Doctor Degree, Osaka University, Mar. 2006

Distribution of Lipoprotein(a) Levels Among Children with Elevated Low-Density Lipoprotein Cholesterol Identified Through Universal Pediatric Lipid Screening
Ryosuke Tani; Keiji Matsunaga; Keita Tanimoto; Tomoko Inoue; Katsufumi Nishioka; Sonoko Kondo; Takashi Iwase; Takashi Kusaka; Hai Ying Fu; Hayato Tada; Masayuki Takamura; Tetsuo Minamino
Journal of Atherosclerosis and Thrombosis, 2026

A Conserved Stress-Inducible Hub Enhancer Governs Natriuretic Peptide Expression and Undergoes Dynamic and Reversible Activation in Human Heart Failure
Ken Matsuoka; Hijiri Inoue; Hyejin Jo; Chisato Okamoto; Hirona Hasuike; Hai Ying Fu; Hidetaka Kioka; Yuki Kuramoto; Takatsugu Segawa; Shunsuke Nishimura; Rina Takamiya; Yohei Miyashita; Yoshihiro Asano; Satoru Yamazaki; Hisakazu Kato; Yasushi Sakata; Seiji Takashima; Osamu Tsukamoto
Oct. 2025

Ultrasonographic Assessment of Achilles Tendon Thickness in Pediatric Patients with Suspected Familial Hypercholesterolemia
Tomoko Inoue; Keiji Matsunaga; Ryosuke Tani; Katsufumi Nishioka; Sonoko Kondo; Takashi Iwase; Hai Ying Fu; Hayato Tada; Masayuki Takamura; Takashi Kusaka; Tetsuo Minamino
Lipidology, Aug. 2025

L-GILZ is essential for cardiac function and protects against pressure overload-induced hypertrophy and dysfunction in mice　　　　　　　　　　　　　　　
Hai Ying Fu; Miki Imazu; Shin Ito; Osamu Tsukamoto; Masafumi Kitakaze
Asia Heart Journal, Jul. 2025, [Reviewed]
Lead

Utility of Discrepancies Between Friedewald and Martin Equations in Predicting Pathogenic Variants of Familial Hypercholesterolemia in Children
Ryosuke Tani; Keiji Matsunaga; Tomoko Inoue; Katsufumi Nishioka; Kanako Irie; Sonoko Kondo; Takashi Iwase; Hai Ying Fu; Shigeru Ito; Tsuyoshi Sasaki; Sumiko Yoshida; Ichiro Yokota; Yoichi Hoshikawa; Katsunori Yokoyama; Takuji Fujisawa; Hayato Tada; Masayuki Takamura; Takashi Kusaka; Tetsuo Minamino
Circulation Journal, May 2025

Potential barriers to reverse cascade screening combined with universal cholesterol screening for paediatric familial hypercholesterolemia: focus on second-degree relatives of a proband
Ryosuke Tani; Keiji Matsunaga; Tomoko Inoue; Katsufumi Nishioka; Kanako Irie; Sonoko Kondo; Takashi Iwase; Hai Ying Fu; Shigeru Ito; Tsuyoshi Sasaki; Sumiko Yoshida; Ichiro Yokota; Yoichi Hoshikawa; Katsunori Yokoyama; Takuji Fujisawa; Hayato Tada; Masayuki Takamura; Takashi Kusaka; Tetsuo Minamino
Rare Disease and Orphan Drugs Journal, May 2025

Partial replacement of d-glucose with d-allose ameliorates peritoneal injury and hyperglycaemia induced by peritoneal dialysis fluid in rats.
Taro Ozaki; Hai Ying Fu; Keisuke Onishi; Shota Yokoyama; Takuro Fujita; Atsushi Tobiume; Tadashi Sofue; Kazuya Akimitsu; Tetsuo Minamino
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, Mar. 2024

Improved Efficiency of the Clinical Diagnostic Criteria for Familial Hypercholesterolemia in Children: A Comparison of the Japan Atherosclerosis Society Guidelines of 2017 and 2022.
Hai Ying Fu; Keiji Matsunaga; Tomoko Inoue; Ryosuke Tani; Kenzo Funatsuki; Takashi Iwase; Sonoko Kondo; Katsufumi Nishioka; Shigeru Ito; Tsuyoshi Sasaki; Ichiro Yokota; Yoichi Hoshikawa; Katsunori Yokoyama; Takuji Fujisawa; Masa-Aki Kawashiri; Hayato Tada; Masayuki Takamura; Takashi Kusaka; Tetsuo Minamino
Journal of atherosclerosis and thrombosis, Feb. 2024

The impact of dietary fat type on lipid profiles in lean mass hyper-responder phenotype.
Yuma Takemura; Tomoko Inoue; Keiji Matsunaga; Ryosuke Tani; Hai Ying Fu; Tetsuo Minamino
Clinical case reports, Feb. 2024

Phenotypic homozygous familial hypercholesterolemia successfully treated with proprotein convertase subtilisin/kexin type 9 inhibitors.
Ryosuke Tani; Keiji Matsunaga; Yuta Toda; Tomoko Inoue; Hai Ying Fu; Tetsuo Minamino
Clinical case reports, Feb. 2024

Universal Screening for Familial Hypercholesterolemia in Children in Kagawa, Japan.
Keiji Matsunaga; Asako Mizobuchi; Hai Ying Fu; Shohei Ishikawa; Hayato Tada; Masa-Aki Kawashiri; Ichiro Yokota; Tsuyoshi Sasaki; Shigeru Ito; Jun Kunikata; Takashi Iwase; Tomohiro Hirao; Katsunori Yokoyama; Yoichi Hoshikawa; Takuji Fujisawa; Kazushige Dobashi; Takashi Kusaka; Tetsuo Minamino
Journal of atherosclerosis and thrombosis, Jun. 2022

Galectin-9 deficiency exacerbates lipopolysaccharide-induced hypothermia and kidney injury.
Keisuke Onishi; Hai Ying Fu; Tadashi Sofue; Atsushi Tobiume; Masahiro Moritoki; Hiroyuki Saiga; Mari Ohmura-Hoshino; Katsuaki Hoshino; Tetsuo Minamino
Clinical and experimental nephrology, Mar. 2022

Loss-of-function mutations in the co-chaperone protein BAG5 cause dilated cardiomyopathy requiring heart transplantation.
Hideyuki Hakui; Hidetaka Kioka; Yohei Miyashita; Shunsuke Nishimura; Ken Matsuoka; Hisakazu Kato; Osamu Tsukamoto; Yuki Kuramoto; Ayako Takuwa; Yusuke Takahashi; Shigeyoshi Saito; Kunio Ohta; Hiroshi Asanuma; Hai Ying Fu; Haruki Shinomiya; Noriaki Yamada; Tomohito Ohtani; Yoshiki Sawa; Masafumi Kitakaze; Seiji Takashima; Yasushi Sakata; Yoshihiro Asano
Science translational medicine, Jan. 2022

ASB2 is a novel E3 ligase of SMAD9 required for cardiogenesis.
Kyung-Duk Min; Masanori Asakura; Manabu Shirai; Satoru Yamazaki; Shin Ito; Hai Ying Fu; Hiroshi Asanuma; Yoshihiro Asano; Tetsuo Minamino; Seiji Takashima; Masafumi Kitakaze
Scientific reports, Nov. 2021

The CR9 element is a novel mechanical load-responsive enhancer that regulates natriuretic peptide genes expression.
Yohei Miyashita; Osamu Tsukamoto; Ken Matsuoka; Kenta Kamikubo; Yuki Kuramoto; Hai Ying Fu; Tomoya Tsubota; Hirona Hasuike; Toshio Takayama; Hiroaki Ito; Tatsuro Hitsumoto; Chisato Okamoto; Hidetaka Kioka; Ryohei Oya; Haruki Shinomiya; Hideyuki Hakui; Yasunori Shintani; Hisakazu Kato; Masafumi Kitakaze; Yasushi Sakata; Yoshihiro Asano; Seiji Takashima
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Apr. 2021

A dipeptidyl peptidase-IV inhibitor improves diastolic dysfunction in Dahl salt-sensitive rats.
Yuri Nakajima; Shin Ito; Masanori Asakura; Kyung-Duk Min; Hai Ying Fu; Miki Imazu; Tatsuro Hitsumoto; Hiroko Takahama; Kazuhiro Shindo; Hiroki Fukuda; Satoru Yamazaki; Hiroshi Asanuma; Masafumi Kitakaze
Journal of molecular and cellular cardiology, Apr. 2019

Anti-HB-EGF Antibody-Mediated Delivery of siRNA to Atherosclerotic Lesions in Mice.
Shota Tsuchida; Takashi Matsuzaki; Masaki Yamato; Keiji Okuda; Hai Ying Fu; Ryo Araki; Shoji Sanada; Hiroshi Asanuma; Yoshihiro Asano; Masanori Asakura; Hiroyuki Hao; Seiji Takashima; Masafumi Kitakaze; Yasushi Sakata; Eisuke Mekada; Tetsuo Minamino
International heart journal, Nov. 2018

Development of a novel one-step production system for injectable liposomes under GMP.
Ryo Araki; Takashi Matsuzaki; Ayumi Nakamura; Daisaku Nakatani; Shoji Sanada; Hai Ying Fu; Keiji Okuda; Masaki Yamato; Shota Tsuchida; Yasushi Sakata; Tetsuo Minamino
Pharmaceutical development and technology, Jul. 2018

Ablation of IL-33 gene exacerbate myocardial remodeling in mice with heart failure induced by mechanical stress.
Punniyakoti T Veeraveedu; Shoji Sanada; Keiji Okuda; Hai Ying Fu; Takashi Matsuzaki; Ryo Araki; Masaki Yamato; Koubun Yasuda; Yasushi Sakata; Tomohiro Yoshimoto; Tetsuo Minamino
Biochemical pharmacology, Aug. 2017

Protein Quality Control Dysfunction in Cardiovascular Complications Induced by Anti-Cancer Drugs.
Hai Ying Fu; Mikio Mukai; Nobuhisa Awata; Yasushi Sakata; Masatsugu Hori; Tetsuo Minamino
Cardiovascular drugs and therapy, Feb. 2017

Apoptosis inhibitor of macrophage depletion decreased M1 macrophage accumulation and the incidence of cardiac rupture after myocardial infarction in mice.
Shohei Ishikawa; Takahisa Noma; Hai Ying Fu; Takashi Matsuzaki; Makoto Ishizawa; Kaori Ishikawa; Kazushi Murakami; Naoki Nishimoto; Akira Nishiyama; Tetsuo Minamino
PloS one, 2017

Chemical Endoplasmic Reticulum Chaperone Alleviates Doxorubicin-Induced Cardiac Dysfunction.
Hai Ying Fu; Shoji Sanada; Takashi Matsuzaki; Yulin Liao; Keiji Okuda; Masaki Yamato; Shota Tsuchida; Ryo Araki; Yoshihiro Asano; Hiroshi Asanuma; Masanori Asakura; Brent A French; Yasushi Sakata; Masafumi Kitakaze; Tetsuo Minamino
Circulation research, Mar. 2016

Targeted Therapy for Acute Autoimmune Myocarditis with Nano-Sized Liposomal FK506 in Rats.
Keiji Okuda; Hai Ying Fu; Takashi Matsuzaki; Ryo Araki; Shota Tsuchida; Punniyakoti V Thanikachalam; Tatsuya Fukuta; Tomohiro Asai; Masaki Yamato; Shoji Sanada; Hiroshi Asanuma; Yoshihiro Asano; Masanori Asakura; Haruo Hanawa; Hiroyuki Hao; Naoto Oku; Seiji Takashima; Masafumi Kitakaze; Yasushi Sakata; Tetsuo Minamino
PloS one, 2016

Liposomal amiodarone augments anti-arrhythmic effects and reduces hemodynamic adverse effects in an ischemia/reperfusion rat model.
Hiroyuki Takahama; Hirokazu Shigematsu; Tomohiro Asai; Takashi Matsuzaki; Shoji Sanada; Hai Ying Fu; Keiji Okuda; Masaki Yamato; Hiroshi Asanuma; Yoshihiro Asano; Masanori Asakura; Naoto Oku; Issei Komuro; Masafumi Kitakaze; Tetsuo Minamino
Cardiovascular drugs and therapy, Apr. 2013

Ablation of C/EBP homologous protein attenuates endoplasmic reticulum-mediated apoptosis and cardiac dysfunction induced by pressure overload.
Hai Ying Fu; Ken-ichiro Okada; Yulin Liao; Osamu Tsukamoto; Tadashi Isomura; Mitsutoshi Asai; Tamaki Sawada; Keiji Okuda; Yoshihiro Asano; Shoji Sanada; Hiroshi Asanuma; Masanori Asakura; Seiji Takashima; Issei Komuro; Masafumi Kitakaze; Tetsuo Minamino
Circulation, Jul. 2010

X-box binding protein 1 regulates brain natriuretic peptide through a novel AP1/CRE-like element in cardiomyocytes.
Tamaki Sawada; Tetsuo Minamino; Hai Ying Fu; Mitsutoshi Asai; Keiji Okuda; Tadashi Isomura; Satoru Yamazaki; Yoshihiro Asano; Ken-ichiro Okada; Osamu Tsukamoto; Shoji Sanada; Hiroshi Asanuma; Masanori Asakura; Seiji Takashima; Masafumi Kitakaze; Issei Komuro
Journal of molecular and cellular cardiology, Jun. 2010

Overexpression of endoplasmic reticulum-resident chaperone attenuates cardiomyocyte death induced by proteasome inhibition.
Hai Ying Fu; Tetsuo Minamino; Osamu Tsukamoto; Tamaki Sawada; Mitsutoshi Asai; Hisakazu Kato; Yoshihiro Asano; Masashi Fujita; Seiji Takashima; Masatsugu Hori; Masafumi Kitakaze
Cardiovascular research, Sep. 2008

Helicobacter pylori infection induces candidate stem cell marker Musashi-1 in the human gastric epithelium.
Hiroaki Murata; Shingo Tsuji; Masahiko Tsujii; Toru Nakamura; Hai Ying Fu; Hiroshi Eguchi; Kayoko Asahi; Hideyuki Okano; Sunao Kawano; Norio Hayashi
Digestive diseases and sciences, Feb. 2008

Geranylgeranylacetone induces cyclooxygenase-2 expression in cultured rat gastric epithelial cells through NF-kappaB.
Tsutomu Nishida; Yuki Yabe; Hai Ying Fu; Yujiro Hayashi; Kayoko Asahi; Hiroshi Eguchi; Shingo Tsuji; Masahiko Tsujii; Norio Hayashi; Sunao Kawano
Digestive diseases and sciences, Aug. 2007

East Asian-type Helicobacter pylori cytotoxin-associated gene A protein has a more significant effect on growth of rat gastric mucosal cells than the Western type.
Hai Ying Fu; Kayoko Asahi; Yujiro Hayashi; Hiroshi Eguchi; Hiroaki Murata; Masahiko Tsujii; Shingo Tsuji; Takeshi Azuma; Sunao Kawano
Journal of gastroenterology and hepatology, Mar. 2007

Helicobacter pylori infection affects Toll-like receptor 4 expression in human gastric mucosa.
Kayoko Asahi; Hai Ying Fu; Yujiro Hayashi; Hiroshi Eguchi; Hiroaki Murata; Masahiko Tsujii; Shingo Tsuji; Hirohisa Tanimura; Sunao Kawano
Hepato-gastroenterology, 2007

Influences of Helicobacter pylori on cyclooxygenase-2 expression and prostaglandinE2 synthesis in rat gastric epithelial cells in vitro.
Hong Shen; Wei-Hao Sun; Qi-Ping Xue; Jing Wu; Yun-Lin Cheng; Guo-Xian Ding; Hai-Ying Fu; Shingo Tsuji; Sunao Kawano
Journal of gastroenterology and hepatology, Apr. 2006

(2E,6Z,10E)-7-hydroxymethyl-3,11,15-trimethyl-2,6,10,14-hexadecatetraen-1-ol (Plaunotol) increases cyclooxygenase-2 expression via nuclear factor kappaB and cyclic AMP response element in rat gastric epithelial cells.
Hai ying Fu; Yuki Yabe; Kayoko Asahi; Yujiro Hayashi; Hiroaki Murata; Hiroshi Eguchi; Masahiko Tsujii; Shingo Tsuji; Sunao Kawano
European journal of pharmacology, Nov. 2005

Gastro-protective agent rebamipide induces cyclooxygenease-2 (COX-2) in gastric epithelial cells.
Hiroaki Murata; Yuki Yabe; Shingo Tsuji; Masahiko Tsujii; Hai Ying Fu; Kayoko Asahi; Hiroshi Eguchi; Sunao Kawano; Norio Hayashi
Digestive diseases and sciences, Oct. 2005

Promoter hypermethylation silences cyclooxygenase-2 (Cox-2) and regulates growth of human hepatocellular carcinoma cells.
Hiroaki Murata; Shingo Tsuji; Masahiko Tsujii; Yasuko Sakaguchi; Hai Ying Fu; Sunao Kawano; Masatsugu Hori
Laboratory investigation; a journal of technical methods and pathology, Aug. 2004

[Ammonia and monochloramine generated by urease in Helicobacter pylori cause gastric mucosal injury].
Hai Ying Fu; Sunao Kawano
Nihon rinsho. Japanese journal of clinical medicine, Feb. 2002

A Novel Therapy for Giant-cell Myocarditis with Nanotechnology
Keiji Okuda; Hai Ying Fu; Shota Tsuchida; Takashi Matsuzaki; Tomohiro Asai; Naoto Oku; Haruo Hanawa; Masafumi Kitakaze; Yasushi Sakata; Tetsuo Minamino
JOURNAL OF CARDIAC FAILURE, Oct. 2014

H-pylori CagA protein down-regulates TGF-beta signal pathway and attenuates TGF-beta-induced RGM1 cell growth inhibition
Hai Ying Fu; Kayoko Asahi; Yujiro Hayashi; Tsutomu Nishida; Hiroaki Murata; Hiroshi Eguchi; Takeshi Azuma; Sunao Kawano
GASTROENTEROLOGY, Apr. 2006

Dual therapy for Helicobacter pylori resistance to anti microbial agents
Hai Ying Fu; Sunao Kawano; Hirohisa Tanimura
Nippon rinsho. Japanese journal of clinical medicine, 2002

Theranostic Development for myocarditis.
Grant-in-Aid for Challenging Research (Exploratory)
Osaka University
30 Jun. 2017 - 31 Mar. 2019

Development of antibody-drug conjugate to diagnose and treat vulnerable plaque
Grant-in-Aid for Scientific Research (B)
01 Apr. 2015 - 31 Mar. 2018