Last Updated :2024/12/19
Researcher Information
Research activity information
Paper
- Molecular autopsy for sudden death in Japan.
Takuma Yamamoto; Yuko Emoto; Takehiko Murase; Takahiro Umehara; Aya Miura; Minori Nishiguchi; Kazuya Ikematsu; Hajime Nishio
Journal of toxicologic pathology, Jan. 2024 - Postmortem Identification of Genetic Variations Associated with Sudden Unexpected Death in Young People.
Aya Miura; Takuma Yamamoto; Kazuhisa Funayama; Akihide Koyama; Hisakazu Takatsuka; Takako Sato; Hajime Nishio
International heart journal, 2024 - A potent and selective cis-amide inhibitor of ryanodine receptor 2 as a candidate for cardiac arrhythmia treatment.
Ryosuke Ishida; Nagomi Kurebayashi; Hiroto Iinuma; Xi Zeng; Shuichi Mori; Masami Kodama; Takashi Murayama; Hiroyuki Masuno; Fumi Takeda; Masatoshi Kawahata; Aya Tanatani; Aya Miura; Hajime Nishio; Takashi Sakurai; Hiroyuki Kagechika
European journal of medicinal chemistry, Dec. 2023 - Screening for Novel Type 2 Ryanodine Receptor Inhibitors by Endoplasmic Reticulum Ca2+ Monitoring.
Mai Takenaka; Masami Kodama; Takashi Murayama; Mari Ishigami-Yuasa; Shuichi Mori; Ryosuke Ishida; Junji Suzuki; Kazunori Kanemaru; Masami Sugihara; Masamitsu Iino; Aya Miura; Hajime Nishio; Sachio Morimoto; Hiroyuki Kagechika; Takashi Sakurai; Nagomi Kurebayashi
Molecular pharmacology, Dec. 2023 - I536T variant of RBM20 affects splicing of cardiac structural proteins that are causative for developing dilated cardiomyopathy.
Takuma Yamamoto; Rie Sano; Aya Miura; Mai Imasaka; Yoshiro Naito; Minori Nishiguchi; Kensuke Ihara; Naruhito Otani; Yoshihiko Kominato; Masaki Ohmuraya; Hidehito Kuroyanagi; Hajime Nishio
Journal of molecular medicine (Berlin, Germany), Dec. 2022 - PROS1 variant in sudden death case of pulmonary embolism caused by calcification in the inferior vena cava: The importance of postmortem genetic analysis.
Aya Miura; Kazuhisa Funayama; Hiromi Nyuzuki; Naoya Takahashi; Takuma Yamamoto; Akihide Koyama; Takeshi Ikeuchi; Hisakazu Takatsuka; Hajime Nishio
Legal medicine (Tokyo, Japan), Mar. 2022 - Sudden Unexpected Death of Infantile Dilated Cardiomyopathy with JPH2 and PKD1 Gene Variants.
Aya Miura; Hidehito Kondo; Takuma Yamamoto; Yasuko Okumura; Hajime Nishio
International heart journal, Sep. 2020 - RNA sequencing reveals abnormal LDB3 splicing in sudden cardiac death.
Takuma Yamamoto; Aya Miura; Kyoko Itoh; Yasuhiro Takeshima; Hajime Nishio
Forensic science international, Sep. 2019 - Autopsy case of acute esophageal necrosis associated with fatal diabetic ketoacidosis
Takuma Yamamoto; Aya Miura; Hajime Nishio
Romanian Journal of Legal Medicine, Jun. 2018 - Morphine and Fentanyl Citrate Induce Retrotransposition of Long Interspersed Element-1.
Noriyuki Okudaira; Yukihito Ishizaka; Hajime Nishio; Hiroshi Sakagami
In vivo (Athens, Greece), 2016 - Identification of arrhythmogenic right ventricular cardiomyopathy-causing gene mutations in young sudden unexpected death autopsy cases.
Takako Sato; Hajime Nishio; Koichi Suzuki
Journal of forensic sciences, Mar. 2015 - Hypertrophy of lymphoid organs is a possible phenotypic characteristic of R420W mutation of the cardiac ryanodine receptor gene: a study using a knock-in mouse model.
Hajime Nishio; Noriyuki Okudaira; Kazufumi Matsushita; Tomohiro Yoshimoto; Takako Sato; Koichi Suzuki
Legal medicine (Tokyo, Japan), Nov. 2014 - Hypertrophy of lymphoid organs is a possible phenotypic characteristic of R420W mutation of the cardiac ryanodine receptor gene: A study using a knock-in mouse model
Hajime Nishio; Noriyuki Okudaira; Kazufumi Matsushita; Tomohiro Yoshimoto; Takako Sato; Koichi Suzuki
LEGAL MEDICINE, Nov. 2014, [Reviewed] - A knock-in mouse model of N-terminal R420W mutation of cardiac ryanodine receptor exhibits arrhythmogenesis with abnormal calcium dynamics in cardiomyocytes.
Noriyuki Okudaira; Masayoshi Kuwahara; Yutaka Hirata; Yoshitaka Oku; Hajime Nishio
Biochemical and biophysical research communications, Sep. 2014 - Retrotransposition of long interspersed element 1 induced by methamphetamine or cocaine.
Noriyuki Okudaira; Yukihito Ishizaka; Hajime Nishio
The Journal of biological chemistry, Sep. 2014 - 〔Major achievements〕A knock-in mouse model of N-terminal R420W mutation of cardiac ryanodine receptor exhibits arrhythmogenesis with abnormal calcium dynamics in cardiomyocytes
Noriyuki Okudaira; Masayoshi Kuwahara; Yutaka Hirata; Yoshitaka Oku; Hajime Nishio
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2014, [Reviewed] - Traumatic basal subarachnoid hemorrhage suspected to have been caused by contrecoup cerebellar contusions: a case report.
Takako Sato; Kento Tsuboi; Masakatsu Nomura; Misa Iwata; Shuntaro Abe; Akiyoshi Tamura; Hitoshi Tsuchihashi; Hajime Nishio; Koichi Suzuki
Legal medicine (Tokyo, Japan), Mar. 2014 - Sudden death of a child because of an intestinal obstruction caused by a large congenital mesenteric defect.
Takako Sato; Shuntaro Abe; Kento Tsuboi; Misa Iwata; Akiyoshi Tamura; Hitoshi Tsuchihashi; Hajime Nishio; Koichi Suzuki
Legal medicine (Tokyo, Japan), May 2012 - Sudden death during exercise in a juvenile with arrhythmogenic right ventricular cardiomyopathy and desmoglein-2 gene substitution: a case report.
Takako Sato; Hajime Nishio; Koichi Suzuki
Legal medicine (Tokyo, Japan), Nov. 2011 - Sudden death during exercise in a juvenile with arrhythmogenic right ventricular cardiomyopathy and desmoglein-2 gene substitution: A case report
Takako Sato; Hajime Nishio; Koichi Suzuki
LEGAL MEDICINE, Nov. 2011, [Reviewed] - An autopsy case of multiple psychotropic drug poisoning.
Naoko Tanaka; Hiroshi Kinoshita; Minori Nishiguchi; Mostofa Jamal; Mitsuru Kumihashi; Motonori Takahashi; Hajime Nishio; Kiyoshi Ameno
Soudni lekarstvi, Jul. 2011 - Postmortem genetic analysis for a sudden death case complicated with Marfan syndrome.
Motonori Takahashi; Takako Sato; Minori Nishiguchi; Koichi Suzuki; Hajime Nishio
Legal medicine (Tokyo, Japan), Nov. 2010 - An autopsy case of carbamazepine poisoning.
Hiroshi Kinoshita; Kimiko Morikawa; Azumi Kuze; Yasushi Nagasaki; Motonori Takahashi; Minori Nishiguchi; Hajime Nishio; Yasuhiro Ueno; Mostofa Jamal; Yusuke Kubo; Naoko Tanaka; Kiyoshi Ameno
Soudni lekarstvi, Apr. 2010 - Detection of metallic elements from paraffin-embedded tissue blocks by energy dispersive X-ray fluorescence spectrometry
Motonori Takahashi; Hiroshi Kinoshita; Minori Nishiguchi; Hajime Nishio
LEGAL MEDICINE, Mar. 2010, [Reviewed] - An autopsy case of poisoning with selective serotonin reuptake inhibitor, paroxetine.
Takahashi Motonori; Kinoshita Hiroshi; Kuse Azumi; Morichika Mai; Nishiguchi Minori; Ouchi Harumi; Minami Takako; Matsui Kiyoshi; Yamamura Takehiko; Motomura Hiroyuki; Ohtsu Nao; Yoshida Shie; Adachi Nobuyuki; Ueno Yasuhiro; Hishida Shigeru; Nishio Hajime
Soudni lekarstvi, Jan. 2010 - Postmortem molecular screening for mutations in ryanodine receptor type 1 (RYR1) gene in psychiatric patients suspected of having died of neuroleptic malignant syndrome
Takako Sato; Hajime Nishio; Misa Iwata; Kento Tsuboi; Akiyoshi Tamura; Tokiko Miyazaki; Koichi Suzuki
FORENSIC SCIENCE INTERNATIONAL, Jan. 2010, [Reviewed] - Identification of newly polymorphic intron 40 markers of the von Willebrand factor gene in a Japanese population
Akiyoshi Tamura; Misa Iwata; Shinya Fukunishi; Hajime Nishio; Koichi Suzuki
Legal Medicine, May 2009 - Identification of malignant hyperthermia-susceptible ryanodine receptor type 1 gene (RYR1) mutations in a child who died in a car after exposure to a high environmental temperature
Hajime Nishio; Takako Sato; Shinya Fukunishi; Akiyoshi Tamura; Misa Iwata; Kento Tsuboi; Koichi Suzuki
Legal Medicine, May 2009 - 〔Major achievements〕Identification of an ethnic-specific variant (V207M) of the KCNQ1 cardiac potassium channel gene in sudden unexplained death and implications from a knock-in mouse model
Hajime Nishio; Masayoshi Kuwahara; Hirokazu Tsubone; Yoshiro Koda; Takako Sato; Shinya Fukunishi; Akiyoshi Tamura; Koichi Suzuki
INTERNATIONAL JOURNAL OF LEGAL MEDICINE, May 2009, [Reviewed] - Postmortem molecular analysis for fatal arrhythmogenic disease in sudden unexplained death
Hajime Nishio; Koichi Suzuki
Legal Medicine, Apr. 2009 - ABO blood grouping of crushed hair sample using immunohistochemical method with a mesh pack
Kiyoshi Matsui; Hajime Nishio; Koichi Suzuki
Japanese Journal of Legal Medicine, Nov. 2008 - Sequence analysis of two de novo mutation alleles at the Y-STR locus
Akiyoshi Tamura; Misa Iwata; Kento Tsuboi; Tokiko Miyazaki; Hajime Nishio; Koichi Suzuki
Forensic Science International: Genetics Supplement Series, Aug. 2008 - Identification of a novel mutation V2321M of the cardiac ryanodine receptor gene of sudden unexplained death and a phenotypic study of the gene mutations
Hajime Nishio; Misa Iwata; Akiyoshi Tamura; Tokiko Miyazaki; Kento Tsuboi; Koichi Suzuki
Legal Medicine, Jul. 2008 - Phenotypic analysis of vertigo 2 Jackson mice with a Kcnq1 potassium channel mutation
Takeshi Takagi; Hajime Nishio; Takeo Yagi; Masayoshi Kuwahara; Hirokazu Tsubone; Nobuhiko Tanigawa; Koichi Suzuki
EXPERIMENTAL ANIMALS, Jul. 2007, [Reviewed] - 〔Major achievements〕Postmortem molecular screening for cardiac ryanodine receptor type 2 mutations in sudden unexplained death - R420W mutated case with characteristics of status thymico-lymphaticus
Hajime Nishio; Misa Iwata; Koichi Suzuki
CIRCULATION JOURNAL, Nov. 2006, [Reviewed] - Ethanol-induced Cas tyrosine phosphorylation and Fyn kinase activation in rat brain
H Nishio; K Suzuki
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, Aug. 2002, [Reviewed]
MISC
- Usefulness of serum mast cell-specific chymase levels for postmortem diagnosis of anaphylaxis
H Nishio; S Takai; M Miyazaki; H Horiuchi; M Osawa; K Uemura; K Yoshida; M Mukaida; Y Ueno; K Suzuki
INTERNATIONAL JOURNAL OF LEGAL MEDICINE, Nov. 2005 - Evidence for involvement of p59fyn in fasting-induced thymic involution
H Nishio; Takase, I; S Fukunishi; T Takagi; A Tamura; T Miyazaki; K Suzuki
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, Aug. 2005 - Three cases of suspected hyperthermia with remarkable elevation of serum mast cell tryptase
H Nishio; K Suzuki
FORENSIC SCIENCE INTERNATIONAL, Apr. 2005 - Fatality due to acute fluoride poisoning in the workplace
Izumi Takase; Koichi Kono; Akiyoshi Tamura; Hajime Nishio; Tomotaro Dote; Koichi Suzuki
Legal Medicine, Jul. 2004 - Serum tryptase levels in sudden infant death syndrome in forensic autopsy cases
H Nishio; K Suzuki
FORENSIC SCIENCE INTERNATIONAL, Jan. 2004 - Sequence analysis of two de novo mutation alleles at the DXS10011 locus
Akiyoshi Tamura; Misa Iwata; Izumi Takase; Tokiko Miyazaki; Kiyoshi Matsui; Hajime Nishio; Koichi Suzuki
Legal Medicine, 2003 - Immunolocalization of peripheral lymph node addressins in normal and neoplastic human thymuses
H Kuwabara; T Krenacs; H Hirano; H Nishio; T Shikata; T Kizaki; M Nagai; K Suzuki; H Mori
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, Sep. 2002 - Phosphorylation of c-Cbl protooncogene product following ethanol administration in rat cerebellum: possible involvement of Fyn kinase
H Nishio; M Otsuka; S Kinoshita; T Tokuoka; M Nakajima; Y Noda; Y Fukuyama; K Suzuki
BRAIN RESEARCH, Sep. 2002 - Repeated fasting stress causes activation of mitogen-activated protein kinases (ERK/JNK) in rat liver
H Nishio; H Kuwabara; H Mori; K Suzuki
HEPATOLOGY, Jul. 2002 - A fatal case of amniotic fluid embolism with elevation of serum mast cell tryptase
H Nishio; K Matsui; T Miyazaki; A Tamura; M Iwata; K Suzuki
FORENSIC SCIENCE INTERNATIONAL, Mar. 2002 - Immunolocalisation of the janus kinases (JAK) - signal transducers and activators of transcription (STAT) pathway in human epidermis
H Nishio; K Matsui; H Tsuji; A Tamura; K Suzuki
JOURNAL OF ANATOMY, May 2001 - Possible involvement of Fyn kinase in ethanol-stimulated Cas tyrosine phosphorylation in rat cerebellum and cerebral cortex
H Nishio; K Matsui; H Tsuji; A Tamura; K Suzuki
JOURNAL OF NEUROCHEMISTRY, Feb. 2001 - Immunolocalization of the mitogen-activated protein kinase signaling pathway in Hassall's corpuscles of the human thymus
H Nishio; K Matsui; H Tsuji; A Tamura; K Suzuki
ACTA HISTOCHEMICA, Feb. 2001 - Immunohistochemical study of the phosphorylated and activated form of c-jun NH2-terminal kinase in human aorta
H Nishio; K Matsui; H Tsuji; A Tamura; K Suzuki
HISTOCHEMICAL JOURNAL, 2001 - Immunolocalization of calcineurin and FKBP12, the FK506-hinding protein, in Hassall's corpuscles of human thymus and epidermis
H Nishio; K Matsui; H Tsuji; A Tamura; K Suzuki
HISTOCHEMISTRY AND CELL BIOLOGY, Jul. 2000 - Expression of the janus kinases - signal transducers and activators of transcription pathway in Hassall's corpuscles of the human thymus
H Nishio; K Matsui; H Tsuji; A Tamura; K Suzuki
HISTOCHEMISTRY AND CELL BIOLOGY, Jun. 2000 - Immunohistochemical study of tyrosine phosphorylation signaling in the involuted thymus
H Nishio; K Matsui; H Tsuji; A Tamura; K Suzuki
FORENSIC SCIENCE INTERNATIONAL, Jun. 2000 - 胸腺退縮におけるチロシンリン酸化の変化
法医病理, 2000 - Sibling incest and formulation of paternity probability: Case report
Akiyoshi Tamura; Hiroko Tsuji; Tokiko Miyazaki; Misa Iwata; Hajime Nishio; Tominori Hashimoto; Kiyofumi Kamiyama; Koichi Suzuki
Legal Medicine, 2000 - Reduction of tyrosine-phosphorylated proteins in involuted thymuses of stressed rats: A study using immunological methods
H Nishino; H Tsuji; A Tamura; K Suzuki
ELECTROPHORESIS, Jan. 2000 - Immunohistochemical study of tyrosine phosphorylation signaling in Hassall's corpuscles of the human thymus
H Nishio; K Matsui; H Tsuji; A Tamura; K Suzuki
ACTA HISTOCHEMICA, Nov. 1999 - Haplotype analysis of a de novo allele at a vWF STR locus using flanking STR loci
Akiyoshi Tamura; Hiroko Tsuji; Hajime Nishio; Koichi Suzuki
Legal Medicine, 1999 - Cyclosporin A attenuates angiotensin (]G0002[)-induced tyrosive phosphorylation in heart
J. Biochem. Mol. Biol. Biophys., 1999 - Possible involvement of calcineurin, protein kinase C, and Src-family kinases in angiotensin II-induced tyrosine phosphorylation of p130cas in rat cardiac muscle
Hajime Nishio; Hiroko Tsuji; Akiyoshi Tamura; Koichi Suzuki
Legal Medicine, 1999 - Estimation of age from the femur of Japanese cadavers
Yutaka Watanabe; Masayoshi Konishi; Masahisa Shimada; Hiroko Tsuji; Hajime Nishio; Koichi Suzuki; Sotaro Iwamoto
Acta Anatomica Nipponica, 1998 - Evidence for myosin-binding phosphatase in heart myofibrils
H Nishio; K Ichikawa; DJ Hartshorne
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jul. 1997 - PP60(C-SRC) EXPRESSION IN RAT SPERMATOGENESIS
H NISHIO; M TOKUDA; T ITANO; H MATSUI; Y TAKEUCHI; O HATASE
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 1995 - THE EVIDENCE FOR POSTMEIOTIC EXPRESSION OF A TESTIS-SPECIFIC ISOFORM OF A REGULATORY SUBUNIT OF CALCINEURIN USING A MONOCLONAL-ANTIBODY
H NISHIO; H MATSUI; LJMP MOIA; S TAKETA; K MIYAMOTO; M TOKUDA; T ITANO; S NAKAHARA; O HATASE
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 1992 - IDENTIFICATION OF A SRC FAMILY PROTEIN SPECIFICALLY EXPRESSED IN RAT ASTROCYTES BY IMMUNOHISTOCHEMISTRY AND DOUBLE IMMUNOFLUORESCENT STUDY
LJMP MOIA; H MATSUI; H NISHIO; T TSUCHIDA; M TOKUDA; T ITANO; S NAGAO; O HATASE
BRAIN RESEARCH, Jul. 1992 - A SYNTHETIC PEPTIDE DERIVED FROM P34CDC2 IS A SPECIFIC AND EFFICIENT SUBSTRATE OF SRC-FAMILY TYROSINE KINASES
HC CHENG; H NISHIO; O HATASE; S RALPH; JH WANG
JOURNAL OF BIOLOGICAL CHEMISTRY, May 1992 - IDENTIFICATION OF TESTIS SPECIFIC CALCINEURIN-BETA SUBUNIT ISOFORM BY A MONOCLONAL-ANTIBODY AND DETECTION OF A SPECIFIC 6 AMINO-ACID-SEQUENCE
H NISHIO; H MATSUI; S ETOH; LJMP MOIA; M TOKUDA; T ITANO; O HATASE
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 1992 - ISOLATION AND SEQUENCE OF RAT TESTIS CDNA FOR A CALCIUM-BINDING POLYPEPTIDE SIMILAR TO THE REGULATORY SUBUNIT OF CALCINEURIN
M SUGIMOTO; H MATSUI; S ETOH; T SHIMIZU; H NISHIO; LJMP MOIA; M TOKUDA; T ITANO; TAKENAKA, I; O HATASE
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 1991 - IDENTIFICATION OF 2 CALCINEURIN-ALPHA ISOFORMS IN BOVINE BRAIN BY 2 DIFFERENT MONOCLONAL-ANTIBODIES
H MATSUI; S ETOH; H NISHIO; M TOKUDA; T ITANO; O HATASE
BIOCHEMISTRY INTERNATIONAL, Aug. 1991 - PEPTIDE CDC2(8-20) IS AN EFFICIENT SUBSTRATE FOR SRC-GENE FAMILY TYROSINE KINASES IN BOVINE-TISSUES
H NISHIO; HC CHENG; CME LITWIN; S ETOH; JH WANG
FASEB JOURNAL, Mar. 1991 - MECHANISM OF TRANSIENT INCREASE IN INTRACELLULAR CONCENTRATION OF FREE CALCIUM-IONS IN HL-60 CELL-DIFFERENTIATION INDUCED BY VITAMIN-D3 AND PHORBOL ESTER
T TASAKA; M TOKUDA; T TAOKA; T ITANO; H MATSUI; S ETOH; H NISHIO; O MIYAMOTO; S IRINO; O HATASE
BIOCHEMISTRY INTERNATIONAL, Jan. 1991 - A POSSIBLE ROLE FOR CALMODULIN IN CA-2+-INDUCED SWELLING OF MITOCHONDRIA
O HATASE; T ITANO; H MATSUI; A DOI; S ETOH; H NISHIO; S NAKAHARA
BIOCHEMISTRY INTERNATIONAL, Oct. 1987
