Profile
2004年 九州大学医学部卒
2004年 虎の門病院 レジデント
2006年 九州大学病院 医員
2007年 九州大学大学院 博士課程
2011年 九州大学医学部 助教
2012年 九州大学病院 学術研究員
2013年 Rutgers NJMS 博士研究員
2018年 山口大学医学部 助教
2023年 和歌山県立医科大学医学部 講師
2024年 兵庫医科大学医学部 教授
Last Updated :2024/12/13
Researcher Information
Research Keyword
Career
- Apr. 2024 - Present
Hyogo Medical University, Department of Physiology, Faculty of Medicine, Professor - Jan. 2023 - Mar. 2024
Wakayama Medical University, Department of Physiology, Associate Professor - Jun. 2018 - Dec. 2022
Graduate School of Medicine, Yamaguchi University, Dept of Surgery and Clinical Science, Assistant Professor - Aug. 2013 - May 2018
Rutgers University New Jersey Medical School, Department of Cell Biology and Molecular Medicine, 博士研究員 - Apr. 2012 - Jul. 2013
Kyushu University, 高度先端・ARO次世代医療センター, 学術研究員 - Jun. 2011 - Mar. 2012
Kyushu University, Graduate School of Medical Sciences, 助教 - Apr. 2006 - Mar. 2007
Kyushu University, 循環器内科, 医員 - Apr. 2004 - Mar. 2006
虎の門病院, 内科レジデント
Research activity information
Award
- Nov. 2019
公益財団法人持田記念医学薬学振興財団, 2019年度持田記念研究助成
齊藤 寿郎 - Oct. 2019
公益財団法人金原一郎記念医学医療振興財団, 第34回基礎医学医療研究助成
齊藤 寿郎 - Feb. 2019
公益信託, 循環器学研究振興基金
齊藤 寿郎 - Jan. 2019
山口大学医学部, ニューフロンティアプロジェクト研究助成
齊藤 寿郎 - Nov. 2018
公益財団法人MSD生命科学財団, 研究助成 2018
齊藤 寿郎 - Mar. 2018
National Institutes of Health, Autophagy as a Common Pathway in Diseases, Travel Award
Toshiro Saito - May 2017
Keystone Symposia, Mitochondria, Metabolism and Heart, Conference Assistant
Toshiro Saito - Nov. 2016
American Heart Association Scientific Sessions, The Louis N. and Arnold M. Katz Basic Science Research Prize for Young Investigators
Toshiro Saito - Jul. 2016
American Heart Association, Postdoctoral Fellowship
Toshiro Saito - Nov. 2015
American Heart Association Scientific Sessions, Early Career Best Science Award
Toshiro Saito - Aug. 2014
日本平滑筋学会, 第10回栗山熙賞
齊藤 寿郎 - Mar. 2013
日本心臓財団, 第26回日本心臓財団・バイエル薬品海外留学助成
齊藤 寿郎
Paper
- Dry preserved multilayered fibroblast cell sheets are a new manageable tool for regenerative medicine to promote wound healing
Yutaro Matsuno; Masashi Yanagihara; Koji Ueno; Toshiro Saito; Hiroshi Kurazumi; Ryo Suzuki; Shunsaku Katsura; Atsunori Oga; Kimikazu Hamano
Scientific Reports, Dec. 2022 - 〔Major achievements〕Perivascular Adipose Tissue Is a Major Source of Nitric Oxide in Saphenous Vein Grafts Harvested via the No-Touch Technique.
Toshiro Saito; Hiroshi Kurazumi; Ryo Suzuki; Kazumasa Matsunaga; Sarii Tsubone; Bochao Lv; Sei Kobayashi; Takashi Nagase; Takahiro Mizoguchi; Makoto Samura; Kotaro Suehiro; Takasuke Harada; Noriyasu Morikage; Akihito Mikamo; Kimikazu Hamano
Journal of the American Heart Association, Jan. 2022, [Reviewed]
Lead - Ulk1-dependent alternative mitophagy plays a protective role during pressure overload in the heart.
Jihoon Nah; Akihiro Shirakabe; Risa Mukai; Peiyong Zhai; Eun-Ah Sung; Andreas Ivessa; Wataru Mizushima; Yasuki Nakada; Toshiro Saito; Chengchen Hu; Yong-Keun Jung; Junichi Sadoshima
Cardiovascular research, Jan. 2022, [Reviewed] - 〔Major achievements〕Alternative Mitophagy Protects the Heart Against Obesity-Associated Cardiomyopathy.
Mingming Tong; Toshiro Saito; Peiyong Zhai; Shin-Ichi Oka; Wataru Mizushima; Michinari Nakamura; Shohei Ikeda; Akihiro Shirakabe; Junichi Sadoshima
Circulation research, Dec. 2021, [Reviewed] - Autologous Multilayered Fibroblast Sheets Can Reinforce Bronchial Stump in a Rat Model.
Sota Yoshimine; Koji Ueno; Junichi Murakami; Toshiro Saito; Ryo Suzuki; Yoshiyuki Asai; Eiji Ikeda; Toshiki Tanaka; Kimikazu Hamano
Seminars in thoracic and cardiovascular surgery, Mar. 2021, [Reviewed] - Autologous transplantation of multilayered fibroblast sheets prevents postoperative pancreatic fistula by regulating fibrosis and angiogenesis.
Keisuke Iwamoto; Toshiro Saito; Yoshihiro Takemoto; Koji Ueno; Masashi Yanagihara; Tomoko Furuya-Kondo; Hiroshi Kurazumi; Yuya Tanaka; Yohei Taura; Eijiro Harada; Kimikazu Hamano
American journal of translational research, 2021, [Reviewed]
Corresponding - Molecular mechanisms and clinical implications of multiple forms of mitophagy in the heart.
Toshiro Saito; Kimikazu Hamano; Junichi Sadoshima
Cardiovascular research, Dec. 2020, [Reviewed]
Lead - Nuclear β-catenin expression is positively regulated by JAB1 in human colorectal cancer cells.
Arata Nishimoto; Yoshihiro Takemoto; Toshiro Saito; Hiroshi Kurazumi; Toshiki Tanaka; Eijiro Harada; Bungo Shirasawa; Kimikazu Hamano
Biochemical and biophysical research communications, Dec. 2020, [Reviewed] - Preserving the endothelium in saphenous vein graft with both conventional and no-touch preparation.
Toshiro Saito; Hiroshi Kurazumi; Ryo Suzuki; Yutaro Matsuno; Akihito Mikamo; Kimikazu Hamano
Journal of cardiothoracic surgery, Oct. 2020, [Reviewed]
Lead - Comprehensive autophagy evaluation in cardiac disease models.
Nina Kaludercic; Maria Chiara Maiuri; Susmita Kaushik; Álvaro F Fernández; Jenny de Bruijn; Francesca Castoldi; Yun Chen; Jumpei Ito; Risa Mukai; Tomokazu Murakawa; Jihoon Nah; Federico Pietrocola; Toshiro Saito; Salwa Sebti; Martina Semenzato; Lorenza Tsansizi; Sebastiano Sciarretta; Julio Madrigal-Matute
Cardiovascular Research, Mar. 2020, [Reviewed] - Hypoxic-conditioned cardiosphere-derived cell sheet transplantation for chronic myocardial infarction.
Akira Fujita; Koji Ueno; Toshiro Saito; Masashi Yanagihara; Hiroshi Kurazumi; Ryo Suzuki; Akihito Mikamo; Kimikazu Hamano
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Dec. 2019, [Reviewed] - 〔Major achievements〕Mitophagy Is Essential for Maintaining Cardiac Function During High Fat Diet-Induced Diabetic Cardiomyopathy.
Mingming Tong; Toshiro Saito; Peiyong Zhai; Shin-Ichi Oka; Wataru Mizushima; Michinari Nakamura; Shohei Ikeda; Akihiro Shirakabe; Junichi Sadoshima
Circulation research, Apr. 2019, [Reviewed] - Mitochondrial LonP1 protects cardiomyocytes from ischemia/reperfusion injury in vivo.
Venkatesh S; Li M; Saito T; Tong M; Rashed E; Mareedu S; Zhai P; Bárcena C; López-Otín C; Yehia G; Sadoshima J; Suzuki CK
Journal of molecular and cellular cardiology, Mar. 2019, [Reviewed] - 〔Major achievements〕An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia.
Saito T; Nah J; Oka SI; Mukai R; Monden Y; Maejima Y; Ikeda Y; Sciarretta S; Liu T; Li H; Baljinnyam E; Fraidenraich D; Fritzky L; Zhai P; Ichinose S; Isobe M; Hsu CP; Kundu M; Sadoshima J
The Journal of Clinical Investigation, Feb. 2019, [Reviewed]
Lead - Trehalose-Induced Activation of Autophagy Improves Cardiac Remodeling After Myocardial Infarction.
Sciarretta S; Yee D; Nagarajan N; Bianchi F; Saito T; Valenti V; Tong M; Del Re DP; Vecchione C; Schirone L; Forte M; Rubattu S; Shirakabe A; Boppana VS; Volpe M; Frati G; Zhai P; Sadoshima J
Journal of the American College of Cardiology, May 2018, [Reviewed] - Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes
Shin-ichi Oka; Tsuyoshi Hirata; Wataru Suzuki; Daichi Naito; Yanbin Chen; Adave Chin; Hiroaki Yaginuma; Toshiro Saito; Narayani Nagarajan; Peiyong Zhai; Santosh Bhat; Kevin Schesing; Dan Shao; Yoko Hirabayashi; Junji Yodoi; Sebastiano Sciarretta; Junichi Sadoshima
JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2017, [Reviewed] - 〔Major achievements〕Cardiomyocyte-specific loss of mitochondrial p32/C1qbp causes cardiomyopathy and activates stress responses
Toshiro Saito; Takeshi Uchiumi; Mikako Yagi; Rie Amamoto; Daiki Setoyama; Yuichi Matsushima; Dongchon Kang
Cardiovascular Research, Aug. 2017, [Reviewed]
Lead - Unexpected Functional Consequences of the Loss of the Autophagy-Related Conjugation System
Toshiro Saito; Junichi Sadoshima
Circulation research, Feb. 2017, [Reviewed]
Lead - Response by Shirakabe et al to letter regarding article, "Drp1-dependent mitochondrial autophagy plays a protective role against pressure overload-induced mitochondrial dysfunction and heart failure"
Akihiro Shirakabe; Peiyong Zhai; Yoshiyuki Ikeda; Toshiro Saito; Yasuhiro Maejima; Chiao-Po Hsu; Masatoshi Nomura; Kensuke Egashira; Beth Levine; Junichi Sadoshima
Circulation, Aug. 2016 - Evaluating mitochondrial autophagy in the mouse heart
Akihiro Shirakabe; Luke Fritzky; Toshiro Saito; Peiyong Zhai; Shigeki Miyamoto; Asa B. Gustafsson; Richard N. Kitsis; Junichi Sadoshima
Journal of molecular and cellular cardiology, Mar. 2016, [Reviewed] - Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload-Induced Mitochondrial Dysfunction and Heart Failure
Akihiro Shirakabe; Peiyong Zhai; Yoshiyuki Ikeda; Toshiro Saito; Yasuhiro Maejima; Chiao-Po Hsu; Masatoshi Nomura; Kensuke Egashira; Beth Levine; Junichi Sadoshima
Circulation, Mar. 2016, [Reviewed] - 〔Major achievements〕Molecular Mechanisms of Mitochondrial Autophagy/Mitophagy in the Heart
Toshiro Saito; Junichi Sadoshima
Circulation research, Apr. 2015, [Reviewed]
Lead - The vascular clock system generates the intrinsic circadian rhythm of vascular contractility
Toshiro Saito
Journal of Smooth Muscle Research, 2015, [Reviewed]
Lead - 〔Major achievements〕Pivotal role of rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility
Toshiro Saito; Mayumi Hirano; Tomomi Ide; Toshihiro Ichiki; Noriyuki Koibuchi; Kenji Sunagawa; Katsuya Hirano
Circulation, Jan. 2013, [Reviewed]
Lead - Protein instability and functional defects caused by mutations of dihydro-orotate dehydrogenase in Miller syndrome patients
JingXian Fang; Takeshi Uchiumi; Mikako Yagi; Shinya Matsumoto; Rie Amamoto; Toshiro Saito; Shinya Takazaki; Tomotake Kanki; Haruyoshi Yamaza; Kazuaki Nonaka; Dongchon Kang
BIOSCIENCE REPORTS, Dec. 2012, [Reviewed] - Localization of mRNAs encoding human mitochondrial oxidative phosphorylation proteins
Shinya Matsumoto; Takeshi Uchiumi; Toshiro Saito; Mikako Yagi; Shinya Takazaki; Tomotake Kanki; Dongchon Kang
MITOCHONDRION, May 2012, [Reviewed] - Ribonucleoprotein Y-box-binding protein-1 regulates mitochondrial oxidative phosphorylation (OXPHOS) protein expression after serum stimulation through binding to OXPHOS mRNA
Shinya Matsumoto; Takeshi Uchiumi; Hiroyuki Tanamachi; Toshiro Saito; Mikako Yagi; Shinya Takazaki; Tomotake Kanki; Dongchon Kang
BIOCHEMICAL JOURNAL, Apr. 2012, [Reviewed]
MISC
- 積層線維芽細胞シートの移植による気管支断端の治癒促進効果の検討
吉峯宗大; 上野耕司; 山本直宗; 岩本圭亮; 村上順一; 斎藤寿郎; 柳原正志; 田中俊樹; 濱野公一
日本再生医療学会総会(Web), 2021 - ラット膵液瘻モデルにおいて、積層化線維芽細胞シートは膵液瘻を予防し、正常膵組織を温存する
岩本 圭亮; 齊藤 寿郎; 山本 直宗; 田中 裕也; 上野 耕司; 柳原 正志; 竹本 圭宏; 原田 栄二郎; 濱野 公一
日本消化器外科学会総会, Dec. 2020 - 大腸癌の抗癌剤抵抗性における、転写因子c-MYCによる代謝系reprogramに関する研究
岩本 圭亮; 齋藤 寿郎; 山本 直宗; 田中 裕也; 釘宮 成二; 竹本 圭宏; 上野 耕司; 柳原 正志; 原田 栄二郎; 濱野 公一
日本外科学会定期学術集会抄録集, Aug. 2020 - Ulk1-Dependent Mitochondrial Autophagy Protects the Heart Against Pressure Overload-Induced Heart Failure
Akihiro Shirakabe; Yoshiyuki Ikeda; Toshiro Saito; Peiyong Zai; Junichi Sadoshima
CIRCULATION, Nov. 2016 - Ulk1 Induces Mitochondrial Autophagy by Regulating Mitochondrial Fission and Alternative Autophagy in the Heart
Toshiro Saito; Junichi Sadoshima
CIRCULATION, Nov. 2016 - Cardiac-specific Ablation of Ulk1, but not of Atg7, Attenuates Mitochondrial Autophagy in the Heart in Response to Energy Stress (Best of Basic Science Abstract)
Toshiro Saito; Junichi Sadoshima
CIRCULATION, Nov. 2015 - Ulk1 Induces Mitochondrial Autophagy Through Rab9-dependent Phagophore Formation in Cardiomyocytes (Best of Basic Science Abstract)
Toshiro Saito; Junichi Sadoshima
CIRCULATION, Nov. 2015 - Autophagy Protects the Heart Against Pressure Overload Induced Heart Failure
Akihiro Shirakabe; Yoshiyuki Ikeda; Peiyong Zai; Toshiro Saito; Junichi Sadoshima
CIRCULATION, Nov. 2015 - Drp1-dependent Mitochondrial Autophagy Plays A Protective Role In Response To Pressure Overload Induced Mitochondrial Dysfunction And Heart Failure
Akihiro Shirakabe; Yoshiyuki Ikeda; Peiyong Zai; Toshiro Saito; Junichi Sadoshima
CIRCULATION, Nov. 2015 - Therapeutic Impact of Autophagy-inducing Peptide on Pressure Overload-induced Heart Failure
Akihiro Shirakabe; Yoshiyuki Ikeda; Peiyong Zai; Toshiro Saito; Junichi Sadoshima
CIRCULATION, Nov. 2015 - Drp1 Accumulates in Mitochondria and Plays a Protective Role in the Heart in Response to Pressure Overload
Akihiro Shirakabe; Yoshiyuki Ikeda; Toshiro Saito; Peiyong Zhai; Junichi Sadoshima
CIRCULATION RESEARCH, Jul. 2015 - Role of the Mitochondrial AAA plus Lon Protease in Cardioprotection
Min Li; Sundararajan Venkatesh; Eman Rashad; Toshiro Saito; Junichi Sadoshima; Carolyn K. Suzuki
CIRCULATION RESEARCH, Jul. 2015 - Ulk1 Plays a Crucial Role in Mitochondrial Autophagy in Cardiomyocytes
Toshiro Saito; Yoshiya Monden; Junichi Sadoshima
CIRCULATION, Nov. 2014 - Vascular Intrinsic Circadian Rhythm of Vascular Contractility under the Regulation of Clock Gene RORα
Saito Toshiro; Ide Tomomi; Ichiki Toshihiro; Sunagawa Kenji; Hirano Katsuya
BME, 2013 - A Clock Gene ROR alpha-mediated Regulation of the Activity of Rho-associated Coiled-coil Protein Kinase 2 (ROCK2) Plays a Key Role in Generating Vascular Intrinsic Circadian Rhythm of Myofilament Ca2+ Sensitivity and Vascular Contractility
Toshiro Saito; Mayumi Hirano; Tomomi Ide; Toshihiro Ichiki; Noriyuki Koibuchi; Kenji Sunagawa; Katsuya Hirano
CIRCULATION RESEARCH, Dec. 2012 - ROCK2 plays a key role in the circadian change in thrombin-induced myosin light chain phosphorylation in smooth muscle
Toshiro Saito; Mayumi Hirano; Katsuya Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011 - Identification of Rho-associated Kinase 2 (ROCK2) as a Key Molecule Generating the Intrinsic Circadian Rhythm of Vascular Contractility
Toshiro Saito; Mayumi Hirano; Tomomi Ide; Kenji Sunagawa; Katsuya Hirano
CIRCULATION, Nov. 2010 - Intrinsic circadian oscillation of myosin light chain phosphorylation in vascular smooth muscle cells
Toshiro Saito; Mayumi Hirano; Tomomi Ide; Kenji Sunagawa; Katsuya Hirano
FASEB JOURNAL, Apr. 2010 - The thrombin-induced myosin light chain phosphorylation exhibits an intrinsic circadian oscillation in vascular smooth muscle
Toshiro Saito; Mayumi Hirano; Katsuya Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010
Lectures, oral presentations, etc.
- 冠動脈バイパス術の大伏在静脈グラフト採取において、No-touch法がグラフト血管の長期開存をもたらす機序に関する研究
齊藤寿郎; 藏澄宏之; 鈴木亮; 美甘章仁; 濱野公一
第62回日本平滑筋学会総会, Dec. 2020, [Invited] - The central role of Ulk1-dependent autophagy in mediating mitophagy in the heart during ischemia and reperfusion
Toshiro Saito; Junichi Sadoshima
Annual Meeting of the Physiological Society of Japan, Mar. 2020 - PRMT5-induced Arginine Methylation Mediates Energy Stress-induced Autophagy in the Heart
Risa Mukai; Toshiro Saito; Peiyong Zhai; Junichi Sadoshima
Basic cardiovascular Science Scientific Sessions, Jul. 2019 - ULK1-dependent Mitophagy is Essential for Maintaining Cardiac Function during High Fat Diet-induced Diabetic Cardiomyopathy.
Tong M; Saito T; Zhai P; Oka SI; Sadoshima J
Experimental Biology, Apr. 2019 - Mitophagy is Essential for Maintaining Cardiac Function During High Fat Diet-Induced Diabetic Cardiomyopathy
Mingming Tong; Toshiro Saito; Peiyong Zhai; Shinichi Oka; Wataru Mizushima; Michinaria Nakamura; Junichi Sadoshima
American Heart Association Scientific Sessions, Nov. 2018 - The Molecular Mechanisms of Mitochondrial Degradation in the Stressed Heart.
Sadoshima J; Saito T
The 18th World Congress of Basic and Clinical Pharmacology, Aug. 2018 - Arginine Methylation Through PRMT5 Mediates Energy Stress-Induced Autophagy in the Heart
Risa Mukai; Toshiro Saito; Peiyong Zhai; Junichi Sadoshima
Basic Cardiovascular Science Scientific Sessions, Jul. 2018 - Atg7-Dependent Autophagy is Essential for Maintaining Cardiac Function with High Fat Diet.
Tong M; Saito T; Zhai P; Oka SI; Sadoshima J
Experimental Biology, Apr. 2018 - The central role of Ulk1-dependent autophagy in mediating mitophagy in the heart
Toshiro Saito; Junichi Sadoshima
National Institutes of Health, Autophagy as a Common Pathway in Diseases, Mar. 2018 - Endogenous Parkin is not essential for mitophagy in response to energy stress in the heart.
Toshiro Saito; Junichi Sadoshima
American Heart Association Scientific Sessions, Nov. 2017 - Cardiac-specific deletion of Ulk1, but not Atg7, impairs mitophagy in the heart during ischemia.
Toshiro Saito; Junichi Sadoshima
American Heart Association Scientific Sessions, Nov. 2017 - An Increased Level of Arginine Methylation Correlates With Starvation-induced Autophagy in the Heart
Risa Mukai; Toshiro Saito; Junichi Sadoshima
American Heart Association Scientific Sessions, Nov. 2017 - Ulk1 Induces Mitochondrial Autophagy by Regulating Mitochondrial Fission and Alternative Autophagy in the Heart.
Toshiro Saito; Junichi Sadoshima
International Congress on Innovations in Coronary Artery Disease, Oct. 2017, [Invited] - 圧負荷誘導心不全におけるDrp1依存性ミトコンドリアオートファジーの役割
白壁章宏; 池田義之; 齊藤寿郎; ペヨンザイ; 畑典武; 浅井邦也; 清水渉; 佐渡島順一
第94回日本生理学会大会, Mar. 2017 - Ulk1 Induces Mitochondrial Autophagy by Regulating Mitochondrial Fission and Alternative Autophagy in the Heart.
Toshiro Saito; Yasuhiro Maejima; Sebastiano Sciarretta; Yoshiyuki Ikeda; Peiyong Zhai; Yoshiya Monden; Junichi Sadoshima
American Heart Association Scientific Sessions, Nov. 2016 - Ulk1-Dependent Mitochondrial Autophagy Protects the Heart Against Pressure Overload-Induced Heart Failure
Akihiro Shirakabe; Yoshiyuki Ikeda; Toshiro Saito; Peiyong Zai; Junichi Sadoshima
American Heart Association Scientific Sessions, Nov. 2016 - Autophagy Protects the Heart Against Pressure Overload Induced Heart Failure.
Shirakabe A; Ikeda Y; Saito T; Zhai P; Sadoshima J
Basic cardiovascular Sciences Scientific Sessions, Jul. 2016 - Cardiac-specific ablation of Ulk1, but not that of Atg7, impairs mitochondrial autophagy in the ischemic heart.
Toshiro Saito; Junichi Sadoshima
American Heart Association Scientific Sessions, Nov. 2015 - Ulk1 induces mitochondrial autophagy through Rab9-dependent phagophore formation in cardiomyocytes.
Toshiro Saito; Junichi Sadoshima
American Heart Association Scientific Sessions, Nov. 2015 - Autophagy Protects the Heart Against Pressure Overload Induced Heart Failure
Akihiro Shirakabe; Yoshiyuki Ikeda; Toshiro Saito; Peiyong Zai; Junichi Sadoshima
American Heart Association Scientifc Sessions, Nov. 2015 - Drp1-dependent Mitochondrial Autophagy Plays A Protective Role In Response To Pressure Overload Induced Mitochondrial Dysfunction And Heart Failure
Akihiro Shirakabe; Yoshiyuki Ikeda; Toshiro Saito; Peiyong Zai; Junichi Sadoshima
American Heart Association Scientifc Sessions, Nov. 2015 - Therapeutic Impact of Autophagy-inducing Peptide on Pressure Overload-induced Heart Failure
Akihiro Shirakabe; Yoshiyuki Ikeda; Toshiro Saito; Peiyong Zai; Junichi Sadoshima
American Heart Association Scientific Sessions, Nov. 2015 - Role of the Mitochondrial AAA+ Lon Protease in Cardioprotection
Min Li; Sundararajan Venkatesh; Eman Rashad; Toshiro Saito; Junichi Sadoshima; Carolyn K Suzuki
Basic Cardiovascular Science Scientific Sessions, Jul. 2015 - Drp1 Accumulates in Mitochondria and Plays a Protective Role in the Heart in Response to Pressure Overload
Akihiro Shirakabe; Yoshiyuki Ikeda; Toshiro Saito; Peiyong Zai; Junichi Sadoshima
Basic Cardiovascular Science Scientific Sessions, Jul. 2015 - Ulk1 plays a crucial role in mitochondrial autophagy in cardiomyocytes.
Toshiro Saito; Yoshiya Monden; Junichi Sadoshima
American Heart Association Scientific Sessions, Nov. 2014 - 血管収縮性の内在性概日リズム形成におけるRho-associated kinase 2の役割に関する研究
齊藤 寿郎
日本平滑筋学会総会, Aug. 2014, [Invited] - Unc-51-like Kinase 1 (Ulk1) plays a crucial role in mitochondrial autophagy in cardiomyocytes.
Toshiro Saito; Junichi Sadoshima
Basic Cardiovascular Sciences Scientific Sessions, Jul. 2014 - Vascular Intrinsic Circadian Rhythm of Vascular Contractility Under the Regulation of Clock Gene RORalpha
Toshiro Saito; Tomomi Ide; Toshihiro Ichiki; Kenji Sunagawa; Katsuya Hirano
annual international conference of the IEEE Engineering in Medicine and Biology Society, Jul. 2013 - Rho-associated Coiled-coil Protein Kinase 2 (ROCK2), as a Clock-controlled Gene, Generates the Vascular Intrinsic Circadian Rhythm of Myofilament Ca2+ Sensitivity and Vascular Contractility
Toshiro Saito; Mayumi Hirano; Tomomi Ide; Toshihiro Ichiki; Noriyuki Koibuchi; Kenji Sunagawa; Katsuya Hirano
日本循環器学会学術集会, Mar. 2013 - A Clock Gene RORalpha-mediated Regulation of the Activity of Rho-associated Coiled-coil Protein Kinase 2 (ROCK2) Plays a Key Role in Generating Vascular Intrinsic Circadian Rhythm of Myofilament Ca2+ Sensitivity and Vascular Contractility
Toshiro Saito; Mayumi Hirano; Tomomi Ide; Toshihiro Ichiki; Noriyuki Koibuchi; Kenji Sunagawa; Katsuya Hirano
American Heart Association Late-Breaking Basic Science, Nov. 2012 - ROCK2 plays a key role in the circadian change in thrombin-induced myosin light chain phosphorylation in smooth muscle
Toshiro Saito; Mayumi Hirano; Katsuya Hirano
日本薬理学会年会, Mar. 2011 - Identification of Rho-associated kinase 2 (ROCK2) as a Key Molecule Generating the Intrinsic Circadian Rhythm of Vascular Contractility.
Toshiro Saito; Mayumi Hirano; Tomomi Ide; Kenji Sunagawa; Katsuya Hirano
American Heart Association Scientific Sessions, Nov. 2010 - Rho kinase Plays a Key Role in the Vascular Intrinsic Clock System that Generates the Circadian Change in Smooth Muscle Contractility
Toshiro Saito; Mayumi Hirano; Tomomi Ide; Kenji Sunagawa; Katsuya Hirano
The International Conference of the Cardiovascular System Dynamics Society, Sep. 2010 - Intrinsic Circadian Oscillation of Myosin Light Chain Phosphorylation in Vascular Smooth Muscle Cell.
Toshiro Saito; Mayumi Hirano; Tomomi Ide; Kenji Sunagawa; Katsuya Hirano
Experimental Biology, Mar. 2010 - The thrombin-induced myosin light chain phosphorylation exhibits an intrinsic circadian oscillation in vascular smooth muscle
Toshiro Saito; Mayumi Hirano; Katsuya Hirano
日本薬理学会年会, Mar. 2010
Affiliated academic society
Research Themes
- Ulk1-Rab9 経路を標的とした、虚血性心疾患に対する新規治療戦略の開発
Nov. 2019 - Oct. 2021 - 虚血性心疾患におけるミトコンドリアのautophagy (mitophagy)の分子機構解明と、これに介入する新規治療法開発
Feb. 2019 - Jan. 2021 - mitophagyの選択的な誘導による、虚血性心疾患に対する新規治療戦略の開発
Oct. 2019 - Sep. 2020 - A new therapeutic strategy targeting autophagy/mitophagy in the
Oct. 2018 - Sep. 2020 - 虚血性心疾患のmitophagy（ミトコンドリアのオートファジー）に関する研究
Feb. 2019 - Jan. 2020 - ULK1 induces mitochondrial autophagy through activation of Drp1.
Jul. 2016 - Jun. 2018 - ミトコンドリアを標的とした、心不全および老化の病態解明と新規治療法の開発
Mar. 2013
