Yamanishi; Yunfeng Xu; Yuko Watanabe; Momoko Yoshida; Akifumi Yamashita; Naohisa Goto; Seiji Nishiguchi; Kazunori Shimada; Hiroshi Nojima; Teruo Yasunaga; Haruki Okamura; Hisato Matsunaga; Hiromichi Yamanishi
International Journal of Molecular Medicine, May 2013, [Reviewed] - Involvement of CD56(bright)CD11c(+) Cells in IL-18-Mediated Expansion of Human gamma delta T Cells
Junko Tsuda; Wen Li; Hiromichi Yamanishi; Hideyuki Yamamoto; Akico Okuda; Shuji Kubo; Zhifeng Ma; Nobuyuki Terada; Yoshimasa Tanaka; Haruki Okamura
JOURNAL OF IMMUNOLOGY, Feb. 2011, [Reviewed] - Effect of IL-18 on Expansion of gamma delta T Cells Stimulated by Zoledronate and IL-2
Wen Li; Shuji Kubo; Akico Okuda; Hideyuki Yamamoto; Haruyasu Ueda; Toshiyuki Tanaka; Hideji Nakamura; Hiromichi Yamanishi; Nobuyuki Terada; Haruki Okamura
JOURNAL OF IMMUNOTHERAPY, Apr. 2010, [Reviewed] - In silico study of whey-acidic-protein domain containing oral protease inhibitors
Yoshiko Idoji; Yuko Watanabe; Akifumi Yamashita; Kyosuke Yamanishi; Seiji Nishiguchi; Kazunori Shimada; Teruo Yasunaga; Hiromichi Yamanishi
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, Apr. 2008, [Reviewed]
MISC
- 神経発達症併存の有無による強迫症患者の遺伝子を含む免疫学的機序に関する比較検討
櫻井 正彦; 山西 恭輔; 細井 幸彦; 荻野 俊; 向井 馨一郎
精神神経学雑誌, Jun. 2024 - インフラマソームを中心とした脳内炎症の制御機構解明
山西 恭輔
上原記念生命科学財団研究報告集, Dec. 2023 - インフラマソームを中心とした末梢炎症がうつ病を引き起こす機序解明と新規治療戦略の模索
山西 恭輔
先進医薬研究振興財団研究成果報告集, Mar. 2023 - IL-18の抗腫瘍作用 effector CD8 T cellの代謝/増殖に及ぼす影響(IL-18 enhances anti-tumor effect of memory CD8+ T cells by augmenting metabolic activity and function)
李 文; 高井 真司; 金 徳男; 山西 恭輔; 山西 博道; 岡村 春樹
日本癌学会総会記事, Sep. 2022 - インターロイキン18の急性ストレス下での脳内炎症と精神症状への影響について
山西 恭輔; 土江 伸誉; 向井 馨一郎; 橋本 卓也; 蒲池 直美; 秦 正樹; 渡辺 優子; 山西 千晶; 岡村 春樹; 松永 寿人
精神神経学雑誌, Apr. 2022 - インターロイキン18(IL-18)の欠損状態がうつ病様変化を呈する前頭前野を中心とした分子メカニズムの探索
山西 恭輔; 宮内 雅弘; 向井 馨一郎; 橋本 卓也; 宇和 典子; 大谷 佐知[桑原]; 前田 誠司; 蒲池 直美; 李 文; 秦 正樹; 渡辺 優子; 山西 博道; 八木 秀司; 岡村 春樹; 松永 寿人
精神神経学雑誌, Sep. 2021 - IL-18を中心とした脳内炎症とうつ病の病態解明と治療法開発
山西 恭輔
先進医薬研究振興財団研究成果報告集, Mar. 2021 - NKとCD8+ T細胞の抗腫瘍作用に対するIL-18の増強効果
李 文; 岡村 春樹; 山西 恭輔; 秦 正樹
日本癌学会総会記事, Oct. 2020 - リスペリドンからパリペリドンへの切り替えにより鎮静、陰性症状の改善が得られた慢性期統合失調症の1例
川谷 冴子; 山西 恭輔; 松永 寿人
精神神経学雑誌, Jan. 2020 - 【パーソナリティ障害と薬物療法】強迫性パーソナリティ障害の現在とこれから その診断および治療(薬物療法を含む)を中心に
松永 寿人; 向井 馨一郎; 山西 恭輔; 橋本 卓也; 宮内 雅弘
精神科, Aug. 2019 - 汚染/洗浄強迫の汚染の方向性による異種性の検討(第2報)
向井 馨一郎; 橋本 卓也; 宮内 雅弘; 中嶋 章浩; 山西 恭輔; 前林 憲誠; 林田 和久; 松永 寿人
精神神経学雑誌, Jun. 2019 - IL-18の欠損状態がうつ病など精神症状発現に及ぼす影響について 神経再生とEpigeneticsな視点から
山西 恭輔; 土江 伸誉; 橋本 卓也; 井窪 薫; 向井 馨一郎; 李 文; 渡辺 優子; 宇和 典子; 山西 博道; 岡村 春樹; 松永 寿人
精神神経学雑誌, Jun. 2019 - オランザピンによる好中球減少が疑われた双極性障害の1例
青木 瑠衣; 山西 恭輔; 宇和 典子; 松永 寿人
精神神経学雑誌, Mar. 2019 - 強迫症に対して短期入院加療が奏功した二症例
橋本 卓也; 向井 馨一郎; 上野 克樹; 山西 恭輔; 前林 憲誠; 林田 和久; 松永 寿人; 吉田 賀一; 松井 徳造
仁明会精神医学研究, Mar. 2019 - 汚染/洗浄強迫の汚染の方向性による異種性の検討(第2報)
向井 馨一郎; 橋本 卓也; 宮内 雅弘; 中嶋 章浩; 山西 恭輔; 前林 憲誠; 林田 和久; 松永 寿人
日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, Nov. 2018 - 汚染/洗浄強迫の汚染の方向性による異種性の検討(第2報)
向井 馨一郎; 橋本 卓也; 宮内 雅弘; 中嶋 章浩; 山西 恭輔; 前林 憲誠; 林田 和久; 松永 寿人
日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, Nov. 2018 - インターロイキン18の欠損状態がうつ病など精神症状発現に及ぼす影響について 精神と免疫のクロストーク
山西 恭輔; 土江 伸誉; 橋本 卓也; 井窪 薫; 向井 馨一郎; 澄田 美保; 大谷 佐知; 原; 前田 誠司; 李 文; 渡邊 優子; 宇和 典子; 早川 徹; 山西 博道; 岡村 春樹; 松永 寿人
精神神経学雑誌, Jun. 2018 - インターロイキン18の欠損状態がうつ病など精神症状発現に及ぼす影響について 精神と免疫のクロストーク
山西 恭輔; 土江 伸誉; 橋本 卓也; 井窪 薫; 向井 馨一郎; 澄田 美保; 大谷 佐知; 原; 前田 誠司; 李 文; 渡邊 優子; 宇和 典子; 早川 徹; 山西 博道; 岡村 春樹; 松永 寿人
精神神経学雑誌, Jun. 2018 - IL-18の欠損状態がうつ病など精神症状発現に及ぼす影響について IL-18欠損マウスを用いた多角的検討
山西 恭輔; 松永 寿人; 土江 伸誉; 橋本 卓也; 井窪 薫; 澄田 美保; 大谷 佐知[桑原]; 前田 誠司; 李 文; 渡辺 優子; 宇和 典子; 早川 徹; 山西 博道; 岡村 春樹
精神神経学雑誌, Jun. 2017 - 【精神医学症候群(第2版)-不安症から秩序破壊的・衝動制御・素行症まで-】 強迫症および関連症群/強迫性障害および関連障害群 強迫性障害概論 現在の強迫症に至るプロセスと強迫スペクトラムを中心に
松永 寿人; 山西 恭輔; 向井 馨一郎
日本臨床, Jun. 2017 - IL-18の欠損状態がうつ病など精神症状発現に及ぼす影響について IL-18欠損マウスを用いた多角的検討
山西 恭輔; 松永 寿人; 土江 伸誉; 橋本 卓也; 井窪 薫; 澄田 美保; 大谷 佐知; 原; 前田 誠司; 李 文; 渡辺 優子; 宇和 典子; 早川 徹; 山西 博道; 岡村 春樹
精神神経学雑誌, Jun. 2017 - Effect of IL-18 on anti-tumor action of 100 inhibitor in mouse models
Wen Li; Yosif El-Darawish; Kyosuke Yamanishi; Hiromichi Yamanishi; Haruki Okamura
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2017 - IL-18 primes murine NK cells for proliferation
Yosif EI-Darawish; Wen Li; Kyosuke Yamanishi; Hiromichi Yamanishi; Haruki Okamura
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2017 - Molecular analysis of neural action mediated by the antipsychotic agent olanzapine in high glucose exposure
Kaoru Ikubo; Kyosuke Yamanishi; Sachi Kuwahara-Otani; Seishi Maeda; Wen Li; Yuko Watanabe; Momoko Yoshida; Tetsu Hayakawa; Haruki Okamura; Hiromichi Yamanishi; Hisato Matsunaga
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, Jun. 2016 - Interleukin-18-deficient mice develop dysfunction of hippocampus resulting in depression-like behavior
Kyosuke Yamanishi; Nobutaka Doe; Kaoru Ikubo; Miho Sumida; Sachi Kuwahara-Otani; Seishi Maeda; Yuko Watanabe; Momoko Yoshida; Wen Li; Tetsu Hayakawa; Haruki Okamura; Hiromichi Yamanishi; Hisato Matsunaga
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, Jun. 2016 - Cancer immunotherapy targeting innate immunity
Zhifeng Ma; Wen Li; Masaki Hata; Yosif El-Darawish; Kyosuke Yamanishi; Hiromichi Yamanishi; Yoshimasa Tanaka; Haruki Okamura
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2016 - Interleukin-18-deficient mice develop dysfunction of hippocampus resulting in depression-like behavior
Kyosuke Yamanishi; Nobutaka Doe; Kaoru Ikubo; Takuya Hashimoto; Miho Sumida; Sachi Kuwahara-Otani; Seishi Maeda; Yuko Watanabe; Wen Li; Tetsu Hayakawa; Haruki Okamura; Hiromichi Yamanishi; Hisato Matsunaga
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2016 - 強迫関連症(Obsessive-Compulsive and Related Disorders:OCRD)を複数併存していた1例
有川 綾子; 三戸 宏典; 本山 美久仁; 山西 恭輔; 林田 和久; 前林 憲誠; 松永 寿人
精神神経学雑誌, Nov. 2015 - 免疫チェックポイント抑制剤の抗腫瘍作用に対するIL-18の増強効果
馬 智峰; 李 文; 吉矢 晋一; 許 雲峰; 秦 正樹; Eldaravish Yosif; Markova Tzvetanka; 山西 恭輔; 山西 博道; 田原 秀晃; 田中 義正; 岡村 春樹
日本癌学会総会記事, Oct. 2015 - Molecular analyses of the mouse brain exposed to chronic mild stress; the relation between depression and physiological dyshomeostasis
Kaoru Ikubo; Kyosuke Yamanishi; Nobutaka Doe; Miho Sumida; Yuko Watanabe; Momoko Yoshida; Wen Li; Haruki Okamura; Hisato Matsunaga; Hiromichi Yamanishi
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2015 - 研究と報告 トウレット障害を併存する強迫性障害の臨床像(第2報) その治療に関する半年間の前方視的検討
林田 和久; 福原 綾子; 三戸 宏典; 山西 恭輔; 向井 馨一郎; 柳澤 嘉伸; 中嶋 章浩; 前林 憲誠; 松永 寿人
精神医学, Dec. 2014 - 強迫性障害患者の10年予後に関する調査(第二報) 再発に関連する臨床要因の検討
中嶋 章浩; 向井 馨一郎; 柳澤 嘉伸; 吉田 賀一; 三戸 宏典; 福原 綾子; 山西 恭輔; 松永 寿人
精神神経学雑誌, Jun. 2014 - 強迫関連性障害(Obsessive-compulsive and related disorders;OCRD)を複数併存していた一例
有川 綾子; 三戸 宏典; 本山 美久仁; 山西 恭輔; 林田 和久; 前林 憲誠; 松永 寿人
精神神経学雑誌, Jun. 2014 - 強迫性障害における巻き込み症状の多角的・前方視的検討 特に病像や予後への影響について
柳澤 嘉伸; 中嶋 章浩; 向井 馨一郎; 吉田 賀一; 三戸 宏典; 福原 綾子; 山西 恭輔; 松永 寿人
精神神経学雑誌, Jun. 2014 - 研究と報告 トウレット障害を併存する強迫性障害の臨床像(第1報) 併存による臨床像への影響に関する多角的検討
福原 綾子; 三戸 宏典; 山西 恭輔; 向井 馨一郎; 柳澤 嘉伸; 中嶋 章浩; 前林 憲誠; 林田 和久; 山田 恒; 松永 寿人
精神医学, Nov. 2013 - 脳卒中易発性高血圧自然発症ラットの血管障害におけるキマーゼの役割
高井 真司; 金 徳男; 陳 紅; 李 文; 山本 英幸; 山西 恭輔; 宮崎 瑞夫; 山西 博道; 岡村 春樹
日本高血圧学会総会プログラム・抄録集, Oct. 2013 - 【難治性精神疾患に対するDBS療法-世界の現状とわが国の課題】 難治性精神疾患の治療と現状 難治性強迫性障害の臨床像と対応
松永 寿人; 三戸 宏典; 山西 恭輔; 林田 和久
日本生物学的精神医学会誌, Mar. 2013 - DSM-5の強迫関連障害(Obsessive-Compulsive and Related Disorders)が複数併存していた一例
福原綾子; 三戸宏典; 山西恭輔; 前林憲誠; 松永寿人
日本精神科診断学会プログラム・抄録集, 2013 - 脳卒中易発性高血圧自然発症ラットの血管障害および生存期間に対するキマーゼ阻害薬の効果
高井真司; 金徳男; 陳紅; 李文; 山本英幸; 山西恭輔; 宮崎瑞夫; 山西博道; 岡村春樹
日本薬理学会近畿部会プログラム・要旨集, 2013 - Interleukin-18 may affect fibroblast growth factor 21 expression in tissue specific manner
Hideyuki Yamamoto; Yunfung Xu; Kyosuke Yamanishi; Wen Li; Yuko Okamatsu; Masayuki Saito; Hiromichi Yamanishi; Haruki Okamura
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2013 - 【精神疾患の典型例を学ぶ】 強迫性障害の典型例
松永 寿人; 三戸 宏典; 山西 恭輔; 林田 和久
精神科治療学, Jul. 2012 - 強迫性障害患者のquality of lifeについて 臨床症状、精神病理、治療反応性などとの多角的関連性検討
福原 綾子; 三戸 宏典; 山西 恭輔; 前林 憲誠; 松永 寿人
精神神経学雑誌, May 2012 - トゥレット症候群を伴う強迫性障害の臨床像と治療 Blonanserinを用いたSSRI強化療法を中心に
山西 恭輔; 荒井 克純; 林田 和久; 前林 憲誠; 三戸 宏典; 福原 綾子; 柳澤 嘉伸; 松永 寿人
精神科, Mar. 2012 - Apelin-APJ system affects mitochondria function in brown adipocytes
Kyosuke Yamanishi; Hideyuki Yamamoto; Yunfung Xu; Yoko Okamatsu; Hisato Matsunaga; Masayuki Saito; Hiromichi Yamanishi; Haruki Okamura
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2012 - Gene expression in the adrenal glands of two spontaneously hypertensive rat strains at 3 and 6 weeks of age
Kyosuke Yamanishi; Hideyuki Yamamoto; Daisuke Okuzaki; Yuko Watanabe; Momoko Yoshida; Seiji Nishiguchi; Kazunori Shimada; Haruki Okamura; Hiroshi Nojima; Teruo Yasunaga; Hiromichi Yamanishi; Hisato Matsunaga
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2011 - In silico study of a novel gene evolved from an ancestral SVIP gene and highly expressed in the adult mouse testes
Momoko Yoshida; Akifumi Yamashita; Yoshiko Idoji; Seiji Nishiguchi; Kazunori Shimada; Teruo Yasunaga; Hiromichi Yamanishi
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, Aug. 2008
Lectures, oral presentations, etc.
- Epigenetic analysis of depression-like behavior in interleukin-18-deficient mice
Kyosuke Yamanishi; Keiichiro Mukai; Takuya Hashimoto; Masahiro Miyauchi; Kaoru Ikubo; Noriko Uwa; Yuko Watanabe; Chiaki Yamanishi; Haruki Okamura; Hisato Matsunaga
24th World Congress on Advances in Oncology and 24 th International Symposium on Molecular Medicine, Oct. 2019 - Histone acetylation and neurogenesis are associated with hippocampal abnormalities in interleukin-18-deficient mice
Kyosuke Yamanishi
23rd World Congress on Advances in Oncology and 22nd International Symposium on Molecular Medicine, Sep. 2018 - An investigation regarding the causal effect of interleukin-18-deficient condition on hippocampal abnormalities and depression-like behavioral changes
Kyosuke Yamanishi
WFSBP 2018 KOBE, Sep. 2018 - Interleukin-18-deficient mice develop dysfunction of hippocampus resulting in depression-like behavior
Kyosuke Yamanishi
WPA XVII World Congress of Psychiatry, Oct. 2017 - Interleukin-18-deficient mice develop dysfunction of hippocampus resulting in depression-like behavior
Kyosuke Yamanishi
21th World Congress on Advances in Oncology and 19th International Symposium on Molecular Medicine, Oct. 2016 - Interleukin-18-deficient mice develop dysfunction of hippocampus resulting in depression-like behavior
Kyosuke Yamanishi
CINP World Congress 2016, Jul. 2016
Affiliated academic society
- 2022 - Present
Japanese Society of Biological Psychiatry（JSBP） - 2017 - Present
The Japanese Psychogeriatric Society - 2017 - Present
The Japanese Society of Neuropsychopharmacology - 2017 - Present
Japan Society for Dementia Research - 2017 - Present
Japanese Society of General Hospital Psychiatry - Apr. 2013 - Present
The Japanese Society of Psychiatry and Neurology
Research Themes
- Exploring immunological and molecular mechanisms involved in obsessive-compulsive disorder with comorbid neurodevelopmental disorders.
Grant-in-Aid for Scientific Research (C)
Hyogo Medical University
01 Apr. 2024 - 31 Mar. 2027 - せん妄患者におけるミクログリアを中心とした病態解明
Jan. 2023 - Dec. 2023 - The investigation of the neuroinflammatory regulation mechanism focusing on inflammasome
研究奨励金
Jan. 2022 - Apr. 2023 - The investigation between psychiatric disorders and neuroinflammation focused by interleukin 18
Grant-in-Aid for Early-Career Scientists
Hyogo Medical University
01 Apr. 2020 - 31 Mar. 2023 - 精神免疫に着目した精神疾患と免疫ネットワーク機構の解明
2023 - 2023 - Establishing new mechanism of interleukin 18 on central nerve system and application for depression
精神薬療分野 若手研究者助成
Dec. 2021 - Nov. 2022 - インターロイキン18を中心とした脳内炎症と精神疾患への作用解明
精神・神経・脳領域
兵庫医科大学
Aug. 2019 - Mar. 2022 - The investigation of the regulation mechanism mediated by mental stress focusing on Interleukin 18
Nov. 2020 - Jun. 2021 - IL-18を中心とした脳内炎症とうつ病の病態解明と治療法開発
精神薬療分野
兵庫医科大学
Dec. 2019 - Nov. 2020 - うつ病へのインターロイキン18の作用解明と新規治療戦略の模索
Grant-in-Aid for Young Scientists (B)
Hyogo College of Medicine
01 Apr. 2017 - 31 Mar. 2020
