Last Updated :2025/09/13
Researcher Information
Field Of Study
Research activity information
Paper
- Effects of Azelastine on Glioblastoma Cells.
Uemichi Y; Yasuda S; Mabuchi M; Nakao S; Nagano S; Shimizu T
Anticancer research, Jul. 2025 - Effects of Lomerizine and Its Metabolite on Glioblastoma Cells.
Uemichi Y; Mabuchi M; Tsuchiya N; Yasuda S; Nakao S; Shimizu T
Anticancer research, Jul. 2024 - Effect of Blonanserin on the Proliferation and Migration of Glioblastoma Cells
N. Tsuchiya; K. Okamoto; S. Nakao; S. Ohmori; T. Shimizu
Pharmazie, May 2023 - Evaluation of Cardiac Adverse Events Associated with Carfilzomib Using a Japanese Real-World Database.
Nakao S; Uchida M; Satoki A; Okamoto K; Uesawa Y; Shimizu T
Oncology, Oct. 2021, [Reviewed]
Lead - Synthesis of deuterated c-linolenic acid and application for biological studies: metabolic tuning and Raman imaging
Dodo K; Sato A; Tamura Y; Egoshi S; Fujiwara K; Oonuma K; Nakao S; Terayama N; Sodeoka M
Chem. Commun., Jan. 2021, [Reviewed] - Identification of HUHS190, a human naftopidil metabolite, as a novel anti-bladder cancer drug
Shimizu T; Yamaguchi K; Yamamoto M; Kurioka R; Kino Y; Matsunaga W; Nakao S; Fukuhara H; Tanaka A; Gotoh A; Mabuchi M
Bioorganic & Medicinal Chemistry Letters, 2020, [Reviewed] - Development of a Water-Soluble Indolylmaleimide Derivative IM-93 Showing Dual Inhibition of Ferroptosis and NETosis
Dodo K; Kuboki E; Shimizu T; Imamura R; Magarisawa M; Takahashi M; Tokuhiro T; Yotsumoto S; Asano K; Nakao S; Terayama N; Suda T; Tanaka M; Sodeoka M
ACS Medicinal Chemistry Letters, Jul. 2019, [Reviewed] - 薬剤師生涯教育としての「化学構造式ワークショップ」の試みとその評価
兵庫医療大学紀要, 2018, [Reviewed] - 虚血再灌流障害の細胞障害機序とその対策
Coronary Intervention, 2018
Lead - Indolylmaleimide Derivative IM-17 Shows Cardioprotective Effects in Ischemia-Reperfusion Injury
Dodo K; Shimizu T; Sasamori J; Aihara K; Terayama N; Nakao S; Iuchi K; Takahashi M; Sodeoka M
ACS Medicinal Chemistry Letters, Jan. 2018, [Reviewed] - 1年次有機化学系科目における授業連携型学習支援の実施とその評価
兵庫医療大学紀要, Nov. 2017, [Reviewed] - Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor
Nakao S; Mabuchi M; Wang S; Kogure Y; Shimizu T; Noguchi K; Tanaka A; Dai Y
Bioorganic & Medicinal Chemistry Letters, May 2017, [Reviewed]
Lead - Systematic Trial for Evaluating Docetaxel in a Human Prostate Cancer Cell DU145 Xenograft Model.
Miyuki Mabuchi; Masahiro Ueda; Yuri Yoshida; Kota Horiike; Kenta Yamaoka; Syuhei Nakao; Tadashi Shimizu; Yuko Ueda; Kazutake Tsujikawa; Akito Tanaka
Anticancer Res., Apr. 2017, [Reviewed] - Improving the bioavailability and anticancer effect of the PCA1/ALKBH3 inhibitor HUHS015 using sodium salt.
Mabuchi M; Shimizu T; Ueda M; Sasakawa Y; Nakao S; Ueda Y; Kawamura A; Tsujikawa K; Tanaka A
In Vivo, Feb. 2015, [Reviewed] - The newly synthesized anticancer drug HUHS1015 is useful for treatment of human gastric cancer
Kaku Y; Tsuchiya A; Kanno T; Nakao S; Shimizu T; Tanaka A; Nishizaki T
Cancer Chemother. Pharmacol., Jan. 2015, [Reviewed] - Newly synthesized anticancer drug HUHS1015 is effective on malignant pleural mesothelioma
Kaku Y; Nagaya H; Tsuchiya A; Kanno T; Gotoh A; Tanaka A; Shimizu T; Nakao S; Tabata C; Nakano T; Nishizaki T
Cancer science, Jul. 2014, [Reviewed] - Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs
Nakao S; Mabuchi M; Shimizu T; Itoh Y; Takeuchi Y; Ueda M; Mizuno H; Shigi N; Ohshio I; Jinguji K; Ueda Y; Yamamoto M; Furukawa T; Aoki S; Tsujikawa K; Tanaka A
Bioorganic & Medicinal Chemistry Letters, Jan. 2014, [Reviewed]
Lead - DCP-LA-Phosphatidylinositol and Its Enantiomer Exhibit Different Bioactivities
Tsuchiya A; Kanno T; Shimizu T; Nakao S; Tanaka A; Nishizaki T
Cellular Physiology and Biochemistry, Jan. 2014, [Reviewed] - A novel PP2A enhancer induces caspase-independent apoptosis of MKN28 gastric cancer cells with high MEK activity
Tsuchiya A; Kanno T; Shimizu T; Nakao S; Tanaka A; Tabata C; Nakano T; Nishizaki T
Cancer Letters, Jan. 2014, [Reviewed] - Effects of Newly Synthesized DCP-LA-Phospholipids on Protein Kinase C and Protein Phosphatases
Kanno T; Tsuchiya A; Shimizu T; Nakao S; Tanaka A; Nishizaki T
Cellular Physiology and Biochemistry, Apr. 2013, [Reviewed]
Lectures, oral presentations, etc.
- 機械学習による骨肉腫治療薬候補化合物の探索
中尾周平; 矢島梨里有; 上通侑樹; 馬渕美雪; 長野秀嗣; 植沢芳広; 清水忠
日本薬学会年会第145年会, Mar. 2025 - ヒト神経膠芽腫細胞に対する機械学習活性予測モデルを用いた in house実験化合物の活性分類
中尾周平; 上通侑樹; 安田聖菜; 馬渕美雪; 長野秀嗣; 植沢芳広; 清水忠
日本薬学会年会第145年会, Mar. 2025 - 神経膠芽腫治療薬候補の探索に向けた機械学習によるQSAR予測モデルの構築
中尾周平、仁木珠優、上通侑樹、馬渕美雪、長野秀嗣、植沢芳広、清水忠
日本薬学会年会第145年会, Mar. 2025 - ビッグデータ解析と実験的手法を組み合わせたCarfilzomibの有害事象予防化合物の探索
中尾周平
日本薬学会年会第144年会, Mar. 2024 - Evaluation of Cardiac Adverse Events Associated with Carfilzomib Using a Japanese Real-World Database
The 32nd Annual Meeting of JSPHCS, Sep. 2022 - An approach to elucidate the mechanism of mesenteric venous sclerosis by combining adverse drug reaction database analysis and experimental methods.
第49回日本毒性学会学術年会, Jun. 2022 - 固相担持された金属錯体を用いたアフィニティー精製法の生体分子への応用
日本薬学会第140回年会, Mar. 2020 - インドリルマレイミド誘導体の開発とラット虚血再灌流障害モデルにおける心保護効果
第36回メディシナルケミストリーシンポジウム, Nov. 2018 - 前立腺癌治療薬を目指したProstate cancer antigen-1(PCA-1/ALKBH3)阻害剤HUHS015 のデザインと合成
第32回メディシナルケミストリーシンポジウム, Nov. 2014 - 新規抗癌剤を目指したNaftopidil 誘導体のデザインと合成
第107回近畿生理学談話会, Oct. 2014 - 2-Mercaptoethanol(2-ME)などの汎用される還元剤によるアフィニティ樹脂からのターゲットタンパク質の選択的溶出法の開拓
第8回ケミカルバイオロジー年会, Jun. 2013
Research Themes
- オラパリブによる重篤な貧血のリスク因子探索と血中濃度測定による治療管理の検討
基盤研究(C)
地方独立行政法人神戸市民病院機構神戸市立医療センター中央市民病院(第1診療部、第2診療部、第3診療部
01 Apr. 2025 - 31 Mar. 2028 - Development of therapeutic agents for glioblastoma based on the synthesis of bronanserin metabolites and new derivatives
Grant-in-Aid for Scientific Research (C)
Hyogo University of Health Sciences
01 Apr. 2021 - 31 Mar. 2024
