Last Updated :2024/09/11
Researcher Information
Research activity information
Paper
- Effects of Lomerizine and Its Metabolite on Glioblastoma Cells.
Yuki Uemichi; Miyuki Mabuchi; Natsumi Tsuchiya; Seina Yasuda; Shuhei Nakao; Tadashi Shimizu
Anticancer research, Jul. 2024, [Reviewed] - Synergistic combination effect of the PCA-1/ALKBH3 Inhibitor HUHS015 on prostate cancer drugs in vitro and in vivo
MIYUKI MABUCHI; KAZUTAKE TSUJIKAWA; AKITO TANAKA
Anti-cancer drugs, 2024, [Reviewed]
Lead - 日本人がん疼痛患者におけるメサドンの血中濃度測定および早期効果判定の可能性に関する検討
中村 豪志; 棚田 大輔; 岡村 佐紀; 乾 貴絵; 土井 陽子; 宮脇 弘樹; 廣瀬 宗孝; 木村 健; 清水 忠; 田中 明人; 馬渕 美雪
2021, [Reviewed]
Last - Identification of HUHS190, a human naftopidil metabolite, as a novel anti-bladder cancer drug.
Shimizu Tadashi; Yamaguchi Keiko; Yamamoto Momoka; Kurioka Rina; Kino Yukari; Matsunaga Wataru; Nakao Syuhei; Fukuhara Hiroshi; Tanaka Akito; Gotoh Akinobu; Mabuchi Miyuki
Bioorganic & medicinal chemistry letters, Jan. 2020, [Reviewed]
Last - Selective Degradation of Splicing Factor CAPERα by AnticancerSulfonamides
上原 泰介; 箕嶋 幸範; 相根 康司; 杉 直子; 三橋 薫; 山本 昇; 神山 洋; 高橋 健太郎; 小竹 良彦; 上杉 麻依; 横井 晃; 井上 篤; 吉田 卓; 馬渕 美雪; 田中 明人; 大和 隆志
日本プロテオーム学会大会要旨集, 2018 - Novel Metabolically Stable PCA-1/ALKBH3 Inhibitor Has Potent Antiproliferative Effects on DU145 Cells In Vivo.
Ueda Masahiro; Shimizu Tadashi; Mabuchi Miyuki; Horiike Kota; Kitae Kaori; Hase Hiroaki; Ueda Yuko; Tsujikawa Kazutake; Tanaka Akito
Anticancer research, Jan. 2018, [Reviewed] - Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor.
Nakao Syuhei; Mabuchi Miyuki; Wang Shenglan; Kogure Yoko; Shimizu Tadashi; Noguchi Koichi; Tanaka Akito; Dai Yi
Bioorganic & medicinal chemistry letters, Jul. 2017, [Reviewed] - Selective degradation of splicing factor CAPERα by anticancer sulfonamides.
Uehara Taisuke; Minoshima Yukinori; Sagane Koji; Sugi Naoko Hata; Mitsuhashi Kaoru Ogawa; Yamamoto Noboru; Kamiyama Hiroshi; Takahashi Kentaro; Kotake Yoshihiko; Uesugi Mai; Yokoi Akira; Inoue Atsushi; Yoshida Taku; Mabuchi Miyuki; Tanaka Akito; Owa Takashi
Nature chemical biology, Jun. 2017, [Reviewed] - Systematic Trial for Evaluating Docetaxel in a Human Prostate Cancer Cell DU145 Xenograft Model.
Mabuchi Miyuki; Ueda Masahiro; Yoshida Yuri; Horiike Kota; Yamaoka Kenta; Nakao Syuhei; Shimizu Tadashi; Ueda Yuko; Tsujikawa Kazutake; Tanaka Akito
Anticancer research, Apr. 2017, [Reviewed]
Lead - A Naphthalimide-Based Cd(2+) Fluorescent Probe with Carbamoylmethyl Groups Working as Chelators and PET-Promoters under Neutral Conditions.
Tsukamoto Koji; Shimabukuro Shota; Mabuchi Miyuki; Maeda Hatsuo
Chemistry (Weinheim an der Bergstrasse, Germany), Jun. 2016, [Reviewed] - Identification and purification of target protein using affinity resin bearing a photo-labile linker.
Mabuchi Miyuki; Shimizu Tadashi; Haramura Masayuki; Tanaka Akito
Bioorganic & medicinal chemistry letters, Aug. 2015, [Reviewed]
Lead - Improvement of solid material for affinity resins by application of long PEG spacers to capture the whole target complex of FK506.
Mabuchi Miyuki; Shimizu Tadashi; Ueda Masahiro; Mitamura Kuniko; Ikegawa Shigeo; Tanaka Akito
Bioorganic & medicinal chemistry letters, Jul. 2015, [Reviewed]
Lead - Development of versatile solid material for affinity resins and its application for the target identification of bioactive compounds
田中 明人; 馬渕 美雪; 清水 忠
Feb. 2015, [Reviewed] - Improving the bioavailability and anticancer effect of the PCA-1/ALKBH3 inhibitor HUHS015 using sodium salt.
Mabuchi Miyuki; Shimizu Tadashi; Ueda Masahiro; Sasakawa Yuka; Nakao Syuhei; Ueda Yuko; Kawamura Akio; Tsujikawa Kazutake; Tanaka Akito
In vivo (Athens, Greece), 2015, [Reviewed]
Lead - DCP-LA Activates Cytosolic PKCε by Interacting with the Phosphatidylserine Binding/Associating Sites Arg50 and Ile89 in the C2-Like Domain.
Kanno Takeshi; Tsuchiya Ayako; Shimizu Tadashi; Mabuchi Miyuki; Tanaka Akito; Nishizaki Tomoyuki
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2015, [Reviewed] - Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs.
Nakao Syuhei; Mabuchi Miyuki; Shimizu Tadashi; Itoh Yoshihiro; Takeuchi Yuko; Ueda Masahiro; Mizuno Hiroaki; Shigi Naoko; Ohshio Ikumi; Jinguji Kentaro; Ueda Yuko; Yamamoto Masatatsu; Furukawa Tatsuhiko; Aoki Shunji; Tsujikawa Kazutake; Tanaka Akito
Bioorganic & medicinal chemistry letters, Feb. 2014, [Reviewed] - Selective elution of target protein from affinity resins by a simple reductant with a thiol group.
Mabuchi Miyuki; Haramura Masayuki; Shimizu Tadashi; Nishizaki Tomoyuki; Tanaka Akito
Bioorganic & medicinal chemistry letters, Dec. 2010, [Reviewed]
Lead - Ameliorating effect of FK614, a novel nonthiazolidinedione peroxisome proliferator-activated receptor gamma agonist, on insulin resistance in Zucker fatty rat.
Minoura Hideaki; Takeshita Shigeru; Yamamoto Tadashi; Mabuchi Miyuki; Hirosumi Jiro; Takakura Shoji; Kawamura Ikuo; Seki Jiro; Manda Toshitaka; Ita Makoto; Mutoh Seitaro
European journal of pharmacology, Sep. 2005, [Reviewed] - Pharmacological characteristics of a novel nonthiazolidinedione insulin sensitizer, FK614.
Minoura Hideaki; Takeshita Shigeru; Ita Makoto; Hirosumi Jiro; Mabuchi Miyuki; Kawamura Ikuo; Nakajima Satoko; Nakayama Osamu; Kayakiri Hiroshi; Oku Teruo; Ohkubo-Suzuki Akiko; Fukagawa Masao; Kojo Hitoshi; Hanioka Kenichi; Yamasaki Noritsugu; Imoto Takafumi; Kobayashi Yoshinori; Mutoh Seitaro
European journal of pharmacology, Jun. 2004, [Reviewed] - Choleretic actions of insulin-like growth factor-I, prednisolone, and ursodeoxycholic acid in rats.
Mabuchi Miyuki; Kawamura Ikuo; Fushimi Mariko; Takeshita Shigeru; Takakura Shoji; Hirosumi Jiro; Mutoh Seitaro
Digestive diseases and sciences, Jul. 2003, [Reviewed]
Lead - Insulin-like growth factor-I enhances choleretic action of FK506 in rats
M. Mabuchi; I. Kawamura; S. Takeshita; M. Fushimi; S. Takakura; J. Hirosumi; S. Mutoh
Transplantation Proceedings, Jun. 2003, [Reviewed]
Lead - Induction of choleresis by immunosuppressant FK506 through stimulation of insulin-like growth factor-I production in the liver of rats.
Kawamura I; Takeshita S; Fushimi M; Mabuchi M; Seki J; Goto T
European journal of pharmacology, May 2001, [Reviewed] - Induction of bone loss by bile duct ligation in rats.
Mabuchi M; Kawamura I; Fushimi M; Inoue T; Takeshita S; Takakura S; Matsuo M; Tomoi M; Goto T
In vivo (Athens, Greece), 2001, [Reviewed]
Lead - Lesser reduction in bone mineral density by the immunosuppressant, FK506, compared with cyclosporine in rats.
Inoue T; Kawamura I; Matsuo M; Aketa M; Mabuchi M; Seki J; Goto T
Transplantation, Sep. 2000, [Reviewed] - Stimulation of choleresis by insulin-like growth factor-I in rats.
Kawamura I; Takeshita S; Fushimi M; Mabuchi M; Seki J; Tomoi M; Goto T
Endocrine journal, Jun. 2000, [Reviewed]
Research Themes
- Search for novel malaria therapeutic agents targeting erythrocytic-stage malaria parasites that are also effective against drug-resistant strains
Mar. 2025 - 病原性メモリーTh2細胞を標的とした難治性アレルギー治療薬の探索
Apr. 2021 - Mar. 2024 - 熱帯熱マラリア原虫が感染可能なヒト化 マウスの作出と新規抗マラリア化合物の 効果判定
Apr. 2020 - Mar. 2021 - 新規抗マラリア薬の探索（MALCPX）
Jan. 2017 - Dec. 2018 - SH-2251 をシード化合物としたアレルギ ー性炎症新規治療戦略の確立
Apr. 2017 - Mar. 2018 - Drug discovery research for clinical application of PCA-1 inhibitors
Grant-in-Aid for Scientific Research (C)
Hyogo University of Health Sciences
Apr. 2015 - Mar. 2018 - 次世代の創薬戦略開拓を目指したユビキ チン-プロテアソームシステム利用による 選択的ターゲットタンパク分解誘導化合 物の創製
2017 - 2018 - PCA-1を分子標的とするfirst-in-classのがん治療創薬
Apr. 2015 - Mar. 2017 - タクロリムス水和物誘導体のデザインと 合成
2015 - 「AquaFirmus beadsなどを用いた生理活性物質への結合蛋白質の同定に関わる技術指導および本化合物への結合蛋白質の同定」に関する研究
2013 - 2014 - ヒドロキシ酢酸のターゲット分子の探索
2009 - 2012 - 自動生細胞数カウント装置の研究と開発
2010 - 2011 - ”siRNAライブラリー等を用いた生物機能制御遺伝子の探索技術及び創薬標的検証技術の研究開発”の再委託
2009 - 2010 - アフィニティ樹脂を用いた化合物KP423のターゲット分子の探索
2009
