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平成 6年 群馬大学医学部附属病院 研修医（皮膚科）
平成 8年 群馬大学大学院 進学
平成10年 東京農工大学農学部附属家畜病院 国内留学
平成11年 米国バージニア州立大学内科学リウマチ・アレルギー分野 留学
平成13年 京都大学医学部附属病院 助手（皮膚科）
平成19年 千葉大学大学院医学研究院 講師，ついで准教授（皮膚科）
平成27年 関西医科大学 准教授（皮膚科），附属病院アレルギーセンター 副センター長（兼任）
令和 2年 京都大学附属病院 特定准教授，ついで大学院医学研究科 准教授（皮膚科），特定教授（難治性疾患研究事業）および京都大学附属病院アレルギーセンター 副センター長（兼任）令和 8年 現職
Last Updated :2026/05/19
Researcher Information
Research activity information
Paper
- 〔Major achievements〕Schnitzler Syndrome as an Autoinflammatory Disease Driven by B‐Cell‐Specific Somatic
MYD88 Mutation
Yuyi Zhou; Yoko Ueki; Naoya Iwata; Hiroshi Oue; Kentaro Kato; Mengyan Li; Kazushi Izawa; Tomoyasu Jo; Seishi Ogawa; Kenji Kabashima; Naotomo Kambe
Allergy, Apr. 2026, [Reviewed]
Last - Interleukin-1: from discovery to therapeutic targeting of the first cytokine
Lori Broderick; Naotomo Kambe; Hal M. Hoffman
Allergology International, Apr. 2026, [Reviewed], [Invited] - A peripheral neurons-basophil axis drives heat-killed Staphylococcus aureus-induced dermatitis via TLR2 signaling pathway.
Hiroyuki Irie; Chisa Nakashima; Yoshihiro Ishida; Naomi Kitayama; Masahiro Hirata; Tatsuki R Kataoka; Toshiya Miyake; Ryota Asahina; Toshiaki Kogame; Satoshi Nakamizo; Saeko Nakajima; Gyohei Egawa; Takashi Nomura; Osamu Takeuchi; Masato Kubo; Naotomo Kambe; Atsushi Otsuka; Kenji Kabashima
The Journal of investigative dermatology, Feb. 2026, [Reviewed] - BCL-6-Positive Cutaneous Mantle Zone Hyperplasia: A Novel Subtype of B-Cell Cutaneous Lymphoid Hyperplasia.
Atsushi Naito; Hiroyuki Irie; Masakazu Fujimoto; Satoshi Nakamizo; Naotomo Kambe; Hironori Haga; Kenji Kabashima
Journal of cutaneous pathology, Jul. 2025, [Reviewed] - Psoriasiform Dermatitis Following Kawasaki Disease: A Case Report and Literature Review
Shota Nakayama; Naotomo Kambe; Hiroyuki Irie; Kazushi Izawa; Ryohei Nishijima; Hiroo Ueno; Masakazu Fujimoto; Takahiro Yasumi; Kenji Kabashima
Pediatric Dermatology, Jul. 2025, [Reviewed] - A case of non‐uremic calciphylaxis in a patient with secondary hyperparathyroidism and panhypopituitarism
Atsushi Naito; Saeko Nakajima; Hiroaki Nakano; Kohdai Furuta; Hiroyuki Irie; Takuro Hakata; Ichiro Yamauchi; Masakazu Fujimoto; Naotomo Kambe; Kenji Kabashima
The Journal of Dermatology, Jun. 2025, [Reviewed] - 〔Major achievements〕Neutrophils predominate as IL1B-expressing cells in Schnitzler syndrome: Insights from the SCan study to evaluate the efficacy and safety of canakinumab in Japanese patients.
Naotomo Kambe; Norimitsu Inoue; Yoko Ueki; Yuyi Zhou; Satoru Yonekura; Kosuke Katsuo; Satoshi Nakamizo; Hiroshi Tsujimoto; Katsuki Ohtani; Hajime Yoshifuji; Tomoyasu Jo; Kazushi Izawa; Mayuko Yamamoto; Koji Takemura; Shin-Ichiro Kagami; Yoshie Kawahara; Yoko Amino; Yumiko Ibi; Satoshi Morita; Nobuo Kanazawa
Allergology international, May 2025, [Reviewed]
Lead - A case of refractory alopecia areata successfully treated by combining delgocitinib ointment with excimer laser
Yukito Kakeji; Toshiaki Kogame; Yosuke Yagi; Naotomo Kambe; Kenji Kabashima
Skin Health and Disease, May 2025, [Reviewed] - Consideration of useful patient-reported outcome measures to identify unmet medical needs of children and adults with autoimmune and autoinflammatory diseases.
Shuji Sumitomo; Toru Hirano; Akinori Moriichi; Yuzaburo Inoue; Hidehiko Narazaki; Mitsuyo Inoue; Naoto Yokogawa; Naotomo Kambe; Tomoyuki Mukai; Kazushi Izawa; Dai Kishida; Hajime Yoshifuji; Ken Yamaji; Ryuta Nishikomori; Masaaki Mori; Takako Miyamae
Modern rheumatology, Apr. 2025, [Reviewed] - 〔Major achievements〕Investigator-initiated, multi-center, single-arm, open-label study of the effectiveness of canakinumab in Japanese patients with Schnitzler syndrome
Naotomo Kambe; Mayuko Yamamoto; Koji Takemura; Shin-ichiro Kagami; Yoshie Kawahara; Hajime Yoshifuji; Tomoyasu Jo; Kazushi Izawa; Satoshi Nakamizo; Norimitsu Inoue; Tatsuya Ito; Yoko Amino; Yumiko Ibi; Satoshi Morita; Nobuo Kanazawa
Allergology International, Apr. 2025, [Reviewed]
Lead - Basophil-Derived IL-4 Production and Its Potential Pro-Tumoural Role in Th2-Polarisation Within Sentinel Lymph Nodes of Primary Cutaneous Melanoma.
Aki Tajima; Fumikazu Yamazaki; Izumi Kishimoto; Ni Ma; Noriko Kume; Andrew F Walls; Naotomo Kambe; Hideaki Tanizaki
Experimental dermatology, Jan. 2025, [Reviewed] - 〔Major achievements〕The decrease in peripheral blood basophils in a mouse model of IgE-induced inflammation involves their migration to lymph nodes.
Ni Ma; Izumi Kishimoto; Aki Tajima; Noriko Kume; Naotomo Kambe; Hideaki Tanizaki
Journal of dermatological science, Nov. 2024, [Reviewed]
Corresponding - Proteasome inhibitor‐associated histiocytoid Sweet's syndrome: Clinical and histological similarities to Nakajo‐Nishimura syndrome suggest a potential mechanism
Ryang Cho; Saeko Nakajima; Yo Kaku; Junko Tezuka; Masakazu Fujimoto; Naotomo Kambe; Kenji Kabashima
The Journal of Dermatology, Oct. 2024, [Reviewed] - Presence of immunoglobulin E‐expressing antibody‐secreting cells in the dermis close to bullous pemphigoid lesions
Fatimah Budair; Naotomo Kambe; Toshiaki Kogame; Masahiro Hirata; Riko Takimoto‐Ito; Alshimaa Mostafa; Takashi Nomura; Kenji Kabashima
Experimental Dermatology, Apr. 2024, [Reviewed] - A case of post herpes zoster granulomatous dermatitis successfully treated with UVA1 phototherapy
Atsushi Naito; Toshiaki Kogame; Naotomo Kambe; Kenji Kabashima
The Journal of Dermatology, Apr. 2024, [Reviewed] - Neutrophilic epitheliotropism, proposed as an auto‐inflammatory condition of neutrophilic urticarial dermatosis including Schnitzler syndrome, is also observed in Japanese cases
Hitomi Nakaizumi; Naotomo Kambe; Hiroyuki Irie; Yo Kaku; Masakazu Fujimoto; Hajime Yoshifuji; Yasuhiro Kazuma; Kazumoto Katagiri; Takuro Kanekura; Kenji Kabashima
The Journal of Dermatology, Apr. 2024, [Reviewed]
Corresponding CYP4F22 p.V215D is a novel variant causative for lamellar ichthyosis
Yoshihiro Ishida; Kazuko Saeki; Marina Ueda; Hyeon‐Cheol Lee‐Okada; Hiromi Doi; Naotomo Kambe; Saeko Nakajima; Takehiko Yokomizo; Kenji Kabashima
Journal of the European Academy of Dermatology and Venereology, Dec. 2023, [Reviewed]- Activation of the pentose phosphate pathway in macrophages is crucial for granuloma formation in sarcoidosis.
Satoshi Nakamizo; Yuki Sugiura; Yoshihiro Ishida; Yoko Ueki; Satoru Yonekura; Hideaki Tanizaki; Hiroshi Date; Akihiko Yoshizawa; Teruasa Murata; Kenji Minatoya; Mikako Katagiri; Seitaro Nomura; Issei Komuro; Seishi Ogawa; Saeko Nakajima; Naotomo Kambe; Gyohei Egawa; Kenji Kabashima
The Journal of clinical investigation, Dec. 2023, [Reviewed] - Human RELA dominant-negative mutations underlie type I interferonopathy with autoinflammation and autoimmunity.
Kunihiko Moriya; Tomohiro Nakano; Yoshitaka Honda; Miyuki Tsumura; Masato Ogishi; Motoshi Sonoda; Masahiko Nishitani-Isa; Takashi Uchida; Mohamed Hbibi; Yoko Mizoguchi; Masataka Ishimura; Kazushi Izawa; Takaki Asano; Fumihiko Kakuta; Daiki Abukawa; Darawan Rinchai; Peng Zhang; Naotomo Kambe; Aziz Bousfiha; Takahiro Yasumi; Bertrand Boisson; Anne Puel; Jean-Laurent Casanova; Ryuta Nishikomori; Shouichi Ohga; Satoshi Okada; Yoji Sasahara; Shigeo Kure
The Journal of experimental medicine, Sep. 2023, [Reviewed] - A case of Kimura disease with atopic dermatitis successfully treated with baricitinib
Marina Ueda; Toshiaki Kogame; Gyohei Egawa; Naotomo Kambe; Kenji Kabashima
The Journal of Dermatology, Jun. 2023, [Reviewed] - Interleukin-13 inhibition by tralokinumab reduces inducible T-cell costimulator-positive innate lymphoid cells in skin lesions of atopic dermatitis.
Toshiaki Kogame; Satoru Yonekura; Paola Lovato; Masahiro Hirata; Riko Takimoto-Ito; Tomoya Takegami; Takayoshi Komatsu-Fujii; Naotomo Kambe; Takashi Nomura; Mads A Røpke; Kenji Kabashima
The British journal of dermatology, Jan. 2023, [Reviewed] - Tofacitinib, a suppressor of NOD2 expression, is a potential treatment for Blau syndrome.
Yoko Ueki; Riko Takimoto-Ito; Megumu K Saito; Hideaki Tanizaki; Naotomo Kambe
Frontiers in immunology, 2023, [Reviewed]
Last - 〔Major achievements〕Summary of the current status of clinically diagnosed cases of Schnitzler syndrome in Japan
Riko Takimoto-Ito; Naotomo Kambe; Toshiaki Kogame; Takashi Nomura; Kazushi Izawa; Tomoyasu Jo; Yasuhiro Kazuma; Hajime Yoshifuji; Yuya Tabuchi; Hiroyasu Abe; Mayuko Yamamoto; Kimiko Nakajima; Ozumi Tomita; Yosuke Yagi; Kazumoto Katagiri; Yuki Matsuzaka; Yohei Takeuchi; Miho Hatanaka; Takuro Kanekura; Sora Takeuchi; Takafumi Kadono; Yuya Fujita; Kiyoshi Migita; Takahiro Fujino; Takahiko Akagi; Tomoyuki Mukai; Tohru Nagano; Mitsuhiro Kawano; Hayato Kimura; Yukari Okubo; Akimichi Morita; Michihiro Hide; Takahiro Satoh; Akihiko Asahina; Nobuo Kanazawa; Kenji Kabashima
Allergology International, Dec. 2022, [Reviewed]
Corresponding - Ten-year-format diary of fever episodes kept over a five-year period by a patient with familial Mediterranean fever.
Naotomo Kambe; Riko Takimoto-Ito; Kenji Kabashima
Clinical and experimental rheumatology, Nov. 2022, [Reviewed]
Lead - Incomplete penetrance of NOD2 C483W mutation underlining Blau syndrome.
Shao-Yu Chang; Naotomo Kambe; Wen-Lang Fan; Jing-Long Huang; Wen-I Lee; Chao-Yi Wu
Pediatric rheumatology online journal, Oct. 2022, [Reviewed] - Anti-BP180, pruritus, and thymus and activation-regulated chemokines as surrogate markers for disease activity in bullous pemphigoid.
S Wada; T Komori; C S de Jesus; T Nomura; T Komura; S Yonekura; R Shibuya; E Adachi; Y Sakurai; M Ishikawa; S Usui; N Kambe; K Kabashima
Journal of the European Academy of Dermatology and Venereology : JEADV, Jul. 2022, [Reviewed] - Panniculitis in dermatomyositis: Two cases with antitranscriptional intermediary factor‐1 antibody as myositis‐specific antibody and review of the literature
Kaori Takezawa; Ikuko Ueda‐Hayakawa; Akihiro Tanaka; Yonsu Son; Fumikazu Yamazaki; Naotomo Kambe; Hiroyuki Okamoto; Manabu Fujimoto
Journal of Cutaneous Immunology and Allergy, Jun. 2022 - Acquired idiopathic generalized anhidrosis following pembrolizumab treatment
K. Furuta; A. Horiguchi; Y. Nakagawa; N. Kambe; T. Kogame
Clinical and Experimental Dermatology, Feb. 2022 - Blau症候群孤発例の長期経過中に非交通性水頭症を併発した1例
出口 晶子; 岩佐 直毅; 尾崎 麻希; 眞野 智生; 桐山 敬生; 中瀬 健太; 神戸 直智; 金澤 伸雄; 中瀬 裕之; 杉江 和馬
臨床神経学, Jan. 2022 - A New Era with the Development of Cytokine-Based Therapy for Pruritus.
Rintaro Shibuya; Riko Takimoto-Ito; Naotomo Kambe; Kenji Kabashima
The Journal of investigative dermatology, Jan. 2022, [Reviewed], [Invited]
Corresponding - The Potential Role of Basophils in Urticaria.
Riko Takimoto-Ito; Ni Ma; Izumi Kishimoto; Kenji Kabashima; Naotomo Kambe
Frontiers in immunology, 2022, [Reviewed], [Invited]
Corresponding - 〔Major achievements〕Decreased peripheral basophil counts in urticaria and mouse model of oxazolone-induced hypersensitivity, the latter suggesting basopenia reflecting migration to skin.
Izumi Kishimoto; Ni Ma; Riko Takimoto-Ito; Chisa Nakashima; Atsushi Otsuka; Andrew F Walls; Hideaki Tanizaki; Naotomo Kambe
Frontiers in immunology, 2022, [Reviewed]
Last - 〔Major achievements〕Potential Benefits of TNF Targeting Therapy in Blau Syndrome, a NOD2-Associated Systemic Autoinflammatory Granulomatosis.
Tomoko Matsuda; Naotomo Kambe; Riko Takimoto-Ito; Yoko Ueki; Satoshi Nakamizo; Megumu K Saito; Syuji Takei; Nobuo Kanazawa
Frontiers in immunology, 2022, [Reviewed], [Invited]
Corresponding - Assessment of type I interferon signatures in undifferentiated inflammatory diseases: A Japanese multicenter experience.
Takayuki Miyamoto; Yoshitaka Honda; Kazushi Izawa; Nobuo Kanazawa; Saori Kadowaki; Hidenori Ohnishi; Masakazu Fujimoto; Naotomo Kambe; Naoya Kase; Takeshi Shiba; Yasuo Nakagishi; Shuji Akizuki; Kosaku Murakami; Masahiro Bamba; Yutaka Nishida; Ayano Inui; Tomoo Fujisawa; Daisuke Nishida; Naomi Iwata; Yoshikazu Otsubo; Shingo Ishimori; Momoko Nishikori; Kiminobu Tanizawa; Tomoyuki Nakamura; Takeshi Ueda; Yoko Ohwada; Yu Tsuyusaki; Masaki Shimizu; Takasuke Ebato; Kousho Iwao; Akiharu Kubo; Toshinao Kawai; Tadashi Matsubayashi; Tatsuhiko Miyazaki; Tomohiro Kanayama; Masahiko Nishitani-Isa; Hiroshi Nihira; Junya Abe; Takayuki Tanaka; Eitaro Hiejima; Satoshi Okada; Osamu Ohara; Megumu K Saito; Junko Takita; Ryuta Nishikomori; Takahiro Yasumi
Frontiers in immunology, 2022, [Reviewed] - Refractory serum immunoglobulin M elevation during anti‐interleukin (IL)‐1‐ or IL‐6‐targeted treatment in four patients with Schnitzler syndrome
Riko Takimoto‐Ito; Naotomo Kambe; Toshiaki Kogame; Atsushi Otsuka; Takashi Nomura; Kazushi Izawa; Yuya Tabuchi; Hajime Yoshifuji; Yohei Takeuchi; Kenji Kabashima
The Journal of Dermatology, Nov. 2021, [Reviewed]
Corresponding - Advances in the pathophysiology of atopic dermatitis revealed by novel therapeutics and clinical trials.
Xiaoliang Yang; Naotomo Kambe; Riko Takimoto-Ito; Kenji Kabashima
Pharmacology & therapeutics, Aug. 2021, [Reviewed], [Invited]
Corresponding - Skin‐associated lymphoid tissue could be a sign of systemic disease: reply from authors
T. Kogame; N. Kambe; R. Takimoto‐Ito; T. Nomura; K. Kabashima
British Journal of Dermatology, Jul. 2021, [Reviewed], [Invited] - Hereditary angioedema with a novel mutation, c.1481G>C, in the SERPING1 gene
Riko Takimoto‐Ito; Naotomo Kambe; Kazushi Izawa; Takahiro Yasumi; Kenji Kabashima
Journal of Cutaneous Immunology and Allergy, Jun. 2021, [Reviewed]
Corresponding - Inducible skin‐associated lymphoid tissue (iSALT) in a patient with Schnitzler syndrome who manifested wheals on recurrent localized erythema
H. Kamido; D. Shimomiya; T. Kogame; R. Takimoto‐Ito; T.R. Kataoka; M. Hirata; C. Ueshima; A. Otsuka; F.M. Ghazawi; T. Nomura; N. Kambe; K. Kabashima
British Journal of Dermatology, Jun. 2021, [Reviewed] - 〔Major achievements〕Anti-TNF treatment corrects IFN-γ–dependent proinflammatory signatures in Blau syndrome patient–derived macrophages
Yohko Kitagawa; Yuri Kawasaki; Yuichi Yamasaki; Naotomo Kambe; Syuji Takei; Megumu K. Saito
Journal of Allergy and Clinical Immunology, Jun. 2021, [Reviewed] - Sustained Surface ICAM-1 Expression and Transient PDGF-B Production by Phorbol Myristate Acetate-Activated THP-1 Cells Harboring Blau Syndrome-Associated NOD2 Mutations.
Mizuho Nishiyama; Hong-Jin Li; Ikuo Okafuji; Akihiko Fujisawa; Mizue Ehara; Naotomo Kambe; Fukumi Furukawa; Nobuo Kanazawa
Children (Basel, Switzerland), Apr. 2021, [Reviewed] - NOD2 Mutation-Associated Case with Blau Syndrome Triggered by BCG Vaccination.
Akiko Arakawa; Naotomo Kambe; Ryuta Nishikomori; Akiyo Tanabe; Masamichi Ueda; Chikako Nishigori; Yoshiki Miyachi; Nobuo Kanazawa
Children (Basel, Switzerland), Feb. 2021, [Reviewed] - CCL2‒CCR2 Signaling in the Skin Drives Surfactant-Induced Irritant Contact Dermatitis through IL-1β‒Mediated Neutrophil Accumulation
Rintaro Shibuya; Yoshihiro Ishida; Sho Hanakawa; Tatsuki R. Kataoka; Yasuhide Takeuchi; Teruasa Murata; Arisa Akagi; Zachary Chow; Toshiaki Kogame; Satoshi Nakamizo; Saeko Nakajima; Gyohei Egawa; Takashi Nomura; Naotomo Kambe; Akihiko Kitoh; Kenji Kabashima
Journal of Investigative Dermatology, 2021, [Reviewed] - 〔Major achievements〕Clinicopathological and molecular features of hereditary leiomyomatosis and renal cell cancer-associated renal cell carcinomas
Mitsuko Furuya; Yasuhiro Iribe; Yoji Nagashima; Naotomo Kambe; Chisato Ohe; Hidefumi Kinoshita; Chika Sato; Takeshi Kishida; Yoichiro Okubo; Kazuyuki Numakura; Hiroshi Nanjo; Noboru Nakaigawa; Kazuhide Makiyama; Hisashi Hasumi; Hiromichi Iwashita; Junichi Ohta; Hiroshi Kitamura; Takahiko Nakajima; Takahiro Yoshida; Masahiro Nakagawa; Reiko Tanaka; Masahiro Yao
Journal of Clinical Pathology, Dec. 2020, [Reviewed] - Hailey–Hailey disease with a novel variant, c.1978dupG, in the ATP2C1 gene
S. Itsukage; N. Kambe; Y. Ueki; C. Sato; H. Nakano
Clinical and Experimental Dermatology, Oct. 2020, [Reviewed]
Corresponding - Blau Syndrome: NOD2-related systemic autoinflammatory granulomatosis.
Sanami Takada; Megumu K Saito; Naotomo Kambe
Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, Oct. 2020, [Reviewed], [Invited]
Last - 〔Major achievements〕Clinical characteristics and treatment of 50 cases of Blau syndrome in Japan confirmed by genetic analysis of the NOD2 mutation.
Tomoko Matsuda; Naotomo Kambe; Yoko Ueki; Nobuo Kanazawa; Kazushi Izawa; Yoshitaka Honda; Atsushi Kawakami; Syuji Takei; Kyoko Tonomura; Masami Inoue; Hiroko Kobayashi; Ikuo Okafuji; Yoshihiko Sakurai; Naoki Kato; Yuta Maruyama; Yuzaburo Inoue; Yoshikazu Otsubo; Teruhiko Makino; Satoshi Okada; Ichiro Kobayashi; Masato Yashiro; Shusaku Ito; Hiroshi Fujii; Yasuhiro Kondo; Nami Okamoto; Shuichi Ito; Naomi Iwata; Utako Kaneko; Mototsugu Doi; Junichi Hosokawa; Osamu Ohara; Megumu K Saito; Ryuta Nishikomori
Annals of the rheumatic diseases, Jul. 2020, [Reviewed]
Corresponding - Mastocytosis with sudden recurrence of rash after a 13-year interval.
Kaori Takezawa; Naotomo Kambe; Yoko Ueki; Saeko Nakajima; Hiroyuki Okamoto
The Journal of dermatology, Apr. 2020, [Reviewed] - Circulating intermediate monocytes produce TARC in sarcoidosis
Izumi Kishimoto; Chuyen Thi Hong Nguyen; Naotomo Kambe; Nhung Thi My Ly; Yoko Ueki; Ikuko Ueda-Hayakawa; Hiroyuki Okamoto
Allergology International, Apr. 2020, [Reviewed]
Corresponding - Spectrum of Genetic Autoinflammatory Diseases Presenting with Cutaneous Symptoms.
Hanna Bonnekoh; Monique Butze; Tilmann Kallinich; Naotomo Kambe; Georgios Kokolakis; Karoline Krause
Acta dermato-venereologica, Mar. 2020, [Reviewed] - Herpes zoster with acute encephalomyelitis: A case report
Yoko Ueki; Ikuko Ueda; Noriko Kume; Fumikazu Yamazaki; Naotomo Kambe; Hiroyuki Okamoto; Satoshi Morise; Masataka Nakamura
Skin Research, 2020 - Successful treatment with hydroxychloroquine for systemic lupus erythematosus with cutaneous involvement accompanied by a xanthomatous reaction
Takezawa, K.; Ueda-Hayakawa, I.; Yamazaki, F.; Kambe, N.; Son, Y.; Okamoto, H.
Lupus, Jan. 2020, [Reviewed] - Hydroxychloroquine for the treatment of lupus erythematosus with cutaneous involvement: clinical efficacy and serial analysis of anti-DNA antibody levels
Ikuko Ueda-Hayakawa; Nhung Thi My Ly; Chuyen Thi Hong Nguyen; Tomoko Matsuda; Fumikazu Yamazaki; Naotomo Kambe; Yonsu Son; Hiroyuki Okamoto
European Journal of Dermatology, Oct. 2019, [Reviewed] - Low-frequency mosaicism in cryopyrin-associated periodic fever syndrome: Mosaicism in systemic autoinflammatory diseases
Nishikomori, R.; Izawa, K.; Kambe, N.; Ohara, O.; Yasumi, T.
International Immunology, Oct. 2019, [Reviewed], [Invited] - Sweet syndrome in a patient with chronic myelogenous leukemia under dasatinib treatment.
Matsuda T; Ueda-Hayakawa I; Kambe N; Fujita S; Okamoto H
The Journal of Dermatology, Apr. 2019, [Reviewed] - Hereditary leiomyomatosis and renal cell cancer syndrome in which skin biopsy enabled diagnosis.
Matsuda T; Kambe N; Ly NTM; Ueda-Hayakawa I; Yamazaki F; Ohe C; Yoshida K; Kinoshita H; Furuya M; Okamoto H
The Journal of Dermatology, Mar. 2019, [Reviewed]
Corresponding - 〔Major achievements〕Basophil count is a sensitive marker for clinical progression in a chronic spontaneous urticaria patient treated with omalizumab
Kishimoto, I.; Kambe, N.; Ly, N.T.M.; Nguyen, C.T.H.; Okamoto, H.
Allergology International, Feb. 2019, [Reviewed]
Corresponding - Two Cases of Autosomal Recessive Woolly Hair/Hypotrichosis with LIPH Gene Mutations
Kaori Takezawa; Ikuko Ueda; Fumikazu Yamazaki; Naotomo Kambe; Hiroyuki Okamoto; Yutaka Shimomura
Skin Research, 2019 - A case of discrete papular lichen myxedematosus
Haruka Goda; Naotomo Kambe; Kaori Kusabiraki; Fumikazu Yamazaki; Hiroyuki Okamoto
Skin Research, 2019 - Case of pityriasis rubra pilaris progressed to generalized erythroderma following blockade of interleukin-17A, but improved after blockade of interleukin-12/23 p40.
Matsuda T; Yamazaki F; Ueda-Hayakawa I; Kambe N; Okamoto H
The Journal of Dermatology, Jan. 2019, [Reviewed] - Expression of precipitating factors of pruritus found in humans in an imiquimod-induced psoriasis mouse model.
Oishi N; Iwata H; Kambe N; Kobayashi N; Fujimoto K; Sato H; Hisaka A; Ueno K; Yamaura K
Heliyon, 2019, [Reviewed] - Four cases of anti-Mi-2 antibody-positive dermatomyositis: relationship between anti-Mi-2 antibody titre and disease severity and activity
T. Matsuda; I. Ueda-Hayakawa; N. Kambe; Y. Son; Y. Ozaki; Y. Hamaguchi; K. Takehara; M. Fujimoto; H. Okamoto
Journal of the European Academy of Dermatology and Venereology, Jun. 2018, [Reviewed] - Up-regulated expression of CD86 on circulating intermediate monocytes correlated with disease severity in psoriasis
Chuyen Thi Hong Nguyen; Naotomo Kambe; Fumikazu Yamazaki; Ikuko Ueda-Hayakawa; Izumi Kishimoto; Hiroyuki Okamoto
Journal of Dermatological Science, May 2018, [Reviewed] - The role of mast cells in autoinflammation
Hanna Bonnekoh; Jörg Scheffel; Naotomo Kambe; Karoline Krause
Immunological Reviews, Mar. 2018, [Reviewed] - Early cutaneous eruptions after oral hydroxychloroquine in a lupus erythematosus patient: A case report and review of the published work
Tomoko Matsuda; Nhung Thi My Ly; Naotomo Kambe; Chuyen Thi Hong Nguyen; Ikuko Ueda-Hayakawa; Yonsu Son; Hiroyuki Okamoto
Journal of Dermatology, Mar. 2018, [Reviewed] - A case of hereditary angioedema with acute abdominal pain during postpartum
Tomoko Matsuda; Naotomo Kambe; Kahori Nakatani; Haruka Goda; Yuki Nomura; Fumikazu Yamazaki; Hiroyuki Okamoto; Takahiko Horiuchi
Skin Research, 2018 - TARC expression in the circulation and cutaneous granulomas correlates with disease severity and indicates Th2-mediated progression in patients with sarcoidosis
Chuyen Thi Hong Nguyen; Naotomo Kambe; Ikuko Ueda-Hayakawa; Izumi Kishimoto; Nhung Thi My Ly; Kana Mizuno; Hiroyuki Okamoto
Allergology International, 2018, [Reviewed] - Palisaded neutrophilic and granulomatous dermatitis associated with systemic lupus erythematosus: possible involvement of CD163+ M2 macrophages in two cases, and a review of published works
Terai S; Ueda-Hayakawa I; Nguyen CTH; Ly NTM; Yamazaki F; Kambe N; Son Y; Okamoto H
Lupus, 2018, [Reviewed] - 〔Major achievements〕Pluripotent stem cell models of Blau syndrome reveal an IFN-γ-dependent inflammatory response in macrophages.
Sanami Takada; Naotomo Kambe; Yuri Kawasaki; Akira Niwa; Fumiko Honda-Ozaki; Kazuki Kobayashi; Mitsujiro Osawa; Ayako Nagahashi; Katsunori Semi; Akitsu Hotta; Isao Asaka; Yasuhiro Yamada; Ryuta Nishikomori; Toshio Heike; Hiroyuki Matsue; Tatsutoshi Nakahata; Megumu K Saito
The Journal of allergy and clinical immunology, Jan. 2018, [Reviewed] - A sporadic case of granulomatous disease negative for NOD2 mutations and mimicking Blau syndrome
F. Oda; M. Murakami; Y. Hanakawa; M. Tohyama; N. Nakano; R. Nishikomori; N. Kambe; K. Sayama
CLINICAL AND EXPERIMENTAL DERMATOLOGY, Jan. 2018, [Reviewed] - Protein contact dermatitis induced by cabbage with recurrent symptoms after oral intake
Izumi Kishimoto; Naotomo Kambe; Chuyen T. H. Nguyen; Tomoko Matsuda; Yuki Nomura; Naoko Uetsu; Hiroyuki Okamoto
JOURNAL OF DERMATOLOGY, Oct. 2017, [Reviewed] - Serum soluble interleukin-2 receptor level is more sensitive than angiotensin-converting enzyme or lysozyme for diagnosis of sarcoidosis and may be a marker of multiple organ involvement
Chuyen Thi Hong Nguyen; Naotomo Kambe; Izumi Kishimoto; Ikuko Ueda-Hayakawa; Hiroyuki Okamoto
JOURNAL OF DERMATOLOGY, Jul. 2017, [Reviewed] - Psoriatic skin lesions induced by abatacept: Case report and review of the published work
Ikuko Ueda-Hayakawa; Chuyen Nguyen Thi Hong; Yoko Ueki; Naotomo Kambe; Hiroyuki Okamoto
JOURNAL OF DERMATOLOGY, Jul. 2017, [Reviewed] - Two cases of birt-hogg-dubé syndrome conrmed by skin biopsy
Tomoko Matsuda; Naotomo Kambe; Ikuko Ueda; Fumikazu Yamazaki; Chuyen Thi Hong Nguyen; Hiroyuki Okamoto
Skin Research, 2017 - A sporadic case of blau syndrome diagnosed at an early time point by skin biopsy
Tomoko Matsuda; Naotomo Kambe; Hiroyuki Okamoto
Skin Research, 2017 - Five cases of necrobiosis lipoidica
Sayaka Terai; Ikuko Ueda; Noriko Kume; Fumikazu Yamazaki; Naotomo Kambe; Hiroyuki Okamoto; Jyunko Taki
Skin Research, 2017 - Innate immunity
Takashi Satoh; Naotomo Kambe
Immunology of the Skin: Basic and Clinical Sciences in Skin Immune Responses, Jan. 2016, [Reviewed] - The role of group IIF-secreted phospholipase A(2) in epidermal homeostasis and hyperplasia
Kei Yamamoto; Yoshimi Miki; Mariko Sato; Yoshitaka Taketomi; Yasumasa Nishito; Choji Taya; Kazuaki Muramatsu; Kazutaka Ikeda; Hiroki Nakanishi; Ryo Taguchi; Naotomo Kambe; Kenji Kabashima; GeRard Lambeau; Michael H. Gelb; Makoto Murakami
JOURNAL OF EXPERIMENTAL MEDICINE, Oct. 2015, [Reviewed] - Case of respiratory discomfort due to myositis after administration of nivolumab
Miri Yoshioka; Naotomo Kambe; Yosuke Yamamoto; Keisuke Suehiro; Hiroyuki Matsue
JOURNAL OF DERMATOLOGY, Oct. 2015, [Reviewed] - Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes
Kenji Nakagawa; Eva Gonzalez-Roca; Alejandro Souto; Toshinao Kawai; Hiroaki Umebayashi; Josep Maria Campistol; Jeronima Canellas; Syuji Takei; Norimoto Kobayashi; Jose Luis Callejas-Rubio; Norberto Ortego-Centeno; Estibaliz Ruiz-Ortiz; Fina Rius; Jordi Anton; Estibaliz Iglesias; Santiago Jimenez-Trevino; Carmen Vargas; Julian Fernandez-Martin; Inmaculada Calvo; Jose Hernandez-Rodriguez; Maria Mendez; Maria Teresa Dordal; Maria Basagana; Segundo Bujan; Masato Yashiro; Tetsuo Kubota; Ryuji Koike; Naoko Akuta; Kumiko Shimoyama; Naomi Iwata; Megumu K. Saito; Osamu Ohara; Naotomo Kambe; Takahiro Yasumi; Kazushi Izawa; Tomoki Kawai; Toshio Heike; Jordi Yaguee; Ryuta Nishikomori; Juan I. Arostegui
ANNALS OF THE RHEUMATIC DISEASES, Mar. 2015, [Reviewed] - Successful treatment of Group A beta-hemolytic Streptococcus infection-associated juvenile cutaneous polyarteritis nodosa with tonsillectomy
Takeshi Yamamoto; Yuzaburo Inoue; Minako Tomiita; Makiko Oikawa; Naotomo Kambe; Takayasu Arima; Naoki Shimojo; Yoichi Kohno
MODERN RHEUMATOLOGY, 2015, [Reviewed] - Ultra-pure soft water improves skin barrier function in children with atopic dermatitis: A randomized, double-blind, placebo-controlled, crossover pilot study
Yaei Togawa; Naotomo Kambe; Naoki Shimojo; Taiji Nakano; Yasunori Sato; Hiroyuki Mochizuki; Akane Tanaka; Hiroshi Matsuda; Hiroyuki Matsue
JOURNAL OF DERMATOLOGICAL SCIENCE, Dec. 2014, [Reviewed] - Oculocutaneous albinism (OCA) in Japanese patients: Five novel mutations
Ken Okamura; Junko Yoshizawa; Yuko Abe; Keiko Hanaoka; Naoyuki Higashi; Yaei Togawa; Seitaro Nakagawa; Naotomo Kambe; Yoko Funasaka; Kentaro Ohko; Yutaka Hozumi; Tamio Suzuki
JOURNAL OF DERMATOLOGICAL SCIENCE, May 2014, [Reviewed] - Ultrasonographic assessment reveals detailed distribution of synovial inflammation in Blau syndrome
Kei Ikeda; Naotomo Kambe; Syuji Takei; Taiji Nakano; Yuzaburo Inoue; Minako Tomiita; Natsuko Oyake; Takashi Satoh; Tsuyoshi Yamatou; Tomohiro Kubota; Ikuo Okafuji; Nobuo Kanazawa; Ryuta Nishikomori; Naoki Shimojo; Hiroyuki Matsue; Hiroshi Nakajima
ARTHRITIS RESEARCH & THERAPY, 2014, [Reviewed] - Preferentially inflamed tendon sheaths in the swollen but not tender joints in a 5-year-old boy with blau syndrome
Kei Ikeda; Naotomo Kambe; Takashi Satoh; Hiroyuki Matsue; Hiroshi Nakajima
Journal of Pediatrics, Nov. 2013, [Reviewed] - Alteration of circulating miRNAs in SSc: MiR-30b regulates the expression of PDGF receptor β
Shigeru Tanaka; Akira Suto; Kei Ikeda; Yoshie Sanayama; Daiki Nakagomi; Taro Iwamoto; Kotaro Suzuki; Naotomo Kambe; Hiroyuki Matsue; Ryutaro Matsumura; Daisuke Kashiwakuma; Itsuo Iwamoto; Hiroshi Nakajima
Rheumatology (United Kingdom), Nov. 2013, [Reviewed] - Linkage of bacterial colonization of skin and the urticaria like rash of NLRP3 mediated autoinflammatory syndromes through mast cell derived TNF α
Yuumi Nakamura; Naotomo Kambe
Journal of Dermatological Science, Aug. 2013, [Reviewed] - Monogenic early-onset sarcoidosis is no longer a variant of "idiopathic" sarcoidosis
Nobuo Kanazawa; Georgi Tchernev; Naotomo Kambe
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Jul. 2013, [Reviewed] - Three school-age cases of xeroderma pigmentosum variant type
Ryusuke Ono; Taro Masaki; Seiji Takeuchi; Ayako Shimizu; Miki Tanioka; Naotomo Kambe; Hiroyuki Matsue; Ryoichi Kamide; Chikako Nishigori
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE, Jun. 2013, [Reviewed] - Mast cell maturation is driven via a group III phospholipase A(2)-prostaglandin D-2-DP1 receptor paracrine axis
Yoshitaka Taketomi; Noriko Ueno; Takumi Kojima; Hiroyasu Sato; Remi Murase; Kei Yamamoto; Satoshi Tanaka; Mariko Sakanaka; Masanori Nakamura; Yasumasa Nishito; Momoko Kawana; Naotomo Kambe; Kazutaka Ikeda; Ryo Taguchi; Satoshi Nakamizo; Kenji Kabashima; Michael H. Gelb; Makoto Arita; Takehiko Yokomizo; Motonao Nakamura; Kikuko Watanabe; Hiroyuki Hirai; Masataka Nakamura; Yoshimichi Okayama; Chisei Ra; Kosuke Aritake; Yoshihiro Urade; Kazushi Morimoto; Yukihiko Sugimoto; Takao Shimizu; Shuh Narumiya; Shuntaro Hara; Makoto Murakami
NATURE IMMUNOLOGY, Jun. 2013, [Reviewed] - NLRP3 activation induces ASC-dependent programmed necrotic cell death, which leads to neutrophilic inflammation
T. Satoh; N. Kambe; H. Matsue
CELL DEATH & DISEASE, May 2013, [Reviewed] - Novel R218X mutation in the fumarate hydratase gene in a patient with Reed's syndrome
Fumi Akita; Naotomo Kambe; Michiyo Nakano; Takashi Satoh; Mari Iwasawa; Yaei Togawa; Hiroyuki Matsue
JOURNAL OF DERMATOLOGY, Jan. 2013, [Reviewed] - Kerion celsi due to Arthroderma incurvatum infection in a Sri Lankan child: species identification and analysis of area-dependent genetic polymorphism
Mari T. Iwasawa; Yaei Togawa; Fumi Akita; Naotomo Kambe; Hiroyuki Matsue; Takashi Yaguchi; Kazuko Nishimura
MEDICAL MYCOLOGY, Oct. 2012, [Reviewed] - Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery
Takayuki Tanaka; Kazutoshi Takahashi; Mayu Yamane; Shota Tomida; Saori Nakamura; Koichi Oshima; Akira Niwa; Ryuta Nishikomori; Naotomo Kambe; Hideki Hara; Masao Mitsuyama; Nobuhiro Morone; John E. Heuser; Takuya Yamamoto; Akira Watanabe; Aiko Sato-Otsubo; Seishi Ogawa; Isao Asaka; Toshio Heike; Shinya Yamanaka; Tatsutoshi Nakahata; Megumu K. Saito
BLOOD, Aug. 2012, [Reviewed] - Critical Role for Mast Cells in Interleukin-1 beta-Driven Skin Inflammation Associated with an Activating Mutation in the NIrp3 Protein
Yuumi Nakamura; Luigi Franchi; Naotomo Kambe; Guangxun Meng; Warren Strober; Gabriel Nunez
IMMUNITY, Jul. 2012, [Reviewed] - Dramatic Clinical Response of Relapsed Metastatic Extramammary Paget's Disease to Trastuzumab Monotherapy
Wakabayashi S; Togawa Y; Yoneyama K; Suehiro K; Kambe N; Matsue H
Case Rep Dermatol Med., Mar. 2012, [Reviewed] - Maximum growth temperature test for cutaneous Mycobacterium chelonae predicts the efficacy of thermal therapy
Rena Ota; Mari T. Iwasawa; Kiyofumi Ohkusu; Naotomo Kambe; Hiroyuki Matsue
JOURNAL OF DERMATOLOGY, Feb. 2012, [Reviewed] - The CD40-CD40L axis and IFN-gamma play critical roles in Langhans giant cell formation
Hidemasa Sakai; Ikuo Okafuji; Ryuta Nishikomori; Junya Abe; Kazushi Izawa; Naotomo Kambe; Takahiro Yasumi; Tatsutoshi Nakahata; Toshio Heike
INTERNATIONAL IMMUNOLOGY, Jan. 2012, [Reviewed] - High Incidence of NLRP3 Somatic Mosaicism in Patients With Chronic Infantile Neurologic, Cutaneous, Articular Syndrome Results of an International Multicenter Collaborative Study
Naoko Tanaka; Kazushi Izawa; Megumu K. Saito; Mio Sakuma; Koichi Oshima; Osamu Ohara; Ryuta Nishikomori; Takeshi Morimoto; Naotomo Kambe; Raphaela Goldbach-Mansky; Ivona Aksentijevich; Genevieve de Saint Basile; Benedicte Neven; Marielle van Gijn; Joost Frenkel; Juan I. Arostegui; Jordi Yaguee; Rosa Merino; Mercedes Ibanez; Alessandra Pontillo; Hidetoshi Takada; Tomoyuki Imagawa; Tomoki Kawai; Takahiro Yasumi; Tatsutoshi Nakahata; Toshio Heike
ARTHRITIS AND RHEUMATISM, Nov. 2011, [Reviewed] - Identification of 736T > A mutation of lipase H in Japanese siblings with autosomal recessive woolly hair
Takashi Yoshimasu; Nobuo Kanazawa; Naotomo Kambe; Motonobu Nakamura; Fukumi Furukawa
JOURNAL OF DERMATOLOGY, Sep. 2011, [Reviewed] - Follicular keratosis and bullous formation are typical signs of extragenital lichen sclerosus
Ayako Kimura; Naotomo Kambe; Takashi Satoh; Yaei Togawa; Keisuke Suehiro; Hiroyuki Matsue
JOURNAL OF DERMATOLOGY, Aug. 2011, [Reviewed] - Lymphocutaneous Type of Nocardiosis Caused by Nocardia vinacea in a Patient with Polymyositis
Mari T. Iwasawa; Yaei Togawa; Noriaki Kamada; Naotomo Kambe; Hiroyuki Matsue; Katsukiyo Yazawa; Takashi Yaguchi; Yuzuru Mikami
MYCOPATHOLOGIA, Jul. 2011, [Reviewed] - 【小児の先天性皮膚疾患】臨床例 小児の色素性乾皮症バリアント型
小野 竜輔; 正木 太朗; 谷岡 未樹; 西谷 奈生; 清水 彩子; 神戸 直智; 松江 弘之; 錦織 千佳子
皮膚病診療, Feb. 2011 - Autoinflammatory diseases and the inflammasome: mechanisms of IL-1β activation leading to neutrophil-rich skin disorders
Kambe Naotomo; Satoh Takashi; Nakamura Yuumi; Iwasawa Mari; Matsue Hiroyuki
Inflammation and Regeneration, 2011 - Dermoscopy of keratosis follicularis squamosa
Michiyo Nakano; Naotomo Kambe; Takashi Satoh; Yaei Togawa; Noriaki Kamada; Hiroyuki Matsue
Dermatology Reports, 2011, [Reviewed] - Melanoma in association with acquired melanocytic nevus in Japan: a review of cases in the literature
Y. Togawa; Y. Nakamura; N. Kamada; N. Kambe; Y. Takahashi; H. Matsue
INTERNATIONAL JOURNAL OF DERMATOLOGY, Dec. 2010, [Reviewed] - Enhanced NF-kappa B activation with an inflammasome activator correlates with activity of autoinflammatory disease associated with NLRP3 mutations outside of exon 3: comment on the article by Jeru et al
Naotomo Kambe; Takashi Satoh; Hideaki Tanizaki; Akihiro Fujisawa; Megumu K. Saito; Ryuta Nishikomori
ARTHRITIS AND RHEUMATISM, Oct. 2010, [Reviewed] - Exanthem with Cryopyrin Associated Periodic Syndromes and Consideration of IL-1 Targeted Therapy for Neutrophilic Predominant Urticaria
WANDERER Alan A.; KAMBE Naotomo; NAKAMURA Yuumi
Allergology International, Sep. 2010 - The inflammasome, an innate immunity guardian, participates in skin urticarial reactions and contact hypersensitivity
Naotomo Kambe; Yuumi Nakamura; Megumu Saito; Ryuta Nishikomori
Allergology International, 2010, [Reviewed] - Mastocytosis
Naotomo Kambe; Akane Tanaka; Yoshiki Miyachi
Therapy of Skin Diseases: A Worldwide Perspective on Therapeutic Approaches and Their Molecular Basis, 2010, [Reviewed] - Agminated acquired melanocytic naevus modified by vitiligo vulgaris arising in the elderly
Y. Nakamura; N. Kambe; N. Deguchi; T. Kawamura; N. Shibagaki; H. Matsue; S. Shimada
CLINICAL AND EXPERIMENTAL DERMATOLOGY, Oct. 2009, [Reviewed] - Murine Fetal Skin-Derived Cultured Mast Cells: A Useful Tool for Discovering Functions of Skin Mast Cells
Hiroyuki Matsue; Naotomo Kambe; Shinji Shimada
JOURNAL OF INVESTIGATIVE DERMATOLOGY, May 2009, [Reviewed] - Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria
Yuumi Nakamura; Naotomo Kambe; Megumu Saito; Ryuta Nishikomori; Yun-Gi Kim; Makoto Murakami; Gabriel Nunez; Hiroyuki Matsue
JOURNAL OF EXPERIMENTAL MEDICINE, May 2009, [Reviewed] - Role of the NOD2 Genotype in the Clinical Phenotype of Blau Syndrome and Early-Onset Sarcoidosis
Ikuo Okafuji; Ryuta Nishikomori; Nobuo Kanazawa; Naotomo Kambe; Akihiro Fujisawa; Shin Yamazaki; Megumu Saito; Takakazu Yoshioka; Tomoki Kawai; Hidemasa Sakai; Hideaki Tanizaki; Toshio Heike; Yoshiki Miyachi; Tatsutoshi Nakahata
ARTHRITIS AND RHEUMATISM, Jan. 2009, [Reviewed] - Erythema elevatum diutinum with primary Sjogren syndrome associated with IgA antineutrophil cytoplasmic antibody
S. Shimizu; Y. Nakamura; Y. Togawa; N. Kamada; N. Kambe; H. Matsue
BRITISH JOURNAL OF DERMATOLOGY, Sep. 2008, [Reviewed] - Cryogloblinaemia type I: serum cryoprecipitate formation at 25 degrees C
Y. Yagi; M. Tanioka; N. Kambe; Y. Matsumura; S. Kore-eda; A. Utani; Y. Miyachi; M. Kato
CLINICAL AND EXPERIMENTAL DERMATOLOGY, May 2008, [Reviewed] - Osteopontin is produced by mast cells and affects IgE-mediated degranulation and migration of mast cells
Akiko Nagasaka; Hiroyuki Matsue; Hironori Matsushima; Rui Aoki; Yuumi Nakamura; Naotomo Kambe; Shigeyuki Kon; Toshimitsu Uede; Shinji Shimada
EUROPEAN JOURNAL OF IMMUNOLOGY, Feb. 2008, [Reviewed] - Disease-associated CIAS1 mutations induce monocyte death, revealing low-level mosaicism in mutation-negative cryopyrin-associated periodic syndrome patients
Megumu Saito; Ryuta Nishikomori; Naotomo Kambe; Akihiro Fujisawa; Hideaki Tanizaki; Kyoko Takeichi; Tomoyuki Imagawa; Tomoko Iehara; Hidetoshi Takada; Tadashi Matsubayashi; Hiroshi Tanaka; Hisashi Kawashima; Kiyoshi Kawakami; Shinji Kagami; Ikuo Okafuji; Takakazu Yoshioka; Souichi Adachi; Toshio Heike; Yoshiki Miyachi; Tatsutoshi Nakahata
BLOOD, Feb. 2008, [Reviewed] - Oral administration of bepotastine besilate suppressed scratching behavior of atopic dermatitis model NC/Nga mice
Hideaki Tanizaki; Naotomo Kambe; Yuumi Nakamura; Akane Tanaka; Hiroshi Matsuda; Yoshiki Miyachi
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2008, [Reviewed] - Food-dependent exercise-induced anaphylaxis induced by low dose aspirin therapy
Hiroko Fujii; Naotomo Kambe; Akihiro Fujisawa; Kunie Kohno; Eishin Morita; Yoshiki Miyachi
Allergology International, 2008, [Reviewed] - Direct development of functionally mature tryptase/chymase double-positive connective tissue-type mast cells from primate embryonic stem cells
Feng Ma; Naotomo Kambe; Dan Wang; Gen Shinoda; Hisanori Fujino; Katsutsugu Umeda; Akihiro Fujisawa; Lina Ma; Hirofumi Suemori; Norio Nakatsuji; Yoshiki Miyachi; Ryuzo Torii; Kohichiro Tsuji; Toshio Heike; Tatsutoshi Nakahataa
STEM CELLS, 2008, [Reviewed] - Chemical burn caused by glycidyl methacrylate
Ayako Shimizu; Noriaki Kamada; Naotomo Kambe; Hiroyuki Matsue
CONTACT DERMATITIS, 2008, [Reviewed] - Multiple dermatomal daughter lesions of postzoster granuloma
E. Araki; N. Kambe; K. Takahashi; Y. Miyachi; A. Utani
BRITISH JOURNAL OF DERMATOLOGY, Jun. 2007, [Reviewed] - 〔Major achievements〕Disease-associated mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells
Akihiro Fujisawa; Naotomo Kambe; Megumu Saito; Ryuta Nishikomori; Hideaki Tanizaki; Nobuo Kanazawa; Souichi Adachi; Toshio Heike; Junji Sagara; Takashi Suda; Tatsutoshi Nakahata; Yoshiki Miyachi
BLOOD, Apr. 2007, [Reviewed]
Corresponding - Involvement of OX40 ligand(+) mast cells in chronic GVHD after allogeneic hematopoietic stem cell transplantation
A. Kotani; T. Hori; T. Fujita; N. Kambe; Y. Matsumura; T. Ishikawa; Y. Miyachi; K. Nagai; Y. Tanaka; T. Uchiyama
BONE MARROW TRANSPLANTATION, Mar. 2007, [Reviewed] - IgE-activated mast cells in combination with pro-inflammatory factors induce T(h)2-promoting dendritic cells
Toshio Kitawaki; Norimitsu Kadowaki; Naoshi Sugimoto; Naotomo Kambe; Toshiyuki Hori; Yoshiki Miyachi; Tatsutoshi Nakahata; Takashi Uchiyama
INTERNATIONAL IMMUNOLOGY, Dec. 2006, [Reviewed] - Type I interferons attenuate T cell activating functions of human mast cells by decreasing TNF-alpha production and OX40 ligand expression while increasing IL-10 production
Tomoko Fujita; Naotomo Kambe; Takashi Uchiyama; Toshiyuki Hori
JOURNAL OF CLINICAL IMMUNOLOGY, Nov. 2006, [Reviewed] - Gene expression profiling of human mast cell subtypes: An in silico study
Hirohisa Saito; Kenji Matsumoto; Shigeru Okumura; Jun-Ichi Kashiwakura; Keisuke Oboki; Hidenori Yokoi; Naotomo Kambe; Ken Ohta; Yoshimichi Okayama
Allergology International, 2006, [Reviewed] - High incidence of NLRP3 somatic mosaicism in patients with chronic infantile neurologic, cutaneous, articular syndrome: Results of an international multicenter collaborative study
Tanaka N; Izawa K; Saito MK; Sakuma M; Oshima K; Ohara O; Nishikomori R; Morimoto T; Kambe N; Goldbach-Mansky R; Aksentijevich I; de Saint; Basile G; Neven B; van Gijn M; Frenkel J; Aróstegui JI; Yagüe J; Merino R; Ibañez M; Pontillo A; Takada H; Imagawa T; Kawai T; Yasumi T; Nakahata T; Heike T
Arthritis Rheum 63(3625-3632), Nov. 2005, [Reviewed] - 〔Major achievements〕Somatic mosaicism of CIAS1 in a patient with chronic infantile neurologic, cutaneous, articular syndrome
M Saito; A Fujisawa; R Nishikomori; N Kambe; M Nakata-Hizume; M Yoshimoto; K Ohmori; Okafuji, I; T Yoshioka; T Kusunoki; Y Miyachi; T Heike; T Nakahata
ARTHRITIS AND RHEUMATISM, Nov. 2005, [Reviewed] - The cytosolic pattern-recognition receptor Nod2 and inflammatory granulomatous disorders
N Kambe; R Nishikomori; N Kanazawa
JOURNAL OF DERMATOLOGICAL SCIENCE, Aug. 2005, [Reviewed] - A novel NF-kappa B inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors
A Tanaka; M Konno; S Muto; N Kambe; E Morii; T Nakahata; A Itai; H Matsuda
BLOOD, Mar. 2005, [Reviewed] - Stem cell factor has a suppressive activity to IgE-mediated chemotaxis of mast cells
J Sawada; S Shimizu; T Tamatani; S Kanegasaki; H Saito; A Tanaka; N Kambe; T Nakahata; H Matsuda
JOURNAL OF IMMUNOLOGY, Mar. 2005, [Reviewed] - Erythema multiforme due to progesterone in a low-dose oral contraceptive pill
R Suzuki; Y Matsumura; N Kambe; H Fujii; T Tachibana; Y Miyachi
BRITISH JOURNAL OF DERMATOLOGY, Feb. 2005, [Reviewed] - Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-kappa B activation: common genetic etiology with Blau syndrome
N Kanazawa; Okafuji, I; N Kambe; R Nishikomori; M Nakata-Hizume; S Nagai; A Fuji; T Yuasa; A Manki; Y Sakurai; M Nakajima; H Kobayashi; L Fujiwara; H Tsutsumi; A Utani; C Nishigori; T Heike; T Nakahata; Y Miyachi
BLOOD, Feb. 2005, [Reviewed] - Suplatast tosilate inhibits human mast cell development from cord blood progenitors
Akihiro Fujisawa; Naotomo Kambe; Tatsutoshi Nakahata; Hiroshi Matsuda; Yoshiki Miyachi
Allergology International, 2005, [Reviewed] - Pustular neutrophilic dermatoses and rapidly growing mycobacterium infection with bilateral cervical lymphadenopathy
A Fujisawa; Y Matsumura; N Kambe; H Fujii; T Tachibana; T Mio; A Takahashi; Y Miyachi
DERMATOLOGY, 2005, [Reviewed] - Presence of a sporadic case of systemic granulomatosis syndrome with a CARD15 mutation
N Kanazawa; S Matsushima; N Kambe; T Tachibana; S Nagai; Y Miyachi
JOURNAL OF INVESTIGATIVE DERMATOLOGY, Mar. 2004, [Reviewed] - 〔Major achievements〕Development of both human connective tissue-type and mucosal-type mast cells in mice from hematopoietic stem cells with identical distribution pattern to human body
N Kambe; H Hiramatsu; M Shimonaka; H Fujino; R Nishikomori; T Heike; M Ito; K Kobayashi; Y Ueyama; N Matsuyoshi; Y Miyachi; T Nakahata
BLOOD, Feb. 2004, [Reviewed]
Lead - An autocrine function of nerve growth factor for cell cycle regulation of vascular endothelial cells
A Tanaka; U Wakita; N Kambe; T Iwasaki; H Matsuda
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 2004, [Reviewed] - What is the physiological function of mast cells?
M Maurer; T Theoharides; RD Granstein; SC Bischoff; J Bienenstock; B Henz; P Kovanen; AM Piliponsky; N Kambe; H Vliagoftis; F Levi-Schaffer; M Metz; Y Miyachi; D Befus; P Forsythe; Y Kitamura; S Galli
EXPERIMENTAL DERMATOLOGY, Dec. 2003, [Reviewed] - Recombinant human (rh) stem cell factor and rhIL-4 stimulate differentiation and proliferation of CD3(+) cells from umbilical cord blood and CD3(+) cells enhance Fc epsilon R1 expression on fetal liver-derived mast cells in the presence of rhIL-4
E Lee; HK Min; CA Oskeritzian; N Kambe; LB Schwartz; HW Chang
CELLULAR IMMUNOLOGY, Nov. 2003, [Reviewed] - Degranulation and cytokine expression in human cord blood-derived mast cells cultured in serum-free medium with recombinant human stem cell factor
TC Moon; E Lee; SH Baek; M Murakami; Kudo, I; NS Kim; JM Lee; HK Min; N Kambe; HW Chang
MOLECULES AND CELLS, Oct. 2003, [Reviewed] - Ion channel gene expression in human lung, skin, and cord blood-derived mast cells
P Bradding; Y Okayama; N Kambe; H Saito
JOURNAL OF LEUKOCYTE BIOLOGY, May 2003, [Reviewed] - Late-phase urticaria Update.
Kambe, N.; Kitao, A.; Nishigori, C.; Miyachi, Y.
Current allergy and asthma reports, Jul. 2002, [Reviewed] - A possible mechanism of mast cell proliferation in mastocytosis
N Kambe; Y Miyachi
JOURNAL OF DERMATOLOGY, Jan. 2002, [Reviewed]
Lead - IL-6 attenuates apoptosis, while neither IL-6 nor IL-10 affect the numbers or protease phenotype of fetal liver-derived human mast cells
M Kambe; N Kambe; CA Oskeritzian; N Schechter; LB Schwartz
CLINICAL AND EXPERIMENTAL ALLERGY, Jul. 2001, [Reviewed] - 〔Major achievements〕Human skin-derived mast cells can proliferate while retaining their characteristic functional and protease phenotypes
N Kambe; M Kambe; JP Kochan; LB Schwartz
BLOOD, Apr. 2001, [Reviewed]
Lead - Human mouse mast cell protease 7-like tryptase genes are pseudogenes
HK Min; N Kambe; LB Schwartz
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Feb. 2001, [Reviewed] - Disialoganglioside GD3 is selectively expressed by developing and mature human mast cells
SL Ren; N Kambe; ZM Du; YL Li; HZ Xia; M Kambe; E Bieberich; A Pozez; M Grimes; RK Yu; AM Irani; LB Schwartz
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Feb. 2001, [Reviewed] - Nerve growth factor prevents apoptosis of cord blood-derived human cultured mast cells synergistically with stem cell factor
N Kanbe; M Kurosawa; Y Miyachi; M Kanbe; H Saitoh; H Matsuda
CLINICAL AND EXPERIMENTAL ALLERGY, Aug. 2000, [Reviewed]
Lead - Production of fibrogenic cytokines by cord blood-derived cultured human mast cells
N Kanbe; M Kurosawa; H Nagata; T Yamashita; F Kurimoto; Y Miyachi
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Jul. 2000, [Reviewed] - An improved procedure for the development of human mast cells from dispersed fetal liver cells in serum-free culture medium
N Kambe; M Kambe; HW Chang; A Matsui; HK Min; M Hussein; CA Oskerizian; J Kochan; AMA Irani; LB Schwartz
JOURNAL OF IMMUNOLOGICAL METHODS, Jun. 2000, [Reviewed] - Nerve growth factor release with mast-cell-derived mediators in a patient with systemic mastocytosis after middle-wave ultraviolet irradiation
M Kurosawa; H Inamura; H Amano; N Kanbe; H Nagata; H Nagai; S Furukawa; Y Miyachi
ALLERGY, Sep. 1999, [Reviewed] - 〔Major achievements〕Human mast cells produce matrix metalloproteinase 9
N Kanbe; A Tanaka; M Kanbe; A Itakura; M Kurosawa; H Matsuda
EUROPEAN JOURNAL OF IMMUNOLOGY, Aug. 1999, [Reviewed]
Lead - Cord-blood-derived human cultured mast cells produce interleukin 13 in the presence of stem cell factor
N Kanbe; M Kurosawa; T Yamashita; F Kurimoto; Y Yanagihara; Y Miyachi
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, Jun. 1999, [Reviewed]
Lead - Response to cyclosporin and low-dose methylprednisolone in aggressive systemic mastocytosis
M Kurosawa; H Amano; N Kanbe; Y Igarashi; H Nagata; T Yamashita; F Kurimoto; Y Miyachi
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, May 1999, [Reviewed] - Cord blood-derived human cultured mast cells produce transforming growth factor beta(1)
N Kanbe; M Kurosawa; H Nagata; H Saitoh; Y Miyachi
CLINICAL AND EXPERIMENTAL ALLERGY, Jan. 1999, [Reviewed] - Cloning and tissue distribution of a novel serine protease esp-1 from human eosinophils
M Inoue; N Kanbe; M Kurosawa; H Kido
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 1998, [Reviewed] - Idiopathic hypereosinophilic syndrome associated with elevated plasma levels of interleukin-10 and soluble interleukin-2 receptor
N Kanbe; M Kurosawa; N Igarashi; A Tamura; T Yamashita; F Kurimoto; Y Miyachi
BRITISH JOURNAL OF DERMATOLOGY, Nov. 1998, [Reviewed]
Lead - Carnoy's fixative reduces the number of chymase-positive cells in immunocytochemical staining of cord-blood-derived human cultured mast cells
N Kanbe; M Kurosawa; Y Miyachi; M Kanbe; D Kempuraj; H Tachimoto; H Saito
ALLERGY, Oct. 1998, [Reviewed]
Lead - Phase-contrast microscopic studies using cinematographic techniques and scanning electron microscopy on IgE-mediated degranulation of cultured human mast cells
M Kurosawa; H Inamura; N Kanbe; Y Igarashi; T Tomita; J Takeda; Y Miyachi
CLINICAL AND EXPERIMENTAL ALLERGY, Aug. 1998, [Reviewed] - Systemic plasmacytosis with deposition of interleukin (IL)-6 and elevated expression of IL-6 mRNA in the skin lesions
N Kanbe; M Kurosawa; S Akimoto; D Sugiyama; J Tamura; Y Hirao; Y Miyachi
BRITISH JOURNAL OF DERMATOLOGY, Apr. 1998, [Reviewed]
Lead - Heterogeneity of mast cells in mastocytosis and inhibitory effect of ketotifen and ranitidine on indolent systemic mastocytosis
M Kurosawa; H Amano; N Kanbe; S Akimoto; Y Takeuchi; T Yamashita; T Hashimoto; F Kurimoto; Y Miyachi
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Dec. 1997, [Reviewed] - 65-kilodalton protein phosphorylation in human peripheral blood eosinophils
M Kurosawa; Y Shimizu; Y Igarashi; H Amano; N Kanbe; Y Matsushima; O Ishikawa; Y Miyachi
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1997, [Reviewed] - Papulonecrotic tuberculid: Positive culture of Mycobacterium tuberculosis from colonic fluid but no identification of its DNA in the skin lesion
O Ishikawa; C Iijima; N Kanbe; Y Okugi; Y Miyachi
EUROPEAN JOURNAL OF DERMATOLOGY, Apr. 1996, [Reviewed]
MISC
- Schnitzler症候群の蕁麻疹様紅斑に好中球の表皮内浸潤を伴うneutrophilic urticarial dermatosisの所見を認めた2例
中泉瞳; 入江浩之; 加来洋; 藤本正数; 吉藤元; 数馬安浩; 神戸直智; 椛島健治
西日本皮膚科, 2024 - 左5趾に細菌性骨髄炎と大細胞転化を伴う皮下浸潤病変を認めた菌状息肉症の1例
入江浩之; 中野宏明; 古田浩大; 遠藤雄一郎; 藤本正数; 神戸直智; 椛島健治
日本皮膚悪性腫瘍学会学術大会プログラム・抄録集, 2024 - 診断に難渋した毛包向性菌状息肉症の1例
内藤 惇; 中溝 聡; 中島 沙恵子; 入江 浩之; 神戸 直智; 椛島 健治; 近藤 摂子
皮膚の科学, Dec. 2023 - 〔Major achievements〕Current topics on urticaria, and urticaria-related diseases introduced in the Japanese urticaria clinical practice guidelines
Naotomo Kambe
Allergology International, Jul. 2023, [Reviewed], [Invited]
Lead - 難治性・希少免疫疾患におけるアンメットニーズの把握とその解決に向けた研究 PRO(patient reported outcome)の検討とICT(information and technology)化に関する研究報告 総括
森雅亮; 山路健; 吉藤元; 西小森隆太; 井澤和司; 岸田大; 盛一享徳; 井上祐三朗; 平野亨; 住友秀次; 楢崎秀彦; 神戸直智; 横川直人; 横川直人; 井上満代; 向井知之; 川邊智宏
難治性・希少免疫疾患におけるアンメットニーズの把握とその解決に向けた研究 令和4年度 総括・分担研究報告書(Web), 2023 - 難治性・希少免疫疾患におけるアンメットニーズの把握とその解決に向けた研究 図書館検索による難治性・希少免疫疾患におけるアンメットニーズの探索研究
森雅亮; 山路健; 吉藤元; 西小森隆太; 岸田大; 井澤和司; 盛一享徳; 山崎晋; 松下雅和; 神戸直智; 伊藤(滝本)莉子; 松田智子; 市川貴規; 田中孝之
難治性・希少免疫疾患におけるアンメットニーズの把握とその解決に向けた研究 令和4年度 総括・分担研究報告書(Web), 2023 - 難治性・希少免疫疾患におけるアンメットニーズの把握とその解決に向けた研究 患者会相談事例の国際生活機能分類(ICF)を用いた解析研究
森雅亮; 山路健; 吉藤元; 西小森隆太; 井澤和司; 岸田大; 盛一享徳; 井上祐三朗; 平野亨; 住友秀次; 楢崎秀彦; 神戸直智; 横川直人; 横川直人; 井上満代; 向井知之; 川邊智宏
難治性・希少免疫疾患におけるアンメットニーズの把握とその解決に向けた研究 令和4年度 総括・分担研究報告書(Web), 2023 - 難治性・希少免疫疾患におけるアンメットニーズの把握とその解決に向けた研究 国際生活機能分類の概念を反映した生活の困難感と健康関連QOLに関する調査について
宮前多佳子; 森雅亮; 山路健; 吉藤元; 西小森隆太; 井澤和司; 岸田大; 盛一享徳; 井上祐三朗; 平野亨; 住友秀次; 楢崎秀彦; 神戸直智; 横川直人; 横川直人; 井上満代; 向井知之; 川邊智宏
難治性・希少免疫疾患におけるアンメットニーズの把握とその解決に向けた研究 令和4年度 総括・分担研究報告書(Web), 2023 - 〔Major achievements〕A picture of atopic dermatitis is worth a thousand words
Naotomo Kambe; Kenji Kabashima
Allergology International, Jan. 2022, [Reviewed], [Invited]
Lead - 難治性・希少免疫疾患におけるアンメットニーズの把握とその解決に向けた研究 PRO(patient reported outcome)の検討とICT(information and technology)化に関する研究
平野亨; 森雅亮; 山路健; 吉藤元; 宮前多佳子; 西小森隆太; 井澤和司; 岸田大; 井上祐三朗; 住友秀次; 楢崎秀彦; 神戸直智; 横川直人; 横川直人; 井上満代; 向井知之; 川邊智宏; 盛一享徳
難治性・希少免疫疾患におけるアンメットニーズの把握とその解決に向けた研究 令和2年度 総括・分担研究報告書(Web), 2021 - 〔Major achievements〕CCL2 serves as a downstream effector of interleukin-1β and tumour necrosis factor-α signalling in Schnitzler syndrome.
KAMBE NAOTOMO
British Journal of Dermatology, Apr. 2019, [Reviewed], [Invited]
Lead - 肥満細胞の研究を通じて
神戸 直智; 中畑 龍俊; 北村 幸彦
皮膚アレルギーフロンティア, Jul. 2016 - 【免疫症候群(第2版)-その他の免疫疾患を含めて-】原発性免疫不全症候群 自己炎症性疾患 インフラマソームに関連しない状態 化膿性無菌性関節炎・壊疽性膿皮症・アクネ(PAPA)症候群
高田 紗奈美; 神戸 直智
日本臨床, Mar. 2016 - Blau症候群
高田 紗奈美; 神戸 直智
日本小児皮膚科学会雑誌, Mar. 2016 - 〔Major achievements〕Role for mast cells in Schnitzler's syndrome: here mast cells master a rash, too
N. Kambe
BRITISH JOURNAL OF DERMATOLOGY, Aug. 2015, [Reviewed], [Invited]
Lead - ブラウ症候群
若林 正一郎; 神戸 直智; 松江 弘之
日本皮膚科学会雑誌, Apr. 2015 - 飼い猫からの感染が考えられたArthroderma vanbreuseghemiiによる体部白癬の1例
若林 正一郎; 岩澤 真理; 鎌田 憲明; 外川 八英; 神戸 直智; 松江 弘之; 矢口 貴志
日本皮膚科学会雑誌, Feb. 2015 - 自己炎症性疾患の治療標的分子の同定および薬剤開発基盤の整備 ブラウ症候群患者由来疾患特異的iPS細胞の樹立と病態解析の試み
神戸直智; 松江弘之; 中野倫代; 江原瑞枝; 高田紗奈美; 中畑龍俊; 斎藤潤
自己炎症性疾患の治療標的分子の同定および薬剤開発基盤の整備 平成26年度 委託業務成果研究報告書, 2015 - 【皮膚における炎症性疾患】炎症を伴う皮膚疾患の病態解明最前線 自己炎症症候群
中川 誠太郎; 松岡 悠美; 神戸 直智
別冊Bio Clinica: 慢性炎症と疾患, Nov. 2014 - Detailed Anatomical Distribution of Synovial Inflammation Revealed By Ultrasound in Patients with Blau Syndrome.
Kei Ikeda; Naotomo Kambe; Syuji Takei; Taiji Nakano; Yuzaburo Inoue; Minako Tomiita; Natsuko Oyake; Takashi Satoh; Tsuyoshi Yamatou; Tomohiro Kubota; Ikuo Okafuji; Nobuo Kanazawa; Ryuta Nishikomori; Naoki Shimojo; Hiroyuki Matsue; Hiroshi Nakajima
ARTHRITIS & RHEUMATOLOGY, Oct. 2014, [Reviewed] - サラゾスルファピリジンによって誘発された天疱瘡の1例
吉岡 未里; 中川 誠太郎; 高田 紗奈美; 鎌田 憲明; 神戸 直智; 松江 弘之
日本皮膚科学会雑誌, Sep. 2014 - 再診時の残錠数に着目した第2世代抗ヒスタミン薬の有効性評価
若林 正一郎; 神戸 直智; 高田 紗奈美; 中川 誠太郎; 林 郁伶; 丸 裕吾; 中野 倫代; 外川 八英; 鎌田 憲明; 松江 弘之
Progress in Medicine, Jun. 2014 - ミノサイクリンが著効したsuperficial granulomatous pyodermaの1例
外川 八英; 山本 洋輔; 鎌田 憲明; 神戸 直智; 松江 弘之; 及川 真喜子
西日本皮膚科, Jun. 2014 - 頻回の二重濾過血漿交換療法(DFPP)を施行するも難治性の水疱性類天疱瘡の1例
山本 洋輔; 若林 正一郎; 鎌田 憲明; 神戸 直智; 松江 弘之
西日本皮膚科, Jun. 2014 - 【内科医のための皮疹の診かたのロジック】 内科疾患と皮疹 自己炎症症候群と皮疹
若林 正一郎; 神戸 直智
Medicina, May 2014 - 若年発症サルコイドーシス/Blau症候群
若林 正一郎; 神戸 直智
日本皮膚科学会雑誌, Apr. 2014 - センチネルリンパ節生検を施行した悪性黒色腫70例におけるセンチネルリンパ節生検の意義
末廣 敬祐; 山本 洋輔; 塚本 利朗; 外川 八英; 鎌田 憲明; 神戸 直智; 松江 弘之
日本皮膚科学会雑誌, Apr. 2014 - 過去3年半に施行した悪性黒色腫術後DAVFeron療法およびDFeron療法における副作用発現の比較
山本 洋輔; 末廣 敬祐; 神戸 直智; 松江 弘之
日本皮膚科学会雑誌, Apr. 2014 - ランゲルハンス細胞組織球症の1例
佐藤 麻有子; 若林 正一郎; 鎌田 憲明; 神戸 直智; 松江 弘之
日本皮膚科学会雑誌, Mar. 2014 - 関節リウマチの治療中に生じたメトトレキサート関連リンパ増殖性疾患の1例
若林 正一郎; 外川 八英; 神戸 直智; 松江 弘之
日本皮膚科学会雑誌, Mar. 2014 - Brunsting-Perry型を思わせる皮疹の分布を初発症状とした類天疱瘡の1例
山本 洋輔; 外川 八英; 神戸 直智; 松江 弘之; 橋本 隆
日本皮膚科学会雑誌, Mar. 2014 - 真皮に母斑細胞を思わせる胞巣を認めた足底悪性黒色腫の1例
山本 洋輔; 末廣 敬祐; 外川 八英; 鎌田 憲明; 神戸 直智; 松江 弘之; 斎田 俊明
日本皮膚科学会雑誌, Feb. 2014 - 表皮嚢腫を合併し妊娠中に増大し悪性黒色腫が疑われた母斑細胞母斑の1例
大津 玉緒; 稲福 和宏; 外川 八英; 小俣 渡; 末廣 敬祐; 岩澤 真理; 鎌田 憲明; 神戸 直智; 松江 弘之
皮膚科の臨床, Dec. 2013 - 皮膚所見から考える自己炎症症候群 (第112回日本皮膚科学会総会 いま望まれる皮膚科心療) -- (教育講演 皮膚から診断する全身疾患)
神戸 直智
日本皮膚科学会雑誌 = The Japanese journal of dermatology, Dec. 2013 - Two considered cases of lupus erythematosus tumidus with systemic involvement
大田 玲奈; 外川 八英; 中込 大樹; 鎌田 憲明; 神戸 直智; 松江 弘之
臨床皮膚科, 01 Nov. 2013 - 【皮膚真菌症(7)】<臨床例>スリランカ人小児に生じたMicrosporum gypseumによるケルスス禿瘡
秋田 文; 岩澤 真理; 外川 八英; 神戸 直智; 西村 和子; 松江 弘之
皮膚病診療, Nov. 2013 - エタネルセプト、メトトレキサート投与中に敗血症性ショックをきたした丹毒の1例
若林 正一郎; 中野 倫代; 中川 誠太郎; 丸 裕吾; 外川 八英; 鎌田 憲明; 神戸 直智; 松江 弘之
皮膚科の臨床, Oct. 2013 - 序 : 自己炎症症候群の概説と現在提唱されている定義・分類 (特集 自己炎症症候群 : 稀な遺伝性疾患からリウマチ・アレルギー疾患へのメッセージ)
江原 瑞枝; 神戸 直智
アレルギー・免疫, Oct. 2013 - Quantitative Image Analysis Of Articular Involvement In Blau Syndrome By Radiographic Calpal Length and Ultrasound Assessment
Tsuyoshi Yamatou; Tomohiro Kubota; Harumi Akaike; Yuichi Yamasaki; Yukiko Nonaka; Yasuhito Nerome; Tomoko Takezaki; Hiroyuki Imanaka; Kei Ikeda; Naotomo Kambe; Syuji Takei; Tomokazu Nagakura
ARTHRITIS AND RHEUMATISM, Oct. 2013 - エレンタールPを長期使用中の患児に生じた爪の白色変化
佐藤 麻有子; 東山 礼一; 神戸 直智; 村山 圭; 市本 景子; 松江 弘之
日本皮膚科学会雑誌, Sep. 2013 - 転倒による手の外傷を契機に発症した続発性皮膚クリプトコッカス症の1例
山本 洋輔; 外川 八英; 岩澤 真理; 鎌田 憲明; 神戸 直智; 渡邊 正治; 渡辺 哲; 亀井 克彦; 松江 弘之
臨床皮膚科, Aug. 2013 - 免疫グロブリン大量療法を施行し視力障害の改善を認めたChurg-Strauss症候群の1例
高田 紗奈美; 外川 八英; 田島 綾子; 鎌田 憲明; 神戸 直智; 松江 弘之; 牧田 荘平; 細川 淳一; 池田 啓
臨床皮膚科, Jul. 2013 - 千葉茨城県境より受診した皮膚悪性腫瘍の進行例
山本 洋輔; 末廣 敬祐; 丸 裕吾; 鎌田 憲明; 神戸 直智; 松江 弘之
日本皮膚科学会雑誌, Jul. 2013 - 非血縁臍帯血移植後に生じた汗孔角化症の1例
佐藤 麻有子; 若林 正一郎; 神戸 直智; 松江 弘之; 角田 治美
日本皮膚科学会雑誌, May 2013 - Programmed cell death induced by CAPS-associated mutant NLRP3 features necrosis that leads to in vivo neutrophilic inflammation
T. Satoh; N. Kambe; H. Matsue
JOURNAL OF INVESTIGATIVE DERMATOLOGY, May 2013 - A Case of Multiple Fixed Drug Eruption Due to not Only Turmeric but Also Mefenamic Acid
TAKADA Sanami; TOGAWA Yaei; WAKABAYASHI Seiichiro; TAJIMA Ayako; NAKANO Michiyo; KAMADA Noriaki; KAMBE Naotomo; MATSUE Hiroyuki
Journal of environmental dermatology and cutaneous allergology, 30 Apr. 2013 - 【アミロイドーシス(2)】 <臨床例>皮膚限局性結節性アミロイドーシス
林 郁伶; 若林 正一郎; 神戸 直智; 松江 弘之
皮膚病診療, Apr. 2013 - Nocardia brasiliensisによる皮膚ノカルジア症の3例
若林 正一郎; 岩澤 真理; 外川 八英; 宮川 健彦; 鎌田 憲明; 神戸 直智; 松江 弘之; 矢口 貴志; 三上 襄
臨床皮膚科, Apr. 2013 - 強皮症患者の血清マイクロRNAの発現とその役割
田中 繁; 須藤 明; 池田 啓; 眞山 快枝; 中込 大樹; 岩本 太郎; 鈴木 浩太郎; 神戸 直智; 松江 弘之; 松村 竜太郎; 柏熊 大輔; 岩本 逸夫; 中島 裕史
アレルギー, Apr. 2013 - Hypertrophic lichen planusの1例
高田 紗奈美; 若林 正一郎; 外川 八英; 神戸 直智; 松江 弘之
角化症研究会記録集, Mar. 2013 - [The present and the prospect of study on Blau syndrome/early-onset sarcoidosis].
Nakano M; Kambe N
Nihon rinsho. Japanese journal of clinical medicine, 2013, [Reviewed] - 皮膚限局性結節性アミロイドーシスの1例
林 郁伶; 若林 正一郎; 中野 倫代; 神戸 直智; 松江 弘之
日本皮膚科学会雑誌, Nov. 2012 - ステロイド投与中に生じたExophiala oligospermaによる黒色菌糸症の1例
若林 正一郎; 岩澤 真理; 丸 裕吾; 神戸 直智; 松江 弘之; 矢口 貴志
日本皮膚科学会雑誌, Nov. 2012 - 当施設において過去2年間に施行した悪性黒色腫術後DAVFeron療法における副作用調査
山本 洋輔; 末廣 敬祐; 鎌田 憲明; 神戸 直智; 松江 弘之
日本皮膚科学会雑誌, Nov. 2012 - 汎発性色素性扁平苔癬に続発した有棘細胞癌の1例
丸 裕; 末廣 敬祐; 若林 正一郎; 神戸 直智; 松江 弘之
日本皮膚科学会雑誌, Oct. 2012 - Helicobacter cinaediによる再発性蜂窩織炎の1例
林 郁伶; 若林 正一郎; 中野 倫代; 末廣 敬祐; 神戸 直智; 松江 弘之; 若林 華恵; 渡邊 正治; 依田 清江
臨床皮膚科, Sep. 2012 - Programed necrotic cell death caused by NLRP3 activation is dispensable for TLR stimulation
T. Satoh; K. Naotomo; H. Matsue
JOURNAL OF INVESTIGATIVE DERMATOLOGY, Sep. 2012 - Ultrapure soft water improves the skin barrier function of child atopic dermatitis: the first report
Y. Togawa; N. Kambe; N. Shimojo; H. Mochizuki; H. Matsuda; A. Tanaka; H. Matsue
JOURNAL OF INVESTIGATIVE DERMATOLOGY, Sep. 2012 - Critical Role for Mast Cells in IL-1 beta-Driven Skin Inflammation Accompanying a Disease-Associated Nlrp3 Mutation
Y. Nakamura; L. Franchi; N. Kambe; G. Meng; W. Strober; G. Nunez
JOURNAL OF INVESTIGATIVE DERMATOLOGY, Sep. 2012 - 外傷を契機に発症した続発性皮膚クリプトコッカス症の1例
山本 洋輔; 外川 八英; 鎌田 憲明; 神戸 直智; 松江 弘之; 渡邊 正治; 渡辺 哲; 亀井 克彦
日本皮膚科学会雑誌, Aug. 2012 - CASE REPORTS : Intravascular Large B-Cell Lymphoma Diagnosed by Random Skin Biopsy
及川 真喜子; 神戸 直智; 川口 岳晴
皮膚科の臨床, Jul. 2012 - 過去2年間に当施設で経験したエクリン汗孔癌9例のまとめ
山本 洋輔; 末廣 敬祐; 鎌田 憲明; 神戸 直智; 松江 弘之
日本皮膚科学会雑誌, Apr. 2012 - Helicobacter cinaediによる再発性蜂窩織炎の1例
林 郁伶; 中野 倫代; 末廣 敬祐; 神戸 直智; 松江 弘之; 若林 正一郎
日本皮膚科学会雑誌, Mar. 2012 - 最近経験した先天性表皮水疱症の2例
木村 亜矢子; 神戸 直智; 松江 弘之; 夏賀 健; 清水 宏
日本皮膚科学会雑誌, Feb. 2012 - CASE REPORTS : Primary Cutaneous Adenoid Cystic Carcinoma Accompanied with Perineural Invasion
木村 亜矢子; 神戸 直智; 末廣 敬祐
皮膚科の臨床, Jan. 2012 - Peripheral CD14+monocytes from early-onset sarcoidosis associated with NOD2 mutation do not show the molecular signature of NF-kappa B signaling
Naotomo Kambe; Takashi Satoh; Hiroyuki Matsue
JOURNAL OF INVESTIGATIVE DERMATOLOGY, Sep. 2011 - Homopolymerization of ASC using FKBP12 chimeric protein induced rapid cell death accompanied with IL-1 beta processing
Takashi Satoh; Naotomo Kambe; Hiroyuki Matsue
JOURNAL OF INVESTIGATIVE DERMATOLOGY, Sep. 2011 - autoinflammatory disorders NLRP3体細胞モザイクはCINCA症候群の25%以上に認められる
田中 尚子; 井澤 和司; 西小森 隆太; 神戸 直智; 河合 朋樹; 酒井 秀政; 八角 高裕; 平家 俊男
日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, Jun. 2011 - 右上肢のCTCLに対して施行した放射線治療後に生じたStewart-Treves症候群の1例
若林 正一郎; 末廣 敬祐; 秋田 文; 中野 倫代; 鎌田 憲明; 神戸 直智; 松江 弘之; 秋田 新介
日本皮膚科学会雑誌, May 2011 - 抗ヒスタミン薬の投与法を語る
椛島 健治; 神戸 直智; 杉浦 一充; 室田 浩之
皮膚アレルギーフロンティア, Mar. 2011 - Case reports: Phylloid hypomelanosis accompanied with mosaic partial trisomy 13
木村 亜矢子; 神戸 直智; 外川 八英
皮膚科の臨床, Mar. 2011 - Case reports: Successful treatment with topical corticosteroid and cryotherapy on multiple satellites of granuloma telangiectaticum
佐藤 貴史; 神戸 直智; 中村 悠美
皮膚科の臨床, Mar. 2011 - Early-onset sarcoidosis/Blau syndrome
Naotomo Kambe; Takashi Satoh; Michiyo Nakano; Yuumi Nakamura; Hiroyuki Matsue
Japanese Journal of Clinical Immunology, 2011, [Reviewed] - NLRP3体細胞モザイクはChronic infantile neurological cutaneous and articular(CINCA)症候群の約25％に認められる
田中尚子; 井澤和司; 斎藤潤; 作間未織; 大嶋宏一; 小原収; 西小森隆太; 森本剛; 神戸直智; 中畑龍俊; 阿部純也; 酒井秀政; 村田祐樹; 河合朋樹; 八角高裕; 平家俊男
厚生労働省難治性疾患克服研究事業 原発性免疫不全症候群に関する調査研究班班会議, Jan. 2011 - A case of the verrucous type of sporotrichosis on the forehead and the effect of potasium iodide
小野 泰伸; 岩澤 真理; 神戸 直智
臨床皮膚科, Nov. 2010 - IL-1β Secretion Through Inflammasome and Histamine-independent Urticaria
KAMBE Naotomo; SATOH Takashi
Journal of environmental dermatology and cutaneous allergology, 31 Oct. 2010 - Enhanced NF-kappa B activation with NLRP3 activator correlates with disease activities in cryopyrin-associated periodic syndrome
Takashi Satoh; Naotomo Kambe; Hiroyuki Matsue
JOURNAL OF INVESTIGATIVE DERMATOLOGY, Sep. 2010 - 【「分子標的薬」時代へ 投与のコツと副反応のコントロール】 新しい分子標的薬のトピックス IL-1をターゲットとした炎症性皮膚疾患の治療
神戸 直智; 西小森 隆太
Visual Dermatology, Jul. 2010 - The 1st JSID Kisaragi Juku: The junior tutors' perspective.
Kenji Kabashima; Riichiro Abe; Satoshi Hirakawa; Naotomo Kambe; Manabu Ohyama; Manabu Fujimoto
Journal of dermatological science, Jun. 2010, [Reviewed] - A case of plaque type cutaneous sarcoidosis accompanied with multiple molluscum contagiosa
木村 亜矢子; 神戸 直智; 外川 八英
臨床皮膚科, Jun. 2010 - Long-term ICAM-1 and transient PDGF-B expression on PMA-activated THP-1 cells harboring early-onset sarcoidosis/Blau syndrome-associated NOD2 mutations
N. Kanazawa; M. Nishiyama; H. Li; I. Okafuji; N. Kambe; E. Furukawa
JOURNAL OF INVESTIGATIVE DERMATOLOGY, Apr. 2010 - 【子どもの皮膚疾患の診かた】 小児皮膚疾患 色素失調症
西小森 隆太; 河合 朋樹; 内尾 寛子; 神戸 直智; 松村 由美
小児科, Apr. 2010 - 〔Major achievements〕KIT Masters Mast Cells in Kids, Too
Naotomo Kambe; B. Jack Longley; Yoshiki Miyachi; Kenji Kabashima
JOURNAL OF INVESTIGATIVE DERMATOLOGY, Mar. 2010, [Reviewed]
Lead - 低用量メトトレキサートパルス療法を導入した若年発症皮膚型結節性多発動脈炎の1例
冨板 美奈子; 有馬 孝恭; 森田 慶紀; 中野 泰至; 下条 直樹; 河野 陽一; 神戸 直智; 及川 真喜子; 中村 悠美; 松江 弘之
日本小児皮膚科学会雑誌, Nov. 2009 - Cryoglobinaemia type I: serum cryoprecipitate formation at 25 degrees C (vol 33, pg 361, 2008)
Y. Yagi; M. Tanioka; N. Kambe
CLINICAL AND EXPERIMENTAL DERMATOLOGY, Oct. 2009 - Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria (vol 206, pg 1037, 2009)
Yuumi Nakamura; Naotomo Kambe; Megumu Saito; Ryuta Nishikomori; Yun-Gi Kim; Makoto Murakami; Gabriel Nunez; Hiroyuki Matsue
JOURNAL OF EXPERIMENTAL MEDICINE, May 2009 - エタネルセプト投与中に全身に多発する膿疱疹を来した関節リウマチの一例
平松 有希子; 池田 啓; 横田 雅也; 高橋 健太郎; 須藤 明; 加々美 新一郎; 廣瀬 晃一; 渡邊 紀彦; 佐藤 貴史; 神戸 直智; 松江 弘之; 中島 裕史
日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, Mar. 2009 - 自然寛解した父親の病因遺伝子変異を引き継ぎ皮疹を発症した若年発症サルコイドーシスの1例
佐藤 貴史; 中村 悠美; 神戸 直智; 松江 弘之; 西小森 隆太
日本皮膚科学会雑誌, Feb. 2009 - Pathophysiological analysis of cryopyrin-associated periodic syndrome
Kambe N; Nakamura Y; Matsue H
Chiba Medical Journal, 2009, [Reviewed] - A case of idiopathic thrombocytopenic purpura suggesting an initial manifestation of systemic lupus erythematosus
Ayako Shimizu; Naotomo Kambe; Yaei Togawa; Noriaki Kamada; Kentarou Ohki; Minako Tomiita; Hiroyuki Matsue
ARCHIVES OF DERMATOLOGICAL RESEARCH, Jan. 2009 - 【小児疾患診療のための病態生理】 リウマチ性疾患とその周辺疾患 自己炎症症候群
西小森 隆太; 斎藤 潤; 岡藤 郁夫; 神戸 直智
小児内科, Nov. 2008 - 免疫疾患の分子基盤最前線 "CIAS1遺伝子変異陰性"CINCA症候群における潜在性CIAS1遺伝子モザイシズムについて
西小森 隆太; 斎藤 潤; 神戸 直智; 藤澤 章弘; 谷崎 英昭; 中村 悠美; 河合 朋樹; 八角 高裕; 村田 祐樹; 谷風 尚子; 酒井 秀政; 田中 孝之; 平家 俊男; 宮地 良樹; 中畑 龍俊
日本臨床免疫学会会誌, Aug. 2008 - Cryopyrin-associated IL-1 beta secretion in mast cells and a role played by mast cells in auto-inflammatory disorders
Y. Nakamura; N. Kambe; H. Matsue
JOURNAL OF INVESTIGATIVE DERMATOLOGY, Apr. 2008 - Direct development of primate connective tissue-type mast cells from immature state of CD34+hemangioblastic progenitors, independently from the development pathway of mucosal-type mast cells
N. Kambe; F. Ma; T. Nakahata
JOURNAL OF INVESTIGATIVE DERMATOLOGY, Apr. 2008 - A case of early-onset sarcoidosis which showed spontaneous regression of his clinical manifestations but inherited skin eruption to his baby: what should we call this systemic inflammatory granulomatosis associated with NOD2 mutation?
N. Kambe; Y. Nakamura; Okafuji, I; R. Nishikomori; N. Kanazawa; H. Matsue
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, Mar. 2008 - Nationwide surveillance of chronic infantile neurological cutaneous and articular syndrome in Japan
M. Saito; R. Nishikomori; N. Kambe; H. Sakai; T. Kawai; A. Kitano; Y. Takaoka; T. Heike; H. Kanegane; T. Nakahata
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, Mar. 2008 - 【Autoinflammatory syndromes】 CINCA症候群の分子病態 CIAS1変異陰性CINCA症候群におけるCIAS1モザイシズム
西小森 隆太; 神戸 直智; 斎藤 潤; 藤澤 章弘
炎症と免疫, Feb. 2008 - "CIAS1遺伝子変異陰性"CINCA症候群における潜在性CIAS1遺伝子モザイシズムについて
西小森 隆太; 谷風 尚子; 酒井 秀政; 田中 孝之; 平家 俊男; 宮地 良樹; 中畑 龍俊; 斎藤 潤; 神戸 直智; 藤澤 章弘; 谷崎 英昭; 中村 悠美; 河合 朋樹; 八角 高裕; 村田 祐樹
日本臨床免疫学会総会抄録集, 2008 - 【蕁麻疹の分類と臨床 アップデート】 遺伝性蕁麻疹の病態と原因遺伝子
神戸 直智; 中村 悠美; 斎藤 潤; 西小森 隆太
アレルギー・免疫, Oct. 2007 - 本邦におけるブラウ症候群および若年性サルコイドーシス20例の臨床像
岡藤 郁夫; 西小森 隆太; 金澤 伸雄; 神戸 直智; 斎藤 潤; 藤澤 章弘; 谷崎 英昭; 平家 俊男; 宮地 良樹; 中畑 龍俊
日本臨床免疫学会会誌, Aug. 2007 - A Family Case of Cryopyrin-associated Periodic Syndrome
Fujisawa Akihiro; Kambe Naotomo; Saito Megumu; Nishikomori Ryuta; Heike Toshio; Miyachi Yoshiki
The Japanese Journal of Dermatology, Aug. 2007 - 若年発症サルコイドーシスの臨床像とNOD2遺伝子変異の相関
金澤 伸雄; 岡藤 郁夫; 谷崎 英昭; 神戸 直智; 西小森 隆太; 中畑 龍俊; 宮地 良樹
日本臨床分子医学会学術総会プログラム・抄録集, Jul. 2007 - ヒトES細胞から肥満細胞への分化誘導
馬 峰; 辻 浩一郎; 神戸 直智; 海老原 康博; 中内 啓光; 中畑 龍俊
Inflammation and Regeneration, Jul. 2007 - Cryopyrinの疾患関連変異は単球系細胞にカテプシンB依存性細胞死を誘導する
斎藤 潤; 神戸 直智; 平家 俊男; 中畑 龍俊; 宮地 良樹
Inflammation and Regeneration, Jul. 2007 - Muckle-Wells症候群の1家系
藤澤 章弘; 神戸 直智; 宮地 良樹; 斎藤 潤; 西小森 隆太
西日本皮膚科, Jun. 2007 - Monoclonal gammopathy of undetermined significance(MGUS)に合併したクリオグロブリン血症の1例
八木 洋輔; 谷岡 未樹; 神戸 直智; 松村 由美; 是枝 哲; 宇谷 厚志; 宮地 良樹; 加藤 真弓
皮膚の科学, Apr. 2007 - 【最近のトピックス2007 Clinical Dermatology 2007】 最近話題の皮膚疾患 自己炎症性疾患 特徴的な皮膚症状を伴う遺伝性周期熱症候群
谷崎 英昭; 神戸 直智; 西小森 隆太; 金澤 伸雄
臨床皮膚科, Apr. 2007 - Autoinflammatory syndromeの新たなる展開 CINCA症候群におけるCIAS1モザイシズムについて
西小森 隆太; 斉藤 潤; 藤澤 章弘; 神戸 直智; 河合 朋樹; 岡藤 郁夫; 平家 俊男; 宮地 良樹; 中畑 龍俊
日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, Apr. 2007 - クライオピリン関連周期熱症候群の本邦11例における臨床像と遺伝子解析のまとめ
藤澤 章弘; 神戸 直智; 谷崎 英昭; 齋藤 潤; 西小森 隆太; 宮地 良樹
日本皮膚科学会雑誌, Mar. 2007 - 若年発症サルコイドーシス本邦17例における臨床像と遺伝子解析のまとめ
谷崎 英昭; 神戸 直智; 岡藤 郁夫; 西小森 隆太; 金澤 伸雄; 宮地 良樹
日本皮膚科学会雑誌, Mar. 2007 - アムロジンによる湿疹型薬疹1例
峯垣 裕介; 谷岡 未樹; 松村 由美; 是枝 哲; 神戸 直智; 松吉 徳久; 宮地 良樹
皮膚の科学, Feb. 2007 - A successful add-on therapy of hypereosinophilic syndrome with suplatast tosilate
Matsumura Y; Kambe N; Nishigori C; Miyachi Y
Skin Research, 2007, [Reviewed] - Assessment of the therapeutic effect of bepotastine besilate on chronic urticaria using a visual analogue scale (VAS)
Dainichi T; Furue M; Murota H; Katayama I; Kambe N; Miyachi Y; Imafuku S; Terao H
Skin Research, 2007, [Reviewed] - Familial Mediterranean fever: MEFV gene mutations and treatment
Megumu Saito; Ryuta Nishikomori; Naotomo Kambe
Japanese Journal of Clinical Immunology, 2007, [Reviewed] - Necrolytic migratory erythema with hyperglucagonemia and zinc deficiency
Nakahigashi K; Tanioka M; Kambe N; Utani A; Miyachi Y
Skin Research, 2007, [Reviewed] - A Case of Anaphylactic Shock Due to Impurities in a Generic Drug
Tanizaki Hideaki; Kambe Naotomo; Taki Reiko; Matsumura Yumi; Kore-eda Tetsu; Toichi Eiko; Miyachi Yoshiki
The Japanese Journal of Dermatology, 2007 - ウイルス感染と宿主応答・宿主側の要因 CIAS1の活性化あるいは疾患関連変異体によって誘導される細胞死はカテプシンB依存性の急速なネクローシス様細胞死である
藤澤 章弘; 神戸 直智; 齋藤 潤; 西小森 隆太
日本免疫学会総会・学術集会記録, Nov. 2006 - CIAS 1体細胞モザイクによって発症したCINCA症候群に対するanakinraの治療効果
神戸 直智; 藤澤 章弘; 西小森 隆太; 齋藤 潤; 中畑 龍俊; 宮地 良樹
日本小児皮膚科学会雑誌, Nov. 2006 - CINCA(chronic infantile neurological cutaneous and articular)症候群
斎藤 潤; 西小森 隆太; 神戸 直智
リウマチ科, Nov. 2006 - Mutational analysis in neonatal-onset multisystem inflammatory disease: Comment on the articles by Frenkel et al and Saito et al - Reply
Megumu Saito; Akihiro Fujisawa; Ryuta Nishikomori; Naotomo Kambe; Yoshiki Miyachi; Toshio Heike; Tatsutoshi Nakahata
ARTHRITIS AND RHEUMATISM, Aug. 2006, [Reviewed] - 成人性肥満細胞症の1例
江川 裕美; 神戸 直智; 谷岡 未樹; 松村 由美; 是枝 哲; 宮地 良樹
皮膚の科学, Aug. 2006 - Reply [3]
Megumu Saito; Akihiro Fujisawa; Ryuta Nishikomori; Naotomo Kambe; Yoshiki Miyachi; Toshio Heike; Tatsutoshi Nakahata
Arthritis and Rheumatism, Aug. 2006 - ジェネリック医薬品に含まれる有効成分以外の副成分を原因とするアナフィラキシーショックの1例
谷崎 英昭; 瀧 玲子; 神戸 直智; 松村 由美; 是枝 哲; 宮地 良樹; 十一 英子
日本皮膚アレルギー学会総会・日本接触皮膚炎学会総会合同学術大会プログラム・抄録集, Jul. 2006 - Castleman's diseaseの1例
瀧 玲子; 谷岡 未樹; 松村 由美; 是枝 哲; 神戸 直智; 松吉 徳久; 宮地 良樹
皮膚の科学, Jun. 2006 - CINCA症候群の男児例
斎藤 潤; 西小森 隆太; 日詰 真美; 岡藤 郁夫; 吉岡 孝和; 八角 高裕; 楠 隆; 平家 俊男; 中畑 龍俊; 神戸 直智; 藤澤 章弘
日本小児科学会雑誌, Jun. 2006 - Somatic mosaicism of CIAS1 in a patient with chronic infantile neurologic, cutaneous, articular syndrome
M Saito; R Nishikomori; A Fujisawa; N Kambe; MN Hizume; Okafuji, I; T Yoshioka; M Yoshimoto; K Omori; T Kusunoki; T Heike; Y Miyachi; T Nakahata
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Feb. 2006 - Development of tryptase and chymase double positive mature mast cells from cynomolgus monkey embryonic stem cells
N Kambe; F Ma; Y Miyachi; T Nakahata
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Feb. 2006 - 小児科学・医療にブレークスルーをもたらした症例・研究 体細胞モザイクで発症したCINCA症候群の男児
斎藤 潤; 西小森 隆太; 藤澤 章弘; 神戸 直智; 岡藤 郁夫; 吉岡 孝和; 平家 俊男; 宮地 良樹; 中畑 龍俊
日本小児科学会雑誌, Feb. 2006 - 若年発症サルコイドーシスは,ブラウ症候群と同じく,細胞内細菌成分受容体Nod2の機能獲得性変異に基づく遺伝子疾患である
金澤 伸雄; 神戸 直智; 宮地 良樹; 岡藤 郁夫; 日詰 真美; 西小森 隆太; 平家 俊男; 中畑 龍俊; 吉村 長久
日本小児皮膚科学会雑誌, Nov. 2005 - CIAS1の体細胞モザイクにより発症したCINCA症候群例
斎藤 潤; 岡藤 郁夫; 吉岡 孝和; 西小森 隆太; 平家 俊男; 神戸 直智; 楠 隆; 八角 高裕; 片村 憲司; 大森 勝之; 中畑 龍俊
日本免疫学会総会・学術集会記録, Nov. 2005 - Early-onset sarcoidosis is closely related with CARD15 gene mutations causing constitutive nuclear factor-kappa B activation
N Kanazawa; Okafuji, I; N Kambe; R Nishikomori; T Heike; T Nakahata; Y Miyachi
JOURNAL OF INVESTIGATIVE DERMATOLOGY, Sep. 2005 - c-kit遺伝子異常が検出されたdiffuse cutaneous mastocytosisの一女児例
平松 英文; 矢野 潤; 宮崎 真紀; 水嶋 康浩; 松原 央; 小林 道弘; 足立 壮一; 中畑 龍俊; 神戸 直智
日本血液学会・日本臨床血液学会総会プログラム・抄録集, Sep. 2005 - 活性化ヒト肥満細胞による単球由来樹状細胞の成熟とTh2反応の誘導
北脇 年雄; 門脇 則光; 杉本 直志; 神戸 直智; 宮地 良樹; 内山 卓
日本血液学会・日本臨床血液学会総会プログラム・抄録集, Sep. 2005 - Generation of mature tryptase/chymase double positive mast cells from a cynomolgus monkey embryonic stem cells
F Ma; N Kambe; D Wang; G Shinoda; K Umeda; H Suemori; N Nakatsuji; K Tsuji; T Hekei; T Nakahata
EXPERIMENTAL HEMATOLOGY, Jul. 2005 - The Mechanism of Mast Cell Development and Its Pathophysiological Functions
KAMBE Naotomo; MIYACHI Yoshiki; NAKAHATA Tatsutoshi
日本小児血液学会雑誌, 30 Jun. 2005 - 活性化ヒト肥満細胞による単球由来樹状細胞の成熟とTh2反応の誘導
北脇 年雄; 門脇 則光; 杉本 直志; 神戸 直智; 宮地 良樹; 内山 卓
日本リンパ網内系学会会誌, Jun. 2005 - Early‐onset sarcoidosis and NOD2: Summary on genetic analysis of Japanese 10 cases
神戸直智; 西小森隆太; 金沢伸雄; 岡藤郁夫; 藤沢章弘; 平家俊男; 中畑龍俊; 宮地良樹
炎症・再生, 25 May 2005 - Early-onset sarcoidosis and NOD2 : Summary on genetic analysis of Japanese 10 cases
KAMBE Naotomo; NISHIKOMORI Ryuta; KANAZAWA Nobuo; OKAFUJI Ikuo; FUJISAWA Akihiro; HEIKE Toshio; NAKAHATA Tatsutoshi; MIYACHI Yoshiki
Ensho Saisei, 25 May 2005 - CINCA症候群の男児例
齋藤 潤; 西小森 隆太; 日詰 真美; 岡藤 郁夫; 吉岡 孝和; 八角 高裕; 楠 隆; 平家 俊男; 中畑 龍俊; 神戸 直智; 藤澤 章弘
日本小児科学会京都地方会会報, May 2005 - Early-onset sarcoidosis and CARD15 mutations: common genetic etiology with Blau syndrome
Okafuji, I; R Nishikomori; N Kanazawa; N Kambe; M Nakata-Hizume; T Yoshioka; T Heike; Y Miyachi; T Nakahata
FASEB JOURNAL, Mar. 2005 - 若年性サルコイドーシスとCARD15(NOD2)遺伝子異常との関係 本邦での11例の検討
岡藤 郁夫; 西小森 隆太; 金澤 伸雄; 神戸 直智; 吉岡 孝和; 齋藤 潤; 楠 隆; 八角 高裕; 片村 憲司; 平家 俊男; 中畑 龍俊
日本免疫学会総会・学術集会記録, Nov. 2004 - ヒト肥満細胞による樹状細胞の活性化とT細胞反応への影響
北脇 年雄; 杉本 直志; 門脇 則光; 神戸 直智; 内山 卓
日本免疫学会総会・学術集会記録, Nov. 2004 - 全身性疾患としてのサルコイドーシスの周辺疾患と鑑別 Blau症候群とサルコイドーシス(Blau syndrome and sarcoidosis)
金澤 伸雄; 西小森 隆太; 神戸 直智
サルコイドーシス/肉芽腫性疾患, Oct. 2004 - 若年性サルコイドーシス本邦報告8例におけるNod2遺伝子変異の検討
神戸 直智; 西小森 隆太; 金澤 伸雄; 岡藤 郁夫; 藤澤 章弘; 平家 俊男; 中畑 龍俊; 宮地 良樹
炎症・再生, Jul. 2004 - 【膠原病・アレルギー疾患】 若年性サルコイドーシスの1例 CARD15(NOD2)遺伝子の異常との関係
西小森 隆太; 金澤 伸雄; 神戸 直智; 錦織 千佳子; 荒川 明子; 岡藤 郁夫; 日詰 真美; 田辺 晶代; 吉岡 孝和; 片村 憲司; 張 璽; 木村 暢佑; 楠 隆; 平家 俊男; 中畑 龍俊
小児科臨床, Jun. 2004 - 肥満細胞はOX40リガンドの発現を介して同種骨髄移植後の慢性GVHDに関与する
神戸 直智; 松村 由美; 宮地 良樹
日本研究皮膚科学会年次学術大会・総会プログラム, Apr. 2004 - ヒト肥満細胞の増殖に対するトシル酸スプラタストの効果
藤澤 章弘; 神戸 直智; 中畑 龍俊; 宮地 良樹
アレルギー, Mar. 2004 - ヒト肥満細胞のマウス生体内での分化・増殖
神戸 直智; 宮地 良樹; 平松 英文; 中畑 龍俊
アレルギー科, Mar. 2004 - QOL Evaluation of the Atopic Dermatitis Patients who Have Eruption on Their Face by Using Skindex29©Japanese Version (First Report) - QOL improvement after the treatment with the tacrolimus ointment
Kambe N; Kanazawa N; Miyachi Y; Suzukamo Y; Fukuhara S.-I
Skin Research, 2004, [Reviewed] - Treatment of intractable prurigo with roxithromycin: Report of three cases
Okano H; Okunaka M; Shimada H; Mori R; Ikoma A; Kambe N; Nishimura Y; Matsumura Y; Toichi E; Kore-Eda S; Takahashi K; Tachibana T; Miyachi Y
Skin Research, 2004, [Reviewed] - Skindex29日本語版を用いた顔面に皮疹を有するアトピー性皮膚炎患者のQOL評価（第1報）タクロリムス含有軟膏の使用によるQOLの変化
神戸直智; 金澤伸雄; 鈴鴨よしみ; 福原俊一; 宮地良樹
皮膚の科学, 2004, [Reviewed] - What is the physiological function of mast cells? Commentary 9
N Kambe; Y Miyachi
EXPERIMENTAL DERMATOLOGY, Dec. 2003 - Development of both human connective tissue type and mucosal type mast cells in mice from hematopoietic stem cells.
N Kambe; H Hiramatsu; M Ito; T Heike; Y Miyachi; T Nakahata
BLOOD, Nov. 2003 - Expression of gp34(OX40L) on mast cells in GVHD patients
A Kotani; T Hori; N Kanbe; Y Matsumura; K Nagai; T Uchiyama
EXPERIMENTAL HEMATOLOGY, Jul. 2003 - Successful Treatment with Octreotide for Intestinal Pseudoobstruction in Two Patients with Systemic Sclerosis
Sugawara N; Abe M; Tamura A; Ishikawa O; Kambe N
Skin Research, 2003, [Reviewed] - Mastocytosis - Pathomechanism and potential treatment focusing on c-kit
Shimonaka M; Kambe N; Miyachi Y
Skin Research, 2003, [Reviewed] - A case of intravascular large B-cell lymphoma accompanied with generalized telangiectasia
小西 朝子; 神戸 直智; 松村 由美
臨床皮膚科, Dec. 2002 - 結合織型ヒト肥満細胞培養法の確立
神戸 直智; 宮地 良樹; 中畑 龍俊
アレルギー, Oct. 2001 - Serum-free culture conditions expand human mast cells in vitro
N Kambe; M Kambe; LB Schwartz
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Feb. 2001 - Effect of anti-allergic drugs on histamine release from mast cells : Analysis with cord blood-derived human cultured mast cells
KANBE Naotomo; KUROSAWA Motohiro; IGARASHI Yasushi; AMANO Hiroo; MATSUSHIMA Youichiro; MIYACHI Yoshiki
炎症 : 日本炎症学会雑誌 : Japanese journal of inflammation, 31 Mar. 1999 - Cord blood-derived cultured human mast cells constitutively express messenger RNA for transforming growth factor beta(1).
N Kanbe; M Kurosawa; Y Miyachi
JOURNAL OF INVESTIGATIVE DERMATOLOGY, Apr. 1998 - Increased fibroblasts proliferation and type I collagen production under the co-culture with human mast cells.
M Abe; O Ishikawa; M Kurosawa; Y Igarashi; H Amano; N Kanbe; Y Miyachi
JOURNAL OF INVESTIGATIVE DERMATOLOGY, Apr. 1997 - A Case of Interstitial Pneumonia Possibly Induced by Colchicine
Kanbe N; Kurosawa M; Takeuchi Y
Japanese Journal of Chest Diseases, 1996, [Reviewed] - 180 ヒト培養肥満細胞からのサイトカイン産生 : TGF-βを中心に
神戸 直智; 安部 正敏; 天野 博雄; 五十嵐 康; 黒沢 元博; 宮地 良樹; 永田 博史; 斉藤 博久; 中畑 龍俊
アレルギー, 1996 - 644 ヒト培養肥満細胞サブタイプに及ぼす神経成長因子の作用
五十嵐 康; 神戸 直智; 天野 博雄; 黒沢 元博; 宮地 良樹; 斉藤 博久; 飯倉 洋治; 中畑 龍俊; 松田 浩珍
アレルギー, 1995
Research Themes
- Analysis of molecular mechanism of granuloma formation by autoinflammation
Grant-in-Aid for Scientific Research (C)
01 Apr. 2019 - 31 Mar. 2022 - Analysis and development of medical treatment for autoinflammatory diseases
Grant-in-Aid for Scientific Research (A)
Kyoto University
01 Apr. 2011 - 31 Mar. 2014 - Molecular mechanism on granuloma formation based on the analysis with cellular and molecular biology
Grant-in-Aid for Scientific Research (B)
Chiba University
01 Apr. 2011 - 31 Mar. 2014 - Development of CINCA syndrome therapy based upon the pathophysiology of CINCA syndrome elucidated by cytoengineering.
Grant-in-Aid for Scientific Research (B)
Kyoto University
2009 - 2011 - Study on causes and pathophysiology of CINCA syndrome patients without CIAS1 gene mutations
Grant-in-Aid for Scientific Research (C)
Kyoto University
2007 - 2008 - 〔Major achievements〕Molecular mechanism of cell death induced by the activation of intracellular pattern recognition receptor, cryopyrin
Grant-in-Aid for Scientific Research (C)
Chiba University
2007 - 2008
