Last Updated :2025/08/21
Researcher Information
Research activity information
Paper
- Carbon‐ion irradiation together with autophagy inhibition and immune checkpoint inhibitors protect against pancreatic cancer development in mouse model
Makoto Sudo; Yaoyao Wang; Jingren Wang; Koubun Yasuda; Keiko Mitani; Shuhei Hayashi; Masaki Ohmuraya; Hiroko Tsutsui; Jiro Fujimoto
Journal of Hepato-Biliary-Pancreatic Sciences, Apr. 2025, [Reviewed] - Retinoblastoma-binding Protein 9 Suppresses Intestinal Inflammation and Inflammation-induced Tumorigenesis in Mice
Kensuke Hamada; Yuki Nakanishi; Yu Muta; Mayuki Omatsu; Kosuke Iwane; Munehiro Ikeda; Jiayu Chen; Yoko Masui; Naoki Aoyama; Nobukazu Agatsuma; Go Yamakawa; Takahiro Utsumi; Hiroki Kitamoto; Makoto Okabe; Yoshiro Itatani; Takumi Adachi; Koubun Yasuda; Shuji Yamamoto; Akihisa Fukuda; Etsushi Kuroda; Masaki Ohmuraya; Kazutaka Obama; Seiichi Hirota; Hiroki Ikeuchi; Kenji Nakanishi; Hiroshi Seno
Cellular and Molecular Gastroenterology and Hepatology, 2025, [Reviewed] - Bisphenol A triggers activation of ocular immune system and aggravates allergic airway inflammation.
Tatsuo Ueda; Takumi Adachi; Tomoya Hayashi; Koubun Yasuda; Kazufumi Matsushita; Eiko Koike; Rie Yanagisawa; Takahiro Nagatake; Jun Kunisawa; Ken J Ishii; Kenzo Tsuzuki; Etsushi Kuroda
Clinical immunology (Orlando, Fla.), Nov. 2024, [Reviewed] - Recombinant RSV G protein vaccine induces enhanced respiratory disease via IL-13 and mucin overproduction
Eigo Kawahara; Kota Senpuku; Yoshino Kawaguchi; Shinya Yamamoto; Koubun Yasuda; Etsushi Kuroda; Noriko Ouji-Sageshima; Toshihiro Ito; Toshiro Hirai; Takehiko Shibata; Yasuo Yoshioka
npj Vaccines, Oct. 2024, [Reviewed] - RAGE in circulating immune cells is fundamental for hippocampal inflammation and cognitive decline in a mouse model of latent chronic inflammation
Dasen Ye; Akio Miyoshi; Tomoe Ushitani; Manabu Kadoya; Masataka Igeta; Kosuke Konishi; Takuhito Shoji; Koubun Yasuda; Shiho Kitaoka; Hideshi Yagi; Etsushi Kuroda; Yasuhiko Yamamoto; Jidong Cheng; Hidenori Koyama
Brain, Behavior, and Immunity, Feb. 2024, [Reviewed] - Autophagy Inhibition Increased Sensitivity of Pancreatic Cancer Cells to Carbon Ion Radiotherapy.
Makoto Sudo; Hiroko Tsutsui; Shuhei Hayashi; Koubun Yasuda; Keiko Mitani; Nana Iwami; Makoto Anzai; Toshiro Tsubouchi; Mitsuaki Ishida; Sohei Satoi; Tatsuaki Kanai; Seiko Hirono; Etsuro Hatano; Jiro Fujimoto
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Jul. 2023, [Reviewed] - IL-33-induced keratoconjunctivitis is mediated by group 2 innate lymphoid cells in mice.
Yuka Hosotani; Koubun Yasuda; Makoto Nagai; Kiyofumi Yamanishi; Nobuo Kanazawa; Fumi Gomi; Yasutomo Imai
Allergology international : official journal of the Japanese Society of Allergology, Apr. 2023, [Reviewed] - Monitoring Cellular Movement with Photoconvertible Fluorescent Protein and Single-Cell RNA Sequencing Reveals Cutaneous Group 2 Innate Lymphoid Cell Subtypes, Circulating ILC2 and Skin-Resident ILC2
Minori Nakatani-Kusakabe; Koubun Yasuda; Michio Tomura; Makoto Nagai; Kiyofumi Yamanishi; Etsushi Kuroda; Nobuo Kanazawa; Yasutomo Imai
JID Innovations, Sep. 2021, [Reviewed] - Thymic stromal lymphopoietin contributes to protection of mice from Strongyloides venezuelensis infection by CD4+ T cell-dependent and -independent pathways.
Atsuhide Koida; Koubun Yasuda; Takumi Adachi; Kazufumi Matsushita; Makoto Yasuda; Shigeru Hirano; Etsushi Kuroda
Biochemical and biophysical research communications, May 2021, [Reviewed]
Corresponding - Dupilumab Effects on Innate Lymphoid Cell and Helper T Cell Populations in Patients with Atopic Dermatitis
Yasutomo Imai; Minori Kusakabe; Makoto Nagai; Koubun Yasuda; Kiyofumi Yamanishi
JID Innovations, Mar. 2021, [Reviewed] - Lung fibroblasts produce IL-33 in response to stimulation with retinoblastoma-binding protein 9 via production of prostaglandin E2.
Takumi Adachi; Koubun Yasuda; Taichiro Muto; Satoshi Serada; Tomohiro Yoshimoto; Ken J Ishii; Etsushi Kuroda; Kimi Araki; Masaki Ohmuraya; Tetsuji Naka; Kenji Nakanishi
International immunology, Sep. 2020, [Reviewed] - Regnase-1 degradation is crucial for IL-33- and IL-25-mediated ILC2 activation.
Kazufumi Matsushita; Hiroki Tanaka; Koubun Yasuda; Takumi Adachi; Ayumi Fukuoka; Shoko Akasaki; Atsuhide Koida; Etsushi Kuroda; Shizuo Akira; Tomohiro Yoshimoto
JCI insight, Feb. 2020, [Reviewed] - Periostin forms a functional complex with IgA in human serum.
Junya Ono; Masayuki Takai; Ayami Kamei; Satoshi Nunomura; Yasuhiro Nanri; Tomohito Yoshihara; Shoichiro Ohta; Koubun Yasuda; Simon J Conway; Yasuyuki Yokosaki; Kenji Izuhara
Allergology international : official journal of the Japanese Society of Allergology, Jan. 2020, [Reviewed] - Role of eosinophils in protective immunity against secondary nematode infections.
Koubun Yasuda; Etsushi Kuroda
Immunological medicine, Dec. 2019, [Reviewed]
Lead - Anti-interleukin-6 receptor antibody treatment ameliorates postoperative adhesion formation.
Naoki Uyama; Hiroko Tsutsui; Songtao Wu; Koubun Yasuda; Etsuro Hatano; Xian-Yang Qin; Soichi Kojima; Jiro Fujimoto
Scientific reports, Nov. 2019, [Reviewed] - IL-33-Induced Atopic Dermatitis-Like Inflammation in Mice Is Mediated by Group 2 Innate Lymphoid Cells in Concert with Basophils.
Yasutomo Imai; Koubun Yasuda; Makoto Nagai; Minori Kusakabe; Masato Kubo; Kenji Nakanishi; Kiyofumi Yamanishi
The Journal of investigative dermatology, Oct. 2019, [Reviewed] - Interleukin-1/-33 Signaling Pathways as Therapeutic Targets for Endometriosis
Toru Kato; Koubun Yasuda; Kazufumi Matsushita; Ken J Ishii; Seiichi Hirota; Tomohiro Yoshimoto; Hiroaki Shibahara
Frontiers in Immunology, Aug. 2019, [Reviewed]
Corresponding - Interleukin-18 in Health and Disease
Koubun Yasuda; Kenji Nakanishi; Hiroko Tsutsui
International Journal of Molecular Sciences, Feb. 2019, [Reviewed]
Lead - B cells with aberrant activation of Notch1 signaling promote Treg and Th2 cell-dominant T-cell responses via IL-33.
Hiroshi Arima; Momoko Nishikori; Yasuyuki Otsuka; Wataru Kishimoto; Kiyotaka Izumi; Koubun Yasuda; Tomohiro Yoshimoto; Akifumi Takaori-Kondo
Blood advances, Sep. 2018, [Reviewed] - Human cystatin SN is an endogenous protease inhibitor that prevents allergic rhinitis.
Fukuoka A; Matsushita K; Morikawa T; Adachi T; Yasuda K; Kiyonari H; Fujieda S; Yoshimoto T
The Journal of allergy and clinical immunology, Aug. 2018, [Reviewed] - Host responses to intestinal nematodes.
Yasuda K; Nakanishi K
International immunology, Mar. 2018, [Reviewed]
Lead - Nematode-Infected Mice Acquire Resistance to Subsequent Infection With Unrelated Nematode by Inducing Highly Responsive Group 2 Innate Lymphoid Cells in the Lung.
Yasuda K; Adachi T; Koida A; Nakanishi K
Frontiers in immunology, 2018, [Reviewed]
Lead - Ablation of IL-33 gene exacerbate myocardial remodeling in mice with heart failure induced by mechanical stress
Punniyakoti T. Veeraveedu; Shoji Sanada; Keiji Okuda; Hai Ying Fu; Takashr Matsuzaki; Ryo Araki; Masaki Yamato; Koubun Yasuda; Yasushi Sakata; Tomohiro Yoshimoto; Tetsuo Minamino
BIOCHEMICAL PHARMACOLOGY, Aug. 2017, [Reviewed] - Expression of IL-33 in ocular surface epithelium induces atopic keratoconjunctivitis with activation of group 2 innate lymphoid cells in mice
Yasutomo Imai; Yuka Hosotani; Hiroto Ishikawa; Koubun Yasuda; Makoto Nagai; Orie Jitsukawa; Fumi Gomi; Kenji Nakanishi; Tomohiro Yoshimoto; Takahiro Nakamura; Kiyofumi Yamanishi
SCIENTIFIC REPORTS, Aug. 2017, [Reviewed] - Activation of group 2 innate lymphoid cells exacerbates and confers corticosteroid resistance to mouse nasal type 2 inflammation
Taiyo Morikawa; Ayumi Fukuoka; Kazufumi Matsushita; Koubun Yasuda; Naruhito Iwasaki; Shoko Akasaki; Shigeharu Fujieda; Tomohiro Yoshimoto
INTERNATIONAL IMMUNOLOGY, May 2017, [Reviewed] - Allergen endotoxins induce T-cell-dependent and non-IgE-mediated nasal hypersensitivity in mice
Naruhito Iwasaki; Kazufumi Matsushita; Ayumi Fukuoka; Masakiyo Nakahira; Makoto Matsumoto; Shoko Akasaki; Koubun Yasuda; Takeshi Shimizu; Tomohiro Yoshimoto
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Jan. 2017, [Reviewed] - Murine allergic rhinitis and nasal T-h2 activation are mediated via TSLP- and IL-33-signaling pathways
Shoko Akasaki; Kazufumi Matsushita; Yukinori Kato; Ayumi Fukuoka; Naruhito Iwasaki; Masakiyo Nakahira; Shigeharu Fujieda; Koubun Yasuda; Tomohiro Yoshimoto
INTERNATIONAL IMMUNOLOGY, Feb. 2016, [Reviewed] - Epithelial-derived nuclear IL-33 aggravates inflammation in the pathogenesis of reflux esophagitis
Jing Shan; Tadayuki Oshima; Taichiro Muto; Koubun Yasuda; Hirokazu Fukui; Jiro Watari; Kenji Nakanishi; Hiroto Miwa
JOURNAL OF GASTROENTEROLOGY, Apr. 2015, [Reviewed] - Immediate-type contact hypersensitivity is reduced in interleukin-33 knockout mice
Yasutomo Imai; Koubun Yasuda; Yoshiko Sakaguchi; Shizue Futatsugi-Yumikura; Tomohiro Yoshimoto; Kenji Nakanishi; Kiyofumi Yamanishi
JOURNAL OF DERMATOLOGICAL SCIENCE, May 2014, [Reviewed] - Importance of both innate immunity and acquired immunity for rapid expulsion of S-venezuelensis
Koubun Yasuda; Makoto Matsumoto; Kenji Nakanishi
FRONTIERS IN IMMUNOLOGY, Mar. 2014, [Reviewed]
Lead - Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice
Yasutomo Imai; Koubun Yasuda; Yoshiko Sakaguchi; Takashi Haneda; Hitoshi Mizutani; Tomohiro Yoshimoto; Kenji Nakanishi; Kiyofumi Yamanishi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Aug. 2013, [Reviewed] - IgG and IgE Collaboratively Accelerate Expulsion of Strongyloides venezuelensis in a Primary Infection
Makoto Matsumoto; Yuki Sasaki; Koubun Yasuda; Toshiyuki Takai; Masamichi Muramatsu; Tomohiro Yoshimoto; Kenji Nakanishi
INFECTION AND IMMUNITY, Jul. 2013, [Reviewed] - Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice
Koubun Yasuda; Taichiro Muto; Tatsukata Kawagoe; Makoto Matsumoto; Yuki Sasaki; Kazufumi Matsushita; Yuko Taki; Shizue Futatsugi-Yumikura; Hiroko Tsutsui; Ken J. Ishii; Tomohiro Yoshimoto; Shizuo Akira; Kenji Nakanishi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Feb. 2012, [Reviewed]
Lead - The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection
Takashi Satoh; Osamu Takeuchi; Alexis Vandenbon; Koubun Yasuda; Yoshiaki Tanaka; Yutaro Kumagai; Tohru Miyake; Kazufumi Matsushita; Toshihiko Okazaki; Tatsuya Saitoh; Kiri Honma; Toshifumi Matsuyama; Katsuyuki Yui; Tohru Tsujimura; Daron M. Standley; Kenji Nakanishi; Kenta Nakai; Shizuo Akira
NATURE IMMUNOLOGY, Oct. 2010, [Reviewed] - Neutrophil-dominant psoriasis-like skin inflammation induced by epidermal-specific expression of Raf in mice (vol 58, pg 28, 2010)
Masahito Tarutani; Yasutomo Imai; Koubun Yasuda; Hiroko Tsutsui; Kenji Nakanishi; Kiyofumi Yamanishi
JOURNAL OF DERMATOLOGICAL SCIENCE, Jul. 2010, [Reviewed] - Contribution of IL-18 to eosinophilic airway inflammation induced by immunization and challenge with Staphylococcus aureus proteins
Mai Kuroda-Morimoto; Hidehisa Tanaka; Nobuki Hayashi; Masakiyo Nakahira; Yasutomo Imai; Michiko Imamura; Koubun Yasuda; Shizue Yumikura-Futatsugi; Kiyoshi Matsui; Toshihiro Nakashima; Kazuhisa Sugimura; Hiroko Tsutsui; Hajime Sano; Kenji Nakanishi
INTERNATIONAL IMMUNOLOGY, Jul. 2010, [Reviewed] - Neutrophil-dominant psoriasis-like skin inflammation induced by epidermal-specific expression of Raf in mice (vol 58, pg 28, 2010)
Masahito Tarutani; Yasutomo Imai; Koubun Yasuda; Hiroko Tsutsui; Kenji Nakanishi; Kiyofumi Yamanishi
JOURNAL OF DERMATOLOGICAL SCIENCE, Jul. 2010, [Reviewed] - Contribution of IL-33 to induction and augmentation of experimental allergic conjunctivitis
Saori Matsuba-Kitamura; Tomohiro Yoshimoto; Koubun Yasuda; Shizue Futatsugi-Yumikura; Yuuko Taki; Taichiro Muto; Tomohiro Ikeda; Osamu Mimura; Kenji Nakanishi
INTERNATIONAL IMMUNOLOGY, Jun. 2010, [Reviewed] - Neutrophil-dominant psoriasis-like skin inflammation induced by epidermal-specific expression of Raf in mice
Masahito Tarutani; Yasutomo Imai; Koubun Yasuda; Hiroko Tsutsui; Kenji Nakanishi; Kiyofumi Yamanishi
JOURNAL OF DERMATOLOGICAL SCIENCE, Apr. 2010, [Reviewed] - IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation (vol 179, pg 4415, 2007)
T. Yoshimoto; K. Yasuda; J. Mizuguchi; K. Nakanishi
JOURNAL OF IMMUNOLOGY, Mar. 2010, [Reviewed] - Contribution of TIR domain-containing adapter inducing IFN-beta-mediated IL-18 release to LPS-induced liver injury in mice
Michiko Imamura; Hiroko Tsutsui; Koubun Yasuda; Ryosuke Uchiyama; Shizue Yumikura-Futatsugi; Keiko Mitani; Shuhei Hayashi; Shizuo Akira; Shun-ichiro Taniguchi; Nico Van Rooijen; Jurg Tschopp; Tetsuya Yamamoto; Jiro Fujimoto; Kenji Nakanishi
JOURNAL OF HEPATOLOGY, Aug. 2009, [Reviewed] - Basophils contribute to T(H)2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4(+) T cells
Tomohiro Yoshimoto; Koubun Yasuda; Hidehisa Tanaka; Masakiyo Nakahira; Yasutomo Imai; Yoshihiro Fujimori; Kenji Nakanishi
NATURE IMMUNOLOGY, Jul. 2009, [Reviewed] - Association of serum interleukin-33 level and the interleukin-33 genetic variant with Japanese cedar pollinosis
M. Sakashita; T. Yoshimoto; T. Hirota; M. Harada; K. Okubo; Y. Osawa; S. Fujieda; Y. Nakamura; K. Yasuda; K. Nakanishi; M. Tamari
CLINICAL AND EXPERIMENTAL ALLERGY, Dec. 2008, [Reviewed] - Freshly isolated Langerhans cells negatively regulate naive T cell activation in response to peptide antigen through cell-to-cell contact
Yasutomo Imai; Nobuki Hayashi; Koubun Yasuda; Hiroko Tsutsui; Hitoshi Mizutani; Kenji Nakanishi
JOURNAL OF DERMATOLOGICAL SCIENCE, Jul. 2008, [Reviewed] - Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system
Yuichi Kondo; Tomohiro Yoshimoto; Koubun Yasuda; Shizue Futatsugi-Yumikura; Mai Morimoto; Nobuki Hayashi; Tomoaki Hoshino; Jiro Fujimoto; Kenji Nakanishi
INTERNATIONAL IMMUNOLOGY, Jun. 2008, [Reviewed] - IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: A novel therapeutic way for Th2-mediated allergic inflammation
Tomohiro Yoshimoto; Takayuki Yoshimoto; Koubun Yasuda; Junichiro Mizuguchi; Kenji Nakanishi
JOURNAL OF IMMUNOLOGY, Oct. 2007, [Reviewed] - Type 1 cytokine/chemokine production by mouse NK cells following activation of their TLR/MyD88-mediated pathways
Junko Sawaki; Hiroko Tsutsui; Nobuki Hayashi; Koubun Yasuda; Shizuo Akira; Takakuni Tanizawa; Kenji Nakanishi
INTERNATIONAL IMMUNOLOGY, Mar. 2007, [Reviewed] - Contribution of IL-18 to atopic-dermatitis-like skin inflammation induced by Staphylocloccus aureus product in mice
M Terada; H Tsutsui; Y Imai; K Yasuda; H Mizutani; K Yamanishi; M Kubo; K Matsui; H Sano; K Nakanishi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jun. 2006, [Reviewed] - ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules
M Yamamoto; K Yaginuma; H Tsutsui; J Sagara; Guan, X; E Seki; K Yasuda; M Yamamoto; S Akira; K Nakanishi; T Noda; S Taniguchi
GENES TO CELLS, Nov. 2004, [Reviewed] - Persistent secretion of IL-18 in the skin contributes to IgE response in mice
H Nakano; H Tsutsui; M Terada; K Yasuda; K Matsui; S Yumikura-Futatsugi; K Yamanaka; H Mizutani; T Yamamura; K Nakanishi
INTERNATIONAL IMMUNOLOGY, May 2003, [Reviewed] - Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells
K Yasuda; M Nagafuku; T Shima; M Okada; T Yagi; T Yamada; Y Minaki; A Kato; S Tani-ichi; T Hamaoka; A Kosugi
JOURNAL OF IMMUNOLOGY, Sep. 2002, [Reviewed]
Lead - Involvement of SHP-1 tyrosine phosphatase in TCR-mediated signaling pathways in lipid rafts
A Kosugi; J Sakakura; K Yasuda; M Ogata; T Hamaoka
IMMUNITY, Jun. 2001, [Reviewed] - A pivotal role of cysteine 3 of Lck tyrosine kinase for localization to glycolipid-enriched microdomains and T cell activation
A Kosugi; F Hayashi; DR Liddicoat; K Yasuda; S Saitoh; T Hamaoka
IMMUNOLOGY LETTERS, Mar. 2001, [Reviewed] - Serine 6 of Lck tyrosine kinase: A critical site for Lck myristoylation, membrane localization, and function in T lymphocytes
K Yasuda; A Kosugi; F Hayashi; S Saitoh; M Nagafuku; Y Mori; M Ogata; T Hamaoka
JOURNAL OF IMMUNOLOGY, Sep. 2000, [Reviewed]
Lead - The role of lipid rafts in T cell receptor (TCR) signaling
Yasuda K; Kosugi A
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2000 - GEM/Raftを介したT細胞活性化機構(III) 変異型Lck分子のGEM/Raftへの局在
林 文枝; 安田 好文; 斉藤 伸一郎; 永福 正和; 榎本 美貴; 濱岡 利之; 小杉 厚
日本免疫学会総会・学術集会記録, Oct. 1999 - Translocation of tyrosine-phosphorylated TCR zeta chain to glycolipid-enriched membrane domains upon T cell activation
A Kosugi; S Saitoh; S Noda; K Yasuda; F Hayashi; M Ogata; T Hamaoka
INTERNATIONAL IMMUNOLOGY, Sep. 1999, [Reviewed] - 膜結合型セマフォリン分子(CD100/MSG)の機能解析 II.リンパ球におけるその受容体の発現の検討
武田 久仁子; 小杉 厚; 斉藤 伸一郎; 木村 恵利香; 藤井 智美; 安田 好文; 古山 達雄; 稲垣 忍; 濱岡 利之
日本臨床免疫学会会誌, Oct. 1998 - A monogalactopyranosyl acylglycerol from Oltmannsiellopsis unicellularis (NIES-359)
MC Rho; K Yasuda; K Matsunaga; Y Ohizumi
PHYTOCHEMISTRY, Apr. 1997, [Reviewed] - A sulfonoglycolipid with Na+, K+-ATPase inhibitory activity, produced by a cultured unique diatom symbiot isolated from a larger foraminifera
MC Rho; K Matsunaga; YH Park; K Yasuda; T Yamasu; S Mayama; Y Ohizumi
PLANTA MEDICA, Dec. 1996, [Reviewed] - A novel inhibitor of platelet aggregation from the Cyanophyceae Oscillatoria rosea (NIES-208)
MC Rho; K Matsunaga; K Yasuda; Y Ohizumi
PLANTA MEDICA, Oct. 1996, [Reviewed] - A novel monogalactosylacylglycerol with inhibitory effect on platelet aggregation from the cyanophyceae Oscillatoria rosea
MC Rho; K Matsunaga; K Yasuda; Y Ohizumi
JOURNAL OF NATURAL PRODUCTS, Mar. 1996, [Reviewed]
MISC
- カスパーゼ1/11が、IL-33の分泌を制御してIL-33誘導性アトピー性皮膚炎の増悪に関与するかもしれない
草壁 みのり; 今井 康友; 安田 好文; 永井 諒; 山西 清文
日本皮膚免疫アレルギー学会雑誌, Oct. 2018 - タクロリムスは2型自然リンパ球が産生するTh2サイトカインの産生を抑制する
細谷 友雅; 今井 康友; 石川 裕人; 安田 好文; 永井 諒; 實川 織江; 中西 憲司; 善本 知広; 山西 清文; 五味 文
日本眼科学会雑誌, Mar. 2018 - A unique DAMP with IL-33-inducing activity increases IL-33-expressing alveolar epithelial type II cells in lungs and induces primary cultured fibroblasts to produce IL-33 in vitro
Takumi Adachi; Koubun Yasuda; Taichiro Muto; Satoshi Serada; Tomohiro Yoshimoto; Tetsuji Naka; Kenji Nakanishi
CYTOKINE, Dec. 2017 - 角粘膜上皮の過剰なIL-33はアトピー性角結膜炎を誘導する
今井 康友; 細谷 友雅; 石川 裕人; 安田 好文; 永井 諒; 實川 織江; 五味 文; 中西 憲司; 善本 知広; 中村 隆宏; 山西 清文
アレルギー, May 2017 - アトピー性角結膜炎モデルとしてのIL-33過剰産生遺伝子改変マウスの有用性
細谷 友雅; 今井 康友; 石川 裕人; 中村 隆宏; 安田 好文; 永井 諒; 實川 織江; 中西 憲司; 善本 知広; 山西 清文; 五味 文
日本眼科学会雑誌, Mar. 2017 - IL-33を表皮で過剰に発現するマウスのアトピー性皮膚炎の発症には好塩基球も関与している
今井 康友; 安田 好文; 山本 雅章; 羽田 孝司; 永井 諒; 善本 知広; 山西 清文
Journal of Environmental Dermatology and Cutaneous Allergology, Oct. 2016 - Skin-specific expression of IL-33 causes atopic dermatitis-like inflammation with activation of group 2 innate lymphoid cells in mice
Y. Imai; K. Yasuda; H. Mizutani; T. Yoshimoto; K. Nakanishi; K. Yamanishi
JOURNAL OF INVESTIGATIVE DERMATOLOGY, May 2014 - Esophageal Epithelial-Derived IL-33 Acts As an Exaggerator of Inflammation in the Pathogenesis of GERD
Tadayuki Oshima; Jing Shan; Taichiro Muto; Koubun Yasuda; Hirokazu Fukui; Jiro Watari; Kenji Nakanishi; Hiroto Miwa
GASTROENTEROLOGY, May 2014 - IL-33 KO mice exhibit the reduced immediate type contact hypersensitivity
Y. Imai; T. Haneda; K. Yasuda; T. Yoshimoto; K. Nakanishi; K. Yamanishi
JOURNAL OF INVESTIGATIVE DERMATOLOGY, May 2013 - Neutrophil-dominant psoriasis-like skin inflammation induced by epidermal-specific expression of Raf in mice (vol 58, pg 28, 2010)
Masahito Tarutani; Yasutomo Imai; Koubun Yasuda; Hiroko Tsutsui; Kenji Nakanishi; Kiyofumi Yamanishi
JOURNAL OF DERMATOLOGICAL SCIENCE, Jul. 2010 - 表皮ランゲルハンス細胞はペプチド抗原によるナイーブT細胞の活性化を細胞間相互作用によって抑制する
今井 康友; 林 伸樹; 安田 好文; 筒井 ひろ子; 水谷 仁; 中西 憲司
Inflammation and Regeneration, Jul. 2008 - 「免疫難病・感染症等の先進医療技術」「IL‐18を標的とした自然型アトピー症の治療戦略」新規DC免疫法:抗原とアジュバントでパルスした樹状細胞はナイーブマウスに迅速かつ顕著なTh2応答を誘導する
今井康友; 今井康友; 安田好文; 今村美智子; 林伸樹; 善本知広; 山西清文; 筒井ひろ子; 水谷仁; 中西憲司
免疫難病・感染症等の先進医療技術 第5回(最終)公開シンポジウム要旨集 平成20年, 2008 - Contribution of TRIF to secretion of mature IL-1 beta and IL-18 via the TLR-mediated caspase-1 activation during extracellular bacterial infection in mice
Michiko Imamura; Koubun Yasuda; Jiro Fujimoto; Shizuo Akira; Hiroko Tsutsui; Kenji Nakanishi
HEPATOLOGY, Oct. 2007 - 376 マウスに移入された抗原とAlumでパルスされたDCはTh2細胞をCaspase-1非依存性に誘導する(抗原提示細胞1,一般演題(デジタルポスター),第57回日本アレルギー学会秋季学術大会)
今井 康友; 安田 好文; 林 伸樹; 松本 真琴; 善本 知広; 水谷 仁; 中西 憲司
アレルギー, 30 Sep. 2007 - ナイーブマウスに移入された抗原とAlumでパルスされたDCはTh2細胞をCaspase-1非依存性に誘導する
今井 康友; 安田 好文; 林 伸樹; 松本 真琴; 善本 知広; 水谷 仁; 中西 憲司
日本臨床免疫学会会誌, Aug. 2007 - Lipid raftを介したT細胞活性化においてLckのキナーゼ活性は必要か
加藤 彰子; 永福 正和; 安田 好文; 皆木 康子; 濱岡 利之; 小杉 厚
日本免疫学会総会・学術集会記録, Dec. 2001 - T細胞の活性化と脂質マイクロドメイン(GEM)(III) GEMにおけるLck及びFynの活性の変化
安田 好文; 小杉 厚; 永福 正和; 皆木 康子; 岡田 雅人; 濱岡 利之
日本免疫学会総会・学術集会記録, Nov. 2000 - GEM/Raftを介したT細胞活性化機構(IV) リン酸化CD3ζ鎖のGEM/Raftへの単独での移行
安田 好文; 小杉 厚; 林 文枝; 永福 正和; 榎本 美貴; 濱岡 利之
日本免疫学会総会・学術集会記録, Oct. 1999 - Signal transduction of a T cell receptor in membrane lipid microdomains.
野田敏司; 斉藤伸一郎; 安田好文; 林文枝; 小杉厚
臨床免疫, Feb. 1999 - A role of DIG fraction in TCR signal transduction: Localization of phosphorylated CD3-zeta and activated lck in DIG on T cell activation
A Kosugi; SI Saitoh; S Noda; K Yasuda; F Hayashi; T Hamaoka
MOLECULAR BIOLOGY OF THE CELL, Nov. 1998 - TCRシグナル伝達における可溶化剤不溶性細胞膜DIG画分の役割(1) T細胞活性化に伴うリン酸化CD3ζと活性型Lck分子の局在
安田 好文; 小杉 厚; 斉藤 伸一郎; 野田 敏司; 濱岡 利之
日本臨床免疫学会会誌, Oct. 1998 - TCRシグナル伝達における可溶化剤不溶性細胞膜DIG画分の役割(2) 変異型Lck分子を用いた解析
林 文枝; 安田 好文; 斉藤 伸一郎; 野田 敏司; 濱岡 利之; 小杉 厚
日本臨床免疫学会会誌, Oct. 1998 - 膜結合型セマフォリン分子(CD100/MSG)の機能解析 II. リンパ球におけるその受容体の発現の検討
武田久仁子; 小杉厚; 斉藤伸一郎; 木村恵利香; 藤井智美; 安田好文; 古山達雄; 稲垣忍; 浜岡利之
日本免疫学会総会・学術集会記録, 1998
Affiliated academic society
Research Themes
- Highly reactive ILC2s in the lungs of Strongyloides venezuelensis infection-experienced mice
Grant-in-Aid for Scientific Research (C)
Hyogo Medical University
01 Apr. 2017 - 31 Mar. 2020 - IL-33R(+) cells and atopic dermatitis
Grant-in-Aid for Young Scientists (B)
Hyogo Medical University
01 Apr. 2017 - 31 Mar. 2019 - Elucidation of immunological onset mechanism of endometriosis and search for preventive/therapeutic techniques
Grant-in-Aid for Challenging Research (Exploratory)
Hyogo Medical University
30 Jun. 2017 - 31 Mar. 2018 - Elucidation of the mechanism of percutaneous sensitized food allergy and development of its control method
Grant-in-Aid for Scientific Research (B)
Hyogo Medical University
01 Apr. 2015 - 31 Mar. 2018 - A role of Loeffler syndrome in Strongyloides-infected mice.
Grant-in-Aid for Scientific Research (C)
Hyogo Medical University
01 Apr. 2013 - 31 Mar. 2016 - Analysis of pollen-driven endogenous IL-33 and basophils in allergic rhinitis manifestation
Grant-in-Aid for Scientific Research (B)
Hyogo Medical University
01 Apr. 2012 - 31 Mar. 2015 - Protective effect of granular leukocytes on host defense against intestinal nematode infection
Grant-in-Aid for Scientific Research (A)
Hyogo Medical University
01 Apr. 2011 - 31 Mar. 2014 - Role of hapten-specific IgE in allergen diversification
Grant-in-Aid for Young Scientists (B)
Hyogo Medical University
2011 - 2012 - Roles of basophils in the inductions of Th2 cells and allergy
Grant-in-Aid for Scientific Research (B)
Hyogo Medical University
2009 - 2011 - Analysis of IL-18-induced type-1 bronchial asthma
Grant-in-Aid for Scientific Research (B)
Hyogo College of Medicine
2004 - 2005 - Treatment of endotoxin-induced tissue damages by the negative regulation of TLR-mediated signal pathways
Grant-in-Aid for Scientific Research (B)
HYOGO COLLEGE OF MEDICINE
2003 - 2004 - The protective roles of IL-18 in host defense against gastro-intestinal nematode infection by in duction of Th2 responses.
Grant-in-Aid for Scientific Research (B)
Hyogo College of Medicine
2002 - 2003 - IL-33の働き
